CASP8 (caspase 8) - Rat Genome Database

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Gene: CASP8 (caspase 8) Chlorocebus sabaeus
Analyze
Symbol: CASP8
Name: caspase 8
RGD ID: 18698809
Description: ENCODES a protein that exhibits cysteine-type endopeptidase activator activity involved in apoptotic process (ortholog); cysteine-type endopeptidase activity (ortholog); death receptor binding (ortholog); INVOLVED IN angiogenesis (ortholog); apoptotic process (ortholog); apoptotic signaling pathway (ortholog); PARTICIPATES IN ceramide signaling pathway; extrinsic apoptotic pathway; FasL mediated signaling pathway; ASSOCIATED WITH Acute Liver Failure (ortholog); Acute Lung Injury (ortholog); acute lymphoblastic leukemia (ortholog); FOUND IN CD95 death-inducing signaling complex (ortholog); cell body (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: caspase-8
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11086,888,654 - 86,944,159 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1086,916,527 - 86,943,829 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040112,478,130 - 112,535,645 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Liver Failure  (ISO)
Acute Lung Injury  (ISO)
acute lymphoblastic leukemia  (ISO)
adenocarcinoma  (ISO)
Alcohol-Related Disorders  (ISO)
allergic contact dermatitis  (ISO)
Alzheimer's disease  (ISO)
atopic dermatitis  (ISO)
autoimmune disease  (ISO)
autoimmune lymphoproliferative syndrome  (ISO)
autoimmune lymphoproliferative syndrome type 2B  (ISO)
Autoimmune Lymphoproliferative Syndrome, Type V  (ISO)
bacterial infectious disease  (ISO)
Brain Contusion  (ISO)
Brain Hypoxia-Ischemia  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
Breast Cancer, Familial  (ISO)
Breast Neoplasms  (ISO)
bronchopulmonary dysplasia  (ISO)
Cerebral Hemorrhage  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
chronic obstructive pulmonary disease  (ISO)
Colorectal Neoplasms  (ISO)
common variable immunodeficiency 1  (ISO)
contact dermatitis  (ISO)
Diabetic Cardiomyopathies  (ISO)
Diabetic Nephropathies  (ISO)
dilated cardiomyopathy  (ISO)
Edema  (ISO)
Esophageal Neoplasms  (ISO)
esophagus adenocarcinoma  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Mammary Neoplasms  (ISO)
Experimental Radiation Injuries  (ISO)
Familial Prostate Cancer  (ISO)
genetic disease  (ISO)
head and neck squamous cell carcinoma  (ISO)
heart disease  (ISO)
Hemorrhagic Shock  (ISO)
hepatocellular carcinoma  (ISO)
Huntington's disease  (ISO)
hyperglycemia  (ISO)
hypertension  (ISO)
Insulin Resistance  (ISO)
kidney disease  (ISO)
liver cirrhosis  (ISO)
Liver Reperfusion Injury  (ISO)
lung cancer  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
melanoma  (ISO)
mitochondrial metabolism disease  (ISO)
Myocardial Reperfusion Injury  (ISO)
nephritis  (ISO)
Neurodevelopmental Disorders  (ISO)
Osteoarthritis, Experimental  (ISO)
pancreatic cancer  (ISO)
papillomavirus infectious disease  (ISO)
pre-malignant neoplasm  (ISO)
primary immunodeficiency disease  (ISO)
Primary Pulmonary Hypertension, 1  (ISO)
Pulmonary Arterial Hypertension  (ISO)
Reperfusion Injury  (ISO)
retinal detachment  (ISO)
sciatic neuropathy  (ISO)
Sepsis  (ISO)
Skin Neoplasms  (ISO)
status epilepticus  (ISO)
Stomach Neoplasms  (ISO)
transient cerebral ischemia  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
Uterine Cervical Neoplasms  (ISO)
Viral Myocarditis  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
apoptotic process  (IEA,ISO)
apoptotic signaling pathway  (IEA,ISO)
cellular response to mechanical stimulus  (IEA)
cellular response to organic cyclic compound  (ISO)
execution phase of apoptosis  (IEA)
extrinsic apoptotic signaling pathway  (IEA,ISO)
extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
heart development  (ISO)
hepatocyte apoptotic process  (ISO)
macrophage differentiation  (ISO)
necroptotic process  (ISO)
negative regulation of canonical NF-kappaB signal transduction  (IEA)
negative regulation of necroptotic process  (IEA,ISO)
neural tube formation  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (IEA)
positive regulation of cell migration  (IEA)
positive regulation of execution phase of apoptosis  (ISO)
positive regulation of extrinsic apoptotic signaling pathway  (ISO)
positive regulation of interleukin-1 beta production  (IEA)
positive regulation of macrophage differentiation  (IEA)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of proteolysis  (IEA)
protein maturation  (IEA)
protein processing  (ISO)
proteolysis  (IEA)
proteolysis involved in protein catabolic process  (IEA)
pyroptotic inflammatory response  (ISO)
regulation of apoptotic process  (IEA)
regulation of apoptotic signaling pathway  (ISO)
regulation of cytokine production  (ISO)
regulation of innate immune response  (ISO)
regulation of thymocyte apoptotic process  (ISO)
response to auditory stimulus  (ISO)
response to cobalt ion  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to lipopolysaccharide  (ISO)
response to tumor necrosis factor  (IEA)
self proteolysis  (ISO)
TRAIL-activated apoptotic signaling pathway  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CASP8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11086,888,654 - 86,944,159 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1086,916,527 - 86,943,829 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040112,478,130 - 112,535,645 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CASP8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382201,233,463 - 201,287,711 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2201,233,443 - 201,361,836 (+)EnsemblGRCh38hg38GRCh38
GRCh372202,098,166 - 202,152,434 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362201,806,411 - 201,860,679 (+)NCBINCBI36Build 36hg18NCBI36
Build 342201,923,718 - 201,972,144NCBI
Celera2195,852,777 - 195,904,249 (+)NCBICelera
Cytogenetic Map2q33.1NCBI
HuRef2193,949,530 - 194,000,819 (+)NCBIHuRef
CHM1_12202,104,145 - 202,158,454 (+)NCBICHM1_1
T2T-CHM13v2.02201,716,914 - 201,768,369 (+)NCBIT2T-CHM13v2.0
Casp8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39158,834,553 - 58,886,663 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl158,834,533 - 58,886,662 (+)EnsemblGRCm39 Ensembl
GRCm38158,795,233 - 58,847,503 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl158,795,374 - 58,847,503 (+)EnsemblGRCm38mm10GRCm38
MGSCv37158,852,218 - 58,904,347 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36158,740,040 - 58,791,559 (+)NCBIMGSCv36mm8
Celera159,314,392 - 59,366,511 (+)NCBICelera
Cytogenetic Map1C1.3NCBI
cM Map129.19NCBI
Casp8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8967,747,109 - 67,806,699 (+)NCBIGRCr8
mRatBN7.2960,263,863 - 60,312,542 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl960,264,075 - 60,312,542 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx968,759,278 - 68,807,629 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0973,875,236 - 73,923,588 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0972,193,497 - 72,241,846 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0965,614,142 - 65,662,624 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl965,614,142 - 65,662,106 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0965,420,843 - 65,469,468 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4957,389,353 - 57,437,803 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1957,536,334 - 57,584,785 (+)NCBI
Celera957,705,001 - 57,753,027 (+)NCBICelera
Cytogenetic Map9q31NCBI
Casp8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955403322,555 - 347,053 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955403322,082 - 348,591 (-)NCBIChiLan1.0ChiLan1.0
CASP8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213103,859,979 - 103,910,906 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B103,874,960 - 103,924,789 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B88,490,611 - 88,542,132 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B206,645,803 - 206,696,468 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B206,669,544 - 206,696,468 (+)Ensemblpanpan1.1panPan2
CASP8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13710,362,071 - 10,402,108 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3710,391,048 - 10,401,822 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3711,274,820 - 11,285,607 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03710,285,147 - 10,307,094 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3710,287,599 - 10,308,036 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13710,276,467 - 10,287,238 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03710,255,470 - 10,266,223 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03710,248,774 - 10,259,550 (+)NCBIUU_Cfam_GSD_1.0
Casp8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303158,584,293 - 158,626,147 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936726554,758 - 595,922 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936726554,627 - 596,334 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CASP8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15104,923,953 - 104,948,468 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115104,923,659 - 104,948,470 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215116,337,232 - 116,340,859 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Casp8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624899424,363 - 451,087 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624899427,064 - 450,931 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 20 20
Low 40
Below cutoff

Sequence


RefSeq Acc Id: ENSCSAT00000008869   ⟹   ENSCSAP00000007003
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1086,916,527 - 86,943,829 (+)Ensembl
RefSeq Acc Id: XM_007965833   ⟹   XP_007964024
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11086,916,935 - 86,944,159 (+)NCBI
Vero_WHO_p1.0NW_023666040112,478,547 - 112,504,495 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007965834   ⟹   XP_007964025
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11086,916,966 - 86,944,159 (+)NCBI
Vero_WHO_p1.0NW_023666040112,478,547 - 112,504,293 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007965835   ⟹   XP_007964026
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11086,888,674 - 86,944,159 (+)NCBI
Vero_WHO_p1.0NW_023666040112,478,547 - 112,535,645 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007965836   ⟹   XP_007964027
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11086,888,674 - 86,944,159 (+)NCBI
Vero_WHO_p1.0NW_023666040112,478,547 - 112,535,645 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007965837   ⟹   XP_007964028
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11086,888,654 - 86,944,159 (+)NCBI
Vero_WHO_p1.0NW_023666040112,478,547 - 112,535,618 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007965839   ⟹   XP_007964030
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11086,916,779 - 86,944,159 (+)NCBI
Vero_WHO_p1.0NW_023666040112,478,130 - 112,504,495 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038001756   ⟹   XP_037857684
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666040112,478,547 - 112,535,480 (-)NCBI
RefSeq Acc Id: XM_038001757   ⟹   XP_037857685
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666040112,478,547 - 112,504,293 (-)NCBI
RefSeq Acc Id: XR_005241473
Type: NON-CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666040112,480,004 - 112,504,495 (-)NCBI
RefSeq Acc Id: XP_007964028   ⟸   XM_007965837
- Peptide Label: isoform X3
RefSeq Acc Id: XP_007964026   ⟸   XM_007965835
- Peptide Label: isoform X3
RefSeq Acc Id: XP_007964027   ⟸   XM_007965836
- Peptide Label: isoform X3
RefSeq Acc Id: XP_007964030   ⟸   XM_007965839
- Peptide Label: isoform X1
- UniProtKB: A0A0D9REG4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007964024   ⟸   XM_007965833
- Peptide Label: isoform X2
RefSeq Acc Id: XP_007964025   ⟸   XM_007965834
- Peptide Label: isoform X3
RefSeq Acc Id: ENSCSAP00000007003   ⟸   ENSCSAT00000008869
RefSeq Acc Id: XP_037857684   ⟸   XM_038001756
- Peptide Label: isoform X3
RefSeq Acc Id: XP_037857685   ⟸   XM_038001757
- Peptide Label: isoform X4


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000010781 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000008869.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  3.40.50.1460 UniProtKB/TrEMBL
InterPro Caspase-8 UniProtKB/TrEMBL
  Caspase-like_dom_sf UniProtKB/TrEMBL
  Caspase_cys_AS UniProtKB/TrEMBL
  Caspase_his_AS UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/TrEMBL
  DED_dom UniProtKB/TrEMBL
  Pept_C14_caspase UniProtKB/TrEMBL
  Pept_C14_p10 UniProtKB/TrEMBL
  Pept_C14_p20 UniProtKB/TrEMBL
  Pept_C14A UniProtKB/TrEMBL
NCBI Gene CASP8 ENTREZGENE
PANTHER CASPASE 10 UniProtKB/TrEMBL
  DED DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam DED UniProtKB/TrEMBL
  Peptidase_C14 UniProtKB/TrEMBL
PRINTS IL1BCENZYME UniProtKB/TrEMBL
PROSITE CASPASE_CYS UniProtKB/TrEMBL
  CASPASE_HIS UniProtKB/TrEMBL
  CASPASE_P10 UniProtKB/TrEMBL
  CASPASE_P20 UniProtKB/TrEMBL
  DED UniProtKB/TrEMBL
SMART CASc UniProtKB/TrEMBL
  DED UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/TrEMBL
  SSF52129 UniProtKB/TrEMBL
UniProt A0A0D9REG4 ENTREZGENE, UniProtKB/TrEMBL