H2-receptor antagonist - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	H2-receptor antagonist	go back to main search page
Accession:	CHEBI:37961	browse the term
Definition:	H2-receptor antagonists are the drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of endogenous histamine.
Synonyms:	related_synonym:	H2 receptor antagonists; H2 receptor blockaders; H2-receptor blocker; H2-receptor blockers; histamine H2 receptor antagonist; histamine H2 receptor antagonists

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Rat (212) Mouse (213) Human (217) Chinchilla (0) Bonobo (0) Dog (1) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (212)

cimetidine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily G member 2

affects transport
multiple interactions

ABCG2 protein affects the transport of Cimetidine
Cimetidine inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]

PMID:15365089 PMID:15722455 PMID:26907376

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

alcohol dehydrogenase 1C (class I), gamma polypeptide

multiple interactions

Cimetidine inhibits the reaction [ADH1C protein results in increased oxidation of Ethanol]

NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892

G

alcohol dehydrogenase 4 (class II), pi polypeptide

multiple interactions

Cimetidine inhibits the reaction [ADH4 protein results in increased oxidation of Ethanol]

NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591

G

alcohol dehydrogenase 5 (class III), chi polypeptide

multiple interactions

Cimetidine inhibits the reaction [ADH5 protein results in increased oxidation of S-hydroxymethylglutathione]

NCBI chr 2:226,975,184...226,987,591
Ensembl chr 2:226,947,466...226,987,591

G

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

multiple interactions

Cimetidine inhibits the reaction [ADH7 protein results in increased oxidation of Ethanol]

NCBI chr 2:226,748,724...226,763,183
Ensembl chr 2:226,741,788...226,763,182

G

adiponectin, C1Q and collagen domain containing

multiple interactions

Cimetidine promotes the reaction [Metformin results in decreased expression of ADIPOQ mRNA]

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

aryl hydrocarbon receptor

affects expression
multiple interactions

Cimetidine affects the expression of AHR protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of AHR protein

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

aldehyde dehydrogenase 1 family, member A1

multiple interactions

Cimetidine inhibits the reaction [ALDH1A1 protein results in increased oxidation of Acetaldehyde]

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

aldehyde dehydrogenase 3 family, member A1

multiple interactions

Cimetidine inhibits the reaction [ALDH3A1 protein results in increased oxidation of benzaldehyde]

NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681

G

apoptotic peptidase activating factor 1

increases activity

Cimetidine results in increased activity of APAF1 protein

NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540

G

androgen receptor

multiple interactions
decreases expression

Cimetidine inhibits the reaction [Dihydrotestosterone binds to AR protein]
Cimetidine results in decreased expression of AR protein

PMID:6835285 PMID:26021711

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

Cimetidine results in increased expression of BAX protein
Cimetidine inhibits the reaction [Ethanol results in increased expression of BAX protein]

PMID:20127008 PMID:27983966

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

Cimetidine results in decreased expression of BCL2 protein
Cimetidine inhibits the reaction [Ethanol results in decreased expression of BCL2 protein]

PMID:20127008 PMID:27983966

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caspase 1

increases activity
multiple interactions

Cimetidine results in increased activity of CASP1 protein
CASP1 protein affects the reaction [Cimetidine results in increased expression of IL18 protein]

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 12

multiple interactions

Cimetidine inhibits the reaction [Ethanol results in increased expression of CASP12 protein]

NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037

G

caspase 3

increases activity
multiple interactions
increases expression

Cimetidine results in increased activity of CASP3 protein
Cimetidine inhibits the reaction [Ethanol results in increased expression of CASP3 protein]
Cimetidine results in increased expression of CASP3 protein

PMID:17273750 PMID:20127008 PMID:26021711 PMID:27983966

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

increases activity

Cimetidine results in increased activity of CASP7 protein

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 8

increases activity

Cimetidine results in increased activity of CASP8 protein

PMID:17273750 PMID:20127008

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

increases activity

Cimetidine results in increased activity of CASP9 protein

PMID:17273750 PMID:20127008

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

C-C motif chemokine ligand 2

multiple interactions

Cimetidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 protein]

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

CD14 molecule

decreases expression

Cimetidine results in decreased expression of CD14 protein

NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261

G

cystatin C

multiple interactions

Cimetidine inhibits the reaction [Cisplatin results in increased expression of CST3]

NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:136,336,920...136,340,822

G

cathepsin D

decreases activity

Cimetidine results in decreased activity of CTSD protein

NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488

G

cathepsin L

decreases activity

Cimetidine results in decreased activity of CTSL protein

NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
decreases expression
decreases activity

Cimetidine inhibits the reaction [Cocaine results in increased expression of CYP1A1 protein]
Cimetidine results in decreased expression of CYP1A1 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of CYP1A1 protein
Cimetidine results in decreased activity of CYP1A1 protein

PMID:11856816 PMID:22733800

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
decreases activity

Cimetidine inhibits the reaction [CYP1A2 protein results in increased metabolism of Tacrine]; NADP promotes the reaction [Cimetidine inhibits the reaction [CYP1A2 protein results in increased metabolism of Tacrine]]; styrofoam analog promotes the reaction [Cimetidine results in decreased activity of CYP1A2 protein]

PMID:7946932 PMID:19909766 PMID:31863871

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 2, subfamily b, polypeptide 3

decreases expression
multiple interactions
decreases activity

Cimetidine results in decreased expression of CYP2B6 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of CYP2B6 protein
Cimetidine results in decreased activity of CYP2B6 protein

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, subfamily 2, polypeptide 11

multiple interactions

Cimetidine inhibits the reaction [CYP2C11 protein results in increased glutathionylation of lamotrigine]

NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066

G

cytochrome P450, family 2, subfamily d, polypeptide 4

decreases activity
multiple interactions

Cimetidine results in decreased activity of CYP2D6 protein
Cimetidine inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]
styrofoam analog promotes the reaction [Cimetidine results in decreased activity of CYP2D6 protein]

PMID:17651725 PMID:19909766

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases expression
multiple interactions

Cimetidine results in decreased expression of CYP2E1 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of CYP2E1 protein

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 2, subfamily j, polypeptide 4

multiple interactions

Cimetidine inhibits the reaction [Cocaine results in increased expression of CYP2J2 protein]

NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
decreases expression
decreases activity

[Monocrotophos co-treated with Cimetidine] results in increased expression of CYP3A4 protein; Cimetidine inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Nifedipine]; styrofoam analog promotes the reaction [Cimetidine results in decreased activity of CYP3A4 protein]
Cimetidine results in decreased expression of CYP3A4 protein

PMID:2271712 PMID:16041596 PMID:18846481 PMID:19909766 PMID:22733800

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

DNA-damage inducible transcript 3

multiple interactions

Cimetidine inhibits the reaction [Ethanol results in increased expression of DDIT3 protein]

