Tert (telomerase reverse transcriptase) - Rat Genome Database

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Pathways
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Gene: Tert (telomerase reverse transcriptase) Ictidomys tridecemlineatus
Analyze
Symbol: Tert
Name: telomerase reverse transcriptase
RGD ID: 12557397
Description: ENCODES a protein that exhibits DNA binding (inferred); identical protein binding (inferred); metal ion binding (inferred); INVOLVED IN cellular response to hypoxia (ortholog); negative regulation of apoptotic process (ortholog); negative regulation of endothelial cell apoptotic process (ortholog); PARTICIPATES IN hypoxia inducible factor pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); acute myeloid leukemia (ortholog); adrenocortical carcinoma (ortholog); FOUND IN TERT-RMRP complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213244,307,679 - 244,331,058 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936815469,020 - 491,697 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936815468,987 - 492,666 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
adrenocortical carcinoma  (ISO)
Alcoholic Liver Diseases  (ISO)
aplastic anemia  (ISO)
Autosomal Dominant Dyskeratosis Congenita  (ISO)
autosomal dominant dyskeratosis congenita 1  (ISO)
autosomal dominant dyskeratosis congenita 2  (ISO)
autosomal recessive dyskeratosis congenita 1  (ISO)
autosomal recessive dyskeratosis congenita 4  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
basal cell carcinoma  (ISO)
beta thalassemia  (ISO)
brain cancer  (ISO)
Brain Hypoxia-Ischemia  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
cervix uteri carcinoma in situ  (ISO)
Chronic Hepatitis B  (ISO)
chronic kidney disease  (ISO)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
chronic recurrent multifocal osteomyelitis  (ISO)
colon adenocarcinoma  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
Cri-du-Chat syndrome  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diarrhea 9  (ISO)
disease of cellular proliferation  (ISO)
Disease Progression  (ISO)
dopamine transporter deficiency syndrome  (ISO)
ductal carcinoma in situ  (ISO)
dyskeratosis congenita  (ISO)
Endometrial Neoplasms  (ISO)
esophageal atresia  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Melanoma  (ISO)
familial melanoma  (ISO)
fibrosarcoma  (ISO)
gallbladder carcinoma  (ISO)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
Genetic Predisposition to Disease  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
hepatocellular clear cell carcinoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
high grade glioma  (ISO)
Hoyeraal Hreidarsson Syndrome  (ISO)
interstitial lung disease  (ISO)
interstitial lung disease 2  (ISO)
kidney disease  (ISO)
leiomyosarcoma  (ISO)
Liver Neoplasms  (ISO)
Liver Reperfusion Injury  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung sarcomatoid carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
lymphoid leukemia  (ISO)
macrocytic anemia  (ISO)
melanoma  (ISO)
microcephaly  (ISO)
multiple myeloma  (ISO)
myelodysplastic syndrome  (ISO)
myeloid neoplasm  (ISO)
nasopharynx carcinoma  (ISO)
nephroblastoma  (ISO)
neuroblastoma  (ISO)
Nonimmune Chronic Idiopathic Neutropenia, Adult  (ISO)
oral squamous cell carcinoma  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
plasma cell leukemia  (ISO)
primary immunodeficiency disease  (ISO)
prostate adenocarcinoma  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary fibrosis  (ISO)
Pulmonary Fibrosis and/or Bone Marrow Failure Syndrome, Telomere-Related, 1  (ISO)
pulmonary hypertension  (ISO)
Refractory Anemia  (ISO)
Refractory Anemia with Excess of Blasts  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
silicosis  (ISO)
small cell carcinoma  (ISO)
Spinal Cord Injuries  (ISO)
stomach cancer  (ISO)
systemic lupus erythematosus  (ISO)
teratoma  (ISO)
Thyroid Neoplasms  (ISO)
transient cerebral ischemia  (ISO)
transitional cell carcinoma  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
Uterine Neoplasms  (ISO)
viral hepatitis  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to hypoxia  (IEA,ISO)
DNA biosynthetic process  (IEA)
DNA strand elongation  (IEA)
establishment of protein localization to telomere  (IEA)
mitochondrion organization  (IEA)
negative regulation of apoptotic process  (ISO)
negative regulation of cellular senescence  (IEA)
