Tert (telomerase reverse transcriptase) - Rat Genome Database

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Pathways
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Gene: Tert (telomerase reverse transcriptase) Chinchilla lanigera
Analyze
Symbol: Tert
Name: telomerase reverse transcriptase
RGD ID: 8838530
Description: ENCODES a protein that exhibits DNA binding (ortholog); identical protein binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN cellular response to hypoxia (ortholog); DNA biosynthetic process (ortholog); DNA strand elongation (ortholog); PARTICIPATES IN hypoxia inducible factor pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); acute myeloid leukemia (ortholog); adrenocortical carcinoma (ortholog); FOUND IN chromosome, telomeric region (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955504651,779 - 670,589 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955504649,248 - 669,796 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
adrenocortical carcinoma  (ISO)
Alcoholic Liver Diseases  (ISO)
aplastic anemia  (ISO)
Autosomal Dominant Dyskeratosis Congenita  (ISO)
autosomal dominant dyskeratosis congenita 1  (ISO)
autosomal dominant dyskeratosis congenita 2  (ISO)
autosomal recessive dyskeratosis congenita 1  (ISO)
autosomal recessive dyskeratosis congenita 4  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
basal cell carcinoma  (ISO)
beta thalassemia  (ISO)
brain cancer  (ISO)
Brain Hypoxia-Ischemia  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
cervix uteri carcinoma in situ  (ISO)
Chronic Hepatitis B  (ISO)
chronic kidney disease  (ISO)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
chronic recurrent multifocal osteomyelitis  (ISO)
colon adenocarcinoma  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
Cri-du-Chat syndrome  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diarrhea 9  (ISO)
disease of cellular proliferation  (ISO)
Disease Progression  (ISO)
dopamine transporter deficiency syndrome  (ISO)
ductal carcinoma in situ  (ISO)
dyskeratosis congenita  (ISO)
Endometrial Neoplasms  (ISO)
esophageal atresia  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Melanoma  (ISO)
familial melanoma  (ISO)
fibrosarcoma  (ISO)
gallbladder carcinoma  (ISO)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
Genetic Predisposition to Disease  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
hepatocellular clear cell carcinoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
high grade glioma  (ISO)
Hoyeraal Hreidarsson Syndrome  (ISO)
idiopathic pulmonary fibrosis  (ISO)
interstitial lung disease  (ISO)
kidney disease  (ISO)
leiomyosarcoma  (ISO)
Liver Neoplasms  (ISO)
Liver Reperfusion Injury  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung sarcomatoid carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
lymphoid leukemia  (ISO)
macrocytic anemia  (ISO)
melanoma  (ISO)
microcephaly  (ISO)
multiple myeloma  (ISO)
myelodysplastic syndrome  (ISO)
myeloid neoplasm  (ISO)
nasopharynx carcinoma  (ISO)
nephroblastoma  (ISO)
neuroblastoma  (ISO)
Nonimmune Chronic Idiopathic Neutropenia, Adult  (ISO)
oral squamous cell carcinoma  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
plasma cell leukemia  (ISO)
primary immunodeficiency disease  (ISO)
prostate adenocarcinoma  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary fibrosis  (ISO)
Pulmonary Fibrosis and/or Bone Marrow Failure Syndrome, Telomere-Related, 1  (ISO)
pulmonary hypertension  (ISO)
Refractory Anemia  (ISO)
Refractory Anemia with Excess of Blasts  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
silicosis  (ISO)
small cell carcinoma  (ISO)
Spinal Cord Injuries  (ISO)
stomach cancer  (ISO)
systemic lupus erythematosus  (ISO)
teratoma  (ISO)
Thyroid Neoplasms  (ISO)
transient cerebral ischemia  (ISO)
transitional cell carcinoma  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
Uterine Neoplasms  (ISO)
viral hepatitis  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to hypoxia  (ISO)
DNA biosynthetic process  (ISO)
DNA strand elongation  (ISO)
establishment of protein localization to telomere  (ISO)
mitochondrion organization  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cellular senescence  (ISO)
negative regulation of endothelial cell apoptotic process  (ISO)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of glial cell proliferation  (ISO)
negative regulation of neuron apoptotic process  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of G1/S transition of mitotic cell cycle  (ISO)
positive regulation of glucose import  (ISO)
positive regulation of hair cycle  (ISO)
positive regulation of miRNA transcription  (ISO)
positive regulation of protein localization to nucleolus  (ISO)
positive regulation of stem cell proliferation  (ISO)
positive regulation of transdifferentiation  (ISO)
positive regulation of vascular associated smooth muscle cell migration  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
positive regulation of Wnt signaling pathway  (ISO)
regulation of protein stability  (ISO)
replicative senescence  (ISO)
response to cadmium ion  (ISO)
RNA-templated DNA biosynthetic process  (ISO)
RNA-templated transcription  (ISO)
siRNA processing  (ISO)
siRNA transcription  (ISO)
telomere maintenance via telomerase  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Tert
