Agt (angiotensinogen) - Rat Genome Database

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Pathways
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Gene: Agt (angiotensinogen) Ictidomys tridecemlineatus
Analyze
Symbol: Agt
Name: angiotensinogen
RGD ID: 12652862
Description: ENCODES a protein that exhibits receptor ligand activity (ortholog); sodium channel regulator activity (ortholog); INVOLVED IN activation of phospholipase C activity (ortholog); aldosterone secretion (ortholog); angiotensin-mediated drinking behavior (ortholog); PARTICIPATES IN angiotensin (1-7) signaling pathway; angiotensin II signaling pathway; angiotensin II signaling pathway via AT1 receptor; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Actin-Accumulation Myopathy (ortholog); Albuminuria (ortholog); FOUND IN extracellular space (ortholog); mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934443,547,972 - 43,555,916 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648419,716,165 - 19,721,261 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648419,713,299 - 19,721,144 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Actin-Accumulation Myopathy  (ISO)
Albuminuria  (ISO)
alcoholic cardiomyopathy  (ISO)
alcoholic hepatitis  (ISO)
Alkalosis  (ISO)
allergic disease  (ISO)
Alzheimer's disease  (ISO)
Anaphylaxis  (ISO)
anemia  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
anuria  (ISO)
aortic aneurysm  (ISO)
Aortic Calcification  (ISO)
Aortic Coarctation  (ISO)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
Bradycardia  (ISO)
breast cancer  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
Cardiotoxicity  (ISO)
Cardiovascular Abnormalities  (ISO)
cardiovascular system disease  (ISO)
carotid artery disease  (ISO)
Catalepsy  (ISO)
cerebrovascular disease  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (ISO)
Chronic Intermittent Hypoxia  (ISO)
chronic myeloid leukemia  (ISO)
cleidocranial dysplasia  (ISO)
cognitive disorder  (ISO)
congenital disorder of glycosylation type IIq  (ISO)
congestive heart failure  (ISO)
corneal neovascularization  (ISO)
COVID-19  (ISO)
Crohn's disease  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Diaphragmatic Hernia  (ISO)
diffuse scleroderma  (ISO)
dilated cardiomyopathy  (ISO)
Dissecting Aneurysm  (ISO)
Drug Overdose  (ISO)
endomyocardial fibrosis  (ISO)
essential hypertension  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (ISO)
Fabry disease  (ISO)
Fetal Growth Retardation  (ISO)
Fibrosis  (ISO)
focal segmental glomerulosclerosis  (ISO)
gastric ulcer  (ISO)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
glomerulonephritis  (ISO)
glucose intolerance  (ISO)
heart disease  (ISO)
Hemorrhage  (ISO)
Henoch-Schoenlein purpura  (ISO)
hydronephrosis  (ISO)
Hyperalgesia  (ISO)
Hyperemia  (ISO)
hyperhomocysteinemia  (ISO)
hyperinsulinism  (ISO)
hypertension  (ISO)
Hypertensive Nephropathy  (ISO)
hypertrophic cardiomyopathy  (ISO)
Hypertrophy  (ISO)
hypokalemia  (ISO)
Hypotension  (ISO)
IgA glomerulonephritis  (ISO)
impotence  (ISO)
Inflammation  (ISO)
inflammatory bowel disease  (ISO)
intermediate coronary syndrome  (ISO)
Intestinal Reperfusion Injury  (ISO)
kidney disease  (ISO)
kidney failure  (ISO)
Left Ventricular Hypertrophy  (ISO)
liver cirrhosis  (ISO)
malignant hypertension  (ISO)
meconium aspiration syndrome  (ISO)
Metabolic Syndrome  (ISO)
microcephaly  (ISO)
middle cerebral artery infarction  (ISO)
mitral valve prolapse  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
Necrosis  (ISO)
Neointima  (ISO)
nephrosis  (ISO)
Neurobehavioral Manifestations  (ISO)
obesity  (ISO)
oligohydramnios  (ISO)
otosclerosis  (ISO)
parathyroid carcinoma  (ISO)
Peptic Ulcer Hemorrhage  (ISO)
pneumonia  (ISO)
polycystic kidney disease  (ISO)
pre-eclampsia  (ISO)
prediabetes syndrome  (ISO)
Pregnancy-Induced Hypertension  (ISO)
Prenatal Exposure Delayed Effects  (ISO)
primary biliary cholangitis  (ISO)
proteinuria  (ISO)
pulmonary edema  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
Puromycin Aminonucleoside Nephrosis  (ISO)
renal hypertension  (ISO)
Renal Tubular Dysgenesis  (ISO)
Reperfusion Injury  (ISO)
retinal vasculitis  (ISO)
retinopathy of prematurity  (ISO)
sciatic neuropathy  (ISO)
sick sinus syndrome  (ISO)
skin melanoma  (ISO)
Stroke  (ISO)
Sudden Death  (ISO)
systemic scleroderma  (ISO)
temporal lobe epilepsy  (ISO)
thrombosis  (ISO)
transient cerebral ischemia  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
vascular disease  (ISO)
Vascular Malformations  (ISO)
Vascular Remodeling  (ISO)
Ventricular Dysfunction, Left  (ISO)
Ventricular Remodeling  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of phospholipase C activity  (ISO)
aldosterone secretion  (ISO)
angiotensin-activated signaling pathway  (IEA)
angiotensin-mediated drinking behavior  (ISO)
angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure  (ISO)
artery smooth muscle contraction  (ISO)
associative learning  (ISO)
astrocyte activation  (ISO)
blood vessel development  (ISO)
brain renin-angiotensin system  (ISO)
branching involved in ureteric bud morphogenesis  (ISO)
cell growth involved in cardiac muscle cell development  (ISO)
