Hmox1 (heme oxygenase 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Hmox1 (heme oxygenase 1) Ictidomys tridecemlineatus
Analyze
Symbol: Hmox1
Name: heme oxygenase 1
RGD ID: 12555898
Description: ENCODES a protein that exhibits arachidonic acid omega-hydroxylase activity (ortholog); enzyme binding (ortholog); heme binding (ortholog); INVOLVED IN angiogenesis (ortholog); cellular response to arsenic-containing substance (ortholog); cellular response to cadmium ion (ortholog); PARTICIPATES IN acute intermittent porphyria pathway; erythropoietic porphyria pathway; heme degradation pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); acute chest syndrome (ortholog); acute kidney failure (ortholog); FOUND IN caveola (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: heme oxygenase (decycling) 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494512,031,937 - 12,038,780 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364925,042,330 - 5,049,311 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364925,042,353 - 5,049,216 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
acute chest syndrome  (ISO)
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
acute myeloid leukemia  (ISO)
adenocarcinoma  (ISO)
adenylosuccinase lyase deficiency  (ISO)
adrenoleukodystrophy  (ISO)
adult respiratory distress syndrome  (ISO)
Altitude Sickness  (ISO)
Alzheimer's disease  (ISO)
arteriosclerosis  (ISO)
asthma  (ISO)
Behcet's disease  (ISO)
berylliosis  (ISO)
Blast Crisis  (ISO)
blood coagulation disease  (ISO)
Brain Death  (ISO)
brain edema  (ISO)
Brain Hypoxia-Ischemia  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
Breast Neoplasms  (ISO)
bronchiolitis obliterans  (ISO)
Carbon Monoxide Poisoning  (ISO)
Carbon Tetrachloride Poisoning  (ISO)
Cardiomegaly  (ISO)
carotid artery disease  (ISO)
carotid artery thrombosis  (ISO)
Cerebral Hemorrhage  (ISO)
cerebral infarction  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
Chronic Tubulointerstitial Nephropathy  (ISO)
colitis  (ISO)
congestive heart failure  (ISO)
contact dermatitis  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
coronary restenosis  (ISO)
cystic fibrosis  (ISO)
diabetic angiopathy  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
Dilatation, Pathologic  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
esophageal cancer  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (ISO)
Experimental Radiation Injuries  (ISO)
factor VIII deficiency  (ISO)
Fever  (ISO)
Fibrosis  (ISO)
gastroparesis  (ISO)
genetic disease  (ISO)
Graft Occlusion, Vascular  (ISO)
Growth Disorders  (ISO)
Helicobacter Infections  (ISO)
Heme Oxygenase 1 Deficiency  (ISO)
hemochromatosis  (ISO)
Hemolysis  (ISO)
hemolytic anemia  (ISO)
Hemorrhagic Shock  (ISO)
Henoch-Schoenlein purpura  (ISO)
hepatic encephalopathy  (ISO)
hepatic veno-occlusive disease  (ISO)
hepatitis  (ISO)
hepatopulmonary syndrome  (ISO)
hepatorenal syndrome  (ISO)
hyperinsulinism  (ISO)
Hyperoxic Lung Injury  (ISO)
Hyperplasia  (ISO)
hypertension  (ISO)
hyperthyroidism  (ISO)
hypertrophic cardiomyopathy  (ISO)
ileus  (ISO)
Inflammation  (ISO)
Insulin Resistance  (ISO)
interstitial lung disease  (ISO)
Intestinal Reperfusion Injury  (ISO)
intracranial vasospasm  (ISO)
iron metabolism disease  (ISO)
ischemia  (ISO)
Kawasaki disease  (ISO)
Kidney Reperfusion Injury  (ISO)
learning disability  (ISO)
limb ischemia  (ISO)
liver disease  (ISO)
Liver Neoplasms  (ISO)
Liver Reperfusion Injury  (ISO)
lung disease  (ISO)
Lung Injury  (ISO)
Lung Neoplasms  (ISO)
Lung Reperfusion Injury  (ISO)
malaria  (ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neointima  (ISO)
Neonatal Hyperbilirubinemia  (ISO)
Neoplasm Invasiveness  (ISO)
neurodegenerative disease  (ISO)
newborn respiratory distress syndrome  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
pancreas disease  (ISO)
Paraparesis  (ISO)
Parkinson's disease  (ISO)
Parkinsonism  (ISO)
Pathologic Constriction  (ISO)
peptic ulcer disease  (ISO)
Perennial Allergic Rhinitis  (ISO)
Pneumococcal Pneumonia  (ISO)
pneumonia  (ISO)
pneumothorax  (ISO)
portal hypertension  (ISO)
pre-eclampsia  (ISO)
Pregnancy-Induced Hypertension  (ISO)
primary biliary cholangitis  (ISO)
Prostatic Neoplasms  (ISO)
Pulmonary Edema of Mountaineers  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
pulmonary sarcoidosis  (ISO)
pulmonary venoocclusive disease  (ISO)
renal hypertension  (ISO)
Reperfusion Injury  (ISO)
Retina Reperfusion Injury  (ISO)
