Adora2a (adenosine A2a receptor) - Rat Genome Database

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Pathways
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Gene: Adora2a (adenosine A2a receptor) Ictidomys tridecemlineatus
Analyze
Symbol: Adora2a
Name: adenosine A2a receptor
RGD ID: 12645635
Description: ENCODES a protein that exhibits alpha-actinin binding (ortholog); G protein-coupled adenosine receptor activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); apoptotic signaling pathway (ortholog); astrocyte activation (ortholog); PARTICIPATES IN adenosine signaling pathway; hypoxia inducible factor pathway; ASSOCIATED WITH amphetamine abuse (ortholog); anxiety disorder (ortholog); asthma (ortholog); FOUND IN asymmetric synapse (ortholog); axolemma (ortholog); axon (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: adenosine A2a receptor, transcript variant X1; adenosine A2a receptor, transcript variant X2; adenosine receptor A2a
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118142,136,447 - 142,156,176 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936619608,441 - 616,779 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936619597,970 - 618,564 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IEA,ISO)
apoptotic signaling pathway  (IEA,ISO)
astrocyte activation  (ISO)
eating behavior  (IEA,ISO)
excitatory postsynaptic potential  (ISO)
G protein-coupled adenosine receptor signaling pathway  (IEA,ISO)
G protein-coupled receptor signaling pathway  (IEA,ISO)
inhibitory postsynaptic potential  (IEA,ISO)
locomotory behavior  (IEA,ISO)
membrane depolarization  (ISO)
negative regulation of alpha-beta T cell activation  (IEA,ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
negative regulation of inflammatory response  (IEA,ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of protein kinase activity  (ISO)
negative regulation of vascular permeability  (ISO)
neuron projection morphogenesis  (ISO)
positive regulation of acetylcholine secretion, neurotransmission  (ISO)
positive regulation of apoptotic signaling pathway  (IEA,ISO)
positive regulation of circadian sleep/wake cycle, sleep  (ISO)
positive regulation of glutamate secretion  (ISO)
positive regulation of long-term synaptic potentiation  (ISO)
positive regulation of protein secretion  (ISO)
positive regulation of synaptic transmission, GABAergic  (IEA,ISO)
positive regulation of synaptic transmission, glutamatergic  (ISO)
positive regulation of urine volume  (ISO)
prepulse inhibition  (ISO)
presynaptic modulation of chemical synaptic transmission  (ISO)
protein kinase C-activating G protein-coupled receptor signaling pathway  (ISO)
regulation of calcium ion transport  (ISO)
regulation of cell communication  (IEA)
regulation of DNA-templated transcription  (ISO)
regulation of mitochondrial membrane potential  (ISO)
regulation of norepinephrine secretion  (ISO)
regulation of signaling  (IEA)
response to alkaloid  (ISO)
response to amphetamine  (IEA,ISO)
response to caffeine  (ISO)
response to inorganic substance  (IEA)
response to purine-containing compound  (IEA)
response to xenobiotic stimulus  (ISO)
signal transduction  (IEA)
synaptic transmission, cholinergic  (ISO)
synaptic transmission, dopaminergic  (IEA,ISO)
synaptic transmission, glutamatergic  (ISO)
vasodilation  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Adora2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118142,136,447 - 142,156,176 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936619608,441 - 616,779 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936619597,970 - 618,564 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADORA2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382224,423,597 - 24,442,357 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2224,417,879 - 24,442,357 (+)EnsemblGRCh38hg38GRCh38
GRCh372224,819,565 - 24,838,325 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362223,153,530 - 23,168,325 (+)NCBINCBI36Build 36hg18NCBI36
Build 342223,153,645 - 23,162,878NCBI
Celera228,623,253 - 8,638,061 (+)NCBICelera
Cytogenetic Map22q11.23NCBI
HuRef227,769,458 - 7,788,241 (+)NCBIHuRef
CHM1_12224,778,238 - 24,796,999 (+)NCBICHM1_1
T2T-CHM13v2.02224,885,210 - 24,903,991 (+)NCBIT2T-CHM13v2.0
Adora2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391075,152,711 - 75,170,626 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1075,152,711 - 75,170,618 (+)EnsemblGRCm39 Ensembl
GRCm381075,316,877 - 75,334,792 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1075,316,877 - 75,334,784 (+)EnsemblGRCm38mm10GRCm38
MGSCv371074,779,688 - 74,797,533 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361074,769,745 - 74,777,652 (+)NCBIMGSCv36mm8
Celera1076,364,032 - 76,382,114 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1038.52NCBI
Adora2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82013,315,270 - 13,332,802 (-)NCBIGRCr8
