Casp8 (caspase 8) - Rat Genome Database

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Pathways
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Gene: Casp8 (caspase 8) Heterocephalus glaber
Analyze
Symbol: Casp8
Name: caspase 8
RGD ID: 18913436
Description: ENCODES a protein that exhibits cysteine-type endopeptidase activator activity involved in apoptotic process (ortholog); cysteine-type endopeptidase activity (ortholog); cysteine-type endopeptidase activity involved in apoptotic process (ortholog); INVOLVED IN angiogenesis (ortholog); apoptotic process (ortholog); apoptotic signaling pathway (ortholog); PARTICIPATES IN ceramide signaling pathway; extrinsic apoptotic pathway; FasL mediated signaling pathway; ASSOCIATED WITH Acute Liver Failure (ortholog); Acute Lung Injury (ortholog); acute lymphoblastic leukemia (ortholog); FOUND IN CD95 death-inducing signaling complex (ortholog); cell body (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: caspase-8
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624899424,363 - 451,087 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624899427,064 - 450,931 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Liver Failure  (ISO)
Acute Lung Injury  (ISO)
acute lymphoblastic leukemia  (ISO)
adenocarcinoma  (ISO)
Alcohol-Related Disorders  (ISO)
allergic contact dermatitis  (ISO)
Alzheimer's disease  (ISO)
atopic dermatitis  (ISO)
autoimmune disease  (ISO)
autoimmune lymphoproliferative syndrome  (ISO)
autoimmune lymphoproliferative syndrome type 2B  (ISO)
Autoimmune Lymphoproliferative Syndrome, Type V  (ISO)
bacterial infectious disease  (ISO)
Brain Contusion  (ISO)
Brain Hypoxia-Ischemia  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
Breast Cancer, Familial  (ISO)
Breast Neoplasms  (ISO)
bronchopulmonary dysplasia  (ISO)
Cerebral Hemorrhage  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
chronic obstructive pulmonary disease  (ISO)
Colorectal Neoplasms  (ISO)
common variable immunodeficiency 1  (ISO)
contact dermatitis  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
dilated cardiomyopathy  (ISO)
Edema  (ISO)
Esophageal Neoplasms  (ISO)
esophagus adenocarcinoma  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Mammary Neoplasms  (ISO)
Experimental Radiation Injuries  (ISO)
Familial Prostate Cancer  (ISO)
genetic disease  (ISO)
head and neck squamous cell carcinoma  (ISO)
heart disease  (ISO)
Hemorrhagic Shock  (ISO)
hepatocellular carcinoma  (ISO)
Huntington's disease  (ISO)
hyperglycemia  (ISO)
hypertension  (ISO)
Insulin Resistance  (ISO)
kidney disease  (ISO)
liver cirrhosis  (ISO)
Liver Reperfusion Injury  (ISO)
lung cancer  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
melanoma  (ISO)
mitochondrial metabolism disease  (ISO)
Myocardial Reperfusion Injury  (ISO)
nephritis  (ISO)
Neurodevelopmental Disorders  (ISO)
Osteoarthritis, Experimental  (ISO)
pancreatic cancer  (ISO)
papillomavirus infectious disease  (ISO)
pre-malignant neoplasm  (ISO)
primary immunodeficiency disease  (ISO)
Primary Pulmonary Hypertension, 1  (ISO)
Pulmonary Arterial Hypertension  (ISO)
Reperfusion Injury  (ISO)
retinal detachment  (ISO)
sciatic neuropathy  (ISO)
Sepsis  (ISO)
Skin Neoplasms  (ISO)
status epilepticus  (ISO)
Stomach Neoplasms  (ISO)
transient cerebral ischemia  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
Uterine Cervical Neoplasms  (ISO)
Viral Myocarditis  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
apoptotic process  (ISO)
apoptotic signaling pathway  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to organic cyclic compound  (ISO)
execution phase of apoptosis  (ISO)
extrinsic apoptotic signaling pathway  (ISO)
extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
heart development  (ISO)
hepatocyte apoptotic process  (ISO)
macrophage differentiation  (ISO)
necroptotic process  (ISO)
negative regulation of canonical NF-kappaB signal transduction  (ISO)
negative regulation of necroptotic process  (ISO)
neural tube formation  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of execution phase of apoptosis  (ISO)
positive regulation of extrinsic apoptotic signaling pathway  (ISO)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of macrophage differentiation  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of proteolysis  (ISO)
protein maturation  (ISO)
protein processing  (ISO)
proteolysis  (ISO)
proteolysis involved in protein catabolic process  (ISO)
pyroptotic inflammatory response  (ISO)
regulation of apoptotic signaling pathway  (ISO)
regulation of cytokine production  (ISO)
regulation of innate immune response  (ISO)
regulation of thymocyte apoptotic process  (ISO)
response to auditory stimulus  (ISO)
response to cobalt ion  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to lipopolysaccharide  (ISO)
response to tumor necrosis factor  (ISO)
self proteolysis  (ISO)
TRAIL-activated apoptotic signaling pathway  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Casp8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624899424,363 - 451,087 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624899427,064 - 450,931 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
CASP8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382201,233,463 - 201,287,711 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2201,233,443 - 201,361,836 (+)EnsemblGRCh38hg38GRCh38
GRCh372202,098,166 - 202,152,434 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362201,806,411 - 201,860,679 (+)NCBINCBI36Build 36hg18NCBI36
Build 342201,923,718 - 201,972,144NCBI
Celera2195,852,777 - 195,904,249 (+)NCBICelera
Cytogenetic Map2q33.1NCBI
HuRef2193,949,530 - 194,000,819 (+)NCBIHuRef
CHM1_12202,104,145 - 202,158,454 (+)NCBICHM1_1
T2T-CHM13v2.02201,716,914 - 201,768,369 (+)NCBIT2T-CHM13v2.0
Casp8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39158,834,553 - 58,886,663 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl158,834,533 - 58,886,662 (+)EnsemblGRCm39 Ensembl
GRCm38158,795,233 - 58,847,503 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl158,795,374 - 58,847,503 (+)EnsemblGRCm38mm10GRCm38
MGSCv37158,852,218 - 58,904,347 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36158,740,040 - 58,791,559 (+)NCBIMGSCv36mm8
Celera159,314,392 - 59,366,511 (+)NCBICelera
Cytogenetic Map1C1.3NCBI
cM Map129.19NCBI
Casp8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8967,747,109 - 67,806,699 (+)NCBIGRCr8
mRatBN7.2960,263,863 - 60,312,542 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl960,264,075 - 60,312,542 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx968,759,278 - 68,807,629 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0973,875,236 - 73,923,588 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0972,193,497 - 72,241,846 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0965,614,142 - 65,662,624 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl965,614,142 - 65,662,106 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0965,420,843 - 65,469,468 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4957,389,353 - 57,437,803 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1957,536,334 - 57,584,785 (+)NCBI
Celera957,705,001 - 57,753,027 (+)NCBICelera
Cytogenetic Map9q31NCBI
Casp8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955403322,555 - 347,053 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955403322,082 - 348,591 (-)NCBIChiLan1.0ChiLan1.0
CASP8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213103,859,979 - 103,910,906 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B103,874,960 - 103,924,789 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B88,490,611 - 88,542,132 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B206,645,803 - 206,696,468 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B206,669,544 - 206,696,468 (+)Ensemblpanpan1.1panPan2
CASP8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13710,362,071 - 10,402,108 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3710,391,048 - 10,401,822 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3711,274,820 - 11,285,607 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03710,285,147 - 10,307,094 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3710,287,599 - 10,308,036 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13710,276,467 - 10,287,238 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03710,255,470 - 10,266,223 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03710,248,774 - 10,259,550 (+)NCBIUU_Cfam_GSD_1.0
Casp8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303158,584,293 - 158,626,147 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936726554,758 - 595,922 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936726554,627 - 596,334 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CASP8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15104,923,953 - 104,948,468 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115104,923,659 - 104,948,470 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215116,337,232 - 116,340,859 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CASP8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11086,888,654 - 86,944,159 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1086,916,527 - 86,943,829 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040112,478,130 - 112,535,645 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000027650   ⟹   ENSHGLP00000027408
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624899424,363 - 451,087 (-)Ensembl
RefSeq Acc Id: XM_004872295   ⟹   XP_004872352
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624899427,064 - 450,930 (-)NCBI
RefSeq Acc Id: XM_004872296   ⟹   XP_004872353
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624899427,064 - 450,931 (-)NCBI
RefSeq Acc Id: XM_004872297   ⟹   XP_004872354
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624899427,064 - 450,389 (-)NCBI
RefSeq Acc Id: XM_013068339   ⟹   XP_012923793
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624899427,064 - 450,389 (-)NCBI
RefSeq Acc Id: XM_021250235   ⟹   XP_021105894
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624899427,064 - 441,005 (-)NCBI
RefSeq Acc Id: XM_021250236   ⟹   XP_021105895
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624899427,064 - 441,005 (-)NCBI
RefSeq Acc Id: XM_021250237   ⟹   XP_021105896
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624899427,064 - 450,931 (-)NCBI
RefSeq Acc Id: XM_021250238   ⟹   XP_021105897
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624899427,064 - 450,389 (-)NCBI
RefSeq Acc Id: XM_021250239   ⟹   XP_021105898
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624899427,064 - 450,931 (-)NCBI
RefSeq Acc Id: XM_021250240   ⟹   XP_021105899
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624899427,064 - 450,389 (-)NCBI
RefSeq Acc Id: XM_021250241   ⟹   XP_021105900
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624899427,064 - 450,389 (-)NCBI
RefSeq Acc Id: XM_021250242   ⟹   XP_021105901
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624899428,994 - 448,099 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_004872353   ⟸   XM_004872296
- Peptide Label: isoform X5
RefSeq Acc Id: XP_021105896   ⟸   XM_021250237
- Peptide Label: isoform X3
RefSeq Acc Id: XP_021105898   ⟸   XM_021250239
- Peptide Label: isoform X4
RefSeq Acc Id: XP_004872352   ⟸   XM_004872295
- Peptide Label: isoform X5
RefSeq Acc Id: XP_021105900   ⟸   XM_021250241
- Peptide Label: isoform X5
RefSeq Acc Id: XP_021105899   ⟸   XM_021250240
- Peptide Label: isoform X5
RefSeq Acc Id: XP_021105897   ⟸   XM_021250238
- Peptide Label: isoform X3
RefSeq Acc Id: XP_012923793   ⟸   XM_013068339
- Peptide Label: isoform X4
RefSeq Acc Id: XP_004872354   ⟸   XM_004872297
- Peptide Label: isoform X5
RefSeq Acc Id: XP_021105895   ⟸   XM_021250236
- Peptide Label: isoform X2
RefSeq Acc Id: XP_021105894   ⟸   XM_021250235
- Peptide Label: isoform X1
RefSeq Acc Id: XP_021105901   ⟸   XM_021250242
- Peptide Label: isoform X6
RefSeq Acc Id: ENSHGLP00000027408   ⟸   ENSHGLT00000027650


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000019495 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000027650 ENTREZGENE
NCBI Gene Casp8 ENTREZGENE