Cxcr4 (C-X-C motif chemokine receptor 4)

Gene: Cxcr4 (C-X-C motif chemokine receptor 4) Ictidomys tridecemlineatus

Analyze

Symbol:

Cxcr4

Name:

C-X-C motif chemokine receptor 4

RGD ID:

12656642

Description:

ENCODES a protein that exhibits small molecule binding (ortholog); INVOLVED IN aorta development (ortholog); blood vessel endothelial cell migration (ortholog); brain development (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; hypoxia inducible factor pathway; sphingosine 1-phosphate signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); Bone Metastasis (ortholog); Breast Neoplasms (ortholog); FOUND IN cell-cell junction (ortholog); endosome (ortholog); growth cone (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

C-X-C chemokine receptor type 4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	101,819,271 - 101,823,136 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936469	39,794,584 - 39,798,459 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936469	39,794,613 - 39,798,448 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute myeloid leukemia (ISO)

Bone Metastasis (ISO)

Breast Neoplasms (ISO)

Cancer Pain (ISO)

cardiomyopathy (ISO)

Cerebral Hemorrhage (ISO)

Chronic Periodontitis (ISO)

clear cell renal cell carcinoma (ISO)

colorectal cancer (ISO)

colorectal carcinoma (ISO)

congestive heart failure (ISO)

COVID-19 (ISO)

esophagus squamous cell carcinoma (ISO)

extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (ISO)

Femoral Fractures (ISO)

Gastro-Enteropancreatic Neuroendocrine Tumor (ISO)

Gastrointestinal Neoplasms (ISO)

genetic disease (ISO)

hemangioblastoma (ISO)

hepatocellular carcinoma (ISO)

Hermansky-Pudlak syndrome (ISO)

Hyperalgesia (ISO)

juvenile rheumatoid arthritis (ISO)

Kidney Reperfusion Injury (ISO)

laryngeal carcinoma (ISO)

larynx cancer (ISO)

leukopenia (ISO)

Liver Metastasis (ISO)

lung adenocarcinoma (ISO)

lung metastasis (ISO)

lung non-small cell carcinoma (ISO)

Lymphatic Metastasis (ISO)

lymphoplasmacytic lymphoma (ISO)

mucoepidermoid carcinoma (ISO)

nasopharynx carcinoma (ISO)

Neoplasm Invasiveness (ISO)

Neoplasm Metastasis (ISO)

Neoplastic Cell Transformation (ISO)

nephrosclerosis (ISO)

Neuralgia (ISO)

obesity (ISO)

osteoporosis (ISO)

osteosarcoma (ISO)

pancreatic adenocarcinoma (ISO)

paroxysmal nocturnal hemoglobinuria (ISO)

primary immunodeficiency disease (ISO)

prostate cancer (ISO)

pulmonary hypertension (ISO)

rectum cancer (ISO)

rheumatoid arthritis (ISO)

Right Ventricular Hypertrophy (ISO)

Spinal Cord Reperfusion Injury (ISO)

stomach cancer (ISO)

T-cell acute lymphoblastic leukemia (ISO)

temporal lobe epilepsy (ISO)

ulcerative colitis (ISO)

Vascular Remodeling (ISO)

WHIM syndrome 1 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

aorta development (ISO)

blood vessel endothelial cell migration (ISO)

brain development (IEA,ISO)

branching involved in blood vessel morphogenesis (ISO)

calcium-mediated signaling (IEA,ISO)

cardiac muscle contraction (ISO)

cell chemotaxis (IEA)

cell migration (ISO)

cellular response to cytokine stimulus (IEA,ISO)

cellular response to organonitrogen compound (ISO)

cellular response to xenobiotic stimulus (ISO)

chemokine-mediated signaling pathway (IEA)

chemotaxis (IEA)

CXCL12-activated CXCR4 signaling pathway (IEA,ISO)

detection of mechanical stimulus involved in sensory perception of pain (ISO)

detection of temperature stimulus involved in sensory perception of pain (ISO)

endothelial cell differentiation (ISO)

endothelial tube morphogenesis (ISO)

epithelial cell development (ISO)

