Casp8 (caspase 8) - Rat Genome Database

Name: Casp8
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Casp8 (caspase 8) Ictidomys tridecemlineatus

Analyze

Symbol:

Casp8

Name:

caspase 8

RGD ID:

12585089

Description:

ENCODES a protein that exhibits cysteine-type endopeptidase activator activity involved in apoptotic process (ortholog); cysteine-type endopeptidase activity (ortholog); cysteine-type endopeptidase activity involved in apoptotic process (ortholog); INVOLVED IN angiogenesis (ortholog); apoptotic process (ortholog); apoptotic signaling pathway (ortholog); PARTICIPATES IN ceramide signaling pathway; extrinsic apoptotic pathway; FasL mediated signaling pathway; ASSOCIATED WITH Acute Liver Failure (ortholog); Acute Lung Injury (ortholog); acute lymphoblastic leukemia (ortholog); FOUND IN CD95 death-inducing signaling complex (ortholog); cell body (ortholog); cytoplasm (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

caspase-8

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CASP8 (caspase 8)	NCBI	Ortholog
Mus musculus (house mouse):	Casp8 (caspase 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Casp8 (caspase 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Casp8 (caspase 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CASP8 (caspase 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CASP8 (caspase 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CASP8 (caspase 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CASP8 (caspase 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Casp8 (caspase 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	158,584,293 - 158,626,147 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936726	554,758 - 595,922 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936726	554,627 - 596,334 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Liver Failure (ISO)

Acute Lung Injury (ISO)

acute lymphoblastic leukemia (ISO)

adenocarcinoma (ISO)

Alcohol-Related Disorders (ISO)

allergic contact dermatitis (ISO)

Alzheimer's disease (ISO)

atopic dermatitis (ISO)

autoimmune disease (ISO)

autoimmune lymphoproliferative syndrome (ISO)

autoimmune lymphoproliferative syndrome type 2B (ISO)

Autoimmune Lymphoproliferative Syndrome, Type V (ISO)

bacterial infectious disease (ISO)

Brain Contusion (ISO)

Brain Hypoxia-Ischemia (ISO)

Brain Injuries (ISO)

breast cancer (ISO)

Breast Cancer, Familial (ISO)

Breast Neoplasms (ISO)

bronchopulmonary dysplasia (ISO)

Cerebral Hemorrhage (ISO)

Chemical and Drug Induced Liver Injury (ISO)

chronic obstructive pulmonary disease (ISO)

Colorectal Neoplasms (ISO)

common variable immunodeficiency 1 (ISO)

contact dermatitis (ISO)

Diabetic Cardiomyopathies (ISO)

Diabetic Nephropathies (ISO)

dilated cardiomyopathy (ISO)

Edema (ISO)

Esophageal Neoplasms (ISO)

esophagus adenocarcinoma (ISO)

esophagus squamous cell carcinoma (ISO)

Experimental Autoimmune Encephalomyelitis (ISO)

Experimental Autoimmune Myocarditis (ISO)

Experimental Diabetes Mellitus (ISO)

Experimental Mammary Neoplasms (ISO)

Experimental Radiation Injuries (ISO)

Familial Prostate Cancer (ISO)

genetic disease (ISO)

head and neck squamous cell carcinoma (ISO)

heart disease (ISO)

Hemorrhagic Shock (ISO)

hepatocellular carcinoma (ISO)

Huntington's disease (ISO)

hyperglycemia (ISO)

hypertension (ISO)

Insulin Resistance (ISO)

kidney disease (ISO)

liver cirrhosis (ISO)

Liver Reperfusion Injury (ISO)

lung cancer (ISO)

Lung Neoplasms (ISO)

lung non-small cell carcinoma (ISO)

melanoma (ISO)

mitochondrial metabolism disease (ISO)

Myocardial Reperfusion Injury (ISO)

nephritis (ISO)

Neurodevelopmental Disorders (ISO)

Osteoarthritis, Experimental (ISO)

pancreatic cancer (ISO)

papillomavirus infectious disease (ISO)

pre-malignant neoplasm (ISO)

primary immunodeficiency disease (ISO)

Primary Pulmonary Hypertension, 1 (ISO)