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

epidermal growth factor receptor

multiple interactions

Cimetidine inhibits the reaction [EGFR protein results in increased phosphorylation of EGFR protein]
[Cimetidine results in decreased abundance of Cyclic AMP] inhibits the reaction [EGFR protein results in increased phosphorylation of EGFR protein]

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

follicle stimulating hormone subunit beta

affects expression

Cimetidine affects the expression of FSHB protein

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

G

gastrin

affects expression

Cimetidine affects the expression of GAST protein

NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496

G

glutathione S-transferase pi 1

affects expression
multiple interactions

Cimetidine affects the expression of GSTP1 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of GSTP1 protein

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

heme oxygenase 1

multiple interactions

[piperine co-treated with Cimetidine co-treated with Pyruvates] inhibits the reaction [Puromycin Aminonucleoside results in increased expression of HMOX1 protein]

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

histamine receptor H 1

multiple interactions

Cimetidine inhibits the reaction [HRH1 results in decreased susceptibility to Morphine]

NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455

G

histamine receptor H 2

multiple interactions
decreases activity
increases expression

[Cimetidine binds to and results in decreased activity of HRH2 protein] results in decreased susceptibility to [Histamine co-treated with [Oxygen deficiency co-treated with Oxygen]]; [Cimetidine binds to and results in decreased activity of HRH2 protein] which affects the susceptibility to Metformin; [Cimetidine binds to and results in decreased activity of HRH2 protein] which results in decreased abundance of Cyclic AMP; Burimamide inhibits the reaction [[Cyclic AMP binds to and results in decreased activity of HRH2 protein] which results in decreased abundance of Cimetidine]; Cimetidine binds to and results in decreased activity of HRH2 protein; Cimetidine binds to and results in increased activity of HRH2 protein; Cimetidine inhibits the reaction [HRH2 protein promotes the reaction [Histamine results in increased expression of IL16 protein]]
Cimetidine results in decreased activity of HRH2 protein
[Cimetidine binds to and results in decreased activity of HRH2 protein] which results in decreased susceptibility to clobenpropit; Cimetidine binds to and results in decreased activity of HRH2 protein; Cimetidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH2 protein] which results in decreased susceptibility to Scopolamine]
Cimetidine binds to and results in increased activity of HRH2 protein; Cimetidine inhibits the reaction [HRH2 results in decreased susceptibility to Morphine]; HRH2 protein affects the reaction [Cimetidine results in increased expression of IL18 protein]
Cimetidine results in increased expression of HRH2 protein

PMID:1912125 PMID:2461127 PMID:6522242 PMID:9681472 PMID:12235264 More...

NCBI chr17:10,366,004...10,407,791
Ensembl chr17:10,368,298...10,407,631

G

heat shock protein family A (Hsp70) member 5

multiple interactions

Cimetidine inhibits the reaction [Ethanol results in increased expression of HSPA5 protein]

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

intercellular adhesion molecule 1

decreases expression

Cimetidine results in decreased expression of ICAM1 protein

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interferon gamma

multiple interactions
increases expression

Cimetidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]]
Cimetidine results in increased expression of IFNG mRNA; Cimetidine results in increased expression of IFNG protein

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 16

multiple interactions

Cimetidine inhibits the reaction [HRH2 protein promotes the reaction [Histamine results in increased expression of IL16 protein]]

NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130

G

interleukin 18

multiple interactions
increases expression

CASP1 protein affects the reaction [Cimetidine results in increased expression of IL18 protein]; Famotidine inhibits the reaction [Cimetidine results in increased expression of IL18 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Cimetidine results in increased expression of IL18 protein]; Ranitidine inhibits the reaction [Cimetidine results in increased expression of IL18 protein]
HRH2 protein affects the reaction [Cimetidine results in increased expression of IL18 protein]

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 beta

multiple interactions

Cimetidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Cimetidine inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

integrin subunit alpha 4

decreases expression

Cimetidine results in decreased expression of ITGA4 protein

NCBI chr 3:64,162,764...64,235,010
Ensembl chr 3:64,163,085...64,233,715

G

integrin subunit alpha X

decreases expression

Cimetidine results in decreased expression of ITGAX protein

NCBI chr 1:182,709,653...182,740,709
Ensembl chr 1:182,719,609...182,740,698

G

LDL receptor related protein 1

decreases expression

Cimetidine results in decreased expression of LRP1 protein

NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910

G

neural cell adhesion molecule 1

decreases expression

Cimetidine results in decreased expression of NCAM mRNA; Cimetidine results in decreased expression of NCAM protein

NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014

G

nuclear factor kappa B subunit 1

multiple interactions

Cimetidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Cimetidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of NFKB1 protein]

PMID:12065299 PMID:12107048

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

nuclear receptor subfamily 1, group I, member 2

decreases expression
multiple interactions

Cimetidine results in decreased expression of NR1I2 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of NR1I2 protein

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

nuclear receptor subfamily 1, group I, member 3

decreases expression
multiple interactions

Cimetidine results in decreased expression of NR1I3 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of NR1I3 protein

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

neurotrophin 3

multiple interactions

Cimetidine inhibits the reaction [Histamine results in increased expression of NTF3 protein]

NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596

G

phosphodiesterase 4B

multiple interactions

Cimetidine inhibits the reaction [Histamine results in increased expression of PDE4B mRNA]

NCBI chr 5:116,799,819...117,369,155
Ensembl chr 5:116,799,971...117,367,696

G

prolactin

affects expression

Cimetidine affects the expression of PRL protein

PMID:435711 PMID:9037573

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

prokineticin 1

decreases expression

Cimetidine results in decreased expression of PROK1 protein

NCBI chr 2:194,850,539...194,859,343
Ensembl chr 2:194,853,991...194,859,250

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Cimetidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Cimetidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of RELA protein]
Cimetidine inhibits the reaction [Ethanol results in increased expression of RELA protein]

PMID:12065299 PMID:12107048 PMID:24300194

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

selectin P

decreases expression

Cimetidine results in decreased expression of SELP protein

NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845

G

solute carrier family 22 member 1

increases uptake
multiple interactions

SLC22A1 protein results in increased uptake of Cimetidine
Cimetidine inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]

PMID:16006492 PMID:19357179

NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678

G

solute carrier family 22 member 2

multiple interactions
increases transport
decreases response to substance
increases uptake

1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A2 protein results in increased uptake of Cimetidine]; Cimetidine inhibits the reaction [SLC22A2 protein affects the transport of Tetraethylammonium]; Cimetidine inhibits the reaction [SLC22A2 protein polymorphism results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Cimetidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Cimetidine inhibits the reaction [SLC22A2 protein results in increased uptake of Ethidium]; p-Aminohippuric Acid inhibits the reaction [SLC22A2 protein results in increased uptake of Cimetidine]
SLC22A2 protein results in increased transport of Cimetidine
SLC22A2 gene polymorphism results in decreased susceptibility to Cimetidine

PMID:15496291 PMID:16006492 PMID:18230276 PMID:19357179 PMID:21599003 More...

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 22 member 3

multiple interactions
increases transport

Cimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Cimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]; Cimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of Metformin]
Cimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]
SLC22A3 protein results in increased transport of Cimetidine

PMID:10966924 PMID:18253050 PMID:19357179 PMID:21697722

NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612

G

solute carrier family 22 member 6

multiple interactions
increases uptake

1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A6 protein results in increased uptake of Cimetidine]; Cimetidine inhibits the reaction [SLC22A6 protein affects the transport of p-Aminohippuric Acid]; p-Aminohippuric Acid inhibits the reaction [SLC22A6 protein results in increased uptake of Cimetidine]

PMID:15496291 PMID:16006492 PMID:16098483

NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173

G

solute carrier family 22 member 7

increases uptake
multiple interactions

SLC22A7 protein results in increased uptake of Cimetidine
Cimetidine inhibits the reaction [SLC22A7 protein results in increased uptake of Glutarates]

PMID:12065749 PMID:16006492

NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921

G

solute carrier family 22 member 8

multiple interactions
increases uptake
affects transport

Cimetidine inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of Cimetidine]
SLC22A8 protein results in increased uptake of Cimetidine
Cimetidine inhibits the reaction [SLC22A8 protein results in increased uptake of p-Aminohippuric Acid]
estradiol-17 beta-glucuronide inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; estrone sulfate inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; Famotidine inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; p-Aminohippuric Acid inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; Penicillin G inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of Cimetidine]; Probenecid promotes the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; Ranitidine inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]

PMID:10224140 PMID:11306713 PMID:15100168 PMID:15319347 PMID:15496291 More...

NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450

G

solute carrier family 47 member 1

affects transport
multiple interactions
decreases activity

SLC47A1 protein affects the transport of Cimetidine
Cimetidine inhibits the reaction [SLC47A1 protein results in increased uptake of Cadmium]
Cimetidine inhibits the reaction [SLC47A1 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Cimetidine inhibits the reaction [SLC47A1 protein results in increased uptake of Cadmium]
Cimetidine results in decreased activity of SLC47A1 protein

PMID:16928787 PMID:21599003 PMID:27871888

NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637

G

solute carrier family 47 member 2

multiple interactions

Cimetidine inhibits the reaction [SLC47A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Cimetidine inhibits the reaction [SLC47A2 protein results in increased uptake of Cadmium]

PMID:21599003 PMID:27871888

NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904

G

solute carrier family 9 member A3

multiple interactions

[piperine co-treated with Cimetidine co-treated with Pyruvates] inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of SLC9A3 protein]

NCBI chr 1:29,124,633...29,167,912
Ensembl chr 1:29,124,674...29,167,417

G

tumor necrosis factor

multiple interactions

Cimetidine inhibits the reaction [Dimaprit inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]
Cimetidine inhibits the reaction [Cocaine results in increased expression of TNF protein]

PMID:9088875 PMID:11856816

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

famotidine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adenylate cyclase activating polypeptide 1

multiple interactions

Famotidine inhibits the reaction [ADCYAP1 protein affects the secretion of Acids]

NCBI chr 9:113,102,632...113,122,500
Ensembl chr 9:113,103,718...113,109,773

G

angiotensinogen

multiple interactions

Famotidine inhibits the reaction [Indomethacin results in increased expression of AGT protein]

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

B-Raf proto-oncogene, serine/threonine kinase

decreases activity

Famotidine results in decreased activity of BRAF protein

NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463

G

carbonic anhydrase 12

multiple interactions

Famotidine binds to and results in decreased activity of CA12 protein

NCBI chr 8:67,274,739...67,330,428
Ensembl chr 8:67,274,359...67,330,440

G

carbonic anhydrase 2

multiple interactions

Famotidine binds to and results in decreased activity of CA2 protein

NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818

G

carbonic anhydrase 6

multiple interactions

Famotidine binds to and results in decreased activity of CA6 protein

NCBI chr 5:160,658,104...160,676,644
Ensembl chr 5:160,658,105...160,676,644

G

carbonic anhydrase 7

multiple interactions

Famotidine binds to and results in decreased activity of CA7 protein

NCBI chr19:429,063...438,478
Ensembl chr19:429,075...438,467

G

catalase

multiple interactions

Famotidine inhibits the reaction [Indomethacin results in decreased activity of CAT protein]; Famotidine inhibits the reaction [Indomethacin results in increased activity of CAT protein]; Quercetin promotes the reaction [Famotidine inhibits the reaction [Indomethacin results in decreased activity of CAT protein]]

PMID:18726076 PMID:19034656 PMID:19497431 PMID:25926722

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

Cd80 molecule

multiple interactions

Famotidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein]]

NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030

G

catenin beta 1

multiple interactions
increases expression

Famotidine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CTNNB1 mRNA]
Famotidine results in increased expression of CTNNB1 mRNA

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

C-X-C motif chemokine ligand 1

increases expression

Famotidine results in increased expression of CXCL1 protein

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

G

cytochrome P450, family 2, subfamily C, polypeptide 6

multiple interactions

Famotidine inhibits the reaction [CYP2C19 gene affects the susceptibility to Lansoprazole]

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

fibroblast growth factor 2

multiple interactions

[Famotidine co-treated with Sucralfate] results in increased expression of FGF2 mRNA

NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221

G

fibroblast growth factor 21

increases expression

Famotidine results in increased expression of FGF21 protein

NCBI chr 1:96,083,360...96,084,911
Ensembl chr 1:96,083,441...96,090,454

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Famotidine inhibits the reaction [[Dimaprit binds to and results in increased activity of HRH2 protein] which results in increased expression of FOS mRNA]; Famotidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH2 protein] which results in increased expression of FOS mRNA]

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

gamma-aminobutyric acid type A receptor subunit alpha 1

multiple interactions

Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG1 protein]]; Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein]]

NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864

G

gamma-aminobutyric acid type A receptor subunit alpha 3

multiple interactions

Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG1 protein]]; Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG2 protein]]

NCBI chr X:150,244,745...150,501,566
Ensembl chr X:150,261,607...150,501,559

G

gamma-aminobutyric acid type A receptor subunit beta 2

multiple interactions

Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG1 protein]]; Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein]]; Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG1 protein]]; Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG2 protein]]

NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251

G

gamma-aminobutyric acid type A receptor subunit gamma 1

multiple interactions

Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG1 protein]]; Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG1 protein]]

NCBI chr14:37,396,217...37,469,606
Ensembl chr14:37,396,294...37,635,956

G

gamma-aminobutyric acid type A receptor subunit gamma 2

multiple interactions

Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG2 protein]]

NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346

G

gastrin

affects expression
increases expression

Famotidine affects the expression of GAST protein
Famotidine results in increased expression of GAST protein

PMID:12503773 PMID:17652263

NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496

G

ghrelin and obestatin prepropeptide

multiple interactions

Famotidine inhibits the reaction [GHRL protein results in increased secretion of Acids]

NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621

G

glycogen synthase kinase 3 beta

multiple interactions

Famotidine inhibits the reaction [Dizocilpine Maleate results in decreased phosphorylation of and results in increased activity of GSK3B protein]; Famotidine inhibits the reaction [Dizocilpine Maleate results in increased expression of GSK3B mRNA]

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

histamine receptor H 2

multiple interactions
decreases activity
increases expression

[Famotidine binds to and results in decreased activity of HRH2 protein] which affects the susceptibility to Metformin; Famotidine binds to and results in decreased activity of HRH2 protein; Famotidine inhibits the reaction [[Dimaprit binds to and results in increased activity of HRH2 protein] which results in increased expression of FOS mRNA]; Famotidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH2 protein] which results in increased expression of FOS mRNA]
Famotidine results in decreased activity of HRH2 protein
[Famotidine binds to and results in decreased activity of HRH2 protein] which affects the susceptibility to Histamine
Famotidine results in increased expression of HRH2 protein

PMID:9187264 PMID:9681472 PMID:12832840 PMID:15961859 PMID:16632449 More...

NCBI chr17:10,366,004...10,407,791
Ensembl chr17:10,368,298...10,407,631

G

heat shock protein family A (Hsp70) member 1A

decreases expression
multiple interactions

Famotidine results in decreased expression of HSPA1A protein
Zinc Compounds analog inhibits the reaction [Famotidine results in decreased expression of HSPA1A protein]; Zinc Sulfate inhibits the reaction [Famotidine results in decreased expression of HSPA1A protein]

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

intercellular adhesion molecule 1

multiple interactions

Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]]

PMID:11752121 PMID:12364868 PMID:12538815

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interferon gamma

multiple interactions

Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]
Famotidine inhibits the reaction [Dimaprit inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNG protein]]

PMID:11752121 PMID:12364868 PMID:19277450

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 10

multiple interactions

Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 12A

multiple interactions

Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]

PMID:11752121 PMID:12364868

NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734

G

interleukin 12B

multiple interactions

Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]

PMID:11752121 PMID:12364868

NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903

G

interleukin 18

multiple interactions

Famotidine inhibits the reaction [Cimetidine results in increased expression of IL18 protein]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]]

PMID:11752121 PMID:12364868 PMID:16723495

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 beta

multiple interactions

[Famotidine co-treated with Sucralfate] results in decreased expression of IL1B mRNA
Famotidine inhibits the reaction [Ethanol results in increased expression of IL1B protein]; Famotidine inhibits the reaction [Indomethacin results in increased expression of IL1B mRNA]

PMID:17717918 PMID:27474069 PMID:27645307

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 2

multiple interactions

Famotidine inhibits the reaction [Dimaprit inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]]

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 4

multiple interactions

Famotidine inhibits the reaction [Dimaprit inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL4 protein]]

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

multiple interactions

Famotidine inhibits the reaction [Ethanol results in increased expression of IL6 protein]; Famotidine inhibits the reaction [Ethanol results in increased secretion of IL6 protein]

PMID:17603938 PMID:27474069

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

mitogen activated protein kinase 1

multiple interactions

Famotidine inhibits the reaction [Histamine results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

Famotidine inhibits the reaction [Histamine results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

matrix metallopeptidase 1

multiple interactions

Famotidine inhibits the reaction [Histamine results in increased expression of MMP1 mRNA]; Famotidine inhibits the reaction [Histamine results in increased secretion of MMP1 protein]

NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097

G

matrix metallopeptidase 9

multiple interactions

Famotidine inhibits the reaction [Ethanol results in increased expression of and results in increased activity of MMP9 protein]; Famotidine inhibits the reaction [Ethanol results in increased expression of MMP9 mRNA]; Famotidine inhibits the reaction [Ethanol results in increased secretion of and results in increased activity of MMP9 protein]; Famotidine inhibits the reaction [Ethanol results in increased secretion of MMP9 protein]

PMID:17603938 PMID:22257724

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

myeloperoxidase

multiple interactions
increases expression

Famotidine inhibits the reaction [Acids results in increased activity of MPO protein]
Famotidine results in increased expression of MPO protein
Famotidine inhibits the reaction [Ethanol results in increased activity of MPO protein]; Famotidine inhibits the reaction [Indomethacin results in increased activity of MPO protein]; Famotidine promotes the reaction [Chlorpheniramine results in decreased activity of MPO protein]; Quercetin promotes the reaction [Famotidine inhibits the reaction [Indomethacin results in increased activity of MPO protein]]

PMID:12023551 PMID:16091555 PMID:16437673 PMID:17603938 PMID:18726076 More...

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

natriuretic peptide B

decreases expression

Famotidine results in decreased expression of NPPB protein

NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168

G

neurotrophin 3

multiple interactions

[Pyrilamine co-treated with Famotidine co-treated with ciproxifan] inhibits the reaction [Histamine results in increased expression of NTF3 protein]; [Pyrilamine co-treated with Famotidine] inhibits the reaction [Histamine results in increased expression of NTF3 protein]; Famotidine inhibits the reaction [Histamine results in increased expression of NTF3 protein]

NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596

G

proliferating cell nuclear antigen

multiple interactions

[Famotidine co-treated with Indomethacin] promotes the reaction [Acetic Acid results in increased expression of PCNA protein]; Famotidine promotes the reaction [Acetic Acid results in increased expression of PCNA protein]

PMID:18853145 PMID:19251492

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

protein phosphatase 3 catalytic subunit alpha

decreases expression

Famotidine results in decreased expression of PPP3CA protein

NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974

G

peroxiredoxin 3

increases expression

Famotidine results in increased expression of PRDX3 protein

NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111

G

prolactin

increases expression

Famotidine results in increased expression of PRL protein

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

prostaglandin-endoperoxide synthase 1

multiple interactions

Famotidine inhibits the reaction [Indomethacin results in increased expression of PTGS1 mRNA]

NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586

G

prostaglandin-endoperoxide synthase 2

multiple interactions

Famotidine inhibits the reaction [Indomethacin results in increased expression of PTGS2 mRNA]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Famotidine inhibits the reaction [Ethanol results in increased expression of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

RT1 class Ia, locus A2

affects expression

Famotidine affects the expression of HLA-E mRNA

NCBI chr20:4,870,939...4,910,183

G

RT1 class II, locus DMb

affects expression

Famotidine affects the expression of HLA-DMB mRNA

NCBI chr20:4,693,102...4,700,340
Ensembl chr20:4,693,103...4,700,340

G

serpin family E member 1

multiple interactions

Heparin promotes the reaction [[Famotidine co-treated with Lipopolysaccharides] results in increased expression of SERPINE1 protein]

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

solute carrier family 19 member 3

multiple interactions
increases uptake

Famotidine inhibits the reaction [SLC19A3 protein results in increased uptake of Metformin]; Famotidine inhibits the reaction [SLC19A3 protein results in increased uptake of Thiamine]
SLC19A3 protein results in increased uptake of Famotidine

NCBI chr 9:84,275,722...84,299,368
Ensembl chr 9:84,277,024...84,299,337

G

solute carrier family 22 member 1

multiple interactions
increases uptake
affects transport

Famotidine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
SLC22A1 protein results in increased uptake of Famotidine
SLC22A1 protein affects the transport of Famotidine

PMID:16006492 PMID:16141367

NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678

G

solute carrier family 22 member 2

increases uptake
multiple interactions

SLC22A2 protein results in increased uptake of Famotidine
Famotidine inhibits the reaction [SLC22A2 protein affects the transport of Tetraethylammonium]; Famotidine inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Famotidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

PMID:15496291 PMID:16006492 PMID:16141367 PMID:21599003

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 22 member 3

multiple interactions
decreases activity

Famotidine inhibits the reaction [SLC22A3 protein affects the transport of 1-Methyl-4-phenylpyridinium]; Famotidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
Famotidine results in decreased activity of SLC22A3 protein

NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612

G

solute carrier family 22 member 8

multiple interactions
increases uptake

estrone sulfate inhibits the reaction [SLC22A8 protein results in increased uptake of Famotidine]; Famotidine inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of Famotidine]
Famotidine inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; Penicillin G inhibits the reaction [SLC22A8 protein results in increased uptake of Famotidine]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of Famotidine]; Probenecid promotes the reaction [SLC22A8 protein results in increased uptake of Famotidine]
Famotidine inhibits the reaction [SLC22A8 protein results in increased uptake of p-Aminohippuric Acid]

PMID:15100168 PMID:15319347 PMID:15496291 PMID:16006492

NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450

G

solute carrier family 47 member 1

multiple interactions

Famotidine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637

G

solute carrier family 47 member 2

multiple interactions

Famotidine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904

G

tachykinin receptor 1

multiple interactions

Famotidine inhibits the reaction [Acids affects the localization of TACR1 protein]

NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733

G

tumor necrosis factor

multiple interactions
increases secretion

Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]
Famotidine results in increased secretion of TNF protein
Famotidine inhibits the reaction [Dimaprit inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TNF protein]]
Famotidine inhibits the reaction [Ethanol results in increased expression of TNF protein]; Famotidine inhibits the reaction [Ethanol results in increased secretion of TNF protein]; Famotidine inhibits the reaction [Indomethacin results in increased expression of TNF mRNA]

PMID:11752121 PMID:12538815 PMID:17603938 PMID:17698507 PMID:19277450 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

loxtidine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

amphiregulin

multiple interactions
decreases expression

[YF 476 co-treated with loxtidine] results in decreased expression of AREG mRNA
loxtidine results in decreased expression of AREG mRNA

NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535

G

regenerating family member 1 alpha

decreases expression
multiple interactions

loxtidine results in decreased expression of REG1 mRNA
[YF 476 co-treated with loxtidine] results in decreased expression of REG1 mRNA

NCBI chr 4:110,892,451...110,895,115
Ensembl chr 4:110,892,453...110,895,570

nizatidine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

calcitonin-related polypeptide alpha

increases expression

Nizatidine results in increased expression of CALCA protein

NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105

G

tachykinin, precursor 1

increases expression

Nizatidine results in increased expression of TAC1 protein

NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178

ranitidine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

multiple interactions

Ranitidine binds to and results in decreased activity of ACHE protein; Ranitidine inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]
Ranitidine affects the reaction [Paraoxon results in decreased activity of ACHE protein]

PMID:15669026 PMID:15669039 PMID:16193528

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

atypical chemokine receptor 3

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ACKR3 mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ACKR3 mRNA]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of ACKR3 mRNA]

PMID:16401727 PMID:16415329

NCBI chr 9:90,799,682...90,811,246
Ensembl chr 9:90,799,686...90,811,237

G

ADAM metallopeptidase with thrombospondin type 1 motif, 1

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ADAMTS1 mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ADAMTS1 mRNA]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of ADAMTS1 mRNA]

PMID:16401727 PMID:16415329

NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103

G

albumin

multiple interactions

[Ranitidine co-treated with Diclofenac] results in decreased expression of ALB protein; Quercetin inhibits the reaction [[Ranitidine co-treated with Diclofenac] results in decreased expression of ALB protein]

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

aldolase, fructose-bisphosphate A

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ALDOA mRNA

NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182

G

angiomotin like 2

multiple interactions

Ranitidine inhibits the reaction [Lipopolysaccharides results in increased expression of AMOTL2 mRNA]

NCBI chr 8:103,303,368...103,319,161
Ensembl chr 8:103,302,992...103,318,910

G

Rho guanine nucleotide exchange factor 11

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ARHGEF11 mRNA

NCBI chr 2:173,074,383...173,195,962
Ensembl chr 2:173,074,368...173,196,010

G

activating transcription factor 3

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ATF3 mRNA; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of ATF3 mRNA]

PMID:16401727 PMID:16415329

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

ATPase Na+/K+ transporting subunit beta 1

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ATP1B1 mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ATP1B1 mRNA]; Ranitidine inhibits the reaction [Lipopolysaccharides results in decreased expression of ATP1B1 mRNA]

PMID:16401727 PMID:16415329

NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459

G

BCL2 associated X, apoptosis regulator

multiple interactions

Ranitidine inhibits the reaction [Rotenone results in increased expression of BAX protein]
Ranitidine inhibits the reaction [Aspirin results in increased expression of BAX protein]

PMID:19723537 PMID:30885738

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

butyrylcholinesterase

multiple interactions

Ranitidine binds to and results in decreased activity of BCHE protein; Ranitidine inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]

PMID:15669026 PMID:16193528

NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148

G

BCL2, apoptosis regulator

multiple interactions

Ranitidine inhibits the reaction [Rotenone results in decreased expression of BCL2 protein]

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

basic helix-loop-helix family, member e40

multiple interactions

Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of BHLHE40 mRNA]

NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774

G

bone morphogenetic protein 2

multiple interactions

Ranitidine inhibits the reaction [Lipopolysaccharides results in decreased expression of BMP2 mRNA]

NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397

G

BCL2 interacting protein 3

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of BNIP3 mRNA

PMID:16401727 PMID:16415329

NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359

G

BTG anti-proliferation factor 2

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of BTG2 mRNA; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of BTG2 mRNA]

PMID:16401727 PMID:16415329

NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628

G

calcitonin-related polypeptide alpha

increases expression

Ranitidine results in increased expression of CALCA protein

NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105

G

caspase 3

multiple interactions

Ranitidine inhibits the reaction [Rotenone results in increased cleavage of and results in increased activity of CASP3 protein]
Ranitidine inhibits the reaction [Aspirin results in increased expression of CASP3 mRNA]; Ranitidine inhibits the reaction [Aspirin results in increased expression of CASP3 protein]; Ranitidine inhibits the reaction [Indomethacin results in increased expression of CASP3 mRNA]; Ranitidine inhibits the reaction [Indomethacin results in increased expression of CASP3 protein]

PMID:19723537 PMID:28648817 PMID:29523851 PMID:30580614 PMID:30885738

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

multiple interactions

Ranitidine inhibits the reaction [Rotenone results in increased cleavage of CASP9 protein]

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions

Ranitidine inhibits the reaction [Indomethacin results in decreased activity of CAT protein]; Ranitidine inhibits the reaction [Indomethacin results in increased activity of CAT protein]

PMID:16169175 PMID:16397915 PMID:17895592 PMID:18087811 PMID:18726076

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cyclin L1

multiple interactions

Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of CCNL1 mRNA]

NCBI chr 2:150,184,865...150,199,524
Ensembl chr 2:150,184,798...150,197,368

G

Cd80 molecule

multiple interactions

Ranitidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein]]

NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030

G

cyclin-dependent kinase 6

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in decreased expression of CDK6 mRNA

NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634

G

cAMP responsive element modulator

multiple interactions

Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of CREM mRNA]

NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989

G

colony stimulating factor 3

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of CSF3 mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of CSF3 mRNA]

NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603

G

cathepsin L

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of CTSL mRNA

NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548

G

C-X-C motif chemokine ligand 1

decreases expression

Ranitidine results in decreased expression of CXCL1 protein

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

G

C-X-C motif chemokine ligand 2

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of CXCL2 mRNA; [Ranitidine co-treated with Lipopolysaccharides] results in increased expression of CXCL2 protein; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of CXCL2 mRNA]; Heparin inhibits the reaction [Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of CXCL2 protein]]; Pentoxifylline inhibits the reaction [[Ranitidine co-treated with Lipopolysaccharides] results in increased expression of CXCL2 protein]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of CXCL2 mRNA]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of CXCL2 protein]

PMID:16401727 PMID:16415329 PMID:17698507

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

dimethylarginine dimethylaminohydrolase 1

multiple interactions

Ranitidine inhibits the reaction [Indomethacin results in decreased expression of DDAH1 mRNA]

NCBI chr 2:234,667,499...234,800,322
Ensembl chr 2:234,667,491...234,799,339

G

DNA-damage-inducible transcript 4

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of DDIT4 mRNA

NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105

G

iodothyronine deiodinase 3

multiple interactions

Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of DIO3 mRNA]

NCBI chr 6:129,285,747...129,287,608
Ensembl chr 6:129,285,749...129,286,660

G

dual specificity phosphatase 1

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of DUSP1 mRNA

NCBI chr10:16,680,478...16,683,275

G

ephrin A1

multiple interactions

Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of EFNA1 mRNA]

NCBI chr 2:174,681,676...174,689,061
Ensembl chr 2:174,681,682...174,690,866

G

EGF-like-domain, multiple 7

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in decreased expression of EGFL7 mRNA

NCBI chr 3:9,404,622...9,416,879
Ensembl chr 3:9,407,520...9,416,879

G

epidermal growth factor receptor

multiple interactions

Ranitidine inhibits the reaction [Indomethacin results in increased expression of EGFR mRNA]

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

egl-9 family hypoxia-inducible factor 3

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of EGLN3 mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of EGLN3 mRNA]

PMID:16401727 PMID:16415329

NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766

G

early growth response 1

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of EGR1 mRNA; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of EGR1 mRNA]

PMID:16401727 PMID:16415329

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

coagulation factor III, tissue factor

multiple interactions

Ranitidine inhibits the reaction [Lipopolysaccharides results in decreased expression of F3 mRNA]

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

G

fibroblast growth factor 23

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of FGF23 mRNA

NCBI chr 4:159,914,267...159,923,821
Ensembl chr 4:159,914,272...159,923,821

G

flavin containing dimethylaniline monoxygenase 3

affects metabolic processing

FMO3 protein affects the metabolism of Ranitidine

NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of FOS mRNA

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

FOS like 2, AP-1 transcription factor subunit

multiple interactions

Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of FOSL2 mRNA]

NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034

G

forkhead box Q1

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of FOXQ1 mRNA

NCBI chr17:32,912,744...32,915,377
Ensembl chr17:32,912,744...32,915,377
Ensembl chr17:32,912,744...32,915,377

G

follistatin

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of FST mRNA; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of FST mRNA]

NCBI chr 2:46,123,260...46,130,584
Ensembl chr 2:46,123,439...46,130,571

G

growth arrest and DNA-damage-inducible, alpha

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of GADD45A mRNA

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

gastrin

affects expression
multiple interactions

Ranitidine affects the expression of GAST protein
Ranitidine inhibits the reaction [GAST protein modified form results in increased secretion of Acids]

PMID:2470453 PMID:12503773

NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496

G

glutamic-oxaloacetic transaminase 1

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of GOT1 mRNA

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

granzyme B

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of GZMB mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of GZMB mRNA]

NCBI chr15:30,343,352...30,346,814
Ensembl chr15:30,173,603...30,346,814

G

H2A clustered histone 25

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of H2A mRNA

NCBI chr10:43,733,702...43,735,254
Ensembl chr10:43,733,668...43,744,874

G

heme oxygenase 1

multiple interactions

Ranitidine inhibits the reaction [Indomethacin results in decreased expression of HMOX1 mRNA]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]

PMID:16415329 PMID:30580614

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

hepatocyte nuclear factor 4, alpha

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in decreased expression of HNF4A mRNA

NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320

G

homer scaffold protein 1

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of HOMER1 mRNA

NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785

G

homeo box A5

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of HOXA5 mRNA

NCBI chr 4:81,302,341...81,306,234
Ensembl chr 4:81,302,353...81,306,234

G

histamine receptor H 2

multiple interactions
decreases activity

[Ranitidine binds to and results in decreased activity of HRH2 protein] which affects the susceptibility to Metformin; Ranitidine binds to and results in decreased activity of HRH2 protein; Ranitidine inhibits the reaction [tiotidine binds to HRH2 protein]
Ranitidine binds to and results in decreased activity of HRH2 protein; Ranitidine inhibits the reaction [Dimaprit binds to and results in increased activity of HRH2 protein]; Ranitidine inhibits the reaction [Melitten results in increased activity of HRH2 protein]
Ranitidine results in decreased activity of HRH2 protein

PMID:6106871 PMID:6835285 PMID:7512805 PMID:9681472 PMID:9819373 More...

