Cflar (CASP8 and FADD like apoptosis regulator) - Rat Genome Database

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Gene: Cflar (CASP8 and FADD like apoptosis regulator) Ictidomys tridecemlineatus
Analyze
Symbol: Cflar
Name: CASP8 and FADD like apoptosis regulator
RGD ID: 12629345
Description: ENCODES a protein that exhibits death receptor binding (ortholog); peptidase activator activity (ortholog); protease binding (ortholog); INVOLVED IN apoptotic process (ortholog); cellular response to dexamethasone stimulus (ortholog); cellular response to epidermal growth factor stimulus (ortholog); PARTICIPATES IN FasL mediated signaling pathway; Trail mediated signaling pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); autoimmune lymphoproliferative syndrome type 2B (ortholog); Autoimmune Lymphoproliferative Syndrome, Type V (ortholog); FOUND IN CD95 death-inducing signaling complex (ortholog); death-inducing signaling complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: CASP8 and FADD-like apoptosis regulator
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303158,411,636 - 158,453,829 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936726381,835 - 423,311 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936726381,888 - 425,565 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA,ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to epidermal growth factor stimulus  (ISO)
cellular response to estradiol stimulus  (ISO)
cellular response to hypoxia  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to nitric oxide  (ISO)
necroptotic process  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of cellular response to transforming growth factor beta stimulus  (ISO)
negative regulation of epithelial cell apoptotic process  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (IEA,ISO)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (IEA,ISO)
negative regulation of hepatocyte apoptotic process  (ISO)
negative regulation of myoblast fusion  (ISO)
negative regulation of necroptotic process  (ISO)
negative regulation of reactive oxygen species biosynthetic process  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (IEA)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of extracellular matrix organization  (ISO)
positive regulation of glomerular mesangial cell proliferation  (ISO)
positive regulation of hepatocyte proliferation  (ISO)
positive regulation of neuron projection development  (ISO)
proteolysis  (IEA)
regulation of apoptotic process  (IEA)
regulation of necroptotic process  (IEA)
regulation of skeletal muscle satellite cell proliferation  (ISO)
response to bacterium  (ISO)
response to hypoxia  (ISO)
response to testosterone  (ISO)
skeletal muscle atrophy  (ISO)
skeletal muscle tissue development  (ISO)
skeletal muscle tissue regeneration  (ISO)
skeletal myofibril assembly  (ISO)
wound healing  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Cflar
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303158,411,636 - 158,453,829 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936726381,835 - 423,311 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936726381,888 - 425,565 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CFLAR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382201,116,164 - 201,176,687 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2201,116,154 - 201,176,687 (+)EnsemblGRCh38hg38GRCh38
GRCh372201,980,887 - 202,041,410 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362201,689,135 - 201,737,260 (+)NCBINCBI36Build 36hg18NCBI36
Build 342201,806,395 - 201,854,507NCBI
Celera2195,735,441 - 195,783,644 (+)NCBICelera
Cytogenetic Map2q33.1NCBI
HuRef2193,832,403 - 193,888,781 (+)NCBIHuRef
CHM1_12201,986,842 - 202,043,389 (+)NCBICHM1_1
T2T-CHM13v2.02201,599,606 - 201,660,139 (+)NCBIT2T-CHM13v2.0
Cflar
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39158,750,353 - 58,798,043 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl158,750,667 - 58,798,043 (+)EnsemblGRCm39 Ensembl
GRCm38158,711,311 - 58,758,884 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl158,711,508 - 58,758,884 (+)EnsemblGRCm38mm10GRCm38
MGSCv37158,770,130 - 58,815,728 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36158,657,840 - 58,699,711 (+)NCBIMGSCv36mm8
Celera159,232,248 - 59,277,933 (+)NCBICelera
Cytogenetic Map1C1.3NCBI
cM Map129.16NCBI
Cflar
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8967,679,502 - 67,747,226 (+)NCBIGRCr8
mRatBN7.2960,185,338 - 60,236,173 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl960,185,452 - 60,237,034 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx968,680,901 - 68,731,637 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0973,796,857 - 73,847,595 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0972,115,115 - 72,165,854 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0965,534,608 - 65,586,395 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl965,534,704 - 65,587,251 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0965,342,359 - 65,390,152 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4957,309,836 - 57,356,635 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1957,475,312 - 57,481,853 (+)NCBI
Celera957,626,739 - 57,673,502 (+)NCBICelera
Cytogenetic Map9q31NCBI
Cflar
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955403412,632 - 434,741 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955403415,092 - 442,214 (-)NCBIChiLan1.0ChiLan1.0
CFLAR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213103,740,494 - 103,799,335 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B103,757,374 - 103,814,330 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B88,373,057 - 88,429,959 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B206,528,943 - 206,585,848 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B206,528,943 - 206,577,045 (+)Ensemblpanpan1.1panPan2
CFLAR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13710,268,407 - 10,307,803 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3710,268,582 - 10,345,095 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3711,153,354 - 11,191,827 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03710,173,456 - 10,212,316 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3710,173,527 - 10,222,398 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13710,154,909 - 10,193,670 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03710,133,242 - 10,172,157 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03710,126,854 - 10,165,741 (+)NCBIUU_Cfam_GSD_1.0
