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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621400
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1i3
Name: nuclear receptor subfamily 1, group I, member 3
Acc ID: CHEBI:3699
Term: cimetidine
Definition: A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Chemical ID: MESH:D002927
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i3decreases expressionISONR1I3 (Homo sapiens)6480464CTDCimetidine results in decreased expression of NR1I3 proteinPMID:22733800
Nr1i3multiple interactionsISONR1I3 (Homo sapiens)6480464CTD[Monocrotophos co-treated with Cimetidine] results in increased expression of NR1I3 proteinPMID:22733800
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