Il13 (interleukin 13) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Il13 (interleukin 13) Ictidomys tridecemlineatus
Analyze
Symbol: Il13
Name: interleukin 13
RGD ID: 12518816
Description: ENCODES a protein that exhibits interleukin-13 receptor binding (ortholog); INVOLVED IN cellular response to cytokine stimulus (ortholog); cellular response to mechanical stimulus (ortholog); inflammatory response (ortholog); PARTICIPATES IN Fc epsilon receptor mediated signaling pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); alcoholic hepatitis (ortholog); allergic conjunctivitis (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: interleukin 13, transcript variant X1; interleukin 13, transcript variant X2; interleukin-13
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213115,527,018 - 115,529,671 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366472,530,491 - 2,532,373 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366472,529,933 - 2,532,503 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (ISO)
alcoholic hepatitis  (ISO)
allergic conjunctivitis  (ISO)
allergic disease  (ISO)
allergic rhinitis  (ISO)
asthma  (ISO)
atopic dermatitis  (ISO)
autistic disorder  (ISO)
autoimmune hepatitis  (ISO)
Breast Neoplasms  (ISO)
Bronchial Hyperreactivity  (ISO)
bronchiolitis obliterans  (ISO)
chlamydia  (ISO)
Chronic Bronchitis  (ISO)
chronic obstructive pulmonary disease  (ISO)
contact dermatitis  (ISO)
COVID-19  (ISO)
cutaneous leishmaniasis  (ISO)
cystic fibrosis  (ISO)
Delayed Hypersensitivity  (ISO)
dermatitis  (ISO)
diffuse scleroderma  (ISO)
drug allergy  (ISO)
Eczema  (ISO)
egg allergy  (ISO)
Endotoxemia  (ISO)
esophagitis  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Myocarditis  (ISO)
extrinsic allergic alveolitis  (ISO)
familial adenomatous polyposis 1  (ISO)
Fibrosis  (ISO)
food allergy  (ISO)
Fungal Lung Diseases  (ISO)
genetic disease  (ISO)
Graves' disease  (ISO)
hepatitis C  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
Human Influenza  (ISO)
Hyperalgesia  (ISO)
Hyperplasia  (ISO)
Immediate Hypersensitivity  (ISO)
Inflammation  (ISO)
invasive ductal carcinoma  (ISO)
Kawasaki disease  (ISO)
lipoid nephrosis  (ISO)
localized scleroderma  (ISO)
lung disease  (ISO)
Lymphatic Metastasis  (ISO)
mastocytosis  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metaplasia  (ISO)
middle cerebral artery infarction  (ISO)
milk allergy  (ISO)
multiple sclerosis  (ISO)
Mycoplasma pneumoniae pneumonia  (ISO)
Nasal Polyps  (ISO)
Neurodevelopmental Disorders  (ISO)
occupational dermatitis  (ISO)
onchocerciasis  (ISO)
ovarian carcinoma  (ISO)
pancreatic cancer  (ISO)
pancreatitis  (ISO)
peanut allergy  (ISO)
peptic esophagitis  (ISO)
Perennial Allergic Rhinitis  (ISO)
Picornaviridae Infections  (ISO)
Plasmodium falciparum malaria  (ISO)
pneumonia  (ISO)
prostatic hypertrophy  (ISO)
Pseudomonas Infections  (ISO)
psoriasis  (ISO)
psoriatic arthritis  (ISO)
pulmonary edema  (ISO)
pulmonary emphysema  (ISO)
pulmonary eosinophilia  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
pulmonary tuberculosis  (ISO)
purpura  (ISO)
Radiation Pneumonitis  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
respiratory allergy  (ISO)
Respiratory Sounds  (ISO)
respiratory syncytial virus infectious disease  (ISO)
Respiratory Tract Granuloma  (ISO)
Respiratory Tract Infections  (ISO)
rheumatoid arthritis  (ISO)
rhinitis  (ISO)
Schistosomiasis Mansoni  (ISO)
Sepsis  (ISO)
sinusitis  (ISO)
Sjogren's syndrome  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
T-cell non-Hodgkin lymphoma  (ISO)
Transplant Rejection  (ISO)
uveitis  (ISO)
vitiligo  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to cytokine stimulus  (IEA,ISO)
cellular response to mechanical stimulus  (ISO)
immune response  (IEA)
inflammatory response  (IEA,ISO)
macrophage activation  (IEA)
microglial cell activation  (ISO)
negative regulation of complement-dependent cytotoxicity  (IEA)
negative regulation of endothelial cell apoptotic process  (IEA)
negative regulation of inflammatory response  (IEA)
negative regulation of NAD(P)H oxidase activity  (ISO)
negative regulation of transforming growth factor beta production  (ISO)
positive regulation of B cell proliferation  (ISO)
positive regulation of cold-induced thermogenesis  (IEA)
positive regulation of connective tissue growth factor production  (ISO)
positive regulation of gene expression  (IEA)
positive regulation of immunoglobulin production  (IEA,ISO)
positive regulation of interleukin-10 production  (IEA)
positive regulation of macrophage activation  (IEA)
positive regulation of mast cell degranulation  (IEA,ISO)
positive regulation of monoatomic ion transport  (ISO)
positive regulation of pancreatic stellate cell proliferation  (ISO)
positive regulation of protein secretion  (ISO)
positive regulation of release of sequestered calcium ion into cytosol  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
regulation of proton transport  (ISO)
response to ethanol  (ISO)
response to lipopolysaccharide  (ISO)
response to mechanical stimulus  (ISO)
response to nicotine  (ISO)
signal transduction  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Il13
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213115,527,018 - 115,529,671 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366472,530,491 - 2,532,373 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366472,529,933 - 2,532,503 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL13
