Abca3 (ATP binding cassette subfamily A member 3) - Rat Genome Database

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Gene: Abca3 (ATP binding cassette subfamily A member 3) Ictidomys tridecemlineatus
Analyze
Symbol: Abca3
Name: ATP binding cassette subfamily A member 3 (Ensembl:ATP-binding cassette sub-family A member 3)
RGD ID: 12500477
Description: ENCODES a protein that exhibits ABC-type transporter activity (inferred); ABC-type xenobiotic transporter activity (inferred); ATP binding (inferred); INVOLVED IN response to glucocorticoid (ortholog); PARTICIPATES IN altered surfactant homeostasis pathway; surfactant homeostasis pathway; transport pathway; ASSOCIATED WITH chromosome 22q11.2 deletion syndrome, distal (ortholog); Colorectal Neoplasms (ortholog); Congenital Pulmonary Lymphangiectasia (ortholog); FOUND IN alveolar lamellar body membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ATP-binding cassette sub-family A member 3; ATP-binding cassette sub-family A member 3, transcript variant X1; ATP-binding cassette sub-family A member 3, transcript variant X2; ATP-binding cassette sub-family A member 3, transcript variant X3; ATP-binding cassette sub-family A member 3, transcript variant X4; ATP-binding cassette sub-family A member 3, transcript variant X5; LOC101964223
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344104,931,363 - 104,975,718 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366941,736,207 - 1,778,116 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366941,735,206 - 1,778,100 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Abca3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344104,931,363 - 104,975,718 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366941,736,207 - 1,778,116 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366941,735,206 - 1,778,100 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38162,275,881 - 2,340,728 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl162,275,881 - 2,340,746 (-)EnsemblGRCh38hg38GRCh38
GRCh37162,325,882 - 2,390,729 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36162,265,880 - 2,330,748 (-)NCBINCBI36Build 36hg18NCBI36
Build 34162,265,883 - 2,330,595NCBI
Celera162,540,308 - 2,605,176 (-)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef162,251,902 - 2,305,693 (-)NCBIHuRef
CHM1_1162,325,836 - 2,390,894 (-)NCBICHM1_1
T2T-CHM13v2.0162,298,327 - 2,363,113 (-)NCBIT2T-CHM13v2.0
Abca3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391724,570,997 - 24,629,178 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1724,570,924 - 24,629,175 (+)EnsemblGRCm39 Ensembl
GRCm381724,351,921 - 24,410,204 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1724,351,950 - 24,410,201 (+)EnsemblGRCm38mm10GRCm38
MGSCv371724,488,991 - 24,547,146 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361724,079,646 - 24,137,801 (+)NCBIMGSCv36mm8
Celera1724,865,306 - 24,922,824 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.38NCBI
Abca3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81013,886,948 - 13,944,286 (+)NCBIGRCr8
mRatBN7.21013,382,439 - 13,439,748 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,382,540 - 13,439,745 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1018,128,894 - 18,186,191 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01017,617,736 - 17,675,035 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01013,116,920 - 13,174,223 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01013,723,365 - 13,780,558 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1013,723,405 - 13,779,963 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01013,539,739 - 13,597,488 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41013,619,865 - 13,665,066 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11013,605,987 - 13,664,059 (+)NCBI
Celera1013,062,889 - 13,120,240 (+)NCBICelera
Cytogenetic Map10q12NCBI
Abca3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544214,933,550 - 14,989,492 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544214,933,550 - 14,989,492 (+)NCBIChiLan1.0ChiLan1.0
ABCA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2182,777,564 - 2,841,351 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1166,558,502 - 6,622,328 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0161,132,435 - 1,196,226 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1162,376,006 - 2,437,427 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl162,376,006 - 2,437,427 (-)Ensemblpanpan1.1panPan2
ABCA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1638,679,312 - 38,712,868 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl638,679,324 - 38,712,648 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha639,912,394 - 39,952,493 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0638,981,385 - 39,021,683 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl638,981,033 - 39,021,741 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1638,666,452 - 38,706,734 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0638,638,971 - 38,679,063 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0639,117,459 - 39,157,746 (+)NCBIUU_Cfam_GSD_1.0
ABCA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl339,698,895 - 39,732,978 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1339,689,133 - 39,732,466 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2342,433,553 - 42,469,125 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103226816
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.152,171,487 - 2,218,851 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606828,821,142 - 28,886,157 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abca3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462482484,430 - 144,062 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462482485,369 - 144,053 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000013218   ⟹   ENSSTOP00000011846
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049366941,736,207 - 1,778,116 (+)Ensembl
RefSeq Acc Id: ENSSTOT00000030933   ⟹   ENSSTOP00000026295
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049366941,738,681 - 1,777,290 (+)Ensembl
RefSeq Acc Id: XM_021734918   ⟹   XP_021590593
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024409344104,932,131 - 104,975,718 (-)NCBI
SpeTri2.0NW_0049366941,735,206 - 1,778,100 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021734919   ⟹   XP_021590594
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024409344104,931,363 - 104,970,803 (-)NCBI
SpeTri2.0NW_0049366941,737,083 - 1,778,100 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021734921   ⟹   XP_021590596
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024409344104,932,131 - 104,975,718 (-)NCBI
SpeTri2.0NW_0049366941,736,620 - 1,778,100 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021734922   ⟹   XP_021590597
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024409344104,932,131 - 104,975,718 (-)NCBI
SpeTri2.0NW_0049366941,735,206 - 1,778,100 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_021590593   ⟸   XM_021734918
- UniProtKB: I3MKK6 (UniProtKB/TrEMBL),   A0A287CY85 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021590597   ⟸   XM_021734922
- UniProtKB: I3MKK6 (UniProtKB/TrEMBL),   A0A287CY85 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021590596   ⟸   XM_021734921
- UniProtKB: I3MKK6 (UniProtKB/TrEMBL),   A0A287CY85 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021590594   ⟸   XM_021734919
- UniProtKB: I3MKK6 (UniProtKB/TrEMBL),   A0A287CY85 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSTOP00000026295   ⟸   ENSSTOT00000030933
RefSeq Acc Id: ENSSTOP00000011846   ⟸   ENSSTOT00000013218
Protein Domains
ABC transporter


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000013206 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000013218.3 UniProtKB/TrEMBL
  ENSSTOT00000030933.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/TrEMBL
  ABC2_TM UniProtKB/TrEMBL
  ABC_transporter-like UniProtKB/TrEMBL
  ABC_transporter_CS UniProtKB/TrEMBL
  ABCA UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene Abca3 ENTREZGENE
PANTHER PHOSPHOLIPID-TRANSPORTING ATPASE ABCA3 UniProtKB/TrEMBL
  PTHR19229 UniProtKB/TrEMBL
Pfam ABC2_membrane_3 UniProtKB/TrEMBL
  ABC_tran UniProtKB/TrEMBL
PROSITE ABC_TRANSPORTER_1 UniProtKB/TrEMBL
  ABC_TRANSPORTER_2 UniProtKB/TrEMBL
SMART AAA UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A287CY85 ENTREZGENE, UniProtKB/TrEMBL
  I3MKK6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-26 Abca3  ATP binding cassette subfamily A member 3  LOC101964223  ATP-binding cassette sub-family A member 3  Symbol and/or name change 5135510 APPROVED
2017-07-13 LOC101964223  ATP-binding cassette sub-family A member 3  Abca3  ATP binding cassette subfamily A member 3  Symbol and/or name change 5135510 APPROVED