Pdia3 (protein disulfide isomerase family A member 3)

Gene: Pdia3 (protein disulfide isomerase family A member 3) Ictidomys tridecemlineatus

Analyze

Symbol:

Pdia3

Name:

protein disulfide isomerase family A member 3

RGD ID:

12728336

Description:

ENCODES a protein that exhibits MHC class I protein binding (ortholog); peptidase activity (ortholog); protein-disulfide reductase (glutathione) activity (ortholog); INVOLVED IN cellular response to interleukin-7 (ortholog); cellular response to nonylphenol (ortholog); cellular response to transforming growth factor beta stimulus (ortholog); ASSOCIATED WITH Acute Coronary Syndrome (ortholog); asphyxia neonatorum (ortholog); autoimmune hepatitis (ortholog); FOUND IN acrosomal vesicle (ortholog); apical plasma membrane (ortholog); cell surface (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	88,961,177 - 88,986,202 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	6,809,195 - 6,836,169 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936471	6,809,181 - 6,834,189 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Coronary Syndrome (ISO)

asphyxia neonatorum (ISO)

autoimmune hepatitis (ISO)

autosomal recessive nonsyndromic deafness 16 (ISO)

Bloom syndrome (ISO)

colorectal cancer (ISO)

Dehydration (ISO)

disease of cellular proliferation (ISO)

hepatocellular carcinoma (ISO)

intellectual disability (ISO)

irritable bowel syndrome (ISO)

liver cirrhosis (ISO)

Myocardial Reperfusion Injury (ISO)

post-traumatic stress disorder (ISO)

Prostatic Neoplasms (ISO)

pulmonary hypertension (ISO)

scrapie (ISO)

Sensorineural Deafness and Male Infertility (ISO)

spinocerebellar ataxia type 17 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to interleukin-7 (IEA,ISO)

cellular response to nonylphenol (ISO)

cellular response to transforming growth factor beta stimulus (ISO)

cellular response to vitamin D (ISO)

circadian rhythm (ISO)

extrinsic apoptotic signaling pathway (IEA,ISO)

peptide antigen assembly with MHC class I protein complex (IEA)

platelet aggregation (IEA,ISO)

positive regulation of extrinsic apoptotic signaling pathway (IEA,ISO)

positive regulation of protein folding (ISO)

protein folding (IEA)

response to benzene (ISO)

response to endoplasmic reticulum stress (IEA)

response to ethanol (ISO)

response to genistein (ISO)

response to hyperoxia (ISO)

response to hypoxia (ISO)

response to ischemia (ISO)

response to leptin (ISO)

response to nutrient levels (ISO)

Cellular Component

acrosomal vesicle (ISO)

apical plasma membrane (ISO)

cell surface (IEA,ISO)

endoplasmic reticulum (IEA)

endoplasmic reticulum lumen (IEA)

extracellular region (ISO)

extracellular space (IEA,ISO)

melanosome (IEA)

MHC class I peptide loading complex (IEA)

smooth endoplasmic reticulum (ISO)

TAP complex (ISO)

Tapasin-ERp57 complex (IEA,ISO)

Molecular Function

identical protein binding (IEA)

isomerase activity (IEA)

MHC class I protein binding (ISO)

peptidase activity (ISO)

protein binding (ISO)

protein disulfide isomerase activity (IEA)

protein-disulfide reductase (glutathione) activity (ISO)

protein-disulfide reductase activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Pdia3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	88,961,177 - 88,986,202 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	6,809,195 - 6,836,169 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936471	6,809,181 - 6,834,189 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PDIA3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	43,746,438 - 43,773,278 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	43,746,394 - 43,773,279 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	44,038,636 - 44,065,476 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	41,825,882 - 41,852,096 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	15	20,928,053 - 20,954,266 (+)	NCBI		Celera
Cytogenetic Map	15	q15.3	NCBI
HuRef	15	20,861,356 - 20,887,666 (+)	NCBI		HuRef
CHM1_1	15	44,156,851 - 44,183,060 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	15	41,553,795 - 41,580,638 (+)	NCBI		T2T-CHM13v2.0

Pdia3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	121,244,383 - 121,269,168 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	121,244,256 - 121,269,168 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	121,413,902 - 121,438,687 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	121,413,775 - 121,438,687 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	121,239,638 - 121,264,423 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	121,105,401 - 121,129,421 (+)	NCBI		MGSCv36	mm8
Celera	2	122,564,601 - 122,589,381 (+)	NCBI		Celera
Cytogenetic Map	2	E5	NCBI
cM Map	2	60.38	NCBI

