RGD Reference Report - Analysis of hTERT expression in exfoliated cells from patients with bladder transitional cell carcinomas using SYBR green real-time fluorescence quantitative PCR. - Rat Genome Database

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Analysis of hTERT expression in exfoliated cells from patients with bladder transitional cell carcinomas using SYBR green real-time fluorescence quantitative PCR.

Authors: Xie, XY  Yang, X  Zhang, JH  Liu, ZJ 
Citation: Xie XY, etal., Ann Clin Biochem. 2007 Nov;44(Pt 6):523-8.
RGD ID: 2291982
Pubmed: PMID:17961306   (View Abstract at PubMed)
DOI: DOI:10.1258/000456307782268093   (Journal Full-text)

AIMS: To investigate whether hTERT mRNA expression could be used as a diagnostic and prognostic marker of bladder transitional cell carcinoma. METHODS: SYBR green I real-time fluorescence quantitative PCR method was used to quantify hTERT mRNA expression in exfoliated cells from patients with bladder transitional cell carcinomas. RESULTS: A significant correlation was observed between the level of hTERT mRNA expression in exfoliated cells collected in urine with pathological grade and clinical stage. CONCLUSIONS: Our results show that SYBR green real-time fluorescence quantitative evaluation of hTERT mRNA could be a useful marker of tumor progression for the early diagnosis and prognosis of bladder cancers.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
transitional cell carcinoma disease_progressionIEP 2291982mRNA:increased expression:urine and urothelial cellRGD 
transitional cell carcinoma disease_progressionISOTERT (Homo sapiens)2291982; 2291982mRNA:increased expression:urine and urothelial cellRGD 

Objects Annotated

Genes (Rattus norvegicus)
Tert  (telomerase reverse transcriptase)

Genes (Mus musculus)
Tert  (telomerase reverse transcriptase)

Genes (Homo sapiens)
TERT  (telomerase reverse transcriptase)


Additional Information