CFLAR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15104,781,616 - 104,835,630 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115104,780,744 - 104,835,631 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215116,105,245 - 116,184,924 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CFLAR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11086,768,252 - 86,819,963 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1086,782,240 - 86,816,652 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040112,604,271 - 112,651,003 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cflar
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462488975,396 - 100,989 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462488976,760 - 108,619 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005338900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013364597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021735655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021735656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021735657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021735658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040294687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040294688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040294690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040294691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040294692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040294693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040294694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040294695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_040294696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002485538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSSTOT00000009643   ⟹   ENSSTOP00000008652
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936726381,835 - 423,311 (+)Ensembl
RefSeq Acc Id: ENSSTOT00000042246   ⟹   ENSSTOP00000025069
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936726381,835 - 423,311 (+)Ensembl
RefSeq Acc Id: XM_005338900   ⟹   XP_005338957
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303158,411,835 - 158,453,829 (+)NCBI
SpeTri2.0NW_004936726381,888 - 424,280 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013364597   ⟹   XP_013220051
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303158,411,636 - 158,453,829 (+)NCBI
SpeTri2.0NW_004936726381,888 - 424,280 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021735656   ⟹   XP_021591331
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303158,411,843 - 158,453,829 (+)NCBI
SpeTri2.0NW_004936726381,888 - 424,280 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021735657   ⟹   XP_021591332
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303158,411,649 - 158,453,829 (+)NCBI
SpeTri2.0NW_004936726381,888 - 424,280 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021735658   ⟹   XP_021591333
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303158,430,182 - 158,453,829 (+)NCBI
SpeTri2.0NW_004936726400,588 - 424,280 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040294687   ⟹   XP_040150621
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303158,413,166 - 158,453,829 (+)NCBI
RefSeq Acc Id: XM_040294688   ⟹   XP_040150622
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303158,413,166 - 158,453,829 (+)NCBI
RefSeq Acc Id: XM_040294690   ⟹   XP_040150624
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303158,412,010 - 158,453,829 (+)NCBI
RefSeq Acc Id: XM_040294691   ⟹   XP_040150625
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303158,411,636 - 158,453,829 (+)NCBI
RefSeq Acc Id: XM_040294692   ⟹   XP_040150626
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303158,411,835 - 158,453,829 (+)NCBI
RefSeq Acc Id: XM_040294693   ⟹   XP_040150627
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303158,413,166 - 158,453,829 (+)NCBI
RefSeq Acc Id: XM_040294694   ⟹   XP_040150628
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303158,413,166 - 158,453,829 (+)NCBI
RefSeq Acc Id: XM_040294695   ⟹   XP_040150629
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303158,430,292 - 158,453,829 (+)NCBI
RefSeq Acc Id: XM_040294696   ⟹   XP_040150630
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303158,411,865 - 158,453,829 (+)NCBI
RefSeq Acc Id: XP_005338957   ⟸   XM_005338900
- Peptide Label: isoform X1
- UniProtKB: I3MDY3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013220051   ⟸   XM_013364597
- Peptide Label: isoform X1
- UniProtKB: I3MDY3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021591331   ⟸   XM_021735656
- Peptide Label: isoform X1
- UniProtKB: I3MDY3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021591332   ⟸   XM_021735657
- Peptide Label: isoform X1
- UniProtKB: I3MDY3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021591333   ⟸   XM_021735658
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_040150625   ⟸   XM_040294691
- Peptide Label: isoform X3
RefSeq Acc Id: XP_040150626   ⟸   XM_040294692
- Peptide Label: isoform X3
RefSeq Acc Id: XP_040150630   ⟸   XM_040294696
- Peptide Label: isoform X3
RefSeq Acc Id: XP_040150624   ⟸   XM_040294690
- Peptide Label: isoform X2
RefSeq Acc Id: XP_040150621   ⟸   XM_040294687
- Peptide Label: isoform X1
- UniProtKB: I3MDY3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040150627   ⟸   XM_040294693
- Peptide Label: isoform X3
RefSeq Acc Id: XP_040150622   ⟸   XM_040294688
- Peptide Label: isoform X1
- UniProtKB: I3MDY3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040150628   ⟸   XM_040294694
- Peptide Label: isoform X3
RefSeq Acc Id: XP_040150629   ⟸   XM_040294695
- Peptide Label: isoform X3
RefSeq Acc Id: ENSSTOP00000008652   ⟸   ENSSTOT00000009643
RefSeq Acc Id: ENSSTOP00000025069   ⟸   ENSSTOT00000042246
Protein Domains
Caspase family p20   DED


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000009642 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000009643.3 UniProtKB/TrEMBL
  ENSSTOT00000042246.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  3.40.50.1460 UniProtKB/TrEMBL
InterPro Caspase-like_dom_sf UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/TrEMBL
  DED_dom UniProtKB/TrEMBL
  Pept_C14_caspase UniProtKB/TrEMBL
  Pept_C14_p20 UniProtKB/TrEMBL
  Pept_C14A UniProtKB/TrEMBL
NCBI Gene Cflar ENTREZGENE
PANTHER CASP8 AND FADD LIKE APOPTOSIS REGULATOR UniProtKB/TrEMBL
  DED DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam DED UniProtKB/TrEMBL
  Peptidase_C14 UniProtKB/TrEMBL
PRINTS IL1BCENZYME UniProtKB/TrEMBL
PROSITE CASPASE_P20 UniProtKB/TrEMBL
  DED UniProtKB/TrEMBL
SMART CASc UniProtKB/TrEMBL
  DED UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/TrEMBL
  SSF52129 UniProtKB/TrEMBL
UniProt I3MDY3 ENTREZGENE, UniProtKB/TrEMBL