negative regulation of endothelial cell apoptotic process  (ISO)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (IEA)
negative regulation of gene expression  (IEA)
negative regulation of glial cell proliferation  (ISO)
negative regulation of neuron apoptotic process  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of G1/S transition of mitotic cell cycle  (ISO)
positive regulation of glucose import  (IEA,ISO)
positive regulation of hair cycle  (IEA)
positive regulation of miRNA transcription  (IEA)
positive regulation of protein localization to nucleolus  (IEA)
positive regulation of stem cell proliferation  (IEA)
positive regulation of transdifferentiation  (ISO)
positive regulation of vascular associated smooth muscle cell migration  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
positive regulation of Wnt signaling pathway  (IEA)
regulation of protein stability  (IEA)
replicative senescence  (IEA)
response to cadmium ion  (ISO)
RNA-templated DNA biosynthetic process  (IEA)
RNA-templated transcription  (IEA)
siRNA processing  (IEA)
siRNA transcription  (IEA)
telomere maintenance via telomerase  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Tert
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213244,307,679 - 244,331,058 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936815469,020 - 491,697 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936815468,987 - 492,666 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TERT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3851,253,167 - 1,295,068 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl51,253,147 - 1,295,068 (-)EnsemblGRCh38hg38GRCh38
GRCh3751,253,282 - 1,295,183 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3651,306,282 - 1,348,162 (-)NCBINCBI36Build 36hg18NCBI36
Build 3451,306,286 - 1,348,159NCBI
Celera51,290,088 - 1,332,097 (-)NCBICelera
Cytogenetic Map5p15.33NCBI
HuRef51,234,692 - 1,275,531 (-)NCBIHuRef
CHM1_151,253,108 - 1,294,322 (-)NCBICHM1_1
T2T-CHM13v2.051,160,074 - 1,202,878 (-)NCBIT2T-CHM13v2.0
Tert
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391373,775,030 - 73,797,962 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1373,775,030 - 73,797,962 (+)EnsemblGRCm39 Ensembl
GRCm381373,626,911 - 73,649,843 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1373,626,911 - 73,649,843 (+)EnsemblGRCm38mm10GRCm38
MGSCv371373,764,449 - 73,786,489 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361374,093,003 - 74,115,043 (+)NCBIMGSCv36mm8
Celera1375,955,877 - 75,977,918 (+)NCBICelera
Cytogenetic Map13C1NCBI
cM Map1340.12NCBI
Tert
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8131,465,766 - 31,488,650 (-)NCBIGRCr8
mRatBN7.2129,637,213 - 29,659,561 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl129,637,506 - 29,659,561 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx129,439,189 - 29,459,951 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0135,439,034 - 35,459,796 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0129,639,816 - 29,660,578 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0132,250,876 - 32,275,330 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl132,251,714 - 32,272,476 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0133,675,744 - 33,697,542 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4130,445,180 - 30,465,942 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera128,286,050 - 28,306,805 (-)NCBICelera
Cytogenetic Map1p11NCBI
Tert
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955504651,779 - 670,589 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955504649,248 - 669,796 (-)NCBIChiLan1.0ChiLan1.0
TERT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v241,514,877 - 1,559,376 (-)NCBINHGRI_mPanPan1-v2
PanPan1.1 Ensembl51,300,960 - 1,338,872 (-)Ensemblpanpan1.1panPan2
TERT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13411,288,622 - 11,307,790 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3411,288,622 - 11,307,951 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3415,798,490 - 15,817,661 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03411,189,290 - 11,208,463 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3411,189,290 - 11,208,512 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13411,240,107 - 11,259,262 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03411,219,414 - 11,238,599 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03411,430,438 - 11,449,614 (+)NCBIUU_Cfam_GSD_1.0