cell population proliferation  (ISO)
cell surface receptor signaling pathway  (ISO)
cell-matrix adhesion  (ISO)
cellular response to angiotensin  (ISO)
cellular response to mechanical stimulus  (ISO)
cytokine production  (ISO)
drinking behavior  (ISO)
ERK1 and ERK2 cascade  (ISO)
establishment of blood-nerve barrier  (ISO)
extracellular matrix organization  (ISO)
female pregnancy  (ISO)
fibroblast proliferation  (ISO)
G protein-coupled receptor signaling pathway  (IEA,ISO)
hormone metabolic process  (ISO)
intracellular sodium ion homeostasis  (ISO)
kidney development  (IEA,ISO)
maintenance of blood vessel diameter homeostasis by renin-angiotensin  (IEA)
MAPK cascade  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of neurotrophin TRK receptor signaling pathway  (IEA)
negative regulation of smooth muscle cell proliferation  (ISO)
negative regulation of tissue remodeling  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
neuron apoptotic process  (ISO)
operant conditioning  (ISO)
organ growth  (ISO)
ovarian follicle rupture  (ISO)
peristalsis  (ISO)
positive regulation of blood pressure  (ISO)
positive regulation of branching involved in ureteric bud morphogenesis  (IEA)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of cardiac muscle cell apoptotic process  (ISO)
positive regulation of cardiac muscle hypertrophy  (ISO)
positive regulation of catalytic activity  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cytokine production  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of endothelial cell migration  (IEA)
positive regulation of epidermal growth factor receptor signaling pathway  (IEA)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of extracellular matrix assembly  (IEA,ISO)
positive regulation of extracellular matrix constituent secretion  (ISO)
positive regulation of extrinsic apoptotic signaling pathway  (IEA)
positive regulation of fatty acid biosynthetic process  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of gap junction assembly  (IEA)
positive regulation of gene expression  (ISO)
positive regulation of insulin receptor signaling pathway  (ISO)
positive regulation of L-arginine import across plasma membrane  (ISO)
positive regulation of L-lysine import across plasma membrane  (ISO)
positive regulation of macrophage derived foam cell differentiation  (IEA)
positive regulation of MAPK cascade  (ISO)
positive regulation of membrane hyperpolarization  (ISO)
positive regulation of miRNA transcription  (IEA,ISO)
positive regulation of multicellular organism growth  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of organ growth  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
positive regulation of protein metabolic process  (IEA)
positive regulation of superoxide anion generation  (ISO)
positive regulation of vascular associated smooth muscle cell migration  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
protein import into nucleus  (ISO)
regulation of apoptotic process  (IEA,ISO)
regulation of blood pressure  (IEA,ISO)
regulation of calcium ion transport  (ISO)
regulation of cardiac conduction  (IEA)
regulation of extracellular matrix assembly  (IEA)
regulation of gene expression  (ISO)
regulation of heart rate  (ISO)
regulation of inflammatory response  (ISO)
regulation of long-term neuronal synaptic plasticity  (ISO)
regulation of norepinephrine secretion  (ISO)
regulation of renal output by angiotensin  (ISO)
regulation of systemic arterial blood pressure by circulatory renin-angiotensin  (ISO)
regulation of systemic arterial blood pressure by renin-angiotensin  (IEA)
regulation of transmission of nerve impulse  (ISO)
renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure  (ISO)
renal system process  (IEA)
renin-angiotensin regulation of aldosterone production  (ISO)
response to angiotensin  (IEA,ISO)
response to cold  (ISO)
response to estradiol  (ISO)
response to mechanical stimulus  (ISO)
response to muscle activity involved in regulation of muscle adaptation  (ISO)
response to salt stress  (ISO)
smooth muscle cell differentiation  (ISO)
smooth muscle cell proliferation  (ISO)
stress-activated MAPK cascade  (ISO)
uterine smooth muscle contraction  (ISO)
vascular associated smooth muscle cell proliferation  (ISO)
vasoconstriction  (IEA,ISO)
vasodilation  (ISO)
vasopressin secretion  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Agt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934443,547,972 - 43,555,916 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648419,716,165 - 19,721,261 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648419,713,299 - 19,721,144 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AGT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381230,702,523 - 230,745,583 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1230,690,776 - 230,745,576 (-)EnsemblGRCh38hg38GRCh38
GRCh371230,838,269 - 230,881,329 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361228,904,892 - 228,916,564 (-)NCBINCBI36Build 36hg18NCBI36
Build 341227,145,019 - 227,156,602NCBI
Celera1204,104,291 - 204,116,358 (-)NCBICelera
Cytogenetic Map1q42.2NCBI
HuRef1201,323,209 - 201,335,277 (-)NCBIHuRef