Pdia3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	128,841,781 - 128,865,733 (+)	NCBI		GRCr8
mRatBN7.2	3	108,388,189 - 108,412,013 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	108,388,245 - 108,413,236 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	112,062,478 - 112,086,451 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	120,657,999 - 120,681,970 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	118,318,399 - 118,342,371 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	113,376,983 - 113,400,707 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	113,376,983 - 113,400,707 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	119,916,772 - 119,940,826 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	108,216,414 - 108,240,138 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	108,117,203 - 108,140,928 (+)	NCBI
Celera	3	107,289,603 - 107,313,229 (+)	NCBI		Celera
Cytogenetic Map	3	q35	NCBI

Pdia3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955416	10,198,099 - 10,220,792 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955416	10,197,957 - 10,221,104 (+)	NCBI	ChiLan1.0	ChiLan1.0

PDIA3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	32,997,271 - 33,023,322 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	37,158,999 - 37,185,059 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	22,706,520 - 22,731,672 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	40,794,144 - 40,821,615 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	40,794,144 - 40,821,763 (+)	Ensembl	panpan1.1		panPan2

PDIA3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	10,487,926 - 10,513,437 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	30	10,487,921 - 10,513,397 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	10,546,317 - 10,571,800 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	10,624,436 - 10,649,938 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	10,624,468 - 10,651,817 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	10,533,603 - 10,559,083 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	10,655,339 - 10,680,999 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	10,775,223 - 10,800,728 (+)	NCBI		UU_Cfam_GSD_1.0

PDIA3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	127,785,772 - 127,814,196 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	127,786,174 - 127,814,096 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	142,615,686 - 142,643,747 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PDIA3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	39,273,982 - 39,300,170 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	39,272,997 - 39,349,966 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	101,691,336 - 101,717,748 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pdia3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624804	10,755,103 - 10,784,337 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624804	10,754,978 - 10,784,641 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005316493	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010003700	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000006894 ⟹ ENSSTOP00000006163

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936471	6,809,195 - 6,836,169 (+)	Ensembl

RefSeq Acc Id:

XM_005316493 ⟹ XP_005316550

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024408640	88,961,177 - 88,986,202 (+)	NCBI
SpeTri2.0	NW_004936471	6,809,181 - 6,834,189 (+)	NCBI

Sequence:

show sequence

GGCCCGAGCCGGGCTAGGGGGTTGGGACCTCCGGCTGCAGGTCCGCTTGGGCTAGACGCGCGAG
CACTGGCAGCCGGTGCGTGGTAGTCGGCTCGATCTCCGCAGCCCCCGCCGAGCCCCGACCCTCC
CGGCCGCCCTCGCCTCACTTCGCCGCCATGCGCCTCCGCCGCCTAGCGCCGTTCCCGGGTGTGG
CGCTTCTCCTAGCCGCGGCCCGCCTTGCTGCTGCCTCCGACGTGCTGGAACTCACGGACGCCAA
CTTCGAGAGTCGCATCTCCGACACGGGCTCTGCCGGCCTCATGCTCGTCGAGTTCTTCGCGCCC
TGGTGTGGACATTGCAAAAGGCTTGCTCCTGAGTATGAAGCTGCAGCTACCAGATTAAAAGGAA
TAGTTCCACTAGCAAAGGTTGATTGCACTGCCAACACAGAGACCTGTAATAAGTATGGGGTCAG
TGGCTATCCAACCCTGAAGATATTTAGAGATGGTGAAGAAGCAGGTGCTTATGATGGGCCTAGG
ACTGCTGATGGAATTGTTAGCCACCTGAAGAAGCAGGCAGGACCCGCTTCAGTGCCTCTTAGGA
CTGAGGAAGAATTCAAGAAGTTCATTAGTGATAAAGATGCCTCTGTGGTGGGTTTTTTCAAGGA
TTTATTCAGTGAAGCGCACTCTGAGTTCCTAAAAGCAGCCAACAACTTGAGGGATAACTACCGA
TTTGCACACACCAATGTTGAATCTCTGGTGAAGGAGTATGATGATAATGGAGAGGGCATCACCT
TATTTCGTCCTCCACATCTTACTAACAAGTTTGAGGACAAAAGTGTGGCATATACAGATCAGAA
ATTGACTAGCAGCAAGATTAAGAAGTTTATCCAGGAAAACATTTTTGGTATCTGTCCTCATATG
ACAGAAGATAATAAAGATTTGATACAAGGCAAGGACTTACTTATGGCTTACTATGATGTGGACT
ATGAAAAGAATGCTAAAGGTTCTAACTACTGGAGGAACAGAGTAATGATGGTGGCAAAGAAATT
CCTGGATGCTGGACACAAACTCAACTGTGCTGTAGCTAGCCGTAAAACCTTTAGCCATGAATTG
TCTGATTTTGGCTTGGAGAGCACTACTGGAGAAGTTCCTGTTGTTGCTATCAGAACTGCGAAAG
GGGAGAAGTTTGTCATGCAGGAGGAATTCTCGCGAGATGGCAAGGCTCTAGAGAGGTTTCTTCA
AGATTACTTTGATGGCAACCTGAAGAGATATCTGAAGTCTGAGCCTATCCCAGAGAGCAATGAT
GGGCCTGTAAAGGTAGTAGTAGCAGAGAATTTTGATGAAATAGTGAATAATGAAAATAAAGATG
TGCTGATTGAATTTTATGCCCCTTGGTGTGGTCACTGTAAGAATCTGGAACCCAAGTATAAAGA
ACTTGGAGAGAAGCTCAGCAAAGACCCAAATATTGTCATAGCCAAGATGGATGCCACAGCCAAT
GATGTGCCTTCTCCATATGAAGTCAGAGGTTTTCCTACTATCTACTTCTCTCCAGCCAACAAGA
AGCTAAGTCCAAAGAAATATGAAGGTGGCCGTGAATTAAATGATTTTATTAGCTATCTACAGCG
AGAAGCTACAAATCCCCCTATAATTCAAGAAGAAAAACCCAAGAAGAAGAAGAAGGCACAGGAA
GATCTCTAAAGCAGCAGCCAAATATACCACTTTGTAAAAGGACTCTTCTACCAGAGATGGGAAA
ACCATTGGGGAGGACTGGGATCCATATGGGATTATTACCTCTCGGGGCTGAGAGGACAGAATGG
ATATAATCTGAATCCTGTTAAATTTTCTCTAAACTGTTTCTTAGCTGCACTGTTTATGGAAATA
CCAGGACCAGTTTGTGTTTGGTTTTGGGAAAAATTATTTGTGTTGGGAAGAATGTTATGGGGGT
GGGGGGATTTGAGTTGGGGGGTTATTTTCTAATTTTTTTTGTACATTTGGAACAGTGACAATAA
ATGAGCCCCCTTTAAAGTGT