Pulmonary Arterial Hypertension (ISO)

Reperfusion Injury (ISO)

retinal detachment (ISO)

sciatic neuropathy (ISO)

Sepsis (ISO)

Skin Neoplasms (ISO)

status epilepticus (ISO)

Stomach Neoplasms (ISO)

transient cerebral ischemia (ISO)

type 1 diabetes mellitus (ISO)

type 2 diabetes mellitus (ISO)

Uterine Cervical Neoplasms (ISO)

Viral Myocarditis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

angiogenesis (ISO)

apoptotic process (IEA,ISO,ISS)

apoptotic signaling pathway (IEA,ISO)

cellular response to mechanical stimulus (IEA)

cellular response to organic cyclic compound (ISO)

execution phase of apoptosis (IEA,ISS)

extrinsic apoptotic signaling pathway (IEA,ISO)

extrinsic apoptotic signaling pathway via death domain receptors (ISO)

heart development (ISO)

hepatocyte apoptotic process (ISO)

macrophage differentiation (ISO)

necroptotic process (ISO)

negative regulation of canonical NF-kappaB signal transduction (IEA)

negative regulation of necroptotic process (IEA,ISO)

neural tube formation (ISO)

positive regulation of apoptotic process (ISO)

positive regulation of canonical NF-kappaB signal transduction (IEA)

positive regulation of cell migration (IEA)

positive regulation of execution phase of apoptosis (ISO)

positive regulation of extrinsic apoptotic signaling pathway (ISO)

positive regulation of interleukin-1 beta production (IEA)

positive regulation of macrophage differentiation (IEA)

positive regulation of neuron apoptotic process (ISO)

positive regulation of proteolysis (IEA)

protein maturation (IEA)

protein processing (ISO)

proteolysis (IEA)

proteolysis involved in protein catabolic process (IEA)

pyroptosis (ISO)

regulation of apoptotic process (IEA)

regulation of apoptotic signaling pathway (ISO)

regulation of cytokine production (ISO)

regulation of innate immune response (ISO)

regulation of thymocyte apoptotic process (ISO)

response to auditory stimulus (ISO)

response to cobalt ion (ISO)

response to estradiol (ISO)

response to ethanol (ISO)

response to lipopolysaccharide (ISO)

response to tumor necrosis factor (IEA)

self proteolysis (ISO)

TRAIL-activated apoptotic signaling pathway (IEA)

Cellular Component

CD95 death-inducing signaling complex (IEA,ISO)

cell body (ISO)

cytoplasm (IEA,ISO)

cytosol (IEA)

death-inducing signaling complex (IEA,ISO)

lamellipodium (IEA)

Noc1p-Noc2p complex (ISO)

nucleoplasm (IEA)

nucleus (ISO)

plasma membrane (ISO)

protein-containing complex (IEA,ISO)

ripoptosome (IEA,ISS)

Molecular Function

cysteine-type endopeptidase activator activity involved in apoptotic process (ISO)

cysteine-type endopeptidase activity (IEA,ISO)

cysteine-type endopeptidase activity involved in apoptotic process (IEA,ISS)

cysteine-type endopeptidase activity involved in apoptotic signaling pathway (IEA)

cysteine-type peptidase activity (IEA)

death effector domain binding (IEA)

death receptor binding (ISO)

endopeptidase activity (ISO)

identical protein binding (IEA)

peptidase activity (IEA)

protein binding (ISO)

protein-containing complex binding (ISO)

scaffold protein binding (IEA)

tumor necrosis factor receptor binding (ISO)

ubiquitin protein ligase binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

ceramide signaling pathway (ISO)

extrinsic apoptotic pathway (ISO)

FasL mediated signaling pathway (ISO)

titanium dioxide nanoparticle response pathway (ISO)

Trail mediated signaling pathway (ISO)

tumor necrosis factor mediated signaling pathway (ISO)