G protein-coupled receptor signaling pathway (IEA)

generation of neurons (ISO)

germ cell development (ISO)

germ cell migration (ISO)

hematopoietic stem cell migration (ISO)

immune response (IEA)

kidney development (ISO)

motor neuron axon guidance (ISO)

myelin maintenance (ISO)

neural precursor cell proliferation (ISO)

neurogenesis (IEA,ISO)

neuron migration (ISO)

neuron recognition (ISO)

osteoclast differentiation (ISO)

positive regulation of calcium ion import (ISO)

positive regulation of cell migration (IEA,ISO)

positive regulation of chemotaxis (ISO)

positive regulation of cold-induced thermogenesis (ISO)

positive regulation of cytosolic calcium ion concentration (IEA)

positive regulation of dendrite extension (ISO)

positive regulation of ERK1 and ERK2 cascade (ISO)

positive regulation of macrophage migration inhibitory factor signaling pathway (IEA)

positive regulation of mesenchymal stem cell migration (ISO)

positive regulation of neurogenesis (ISO)

positive regulation of oligodendrocyte differentiation (ISO)

positive regulation of protein phosphorylation (ISO)

positive regulation of vascular wound healing (ISO)

positive regulation of vasculature development (IEA)

regulation of calcium ion transport (ISO)

regulation of cell adhesion (IEA)

regulation of cell migration (ISO)

regulation of chemotaxis (IEA,ISO)

regulation of neuron migration (ISO)

regulation of programmed cell death (ISO)

regulation of viral process (ISO)

response to activity (ISO)

response to hypoxia (IEA)

response to organic cyclic compound (ISO)

response to tacrolimus (ISO)

response to ultrasound (ISO)

T cell proliferation (ISO)

telencephalon cell migration (ISO)

ventricular septum development (ISO)

Cellular Component

anchoring junction (IEA)

cell leading edge (IEA)

cell surface (IEA)

cell-cell junction (ISO)

cytoplasmic vesicle (IEA)

early endosome (IEA)

endosome (IEA,ISO)

external side of plasma membrane (IEA)

growth cone (ISO)

late endosome (IEA)

lysosome (IEA)

membrane (IEA)

plasma membrane (IEA)

protein-containing complex (IEA)

Molecular Function

actin binding (IEA)

C-C chemokine binding (IEA)

C-C chemokine receptor activity (IEA)

C-X-C motif chemokine 12 receptor activity (IEA)

chemokine receptor activity (IEA)

cytokine binding (IEA)

G protein-coupled receptor activity (IEA)

myosin light chain binding (IEA)

protein binding (ISO)

small molecule binding (ISO)

ubiquitin binding (IEA)

ubiquitin protein ligase binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

ephrin - ephrin receptor bidirectional signaling axis (ISO)

hypoxia inducible factor pathway (ISO)

sphingosine 1-phosphate signaling pathway (ISO)

syndecan signaling pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Cxcr4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	101,819,271 - 101,823,136 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936469	39,794,584 - 39,798,459 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936469	39,794,613 - 39,798,448 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CXCR4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	136,114,349 - 136,118,149 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	136,114,349 - 136,119,177 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	136,871,919 - 136,875,719 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	136,588,389 - 136,592,195 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	136,705,651 - 136,709,457	NCBI
Celera	2	130,582,637 - 130,586,442 (-)	NCBI		Celera
Cytogenetic Map	2	q22.1	NCBI
HuRef	2	128,864,423 - 128,868,228 (-)	NCBI		HuRef
CHM1_1	2	136,877,321 - 136,881,126 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	136,558,831 - 136,562,630 (-)	NCBI		T2T-CHM13v2.0

Cxcr4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	128,515,936 - 128,520,036 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	128,515,936 - 128,520,030 (-)	Ensembl		GRCm39 Ensembl
GRCm38	1	128,588,199 - 128,592,299 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	128,588,199 - 128,592,293 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	130,484,776 - 130,488,876 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	130,415,745 - 130,419,822 (-)	NCBI		MGSCv36	mm8
Celera	1	131,222,729 - 131,226,820 (-)	NCBI		Celera
Cytogenetic Map	1	E4	NCBI
cM Map	1	56.43	NCBI