CHM1_11232,111,282 - 232,123,349 (-)NCBICHM1_1
T2T-CHM13v2.01230,083,077 - 230,126,137 (-)NCBIT2T-CHM13v2.0
Agt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398125,283,326 - 125,296,445 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8125,283,273 - 125,296,445 (-)EnsemblGRCm39 Ensembl
GRCm388124,556,587 - 124,569,706 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8124,556,534 - 124,569,706 (-)EnsemblGRCm38mm10GRCm38
MGSCv378127,080,487 - 127,093,607 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368127,442,677 - 127,455,773 (-)NCBIMGSCv36mm8
Celera8128,860,995 - 128,873,954 (-)NCBICelera
Cytogenetic Map8E2NCBI
cM Map872.81NCBI
Agt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81969,426,540 - 69,447,017 (-)NCBIGRCr8
mRatBN7.21952,529,139 - 52,549,618 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1952,529,185 - 52,540,977 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1959,313,724 - 59,325,510 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01960,165,792 - 60,177,589 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01962,240,179 - 62,251,965 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01957,321,594 - 57,333,460 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1957,321,640 - 57,333,433 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01968,026,182 - 68,038,550 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41954,738,556 - 54,750,349 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11954,743,436 - 54,755,230 (-)NCBI
Celera1951,899,180 - 51,910,819 (-)NCBICelera
Cytogenetic Map19q12NCBI
Agt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554927,866,833 - 7,873,357 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554927,863,662 - 7,874,863 (+)NCBIChiLan1.0ChiLan1.0
AGT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2118,492,156 - 18,503,638 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1118,684,644 - 18,696,136 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01206,252,141 - 206,263,830 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11211,279,015 - 211,291,044 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1211,279,015 - 211,291,044 (-)Ensemblpanpan1.1panPan2
AGT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.148,681,192 - 8,694,059 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl48,683,798 - 8,693,880 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha48,672,874 - 8,685,743 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.048,705,485 - 8,718,357 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl48,705,603 - 8,718,382 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.148,709,653 - 8,722,523 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.048,831,567 - 8,844,457 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.049,061,768 - 9,074,658 (+)NCBIUU_Cfam_GSD_1.0
AGT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1459,643,292 - 59,656,833 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11459,643,030 - 59,656,835 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21464,380,799 - 64,385,995 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AGT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12567,964,840 - 67,977,006 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2567,962,401 - 67,973,324 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605569,870,396 - 69,882,850 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Agt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477518,849,118 - 18,855,577 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477518,846,222 - 18,856,093 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005320380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010004404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSTOT00000024079   ⟹   ENSSTOP00000016669
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493648419,716,165 - 19,721,261 (+)Ensembl
RefSeq Acc Id: XM_005320380   ⟹   XP_005320437
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934443,547,972 - 43,555,916 (+)NCBI
SpeTri2.0NW_00493648419,713,299 - 19,721,144 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005320437 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000016669.1
GenBank Protein KAG3257876 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_005320437   ⟸   XM_005320380
- UniProtKB: I3MX24 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSTOP00000016669   ⟸   ENSSTOT00000024079
Protein Domains
SERPIN


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000029164 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000024079.2 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/TrEMBL
InterPro Angiotensinogen UniProtKB/TrEMBL
  Angiotensinogen_serpin_dom UniProtKB/TrEMBL
  Serpin_dom UniProtKB/TrEMBL
  Serpin_fam UniProtKB/TrEMBL
  Serpin_sf UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/TrEMBL
NCBI Gene Agt ENTREZGENE
PANTHER ANGIOTENSINOGEN UniProtKB/TrEMBL
  PTHR11461 UniProtKB/TrEMBL
Pfam Serpin UniProtKB/TrEMBL
PRINTS ANGIOTENSNGN UniProtKB/TrEMBL
SMART SERPIN UniProtKB/TrEMBL
Superfamily-SCOP SSF56574 UniProtKB/TrEMBL
UniProt I3MX24 ENTREZGENE, UniProtKB/TrEMBL