mRatBN7.22013,315,848 - 13,333,386 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2013,315,853 - 13,333,386 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2014,022,398 - 14,039,933 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02013,383,344 - 13,400,756 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02013,855,867 - 13,873,399 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02014,265,251 - 14,282,873 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2014,265,252 - 14,282,873 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02016,449,385 - 16,466,147 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42013,815,719 - 13,834,131 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12013,815,944 - 13,825,845 (-)NCBI
Celera2014,801,379 - 14,818,841 (-)NCBICelera
Cytogenetic Map20p12NCBI
Adora2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554557,895,974 - 7,906,505 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554557,886,720 - 7,906,214 (+)NCBIChiLan1.0ChiLan1.0
ADORA2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22334,212,582 - 34,231,247 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12236,943,248 - 36,961,861 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0225,233,876 - 5,248,622 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12222,099,404 - 22,114,189 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2222,104,253 - 22,114,189 (+)Ensemblpanpan1.1panPan2
ADORA2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12628,141,076 - 28,150,600 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2628,141,076 - 28,150,598 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2627,207,866 - 27,225,894 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02629,536,347 - 29,554,384 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2629,534,227 - 29,554,392 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12627,619,698 - 27,637,726 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02627,237,300 - 27,255,320 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02628,226,384 - 28,244,417 (+)NCBIUU_Cfam_GSD_1.0
ADORA2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1449,468,877 - 49,485,850 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11449,467,186 - 49,485,845 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21452,914,635 - 52,931,654 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADORA2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1197,691,678 - 7,706,781 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl197,691,536 - 7,706,926 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660854,894,557 - 4,913,637 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adora2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247479,851,153 - 9,860,094 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247479,846,254 - 9,860,938 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000029443   ⟹   ENSSTOP00000018606
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936619608,441 - 616,779 (+)Ensembl
RefSeq Acc Id: XM_005334448   ⟹   XP_005334505
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118142,136,447 - 142,155,984 (-)NCBI
SpeTri2.0NW_004936619598,077 - 618,564 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013362470   ⟹   XP_013217924
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118142,136,447 - 142,156,176 (-)NCBI
SpeTri2.0NW_004936619597,970 - 618,564 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040289330   ⟹   XP_040145264
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118142,136,447 - 142,147,033 (-)NCBI
RefSeq Acc Id: XM_040289331   ⟹   XP_040145265
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118142,136,447 - 142,146,752 (-)NCBI
RefSeq Acc Id: XM_040289332   ⟹   XP_040145266
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118142,136,447 - 142,151,390 (-)NCBI
RefSeq Acc Id: XM_040289333   ⟹   XP_040145267
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405118142,136,447 - 142,146,309 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_013217924   ⟸   XM_013362470
- UniProtKB: I3N2L0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005334505   ⟸   XM_005334448
- UniProtKB: I3N2L0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040145266   ⟸   XM_040289332
- UniProtKB: I3N2L0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040145264   ⟸   XM_040289330
- UniProtKB: I3N2L0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040145265   ⟸   XM_040289331
- UniProtKB: I3N2L0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040145267   ⟸   XM_040289333
- UniProtKB: I3N2L0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSSTOP00000018606   ⟸   ENSSTOT00000029443
Protein Domains
G-protein coupled receptors family 1 profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000019368 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000029443.2 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro Adeno_A2A_rcpt UniProtKB/TrEMBL
  Adenosn_rcpt UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
NCBI Gene Adora2a ENTREZGENE
PANTHER ADENOSINE RECEPTOR A2A UniProtKB/TrEMBL
  OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS ADENOSINA2AR UniProtKB/TrEMBL
  ADENOSINER UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt I3N2L0 ENTREZGENE, UniProtKB/TrEMBL