RGD Reference Report - Fractalkine-induced smooth muscle cell proliferation in pulmonary hypertension. - Rat Genome Database

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Fractalkine-induced smooth muscle cell proliferation in pulmonary hypertension.

Authors: Perros, F  Dorfmuller, P  Souza, R  Durand-Gasselin, I  Godot, V  Capel, F  Adnot, S  Eddahibi, S  Mazmanian, M  Fadel, E  Herve, P  Simonneau, G  Emilie, D  Humbert, M 
Citation: Perros F, etal., Eur Respir J. 2007 May;29(5):937-43. Epub 2006 Dec 20.
RGD ID: 4891893
Pubmed: PMID:17182651   (View Abstract at PubMed)
DOI: DOI:10.1183/09031936.00104706   (Journal Full-text)

Pulmonary hypertension is characterised by a progressive increase in pulmonary arterial resistance due to endothelial and smooth muscle cell proliferation resulting in chronic obstruction of small pulmonary arteries. There is evidence that inflammatory mechanisms may contribute to the pathogenesis of human and experimental pulmonary hypertension. The aim of the study was to address the role of fractalkine (CX3CL1) in the inflammatory responses and pulmonary vascular remodelling of a monocrotaline-induced pulmonary hypertension model. The expression of CX3CL1 and its receptor CX3CR1 was studied in monocrotaline-induced pulmonary hypertension by means of immunohistochemistry and quantitative reverse-transcription PCR on laser-captured microdissected pulmonary arteries. It was demonstrated that CX3CL1 was expressed by inflammatory cells surrounding pulmonary arterial lesions and that smooth muscle cells from these vessels had increased CX3CR1 expression. It was then shown that cultured rat pulmonary artery smooth muscle cells expressed CX3CR1 and that CX3CL1 induced proliferation but not migration of these cells. In conclusion, the current authors proposed that fractalkine may act as a growth factor for pulmonary artery smooth muscle cells. Chemokines may thus play a role in pulmonary artery remodelling.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
pulmonary hypertension  ISOCx3cr1 (Rattus norvegicus)4891893; 4891893mRNA and protein:increased expression:lungRGD 
pulmonary hypertension  IEP 4891893mRNA and protein:increased expression:lungRGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
positive regulation of smooth muscle cell proliferation  IDA 4891893 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cx3cl1  (C-X3-C motif chemokine ligand 1)
Cx3cr1  (C-X3-C motif chemokine receptor 1)

Genes (Mus musculus)
Cx3cr1  (C-X3-C motif chemokine receptor 1)

Genes (Homo sapiens)
CX3CR1  (C-X3-C motif chemokine receptor 1)


Additional Information