RGD Reference Report - Caspase-8: a key role in the pathogenesis of diabetic embryopathy. - Rat Genome Database

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Caspase-8: a key role in the pathogenesis of diabetic embryopathy.

Authors: Zhao, Z  Yang, P  Eckert, RL  Reece, EA 
Citation: Zhao Z, etal., Birth Defects Res B Dev Reprod Toxicol. 2009 Feb;86(1):72-7.
RGD ID: 2311428
Pubmed: PMID:19194987   (View Abstract at PubMed)
PMCID: PMC2838243   (View Article at PubMed Central)
DOI: DOI:10.1002/bdrb.20185   (Journal Full-text)

Maternal diabetes causes neural tube defects in embryos, which are associated with increased apoptosis in the neuroepithelium. Many factors, including effector caspases, have been shown to be involved in the events. However, the key regulators have not been identified and the underlying mechanisms remain to be addressed. Caspase-8, an initiator caspase, has been shown to be altered in diabetic embryopathy, suggesting a role as an upstream apoptotic regulator. Using mouse embryos as a model system, this study demonstrates that caspase-8 is required for the production of hyperglycemia-associated embryonic malformations. Caspase-8 was shown to be expressed in the developing neural tube. Its activity, as evidenced by enhanced cleavage, was increased by hyperglycemia. These changes were associated with increased formation of the active cleavage of Bid. Inhibition of caspase-8 activity in high glucose-challenged embryos reduced the rate of embryonic malformation and this was associated with decreased apoptosis in the neuroepithelium of the neural tube. Inhibition of caspase-8 activity also reduced hyperglycemia-induced Bid activation and caspase-9 cleavage. These data suggest that caspase-8 may control diabetic embryopathy-associated apoptosis via regulation of the Bid-stimulated mitochondrion/caspase-9 pathway.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hyperglycemia  ISOCasp8 (Mus musculus)2311428; 2311428 RGD 
hyperglycemia  IEP 2311428 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Casp8  (caspase 8)

Genes (Mus musculus)
Casp8  (caspase 8)

Genes (Homo sapiens)
CASP8  (caspase 8)


Additional Information