Cxcr4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	42,630,383 - 42,634,288 (-)	NCBI		GRCr8
mRatBN7.2	13	40,077,976 - 40,081,883 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	40,077,976 - 40,081,883 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	42,673,402 - 42,677,295 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	43,961,532 - 43,965,425 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	41,206,597 - 41,210,496 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	45,314,952 - 45,318,856 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	45,314,933 - 45,318,878 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	50,394,128 - 50,398,032 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	41,308,286 - 41,312,190 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	41,322,328 - 41,326,213 (-)	NCBI
Celera	13	40,447,190 - 40,451,093 (-)	NCBI		Celera
Cytogenetic Map	13	q13	NCBI

Cxcr4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955440	3,455,153 - 3,460,109 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955440	3,456,165 - 3,460,024 (-)	NCBI	ChiLan1.0	ChiLan1.0

CXCR4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	38,813,034 - 38,816,868 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	38,828,003 - 38,831,837 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	23,744,271 - 23,748,106 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	140,185,803 - 140,189,626 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	140,181,829 - 140,189,647 (-)	Ensembl	panpan1.1		panPan2

CXCR4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	19	38,874,650 - 38,877,740 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	19	38,874,145 - 38,877,740 (-)	NCBI	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	19	39,115,923 - 39,119,630 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	19	40,316,370 - 40,320,084 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	19	40,316,772 - 40,320,037 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	19	38,959,603 - 38,963,312 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	19	39,119,612 - 39,123,328 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	19	40,352,845 - 40,356,556 (-)	NCBI		UU_Cfam_GSD_1.0

CXCR4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	15,663,494 - 15,667,232 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	15,663,652 - 15,666,706 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	18,125,415 - 18,128,469 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CXCR4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	20,336,470 - 20,340,308 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	20,336,247 - 20,340,309 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666061	2,116,532 - 2,120,394 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cxcr4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624732	35,472,760 - 35,477,528 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624732	35,473,740 - 35,477,482 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005315834	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000362	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000006315 ⟹ ENSSTOP00000005647

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936469	39,794,584 - 39,798,459 (+)	Ensembl

RefSeq Acc Id:

XM_005315834 ⟹ XP_005315891

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405303	101,819,271 - 101,823,136 (-)	NCBI
SpeTri2.0	NW_004936469	39,794,613 - 39,798,448 (+)	NCBI

Sequence:

show sequence

AACTTCAATCTGTTGGCTGTTGCAGCAGGTAGCAAAGTGACCCTGAGGACCTGAGTTCTCCCGT
GGCTTCTGCGACTGGAGAAGGAGCGGCTACCATGGAAGGGATCAGTATATACACCTCAGATAAC
TACTCGGAGGAATTGGGCTCAGGGGACTATGATTCTATAAAGGAACCCTGCTTCCGAGAGGAAA
GTGCCCATTTCAACCGTATCTTCCTGCCCACCATCTACTCCATCATCTTTTTGACTGGCATTGT
GGGCAACGGATTGGTGATCCTGGTCATGGGTTACCAGAAGAAATTGAGAAGCATGACGGACAAG
TACCGGCTGCATCTGTCAGTGGCCGACCTCCTTTTTGTCATCACACTTCCATTCTGGGCTGTTG
ATGCTGTGGCAAATTGGTACTTTGGGAAATTTCTATGCAAAGCAGTCCATGTCATCTATACTGT
CAACCTGTATAGTAGTGTCCTCATCCTGGCCTTTATCAGTCTGGACCGATACCTGGCCATTGTT
CATGCCACCAATAGTCAGAGGCCAAGAAAGCTGTTGGCTGAAAAGGCGGTGTATGTTGGCGTCT
GGATCCCTGCTCTCCTGCTAACTATTCCTGATTTAATCTTTGCCAATATCAGTGAGGCAGAAGG
GAAATATATCTGTGACCGCTTTTACCCCAATGACTTGTGGGTAGTTGTATTCCAGTTTCAGCAC
ATCATGGTTGGCCTTATCCTGCCTGGTATTGTCATCCTGTCCTGCTATTGCATTATCATCTCTA
AGCTGTCACACTCCAAGGGCCACCAGAAGCGCAAAGCACTCAAGACCACCGTCATCCTCATCCT
GGCTTTCTTTGCCTGCTGGCTGCCCTACTACATTGGGATCAGTATCGACTCTTTCATTCTTCTA
GAAATCATCAAACAAGGATGTGAATTTGAGAACACTGTGCACAAGTGGATTTCCATCACTGAGG
CCCTTGCATTTTTCCACTGTTGCCTGAATCCCATCCTCTATGCCTTCCTTGGAGCCAAATTTAA
AACCTCAGCCCAGCATGCACTCACCTCTGTGAGCAGAGGGTCCAGCCTCAAGATTCTCTCCAAA
GGCAAACGAGGTGGACATTCTTCTGTTTCAACTGAGTCTGAGTCTTCAAGTTTTCACTCCAGCT
AACGTTGATGTAAAAGACTTTTTTTTTATATGAAAAAGAACTTTTTTTTAAGTTACACGTTTTT
CAGATATAAAAGACTGACCAATACTGTACAGTTTTTATTGACTGTTGGATTTTTGTCTTGTGTT
TTTTAGTTTTTGTGAGGTTTAATTGACTTATTTATATAAATATTTTTTTGTTTGTTTCATGTTA
ATGAGTGTCTAGGCAGGACCTGTGGCCAAGTTCTTAGTTGCTGTATGTCTGGTTGTAAGACTTT
AGAAAAGGGAACTGAACATTCTAGAGTGTGTAGTGAATCACGTAAAGCTAGAAATTATCCTCAG
CTGTTTGTGCATAAATAATCTTTCCATTCCAGTGGAACATCTTTTTTTTCCTCCCCTTTTCTTA
AGTTTTTTGGTTACACTGTGTGATTTTGCTCTAGAAGACAGCACTTATAACCAAAGTCTTAAGT
GGTATAGAAATGCTGGTTTTTCAGTTTTCAGGAATGGGTTGATTTCAGCACCTACAATGTACAG
TCTTGTATTAAGTTGTTAATAAAAGTACATGATAAACTT

hide sequence

Protein Sequences


Protein RefSeqs	XP_005315891	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000005647.2
GenBank Protein	KAG3274408	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005315891 ⟸ XM_005315834

- UniProtKB:

I3M7N9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEGISIYTSDNYSEELGSGDYDSIKEPCFREESAHFNRIFLPTIYSIIFLTGIVGNGLVILVMG
YQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGKFLCKAVHVIYTVNLYSSVLILA
FISLDRYLAIVHATNSQRPRKLLAEKAVYVGVWIPALLLTIPDLIFANISEAEGKYICDRFYPN
DLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYY
IGISIDSFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSAQHALTSV
SRGSSLKILSKGKRGGHSSVSTESESSSFHSS

hide sequence

RefSeq Acc Id:

ENSSTOP00000005647 ⟸ ENSSTOT00000006315

Protein Domains

G-protein coupled receptors family 1 profile

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000006334	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000006315.3	UniProtKB/TrEMBL
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	Chemokine_CXCR4_N_dom	UniProtKB/TrEMBL
	Chemokine_rcpt	UniProtKB/TrEMBL
	CXCR4/ACKR2	UniProtKB/TrEMBL
	GPCR_Rhodpsn	UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/TrEMBL
NCBI Gene	Cxcr4	ENTREZGENE
PANTHER	C-X-C CHEMOKINE RECEPTOR TYPE 4	UniProtKB/TrEMBL
	CELL ADHESION MOLECULE	UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/TrEMBL
	CXCR4_N	UniProtKB/TrEMBL
PRINTS	CCCHEMOKINER	UniProtKB/TrEMBL
	CXCCHMKINER4	UniProtKB/TrEMBL
	GPCRRHODOPSN	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/TrEMBL
UniProt	I3M7N9	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - PID (archival)