TERT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1679,258,591 - 79,276,421 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11679,258,591 - 79,276,421 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21685,917,150 - 85,935,085 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TERT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.141,082,894 - 1,119,373 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl41,083,384 - 1,117,468 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605435,649,406 - 35,684,819 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tert
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624751624,569 - 647,198 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000021375   ⟹   ENSSTOP00000019046
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936815469,020 - 491,697 (+)Ensembl
RefSeq Acc Id: XM_005340748   ⟹   XP_005340805
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213244,307,687 - 244,331,058 (+)NCBI
SpeTri2.0NW_004936815468,987 - 492,666 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040271942   ⟹   XP_040127876
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213244,307,685 - 244,331,058 (+)NCBI
RefSeq Acc Id: XM_040271943   ⟹   XP_040127877
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213244,307,685 - 244,331,058 (+)NCBI
RefSeq Acc Id: XM_040271944   ⟹   XP_040127878
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213244,307,686 - 244,331,058 (+)NCBI
RefSeq Acc Id: XM_040271945   ⟹   XP_040127879
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213244,307,686 - 244,331,058 (+)NCBI
RefSeq Acc Id: XM_040271946   ⟹   XP_040127880
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213244,307,680 - 244,329,642 (+)NCBI
RefSeq Acc Id: XM_040271947   ⟹   XP_040127881
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213244,307,687 - 244,331,058 (+)NCBI
RefSeq Acc Id: XM_040271948   ⟹   XP_040127882
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213244,307,681 - 244,327,432 (+)NCBI
RefSeq Acc Id: XM_040271949   ⟹   XP_040127883
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213244,307,679 - 244,320,893 (+)NCBI
RefSeq Acc Id: XM_040271950   ⟹   XP_040127884
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213244,307,681 - 244,327,432 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_005340805   ⟸   XM_005340748
- Peptide Label: isoform X2
- UniProtKB: I3N3V0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040127883   ⟸   XM_040271949
- Peptide Label: isoform X9
RefSeq Acc Id: XP_040127880   ⟸   XM_040271946
- Peptide Label: isoform X6
- UniProtKB: I3N3V0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040127884   ⟸   XM_040271950
- Peptide Label: isoform X10
- UniProtKB: I3N3V0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040127882   ⟸   XM_040271948
- Peptide Label: isoform X8
- UniProtKB: I3N3V0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040127876   ⟸   XM_040271942
- Peptide Label: isoform X1
- UniProtKB: I3N3V0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040127877   ⟸   XM_040271943
- Peptide Label: isoform X3
- UniProtKB: I3N3V0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040127878   ⟸   XM_040271944
- Peptide Label: isoform X4
- UniProtKB: I3N3V0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040127879   ⟸   XM_040271945
- Peptide Label: isoform X5
- UniProtKB: I3N3V0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040127881   ⟸   XM_040271947
- Peptide Label: isoform X7
- UniProtKB: I3N3V0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSSTOP00000019046   ⟸   ENSSTOT00000021375
Protein Domains
Reverse transcriptase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000023072 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000021375.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.132.70 UniProtKB/TrEMBL
  1.10.357.90 UniProtKB/TrEMBL
  3.30.70.2630 UniProtKB/TrEMBL
InterPro DNA/RNA_pol_sf UniProtKB/TrEMBL
  RT_dom UniProtKB/TrEMBL
  Telomerase_RBD UniProtKB/TrEMBL
  Telomerase_RT UniProtKB/TrEMBL
  TERT_C UniProtKB/TrEMBL
NCBI Gene Tert ENTREZGENE
PANTHER PTHR12066 UniProtKB/TrEMBL
  TELOMERASE REVERSE TRANSCRIPTASE UniProtKB/TrEMBL
Pfam RVT_1 UniProtKB/TrEMBL
  Telomerase_RBD UniProtKB/TrEMBL
  TERT_C UniProtKB/TrEMBL
PRINTS TELOMERASERT UniProtKB/TrEMBL
PROSITE RT_POL UniProtKB/TrEMBL
SMART Telomerase_RBD UniProtKB/TrEMBL
Superfamily-SCOP SSF56672 UniProtKB/TrEMBL
UniProt I3N3V0 ENTREZGENE, UniProtKB/TrEMBL