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385132,656,522 - 132,661,110 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5132,656,263 - 132,661,110 (+)EnsemblGRCh38hg38GRCh38
GRCh375131,992,214 - 131,996,802 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365132,021,764 - 132,024,700 (+)NCBINCBI36Build 36hg18NCBI36
Build 345132,021,763 - 132,024,700NCBI
Celera5128,123,995 - 128,126,931 (+)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5127,186,169 - 127,189,105 (+)NCBIHuRef
CHM1_15131,427,162 - 131,430,098 (+)NCBICHM1_1
T2T-CHM13v2.05133,176,323 - 133,180,911 (+)NCBIT2T-CHM13v2.0
Il13
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,522,150 - 53,525,529 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1153,522,151 - 53,525,529 (-)EnsemblGRCm39 Ensembl
GRCm381153,631,323 - 53,634,702 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,631,324 - 53,634,702 (-)EnsemblGRCm38mm10GRCm38
MGSCv371153,444,825 - 53,448,204 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361153,474,747 - 53,478,125 (-)NCBIMGSCv36mm8
Celera1158,210,849 - 58,214,228 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.98NCBI
Il13
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81038,290,926 - 38,293,483 (-)NCBIGRCr8
mRatBN7.21037,790,130 - 37,792,687 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1037,790,130 - 37,792,737 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1042,482,076 - 42,484,637 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01041,972,140 - 41,974,701 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01037,475,862 - 37,478,423 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01038,982,909 - 38,985,466 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1038,982,909 - 38,985,466 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01038,764,639 - 38,767,196 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41039,093,512 - 39,096,069 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11039,102,758 - 39,105,316 (-)NCBI
Celera1037,134,342 - 37,136,897 (-)NCBICelera
Cytogenetic Map10q22NCBI
Il13
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554084,046,406 - 4,049,795 (+)NCBIChiLan1.0ChiLan1.0
IL13
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24127,968,733 - 127,973,681 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15126,108,155 - 126,113,245 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05128,073,863 - 128,078,453 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15134,235,788 - 134,240,548 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5134,235,788 - 134,240,548 (+)Ensemblpanpan1.1panPan2
IL13
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11120,957,870 - 20,961,391 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1120,958,464 - 20,961,388 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1119,759,917 - 19,762,847 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01121,744,389 - 21,747,318 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1121,744,389 - 21,747,315 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11120,462,871 - 20,465,798 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01120,310,464 - 20,313,371 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01120,952,917 - 20,955,847 (+)NCBIUU_Cfam_GSD_1.0
IL13
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2134,972,623 - 134,975,093 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12134,972,099 - 134,976,672 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22140,441,025 - 140,444,068 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IL13
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12335,475,762 - 35,479,419 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2335,476,490 - 35,478,869 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603442,463,847 - 42,466,277 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il13
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473339,428,095 - 39,429,843 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473339,427,189 - 39,430,019 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000007961   ⟹   ENSSTOP00000007125
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049366472,530,491 - 2,532,373 (-)Ensembl
RefSeq Acc Id: XM_005335814   ⟹   XP_005335871
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213115,527,018 - 115,529,671 (-)NCBI
SpeTri2.0NW_0049366472,529,933 - 2,532,503 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005335871 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000007125.3
GenBank Protein KAG3265517 (Get FASTA)   NCBI Sequence Viewer  
  KAG3265518 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_005335871   ⟸   XM_005335814
- UniProtKB: I3MAR4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSTOP00000007125   ⟸   ENSSTOT00000007961


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000007967 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000007961.3 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.10 UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/TrEMBL
  IL-13 UniProtKB/TrEMBL
  IL-4/IL-13 UniProtKB/TrEMBL
NCBI Gene Il13 ENTREZGENE
PANTHER INTERLEUKIN-13 UniProtKB/TrEMBL
  INTERLEUKIN-13 UniProtKB/TrEMBL
Pfam IL13 UniProtKB/TrEMBL
PRINTS INTRLEUKIN13 UniProtKB/TrEMBL
SMART IL4_13 UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/TrEMBL
UniProt I3MAR4 ENTREZGENE, UniProtKB/TrEMBL