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955504651,779 - 670,589 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955504649,248 - 669,796 (-)NCBIChiLan1.0ChiLan1.0
TERT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3851,253,167 - 1,295,068 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl51,253,147 - 1,295,068 (-)EnsemblGRCh38hg38GRCh38
GRCh3751,253,282 - 1,295,183 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3651,306,282 - 1,348,162 (-)NCBINCBI36Build 36hg18NCBI36
Build 3451,306,286 - 1,348,159NCBI
Celera51,290,088 - 1,332,097 (-)NCBICelera
Cytogenetic Map5p15.33NCBI
HuRef51,234,692 - 1,275,531 (-)NCBIHuRef
CHM1_151,253,108 - 1,294,322 (-)NCBICHM1_1
T2T-CHM13v2.051,160,074 - 1,202,878 (-)NCBIT2T-CHM13v2.0
Tert
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391373,775,030 - 73,797,962 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1373,775,030 - 73,797,962 (+)EnsemblGRCm39 Ensembl
GRCm381373,626,911 - 73,649,843 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1373,626,911 - 73,649,843 (+)EnsemblGRCm38mm10GRCm38
MGSCv371373,764,449 - 73,786,489 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361374,093,003 - 74,115,043 (+)NCBIMGSCv36mm8
Celera1375,955,877 - 75,977,918 (+)NCBICelera
Cytogenetic Map13C1NCBI
cM Map1340.12NCBI
Tert
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8131,465,766 - 31,488,650 (-)NCBIGRCr8
mRatBN7.2129,637,213 - 29,659,561 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl129,637,506 - 29,659,561 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx129,439,189 - 29,459,951 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0135,439,034 - 35,459,796 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0129,639,816 - 29,660,578 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0132,250,876 - 32,275,330 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl132,251,714 - 32,272,476 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0133,675,744 - 33,697,542 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4130,445,180 - 30,465,942 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera128,286,050 - 28,306,805 (-)NCBICelera
Cytogenetic Map1p11NCBI
TERT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v241,514,877 - 1,559,376 (-)NCBINHGRI_mPanPan1-v2
PanPan1.1 Ensembl51,300,960 - 1,338,872 (-)Ensemblpanpan1.1panPan2
TERT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13411,288,622 - 11,307,790 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3411,288,622 - 11,307,951 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3415,798,490 - 15,817,661 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03411,189,290 - 11,208,463 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3411,189,290 - 11,208,512 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13411,240,107 - 11,259,262 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03411,219,414 - 11,238,599 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03411,430,438 - 11,449,614 (+)NCBIUU_Cfam_GSD_1.0
Tert
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213244,307,679 - 244,331,058 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936815469,020 - 491,697 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936815468,987 - 492,666 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TERT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1679,258,591 - 79,276,421 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11679,258,591 - 79,276,421 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21685,917,150 - 85,935,085 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TERT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.141,082,894 - 1,119,373 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl41,083,384 - 1,117,468 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605435,649,406 - 35,684,819 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tert
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624751624,569 - 647,198 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000008914   ⟹   ENSCLAP00000008786
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955504651,779 - 670,589 (-)Ensembl
RefSeq Acc Id: XM_013505898   ⟹   XP_013361352
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955504649,248 - 669,796 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013361352 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000008786.1
Reference Protein Sequences
RefSeq Acc Id: XP_013361352   ⟸   XM_013505898
- Sequence:
RefSeq Acc Id: ENSCLAP00000008786   ⟸   ENSCLAT00000008914
Protein Domains
Reverse transcriptase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000006143 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000008914.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.132.70 UniProtKB/TrEMBL
  1.10.357.90 UniProtKB/TrEMBL
  3.30.70.2630 UniProtKB/TrEMBL
InterPro DNA/RNA_pol_sf UniProtKB/TrEMBL
  RT_dom UniProtKB/TrEMBL
  Telomerase_RBD UniProtKB/TrEMBL
  Telomerase_RT UniProtKB/TrEMBL
  TERT_C UniProtKB/TrEMBL
NCBI Gene Tert ENTREZGENE
PANTHER PTHR12066 UniProtKB/TrEMBL
  TELOMERASE REVERSE TRANSCRIPTASE UniProtKB/TrEMBL
Pfam Telomerase_RBD UniProtKB/TrEMBL
  TERT_C UniProtKB/TrEMBL
PRINTS TELOMERASERT UniProtKB/TrEMBL
PROSITE RT_POL UniProtKB/TrEMBL
SMART Telomerase_RBD UniProtKB/TrEMBL
Superfamily-SCOP SSF56672 UniProtKB/TrEMBL
UniProt A0A8C2V213_CHILA UniProtKB/TrEMBL