hide sequence

Protein Sequences


Protein RefSeqs	XP_005316550	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000006163.2
GenBank Protein	KAG3261761	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005316550 ⟸ XM_005316493

- UniProtKB:

I3M8Q8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MRLRRLAPFPGVALLLAAARLAAASDVLELTDANFESRISDTGSAGLMLVEFFAPWCGHCKRLA
PEYEAAATRLKGIVPLAKVDCTANTETCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHL
KKQAGPASVPLRTEEEFKKFISDKDASVVGFFKDLFSEAHSEFLKAANNLRDNYRFAHTNVESL
VKEYDDNGEGITLFRPPHLTNKFEDKSVAYTDQKLTSSKIKKFIQENIFGICPHMTEDNKDLIQ
GKDLLMAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDAGHKLNCAVASRKTFSHELSDFGLESTT
GEVPVVAIRTAKGEKFVMQEEFSRDGKALERFLQDYFDGNLKRYLKSEPIPESNDGPVKVVVAE
NFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATANDVPSPYEVR
GFPTIYFSPANKKLSPKKYEGGRELNDFISYLQREATNPPIIQEEKPKKKKKAQEDL

hide sequence

RefSeq Acc Id:

ENSSTOP00000006163 ⟸ ENSSTOT00000006894

Protein Domains

Thioredoxin

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000006893	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000006894.3	UniProtKB/TrEMBL
Gene3D-CATH	Glutaredoxin	UniProtKB/TrEMBL
InterPro	Disulphide_isomerase	UniProtKB/TrEMBL
	PDIA3_PDI_b	UniProtKB/TrEMBL
	Prot_disulphide_isomerase	UniProtKB/TrEMBL
	Thioredoxin-like_sf	UniProtKB/TrEMBL
	Thioredoxin_CS	UniProtKB/TrEMBL
	Thioredoxin_domain	UniProtKB/TrEMBL
NCBI Gene	Pdia3	ENTREZGENE
PANTHER	PROTEIN DISULFIDE ISOMERASE	UniProtKB/TrEMBL
	PROTEIN DISULFIDE-ISOMERASE A3	UniProtKB/TrEMBL
Pfam	Thioredoxin	UniProtKB/TrEMBL
	Thioredoxin_6	UniProtKB/TrEMBL
PRINTS	THIOREDOXIN	UniProtKB/TrEMBL
PROSITE	THIOREDOXIN_1	UniProtKB/TrEMBL
	THIOREDOXIN_2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52833	UniProtKB/TrEMBL
UniProt	I3M8Q8	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD