Tgfbr2 (transforming growth factor beta receptor 2) - Rat Genome Database

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Gene: Tgfbr2 (transforming growth factor beta receptor 2) Ictidomys tridecemlineatus
Analyze
Symbol: Tgfbr2
Name: transforming growth factor beta receptor 2
RGD ID: 12475525
Description: ENCODES a protein that exhibits mitogen-activated protein kinase kinase kinase binding (ortholog); molecular adaptor activity (ortholog); transforming growth factor beta binding (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); animal organ regeneration (ortholog); branching involved in blood vessel morphogenesis (ortholog); PARTICIPATES IN altered transforming growth factor-beta Smad dependent signaling pathway; colorectal cancer pathway; glypican signaling pathway; ASSOCIATED WITH aortic aneurysm (ortholog); arteriosclerosis (ortholog); bone disease (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog); transforming growth factor beta ligand-receptor complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: TGF-beta receptor type-2; transforming growth factor beta receptor 2, transcript variant X1; transforming growth factor beta receptor 2, transcript variant X2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118188,186,107 - 188,270,859 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647321,324,658 - 21,409,430 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647321,324,669 - 21,409,430 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
aortic aneurysm  (ISO)
arteriosclerosis  (ISO)
bone disease  (ISO)
Bone Fractures  (ISO)
Bone Neoplasms  (ISO)
Brain Neoplasms  (ISO)
carcinoma  (ISO)
Carotid Artery Injuries  (ISO)
cholangiocarcinoma  (ISO)
cleft soft palate  (ISO)
colon cancer  (ISO)
Colonic Neoplasms  (ISO)
colorectal cancer  (ISO)
connective tissue disease  (ISO)
Craniofacial Abnormalities  (ISO)
Diabetic Nephropathies  (ISO)
DiGeorge syndrome  (ISO)
Dissecting Aneurysm  (ISO)
Ehlers-Danlos syndrome  (ISO)
esophageal cancer  (ISO)
Esophageal Neoplasms  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Arthritis  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (ISO)
Eye Abnormalities  (ISO)
Familial Thoracic Aortic Aneurysm 1  (ISO)
Fatigue  (ISO)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
hepatoblastoma  (ISO)
hepatocellular carcinoma  (ISO)
hereditary nonpolyposis colorectal cancer type 6  (ISO)
Hyperplasia  (ISO)
inguinal hernia  (ISO)
kidney disease  (ISO)
Loeys-Dietz syndrome  (ISO)
Loeys-Dietz syndrome 1  (ISO)
Loeys-Dietz syndrome 2  (ISO)
Loeys-Dietz Syndrome, Type 1b  (ISO)
Lung Neoplasms  (ISO)
Lynch syndrome  (ISO)
Marfan syndrome  (ISO)
Marfan Syndrome Type 2  (ISO)
Marfanoid Hypermobility Syndrome  (ISO)
membranoproliferative glomerulonephritis  (ISO)
Microsatellite Instability  (ISO)
migraine  (ISO)
mismatch repair cancer syndrome  (ISO)
multiple acyl-CoA dehydrogenase deficiency  (ISO)
myocardial infarction  (ISO)
Neoplasm Metastasis  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
Radiation Injuries  (ISO)
Reperfusion Injury  (ISO)
thoracic aortic aneurysm  (ISO)
type 2 diabetes mellitus  (ISO)
vasculogenic impotence  (ISO)
Wolff-Parkinson-White syndrome  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (ISO)
animal organ regeneration  (ISO)
aorta morphogenesis  (IEA)
aortic valve morphogenesis  (IEA)
apoptotic process  (IEA)
artery morphogenesis  (IEA)
atrioventricular valve morphogenesis  (IEA)
brain development  (IEA)
branching involved in blood vessel morphogenesis  (IEA,ISO)
bronchus development  (IEA,ISO)
bronchus morphogenesis  (IEA,ISO)
cardiac left ventricle morphogenesis  (IEA)
cartilage development  (IEA)
cell differentiation  (IEA)
cell proliferation involved in endocardial cushion morphogenesis  (ISO)
cell surface receptor protein serine/threonine kinase signaling pathway  (IEA)
digestive tract development  (ISO)
embryo implantation  (ISO)
embryonic cranial skeleton morphogenesis  (IEA)
embryonic hemopoiesis  (IEA)
endocardial cushion fusion  (IEA)
epithelial to mesenchymal transition  (IEA)
gastrulation  (IEA,ISO)
growth plate cartilage chondrocyte growth  (IEA,ISO)
growth plate cartilage development  (IEA,ISO)
heart development  (IEA,ISO)
heart looping  (IEA)
in utero embryonic development  (IEA,ISO)
inferior endocardial cushion morphogenesis  (IEA)
Langerhans cell differentiation  (IEA,ISO)
lens development in camera-type eye  (IEA,ISO)
lens fiber cell apoptotic process  (IEA,ISO)
lung development  (IEA,ISO)
lung lobe morphogenesis  (IEA,ISO)
lung morphogenesis  (IEA,ISO)
mammary gland morphogenesis  (IEA,ISO)
membranous septum morphogenesis  (IEA)
miRNA transport  (IEA)
negative regulation of cardiac muscle cell proliferation  (ISO)
negative regulation of cell population proliferation  (ISO)
Notch signaling pathway  (IEA,ISO)
outflow tract morphogenesis  (IEA)
outflow tract septum morphogenesis  (IEA)
positive regulation of angiogenesis  (IEA,ISO)
positive regulation of B cell tolerance induction  (IEA,ISO)
positive regulation of CD4-positive, alpha-beta T cell proliferation  (IEA)
positive regulation of epithelial cell migration  (IEA,ISO)
positive regulation of epithelial to mesenchymal transition  (IEA)
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation  (IEA)
positive regulation of mesenchymal cell proliferation  (IEA)
positive regulation of NK T cell differentiation  (IEA,ISO)
positive regulation of reactive oxygen species metabolic process  (IEA)
positive regulation of skeletal muscle tissue regeneration  (ISO)
positive regulation of SMAD protein signal transduction  (IEA)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of T cell tolerance induction  (IEA,ISO)
positive regulation of tolerance induction to self antigen  (IEA,ISO)
receptor-mediated endocytosis  (ISO)
regulation of cell population proliferation  (IEA,ISO)
regulation of gene expression  (IEA,ISO)
regulation of stem cell differentiation  (IEA)
regulation of stem cell proliferation  (IEA,ISO)
response to cholesterol  (IEA)
response to estrogen  (ISO)
response to glucose  (ISO)
response to hypoxia  (ISO)
response to mechanical stimulus  (ISO)
response to nutrient  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to steroid hormone  (ISO)
response to xenobiotic stimulus  (IEA)
roof of mouth development  (IEA)
secondary palate development  (IEA)
SMAD protein signal transduction  (IEA,ISO)
smoothened signaling pathway  (IEA,ISO)
superior endocardial cushion morphogenesis  (ISO)
trachea formation  (IEA,ISO)
trachea morphogenesis  (IEA,ISO)
transforming growth factor beta receptor signaling pathway  (IEA,ISO)
tricuspid valve morphogenesis  (IEA)
vasculogenesis  (IEA,ISO)
ventricular septum morphogenesis  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Tgfbr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118188,186,107 - 188,270,859 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647321,324,658 - 21,409,430 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647321,324,669 - 21,409,430 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TGFBR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38330,606,356 - 30,694,142 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl330,606,601 - 30,694,142 (+)EnsemblGRCh38hg38GRCh38
GRCh37330,647,994 - 30,735,634 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36330,622,998 - 30,710,638 (+)NCBINCBI36Build 36hg18NCBI36
Build 34330,623,041 - 30,708,147NCBI
Celera330,584,920 - 30,672,564 (+)NCBICelera
Cytogenetic Map3p24.1NCBI
HuRef330,590,599 - 30,678,240 (+)NCBIHuRef
CHM1_1330,598,177 - 30,685,783 (+)NCBICHM1_1
T2T-CHM13v2.0330,608,862 - 30,696,629 (+)NCBIT2T-CHM13v2.0
Tgfbr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399115,916,763 - 116,004,431 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9115,913,361 - 116,004,428 (-)EnsemblGRCm39 Ensembl
GRCm389116,087,695 - 116,175,363 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9116,084,293 - 116,175,360 (-)EnsemblGRCm38mm10GRCm38
MGSCv379115,996,813 - 116,084,481 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369115,936,405 - 116,023,987 (-)NCBIMGSCv36mm8
Celera9116,548,860 - 116,637,499 (-)NCBICelera
Cytogenetic Map9F3NCBI
cM Map968.39NCBI
Tgfbr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88124,672,677 - 124,761,741 (-)NCBIGRCr8
mRatBN7.28115,794,537 - 115,883,615 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8115,794,537 - 115,883,228 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8121,401,503 - 121,487,689 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08119,600,574 - 119,686,750 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08117,443,698 - 117,530,245 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08124,310,288 - 124,399,345 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8124,312,754 - 124,399,494 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08123,585,765 - 123,671,209 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48120,593,595 - 120,680,453 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18120,613,331 - 120,700,190 (-)NCBI
Celera8115,012,175 - 115,096,500 (-)NCBICelera
Cytogenetic Map8q32NCBI
Tgfbr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543021,932,553 - 22,001,837 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543021,919,338 - 21,999,688 (+)NCBIChiLan1.0ChiLan1.0
TGFBR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2230,595,399 - 30,683,103 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1330,600,475 - 30,687,834 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0330,536,187 - 30,623,653 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1330,854,071 - 30,941,378 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl330,854,460 - 30,938,856 (+)Ensemblpanpan1.1panPan2
TGFBR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12313,886,869 - 13,946,480 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2313,889,000 - 13,977,636 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2313,869,985 - 13,959,686 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02314,182,445 - 14,272,114 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2314,182,447 - 14,272,161 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12313,979,792 - 14,069,422 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02314,125,731 - 14,215,435 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02314,144,194 - 14,234,152 (-)NCBIUU_Cfam_GSD_1.0
TGFBR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1316,784,490 - 16,878,160 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11316,784,370 - 16,875,828 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21318,707,787 - 18,712,636 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TGFBR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11575,112,903 - 75,200,263 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1575,112,561 - 75,197,711 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604148,399,611 - 48,486,893 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tgfbr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247888,447,542 - 8,535,959 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247888,447,679 - 8,535,821 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSSTOT00000028455   ⟹   ENSSTOP00000023691
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493647321,324,658 - 21,409,430 (+)Ensembl
RefSeq Acc Id: ENSSTOT00000037765   ⟹   ENSSTOP00000024905
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493647321,324,720 - 21,409,430 (+)Ensembl
RefSeq Acc Id: XM_005317310   ⟹   XP_005317367
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118188,186,157 - 188,270,859 (+)NCBI
SpeTri2.0NW_00493647321,324,735 - 21,409,430 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005317311   ⟹   XP_005317368
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118188,186,107 - 188,270,859 (+)NCBI
SpeTri2.0NW_00493647321,324,669 - 21,409,430 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005317367 (Get FASTA)   NCBI Sequence Viewer  
  XP_005317368 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000023691.1
  ENSSTOP00000024905.1
GenBank Protein KAG3279545 (Get FASTA)   NCBI Sequence Viewer  
  KAG3279546 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_005317368   ⟸   XM_005317311
- Peptide Label: isoform X2
- UniProtKB: I3NH44 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005317367   ⟸   XM_005317310
- Peptide Label: isoform X1
- UniProtKB: A0A287CU99 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSTOP00000023691   ⟸   ENSSTOT00000028455
RefSeq Acc Id: ENSSTOP00000024905   ⟸   ENSSTOT00000037765
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000019376 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000028455.2 UniProtKB/TrEMBL
  ENSSTOT00000037765.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.60.10 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  Snake_toxin-like_sf UniProtKB/TrEMBL
  TGFB_receptor UniProtKB/TrEMBL
  Transform_growth_fac-b_typ-2 UniProtKB/TrEMBL
  Transforming_GF_b_rcpt_2_ecto UniProtKB/TrEMBL
NCBI Gene Tgfbr2 ENTREZGENE
PANTHER PTHR23255 UniProtKB/TrEMBL
  TGF-BETA RECEPTOR TYPE-2 UniProtKB/TrEMBL
Pfam ecTbetaR2 UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL
PIRSF TGFRII UniProtKB/TrEMBL
PRINTS ACTIVIN2R UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
  SSF57302 UniProtKB/TrEMBL
UniProt A0A287CU99 ENTREZGENE, UniProtKB/TrEMBL
  I3NH44 ENTREZGENE, UniProtKB/TrEMBL