NCBI chr17:10,366,004...10,407,791
Ensembl chr17:10,368,298...10,407,631

G

heat shock protein family A (Hsp70) member 1A

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of HSPA1A mRNA

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family B (small) member 8

multiple interactions

Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of HSPB8 mRNA]

NCBI chr12:40,176,405...40,205,002
Ensembl chr12:40,176,532...40,191,185

G

intercellular adhesion molecule 1

multiple interactions

Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]]

PMID:11752121 PMID:12538815

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

inhibitor of DNA binding 2

multiple interactions

Ranitidine inhibits the reaction [Lipopolysaccharides results in decreased expression of ID2 mRNA]

NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400

G

inhibitor of DNA binding 4

multiple interactions

Ranitidine inhibits the reaction [Lipopolysaccharides results in decreased expression of ID4 mRNA]

NCBI chr17:16,389,387...16,391,956
Ensembl chr17:16,389,387...16,392,470

G

interferon gamma

multiple interactions

Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]]
[IFNG protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Ranitidine; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of IFNG mRNA]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of IFNG protein]

PMID:10569698 PMID:11752121 PMID:16415329 PMID:17698507 PMID:19362101

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interferon-related developmental regulator 1

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of IFRD1 mRNA

NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990

G

immunoglobulin superfamily, member 10

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of IGSF10 mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of IGSF10 mRNA]

NCBI chr 2:143,575,710...143,605,044
Ensembl chr 2:143,576,070...143,604,773

G

interleukin 10

multiple interactions

Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of IL10 protein]
Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]

PMID:11752121 PMID:17698507

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 12A

multiple interactions

Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; Ranitidine inhibits the reaction [Histamine results in decreased expression of IL12A protein]

PMID:9819373 PMID:11752121

NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734

G

interleukin 12B

multiple interactions

Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; Ranitidine inhibits the reaction [Histamine results in decreased expression of IL12B protein]

PMID:9819373 PMID:11752121

NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903

G

interleukin 18

multiple interactions

Ranitidine inhibits the reaction [Cimetidine results in increased expression of IL18 protein]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]]

PMID:11752121 PMID:16723495

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 alpha

multiple interactions

[IFNG protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Ranitidine

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

multiple interactions
increases expression

Pentoxifylline inhibits the reaction [Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; Ranitidine inhibits the reaction [Capsaicin results in increased expression of IL1B protein]; Ranitidine inhibits the reaction [Indomethacin results in increased expression of IL1B mRNA]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein]
Ranitidine results in increased expression of IL1B protein

PMID:15265675 PMID:17698507 PMID:30580614

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 4

multiple interactions

Ranitidine inhibits the reaction [Indomethacin results in increased expression of IL4 protein]

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of IL6 mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of IL6 mRNA]; Pentoxifylline inhibits the reaction [Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; Ranitidine inhibits the reaction [Capsaicin results in increased expression of IL6 protein]; Ranitidine inhibits the reaction [Indomethacin results in increased expression of IL6 protein]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]

PMID:15265675 PMID:16401727 PMID:16415329 PMID:17698507 PMID:28648817

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

inhibin subunit beta E

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in decreased expression of INHBE mRNA

NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172

G

insulin induced gene 1

multiple interactions

Ranitidine inhibits the reaction [Lipopolysaccharides results in decreased expression of INSIG1 mRNA]

NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952

G

insulin induced gene 2

multiple interactions

Ranitidine inhibits the reaction [Lipopolysaccharides results in decreased expression of INSIG2 mRNA]

NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923

G

insulin receptor substrate 2

multiple interactions

Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of IRS2 mRNA]

NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482

G

inositol-trisphosphate 3-kinase C

multiple interactions

Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of ITPKC mRNA]

NCBI chr 1:82,500,957...82,522,533
Ensembl chr 1:82,500,957...82,522,779

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of JUN mRNA]

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

KLF transcription factor 4

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of KLF4 mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of KLF4 mRNA]

PMID:16401727 PMID:16415329

NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602

G

KLF transcription factor 6

multiple interactions

Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of KLF6 mRNA]

NCBI chr17:64,539,456...64,548,451
Ensembl chr17:64,531,463...64,588,570

G

mitogen activated protein kinase 1

multiple interactions

Ranitidine inhibits the reaction [Rotenone results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

Ranitidine inhibits the reaction [Rotenone results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

MAPK activated protein kinase 2

increases expression
multiple interactions

Ranitidine results in increased expression of MAPKAPK2 mRNA
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of MAPKAPK2 mRNA

PMID:16401727 PMID:16415329

NCBI chr13:42,513,762...42,560,061
Ensembl chr13:42,513,762...42,560,457

G

matrix metallopeptidase 9

multiple interactions

Ranitidine inhibits the reaction [Ethanol results in increased secretion of and results in increased activity of MMP9 protein]; Ranitidine inhibits the reaction [Indomethacin results in increased expression of MMP9 protein]

PMID:17603938 PMID:29523851

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

myeloperoxidase

decreases expression
multiple interactions

Ranitidine results in decreased expression of MPO protein
Ranitidine inhibits the reaction [Aspirin results in increased expression of MPO protein]; Ranitidine inhibits the reaction [Indomethacin results in increased activity of MPO protein]

PMID:12023551 PMID:16169175 PMID:17895592 PMID:18726076 PMID:28648817 More...

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions

Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of MYC mRNA]

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

NEDD4 like E3 ubiquitin protein ligase

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of NEDD4L mRNA

NCBI chr18:58,393,759...58,726,709
Ensembl chr18:58,393,509...58,723,137

G

NFE2 like bZIP transcription factor 2

multiple interactions

Ranitidine inhibits the reaction [Indomethacin results in decreased expression of NFE2L2 mRNA]

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nerve growth factor

multiple interactions

Ranitidine inhibits the reaction [Capsaicin results in increased expression of NGF protein]

NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452

G

nocturnin

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of NOCT mRNA

NCBI chr 2:135,271,189...135,291,407
Ensembl chr 2:135,271,189...135,291,400

G

nitric oxide synthase 2

multiple interactions

Ranitidine inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

Ranitidine inhibits the reaction [Indomethacin results in decreased expression of NQO1 protein]

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 4, group A, member 1

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of NR4A1 mRNA

NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297

G

nuclear protein 1, transcriptional regulator

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of NUPR1 mRNA

NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281

G

prolyl 4-hydroxylase subunit alpha 1

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of P4HA1 mRNA

NCBI chr20:27,302,046...27,352,098
Ensembl chr20:27,302,141...27,352,786

G

poly (ADP-ribose) polymerase 1

multiple interactions

Ranitidine inhibits the reaction [Rotenone results in increased cleavage of PARP1 protein]

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

phosphofructokinase, liver type

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of PFKL mRNA

NCBI chr20:10,664,285...10,686,324
Ensembl chr20:10,664,272...10,686,315

G

protein phosphatase 1, regulatory subunit 15A

multiple interactions

Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of PPP1R15A mRNA]

NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171

G

prolactin regulatory element binding

multiple interactions

Ranitidine inhibits the reaction [Lipopolysaccharides results in increased expression of PREB mRNA]

NCBI chr 6:25,418,805...25,422,594
Ensembl chr 6:25,418,776...25,422,590

G

prolactin

affects expression
increases secretion

Ranitidine affects the expression of PRL protein
Ranitidine results in increased secretion of PRL protein

PMID:7878608 PMID:9037573

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

prostaglandin-endoperoxide synthase 2

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of PTGS2 mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of PTGS2 mRNA]; Ranitidine inhibits the reaction [Indomethacin results in increased expression of PTGS2 mRNA]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]

PMID:16401727 PMID:16415329 PMID:29523851

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

PVR cell adhesion molecule

multiple interactions

Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of PVR mRNA]

NCBI chr 1:79,561,294...79,576,700
Ensembl chr 1:79,546,879...79,576,715

G

Rac family small GTPase 1

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of RAC1 mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of RAC1 mRNA]

NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Ranitidine inhibits the reaction [Indomethacin results in increased expression of RELA mRNA]; Ranitidine inhibits the reaction [Indomethacin results in increased expression of RELA protein]

PMID:28648817 PMID:30580614

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

renin

affects activity

Ranitidine affects the activity of REN protein

NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489

G

regulator of G-protein signaling 2

multiple interactions

Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of RGS2 mRNA]

NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385

G

regulator of G-protein signaling 4

multiple interactions

Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of RGS4 mRNA]

NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068

G

ras homolog family member B

multiple interactions

Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of ARHB mRNA]

NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108

G

serpin family E member 1

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of SERPINE1 mRNA; Heparin inhibits the reaction [Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein]]; Pentoxifylline inhibits the reaction [Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein]]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 mRNA]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein]

PMID:16401727 PMID:16415329 PMID:17698507

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

SH2B adaptor protein 2

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of APS mRNA

NCBI chr12:20,427,057...20,456,845
Ensembl chr12:20,429,043...20,456,844

G

SH3 and multiple ankyrin repeat domains 3

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in decreased expression of SHANK3 mRNA

NCBI chr 7:120,568,707...120,630,796
Ensembl chr 7:120,570,402...120,630,374

G

salt-inducible kinase 1

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of SIK1 mRNA; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SIK1 mRNA]

NCBI chr20:9,949,407...9,959,036
Ensembl chr20:9,947,396...9,958,991

G

solute carrier family 16, member 6

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of SLC16A6 mRNA

NCBI chr10:94,424,377...94,447,482
Ensembl chr10:94,426,244...94,448,779

G

solute carrier family 20 member 1

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of SLC20A1 mRNA

NCBI chr 3:116,427,095...116,441,049
Ensembl chr 3:116,427,098...116,441,051

G

solute carrier family 22 member 1

multiple interactions
increases uptake
affects transport

Ranitidine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Ranitidine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
SLC22A1 protein results in increased uptake of Ranitidine
SLC22A1 protein affects the transport of Ranitidine

PMID:16006492 PMID:16141367 PMID:16263091

NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678

G

solute carrier family 22 member 2

increases uptake
multiple interactions

SLC22A2 protein results in increased uptake of Ranitidine
Ranitidine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Ranitidine inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

PMID:16006492 PMID:16141367 PMID:16263091

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 22 member 3

multiple interactions

Ranitidine inhibits the reaction [SLC22A3 protein affects the transport of 1-Methyl-4-phenylpyridinium]; Ranitidine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Ranitidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

PMID:16141367 PMID:16263091

NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612

G

solute carrier family 22 member 6

increases uptake

SLC22A6 protein results in increased uptake of Ranitidine

NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173

G

solute carrier family 22 member 7

increases uptake

SLC22A7 protein results in increased uptake of Ranitidine

NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921

G

solute carrier family 22 member 8

increases uptake
multiple interactions

SLC22A8 protein results in increased uptake of Ranitidine
Penicillin G inhibits the reaction [SLC22A8 protein results in increased uptake of Ranitidine]; Probenecid promotes the reaction [SLC22A8 protein results in increased uptake of Ranitidine]; Ranitidine inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]

PMID:15319347 PMID:16006492

NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450

G

solute carrier family 2 member 1

multiple interactions

Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SLC2A1 mRNA]

NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416

G

solute carrier family 38, member 2

multiple interactions

Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SLC38A2 mRNA]

NCBI chr 7:127,851,267...127,863,482
Ensembl chr 7:127,851,267...127,863,436

G

solute carrier family 47 member 1

multiple interactions

Ranitidine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637

G

solute carrier family 47 member 2

multiple interactions

Ranitidine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904

G

solute carrier family 5 member 3

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of SLC5A3 mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of SLC5A3 mRNA]

NCBI chr11:31,313,847...31,316,293
Ensembl chr11:31,295,476...31,318,883

G

STE20-like kinase

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of SLK mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of SLK mRNA]

NCBI chr 1:246,473,712...246,529,643
Ensembl chr 1:246,473,712...246,526,530

G

sphingosine kinase 1

multiple interactions

Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SPHK1 mRNA]

NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240

G

tachykinin, precursor 1

increases expression

Ranitidine results in increased expression of TAC1 protein

NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178

G

transferrin receptor

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of TFRC mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of TFRC mRNA]

NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257

G

tumor necrosis factor

multiple interactions

Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]
[IFNG protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Ranitidine; Ranitidine inhibits the reaction [Aspirin results in increased expression of TNF protein]; Ranitidine inhibits the reaction [Capsaicin results in increased expression of TNF protein]; Ranitidine inhibits the reaction [Indomethacin results in increased expression of TNF protein]; Ranitidine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]

PMID:11752121 PMID:12023551 PMID:12538815 PMID:15265675 PMID:17698507 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF alpha induced protein 6

multiple interactions

Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of TNFAIP6 mRNA]

NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649

G

TNF receptor superfamily member 12A

multiple interactions

Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of TNFRSF12A mRNA]

NCBI chr10:12,707,077...12,709,071
Ensembl chr10:12,689,890...12,709,045

G

tropomyosin 3

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of TPM3 mRNA

NCBI chr 2:175,517,198...175,545,014
Ensembl chr 2:175,517,226...175,545,013

G

trafficking kinesin protein 2

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of TRAK2 mRNA

NCBI chr 9:60,348,531...60,414,036
Ensembl chr 9:60,350,012...60,413,996

G

ubiquitin-conjugating enzyme E2B

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of UBE2B mRNA

NCBI chr10:36,248,434...36,263,379
Ensembl chr10:36,248,438...36,264,665

G

vascular endothelial growth factor A

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of VEGFA mRNA

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

zinc finger and BTB domain containing 10

multiple interactions

[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ZBTB10 mRNA

NCBI chr 2:92,475,254...92,509,892
Ensembl chr 2:92,479,014...92,512,515

G

zinc finger FYVE-type containing 27

multiple interactions

Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of ZFYVE27 mRNA]

NCBI chr 1:240,979,831...241,003,193
Ensembl chr 1:240,979,842...241,003,193

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19844
role	19820
biological role	19818
pharmacological role	19064
antagonist	17248
histamine antagonist	4891
H2-receptor antagonist	212
aminopotentidine	0
cimetidine +	69
famotidine +	61
loxtidine	2
nizatidine	2
oxmetidine	0
pibutidine	0
pibutidine hydrochloride	0
ranitidine +	136
Path 2
Term	Annotations
CHEBI ontology	19844
role	19820
application	19663
pharmaceutical	19504
drug	19504
neurotransmitter agent	16746
histaminergic drug	4893
histamine antagonist	4891
H2-receptor antagonist	212
aminopotentidine	0
cimetidine +	69
famotidine +	61
loxtidine	2
nizatidine	2
oxmetidine	0
pibutidine	0
pibutidine hydrochloride	0
ranitidine +	136

paths to the root