retinal disease  (ISO)
retinal ischemia  (ISO)
Rhabdomyolysis  (ISO)
Right Ventricular Hypertrophy  (ISO)
sciatic neuropathy  (ISO)
sickle cell anemia  (ISO)
silicosis  (ISO)
Sjogren's syndrome  (ISO)
Spinal Cord Injuries  (ISO)
spinocerebellar ataxia type 17  (ISO)
status epilepticus  (ISO)
Stomach Neoplasms  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
systemic mastocytosis  (ISO)
Testis Reperfusion Injury  (ISO)
thrombosis  (ISO)
toxic shock syndrome  (ISO)
type 2 diabetes mellitus  (ISO)
varicocele  (ISO)
Vascular System Injuries  (ISO)
Ventricular Fibrillation  (ISO)
viral pneumonia  (ISO)
visceral leishmaniasis  (ISO)
Wounds and Injuries  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
cellular response to arsenic-containing substance  (IEA,ISO)
cellular response to cadmium ion  (IEA,ISO)
cellular response to cisplatin  (IEA,ISO)
cellular response to heat  (IEA)
cellular response to hypoxia  (IEA)
cellular response to nutrient  (ISO)
epithelial cell apoptotic process  (IEA,ISO)
erythrocyte homeostasis  (IEA)
heme catabolic process  (IEA,ISO)
heme metabolic process  (IEA,ISO)
heme oxidation  (IEA)
intracellular iron ion homeostasis  (IEA)
intracellular signal transduction  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (ISO)
liver regeneration  (ISO)
macroautophagy  (IEA,ISO)
multicellular organismal-level iron ion homeostasis  (IEA)
negative regulation by host of viral transcription  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of DNA binding  (ISO)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of epithelial cell apoptotic process  (ISO)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (IEA)
negative regulation of ferroptosis  (ISO)
negative regulation of macroautophagy  (IEA,ISO)
negative regulation of mast cell cytokine production  (ISO)
negative regulation of mast cell degranulation  (ISO)
negative regulation of muscle cell apoptotic process  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of smooth muscle cell proliferation  (IEA,ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
negative regulation of viral life cycle  (ISO)
positive regulation of angiogenesis  (IEA,ISO)
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (IEA)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of cell migration involved in sprouting angiogenesis  (IEA)
positive regulation of epithelial cell apoptotic process  (IEA,ISO)
positive regulation of macroautophagy  (IEA,ISO)
positive regulation of smooth muscle cell proliferation  (IEA)
regulation of blood pressure  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
response to 3-methylcholanthrene  (ISO)
response to arachidonic acid  (ISO)
response to estrogen  (ISO)
response to hydrogen peroxide  (ISO)
response to hypoxia  (ISO)
response to nicotine  (IEA)
response to oxidative stress  (IEA,ISO)
response to xenobiotic stimulus  (ISO)
small GTPase-mediated signal transduction  (ISO)
wound healing involved in inflammatory response  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Hmox1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494512,031,937 - 12,038,780 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364925,042,330 - 5,049,311 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364925,042,353 - 5,049,216 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HMOX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382235,381,096 - 35,394,207 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2235,380,361 - 35,394,214 (+)EnsemblGRCh38hg38GRCh38
GRCh372235,777,089 - 35,790,200 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362234,107,087 - 34,120,194 (+)NCBINCBI36Build 36hg18NCBI36
Build 342234,101,640 - 34,114,748NCBI
Celera2219,579,740 - 19,592,881 (+)NCBICelera
Cytogenetic Map22q12.3NCBI
HuRef2218,737,577 - 18,750,716 (+)NCBIHuRef
CHM1_12235,735,791 - 35,748,937 (+)NCBICHM1_1
T2T-CHM13v2.02235,839,114 - 35,852,226 (+)NCBIT2T-CHM13v2.0
Hmox1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39875,820,246 - 75,827,221 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl875,820,249 - 75,827,217 (+)EnsemblGRCm39 Ensembl
GRCm38875,093,618 - 75,100,593 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl875,093,621 - 75,100,589 (+)EnsemblGRCm38mm10GRCm38
MGSCv37877,617,517 - 77,624,492 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36877,989,694 - 77,996,657 (+)NCBIMGSCv36mm8
Celera879,400,848 - 79,407,824 (+)NCBICelera
Cytogenetic Map8C1NCBI
cM Map835.59NCBI
Hmox1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81913,452,365 - 13,479,823 (+)NCBIGRCr8
mRatBN7.21913,466,287 - 13,474,082 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1913,467,244 - 13,474,079 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1913,440,832 - 13,447,675 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01914,206,098 - 14,212,941 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01913,487,026 - 13,493,858 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01914,508,634 - 14,515,455 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1914,508,616 - 14,515,456 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01925,622,556 - 25,629,377 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41913,963,139 - 13,969,960 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11913,967,964 - 13,974,784 (+)NCBI
Celera1913,334,259 - 13,341,080 (+)NCBICelera
Cytogenetic Map19p11NCBI
Hmox1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540543,124,510 - 43,130,979 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540543,124,447 - 43,128,873 (+)NCBIChiLan1.0ChiLan1.0
HMOX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22345,322,157 - 45,335,267 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12248,018,985 - 48,034,597 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02216,388,368 - 16,401,289 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12234,230,825 - 34,244,063 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2234,230,825 - 34,244,063 (+)Ensemblpanpan1.1panPan2
HMOX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11028,744,404 - 28,751,544 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1028,743,795 - 28,751,773 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1028,683,213 - 28,689,972 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01029,531,402 - 29,538,230 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1029,530,793 - 29,539,227 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11029,255,139 - 29,261,959 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01029,565,774 - 29,572,612 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01029,745,379 - 29,752,300 (-)NCBIUU_Cfam_GSD_1.0
HMOX1
(Sus scrofa - pig)		 No map positions available.
HMOX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11918,144,466 - 18,157,944 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1918,144,545 - 18,157,971 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045107,791,541 - 107,805,610 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hmox1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624750342,146 - 345,887 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624750341,699 - 346,005 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005322307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSTOT00000008917   ⟹   ENSSTOP00000007990
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364925,042,814 - 5,048,148 (-)Ensembl
RefSeq Acc Id: ENSSTOT00000040235   ⟹   ENSSTOP00000026514
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364925,042,330 - 5,049,311 (-)Ensembl
RefSeq Acc Id: XM_005322307   ⟹   XP_005322364
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494512,031,937 - 12,038,780 (-)NCBI
SpeTri2.0NW_0049364925,042,353 - 5,049,216 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005322364 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000007990.3
  ENSSTOP00000026514.1
GenBank Protein KAG3291055 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_005322364   ⟸   XM_005322307
- UniProtKB: A0A287CZ33 (UniProtKB/TrEMBL),   I3MCJ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSTOP00000007990   ⟸   ENSSTOT00000008917
RefSeq Acc Id: ENSSTOP00000026514   ⟸   ENSSTOT00000040235


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000008923 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000008917.3 UniProtKB/TrEMBL
  ENSSTOT00000040235.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.910.10 UniProtKB/TrEMBL
InterPro Haem_Oase UniProtKB/TrEMBL
  Haem_Oase-like UniProtKB/TrEMBL
  Haem_Oase-like_multi-hlx UniProtKB/TrEMBL
  Haem_oxygenase_CS UniProtKB/TrEMBL
NCBI Gene Hmox1 ENTREZGENE
PANTHER HEME OXYGENASE 1 UniProtKB/TrEMBL
  PTHR10720 UniProtKB/TrEMBL
Pfam Heme_oxygenase UniProtKB/TrEMBL
PRINTS HAEMOXYGNASE UniProtKB/TrEMBL
PROSITE HEME_OXYGENASE UniProtKB/TrEMBL
Superfamily-SCOP SSF48613 UniProtKB/TrEMBL
UniProt A0A287CZ33 ENTREZGENE, UniProtKB/TrEMBL
  I3MCJ9 ENTREZGENE, UniProtKB/TrEMBL