References

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

Casp8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	158,584,293 - 158,626,147 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936726	554,758 - 595,922 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936726	554,627 - 596,334 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CASP8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	201,233,463 - 201,287,711 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	201,233,443 - 201,361,836 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	202,098,166 - 202,152,434 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	201,806,411 - 201,860,679 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	201,923,718 - 201,972,144	NCBI
Celera	2	195,852,777 - 195,904,249 (+)	NCBI		Celera
Cytogenetic Map	2	q33.1	NCBI
HuRef	2	193,949,530 - 194,000,819 (+)	NCBI		HuRef
CHM1_1	2	202,104,145 - 202,158,454 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	201,716,914 - 201,768,369 (+)	NCBI		T2T-CHM13v2.0

Casp8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	58,834,553 - 58,886,663 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	58,834,533 - 58,886,662 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	58,795,233 - 58,847,503 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	58,795,374 - 58,847,503 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	58,852,218 - 58,904,347 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	58,740,040 - 58,791,559 (+)	NCBI		MGSCv36	mm8
Celera	1	59,314,392 - 59,366,511 (+)	NCBI		Celera
Cytogenetic Map	1	C1.3	NCBI
cM Map	1	29.19	NCBI

Casp8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	67,747,109 - 67,806,699 (+)	NCBI		GRCr8
mRatBN7.2	9	60,263,863 - 60,312,542 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	60,264,075 - 60,312,542 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	68,759,278 - 68,807,629 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	73,875,236 - 73,923,588 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	72,193,497 - 72,241,846 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	65,614,142 - 65,662,624 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	65,614,142 - 65,662,106 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	65,420,843 - 65,469,468 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	57,389,353 - 57,437,803 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	57,536,334 - 57,584,785 (+)	NCBI
Celera	9	57,705,001 - 57,753,027 (+)	NCBI		Celera
Cytogenetic Map	9	q31	NCBI

Casp8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955403	322,555 - 347,053 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955403	322,082 - 348,591 (-)	NCBI	ChiLan1.0	ChiLan1.0

CASP8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	103,859,979 - 103,910,906 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	103,874,960 - 103,924,789 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	88,490,611 - 88,542,132 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	206,645,803 - 206,696,468 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	206,669,544 - 206,696,468 (+)	Ensembl	panpan1.1		panPan2

CASP8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	37	10,362,071 - 10,402,108 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	37	10,391,048 - 10,401,822 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	37	11,274,820 - 11,285,607 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	37	10,285,147 - 10,307,094 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	37	10,287,599 - 10,308,036 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	37	10,276,467 - 10,287,238 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	37	10,255,470 - 10,266,223 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	37	10,248,774 - 10,259,550 (+)	NCBI		UU_Cfam_GSD_1.0

CASP8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	104,923,953 - 104,948,468 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	104,923,659 - 104,948,470 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	116,337,232 - 116,340,859 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CASP8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	86,888,654 - 86,944,159 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	86,916,527 - 86,943,829 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	112,478,130 - 112,535,645 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Casp8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624899	424,363 - 451,087 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624899	427,064 - 450,931 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005338903	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040294699	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000362	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000011344 ⟹ ENSSTOP00000010179

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936726	554,758 - 595,922 (+)	Ensembl

RefSeq Acc Id:

XM_005338903 ⟹ XP_005338960

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405303	158,584,293 - 158,626,147 (+)	NCBI
SpeTri2.0	NW_004936726	554,627 - 596,334 (+)	NCBI

Sequence:

show sequence

TGGTTCTTTTGACTGAGAATTTTTCTTTCTCTTTTGCCAAAGATCAGAGTCTGCCCTTCTGCTG
GAAGAAAATGTTTTCTTTCACAGGTGCTCCTTGCTTTATCTCTGGTAATTTTTAAAAATCCTGC
TAAATTCACTAGTACATTCTGGACGGGAGAACAGAGAGAAACAGGAAGAAGGGAGCTGGAGGAG
GCAGACAAGCCGGTAGAGTGATCGAAAGTAAAAGAAAGCTTCTTCCTGGAGTCCCCGCCCCCCA
CCAGTCTGTTTTTCGGGGATTTTCTCCCCTGTGGACGAGTCTTGGATATTGAAGCATTTGGAAT
TAGGCAGTTTGGGGGACGTGGTGACTGGGATGTTTCCGGAAAAGGTTGGAACAGATGCACGGAG
AGTCATAGAAGAGACCTGCGAGGAAGGTGCTGCTGTTGTGAGGGACCCAGGATTTGCCTCTGGT
TACTTCTCCTACCTTTTGTCAAGGATGGATTTCAACAAATGTCTTTACGATATTGGGGAACAAC
TGGGCAGCGATGAGTTGTCCTCCCTCAAGTTCTTATGTCTGGAATATATCCCACAAAAGAAGCA
GGAGCCCATCAAGGATGCTTTGAAGCTATTCCAGACACTTCAGGAAAAGGGAATGTTGGAGGAA
AACAATCTGTCCTTCTTGAAGGAGTTGCTTTTCCGAATTAATAGACTGGACCTGCTGACCACTA
TCCTGAATACCAGCAAGGAGGATATGGTGTGGGAACTTCAGATTCCCGGCAAGGCCCAGATTTC
TGCCTATAGGGTCATGCTTTTTCAGATTTCAGAAGATGTAAATAAACTGGAATTGAAGTCTTTT
AAGTTTCTTTTGAGCAAGGATATCTCCAAGTGTAAGCTGGATGACGACATGAGCTTGCTCGACA
TTTTCATAGAGATGGAGAAGAAGCTCATCCTAGGAAAGAGAAACCTGGGAACCCTGAAAAATAT
CTGTGAACAAATCAACAAGAGCCTGCTGAAGATCATTGAGAATTATGAAGAATTAAGCAGAGAG
AGAAGAATGAGTCCTGAAAGAAGAACAGATGCACTTTTAAATGGGGAGGAGTCCTTGGGGATGT
TGACATTGTCGGACTCTCCAGGAGAACAGGACAGTGACTCACAGACATCAGACAAAGTTTACCA
AATGAAAAACAAACCTCGGGGATACTGTTTGATTTTCAACAACTATGATTTTAGCATGGCACGG
AAGGATATGCCCAAGCTCCACAACATTAAGGATAGGAAAGGATCAGATTTGGATGAAGAGGCTT
TGAGCAAGACCTTTAAGGAGCTTCATTTTGAAATAGTATGTTACAAAGATTCTACAGCCAAGGA
AATCTGTGAAGTTCTAAAATTCTACCAAAGTGAAGACCATAATAATAAAGATTGTTTCATCTGC
TGTATCCTCTCGCATGGAGACGAGGGCATAATCTATGGCACTGATGGACAGAAGGTCTCCATCT
TTGAGCTGACCTCTTATTTCACTGGTTCAAAGTGCCCTTCCCTTGCTGGGAAACCTAAAGTCTT
TTTTATTCAGGCTTGTCAAGGGGATAACTACCAGAAAGGTGTACTTGTTGAAACCGACTCAAAG
CAGAAGGACCCCTACTTAGAGATGGATTTATCATTTCAAAAGAGTTATATCCCAGATGAAGCTG
ACTTTCTGTTGGGGATGGCCACTGTGAGCAACTGTGTTTCCTATCGAAATCCCATGGAGGGAAC
CTGGTATATCCAGTCCCTTTGCCAGAGACTGAGAGAAAGATGTCCTCGAGGCGATGATATTCTC
ACCATCCTGACTGAAGTGAACTATGAAGTGAGCAATAAGGATGATAAGAAGAACATGGGGAAAC
AGATGCCACAGCCCACTTTTACATTAAGGAAAAAACTCTTCTTTCCTCTTGATTGATGTTACAT
CATTGTGTAACACTATGCTTTATTTATTAAGTATTTTTTTATTTGTTGTAATTAGTGTTAGTTA
ATTATAAAATATTAACTGCACTTTTCTTTTAAGGCAGAGAGGGAATGAGGAACTAAGTATTTTT
TTCATAAAAAATTGTGTTTTTAAATATACAACATTATCTTCAATTATTACATCAAAACCATTTT
GTCCATACTATAATTACTATAATCATTACTATAATCAATTCACTTTATGCATTTGAATCAAGAA
CATTTTAATTCTTATATGAATTCAAGTCCTTGCTATGCAATATCAGCCACTATTAGACATTCAC
AGTTATGGTATAATTTTAACTATTTTTAACAAGATGAAAAAGTACTACTTAAAAGTAAATAAGA
ACTTAATTCCTCTCTTTTCAAGCCATCTAATACACTACTTTCAAAATATTTAAATTTGAAAAAT
TAAAATTTTAAATAAAGAGAGCAAAGGCTCTCTTATTGAGTTACATCTCAGCTTTTTTTTTTTC
ATTTTCTGTTGCTCTTTCACATATTTTTTCATATGCTTGTAGGATTCGCTGTTCTTGCTAATGA
AGCATTTTAGTATTTCATATA

hide sequence

RefSeq Acc Id:

XM_040294699 ⟹ XP_040150633

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405303	158,584,293 - 158,626,147 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_005338960	(Get FASTA)	NCBI Sequence Viewer
	XP_040150633	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000010179.3
GenBank Protein	KAG3274978	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005338960 ⟸ XM_005338903
- Peptide Label:	isoform X1
- UniProtKB:	I3MH56 (UniProtKB/TrEMBL)
- Sequence:	show sequence MFPEKVGTDARRVIEETCEEGAAVVRDPGFASGYFSYLLSRMDFNKCLYDIGEQLGSDELSSLK FLCLEYIPQKKQEPIKDALKLFQTLQEKGMLEENNLSFLKELLFRINRLDLLTTILNTSKEDMV WELQIPGKAQISAYRVMLFQISEDVNKLELKSFKFLLSKDISKCKLDDDMSLLDIFIEMEKKLI LGKRNLGTLKNICEQINKSLLKIIENYEELSRERRMSPERRTDALLNGEESLGMLTLSDSPGEQ DSDSQTSDKVYQMKNKPRGYCLIFNNYDFSMARKDMPKLHNIKDRKGSDLDEEALSKTFKELHF EIVCYKDSTAKEICEVLKFYQSEDHNNKDCFICCILSHGDEGIIYGTDGQKVSIFELTSYFTGS KCPSLAGKPKVFFIQACQGDNYQKGVLVETDSKQKDPYLEMDLSFQKSYIPDEADFLLGMATVS NCVSYRNPMEGTWYIQSLCQRLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLR KKLFFPLD hide sequence

RefSeq Acc Id:	XP_040150633 ⟸ XM_040294699
- Peptide Label:	isoform X2

RefSeq Acc Id:

ENSSTOP00000010179 ⟸ ENSSTOT00000011344

Protein Domains

Caspase family p10 Caspase family p20 DED

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000011342	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000011344.3	UniProtKB/TrEMBL
Gene3D-CATH	1.10.533.10	UniProtKB/TrEMBL
	3.40.50.1460	UniProtKB/TrEMBL
InterPro	Caspase-8	UniProtKB/TrEMBL
	Caspase-like_dom_sf	UniProtKB/TrEMBL
	Caspase_cys_AS	UniProtKB/TrEMBL
	Caspase_his_AS	UniProtKB/TrEMBL
	DEATH-like_dom_sf	UniProtKB/TrEMBL
	DED_dom	UniProtKB/TrEMBL
	Pept_C14_caspase	UniProtKB/TrEMBL
	Pept_C14_p10	UniProtKB/TrEMBL
	Pept_C14_p20	UniProtKB/TrEMBL
	Pept_C14A	UniProtKB/TrEMBL
NCBI Gene	Casp8	ENTREZGENE
PANTHER	CASP8 AND FADD-LIKE APOPTOSIS REGULATOR A-RELATED	UniProtKB/TrEMBL
	DED DOMAIN-CONTAINING PROTEIN	UniProtKB/TrEMBL
Pfam	DED	UniProtKB/TrEMBL
	Peptidase_C14	UniProtKB/TrEMBL
PRINTS	IL1BCENZYME	UniProtKB/TrEMBL
PROSITE	CASPASE_CYS	UniProtKB/TrEMBL
	CASPASE_HIS	UniProtKB/TrEMBL
	CASPASE_P10	UniProtKB/TrEMBL
	CASPASE_P20	UniProtKB/TrEMBL
	DED	UniProtKB/TrEMBL
SMART	CASc	UniProtKB/TrEMBL
	DED	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47986	UniProtKB/TrEMBL
	SSF52129	UniProtKB/TrEMBL
UniProt	I3MH56	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)