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GENE - TERM ANNOTATION REPORT

RGD ID: 12557397
Species: Ictidomys tridecemlineatus
RGD Object: Gene
Symbol: Tert
Name: telomerase reverse transcriptase
Acc ID: DOID:9007071
Term: Hereditary Neoplastic Syndromes
Definition: The condition of a pattern of malignancies within a family, but not every individual's necessarily having the same neoplasm. Characteristically the tumor tends to occur at an earlier than average age, individuals may have more than one primary tumor, the tumors may be multicentric, usually more than 25 percent of the individuals in direct lineal descent from the proband are affected, and the cancer predisposition in these families behaves as an autosomal dominant trait with about 60 percent penetrance.
Definition Source(s): MESH:D009386
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tert ISOTERT (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Hereditary Cancer Syndrome | ClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome | ClinVar Annotator: match by term: Hereditary neoplastic syndromePMID:15814878 PMID:15885610 PMID:18302718 PMID:18460650 PMID:18635888 PMID:19489057 PMID:19561322 PMID:19674077 PMID:19760749 PMID:20044353 PMID:20301779 PMID:20502709 PMID:20858879 PMID:21520174 PMID:22424236 PMID:22853774 PMID:23538340 PMID:23716176 PMID:23901009 PMID:24033266 PMID:25741868 PMID:25785092 PMID:26024875 PMID:27848944 PMID:28104920 PMID:28492532 PMID:28495683 PMID:29483670 PMID:30523342 PMID:34019641
Tert ISOTERT (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndromePMID:15814878 PMID:18302718 PMID:18460650 PMID:19561322 PMID:19760749 PMID:20301779 PMID:20502709 PMID:22853774 PMID:23901009 PMID:25741868 PMID:26024875 PMID:26365799 PMID:28154186 PMID:28492532 PMID:28813500 PMID:29483670
Tert ISOTERT (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome | ClinVar Annotator: match by term: Hereditary neoplastic syndromePMID:15814878 PMID:18302718 PMID:18460650 PMID:18635888 PMID:19561322 PMID:19760749 PMID:20044353 PMID:20301779 PMID:20502709 PMID:22853774 PMID:23901009 PMID:25741868 PMID:26024875 PMID:26365799 PMID:28154186 PMID:28492532 PMID:28495683 PMID:28813500 PMID:29483670
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