Klf4 (KLF transcription factor 4) - Rat Genome Database

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Gene: Klf4 (KLF transcription factor 4) Rattus norvegicus
Analyze
Symbol: Klf4
Name: KLF transcription factor 4
RGD ID: 621445
Description: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; histone deacetylase binding activity; and phosphatidylinositol 3-kinase regulator activity. Involved in several processes, including cellular response to endothelin; negative regulation of intracellular signal transduction; and regulation of DNA-templated transcription. Located in chromatin. Part of transcription regulator complex. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human KLF4 (KLF transcription factor 4); INTERACTS WITH (-)-epigallocatechin 3-gallate; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GKLF; Krueppel-like factor 4; Kruppel like factor 4; Kruppel-like factor 4 (gut); MGC93286
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Klf4m2Mcwi ; Klf4m1Mcwi ; Klf4m3Mcwi
Genetic Models: SS-Klf4m3Mcwi ; SS-Klf4m2Mcwi ; SS-Klf4m1Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8575,074,107 - 75,079,182 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl575,074,236 - 75,078,592 (-)EnsemblGRCr8
mRatBN7.2570,278,843 - 70,283,751 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl570,278,972 - 70,283,602 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx572,152,882 - 72,157,243 (-)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0573,983,387 - 73,987,747 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0573,955,520 - 73,959,880 (-)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd575,107,047 - 75,111,408 (-)NCBI
Lyon_Normotensive576,773,666 - 76,778,027 (-)NCBI
Lyon_Hypertensive575,995,460 - 75,999,821 (-)NCBI
F344_StmMcwi569,876,359 - 69,880,719 (-)NCBI
Rnor_6.0572,283,311 - 72,287,669 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl572,283,313 - 72,287,669 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.0576,447,643 - 76,452,001 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4573,446,928 - 73,451,286 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera569,133,658 - 69,138,016 (-)NCBICelera
RGSC_v3.1573,452,042 - 73,456,399 (-)NCBI
Cytogenetic Map5q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(20S)-ginsenoside Rg3  (ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-palmitoylglycerol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
acetamiprid  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
amiodarone  (ISO)
ammonium chloride  (EXP)
angiotensin II  (ISO)
antirheumatic drug  (ISO)
Antrocin  (ISO)
aprepitant  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP)
captan  (ISO)
Carbaprostacyclin  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
CGP 52608  (ISO)
chlorothalonil  (ISO)
chlorpromazine  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysin  (ISO)
ciglitazone  (EXP)
cisplatin  (ISO)
cobalt dichloride  (EXP)
cocaine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (ISO)
coptisine  (ISO)
corticosterone  (EXP)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
D-glucose  (ISO)
D-penicillamine  (EXP)
DDE  (ISO)
DDT  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dieldrin  (ISO)
diethylstilbestrol  (ISO)
dimethyl sulfoxide  (EXP)
dinophysistoxin 1  (ISO)
dioxygen  (EXP,ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
enilconazole  (ISO)
entinostat  (ISO)
ethanol  (EXP)
ethylbenzene  (ISO)
etoposide  (ISO)
fenamidone  (ISO)
fenvalerate  (EXP)
ferric oxide  (ISO)
flavonoids  (EXP)
florfenicol  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
fructose  (ISO)
fulvestrant  (EXP)
furan  (EXP)
gemfibrozil  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
geraniol  (ISO)
glucose  (ISO)
glutathione  (ISO)
glycidol  (EXP)
heparin  (EXP)
hydrogen peroxide  (EXP)
hydroquinone  (ISO)
indometacin  (ISO)
ionomycin  (ISO)
irinotecan  (ISO)
iron dichloride  (ISO)
L-methionine  (ISO)
lamivudine  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (EXP,ISO)
LY294002  (EXP,ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
medroxyprogesterone acetate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mifepristone  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nicotinamide  (EXP)
nicotine  (ISO)
nimesulide  (ISO)
okadaic acid  (ISO)
oxybenzone  (ISO)
oxytocin  (ISO)
ozone  (EXP,ISO)
Paeonol  (EXP)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
poly(I:C)  (ISO)
potassium chromate  (ISO)
procymidone  (ISO)
progesterone  (ISO)
prothioconazole  (ISO)
Prothioconazole-desthio  (ISO)
Pyridostigmine bromide  (ISO)
pyrogallol  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
ranitidine  (EXP)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
scopolamine  (EXP)
silibinin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dichromate  (ISO)
Soman  (EXP)
streptozocin  (EXP)
succimer  (ISO)
sulforaphane  (ISO)
taurocholic acid  (ISO)
telmisartan  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
toluene  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
trichostatin A  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
wogonin  (ISO)
wortmannin  (EXP)
XMU-MP-1  (ISO)
zidovudine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
canonical Wnt signaling pathway  (IEA,ISO)
cell differentiation  (ISO)
cellular response to endothelin  (IEA,IEP)
cellular response to growth factor stimulus  (IEA,ISO)
cellular response to hydrogen peroxide  (IEP)
cellular response to laminar fluid shear stress  (IEA,ISO)
cellular response to leukemia inhibitory factor  (ISO)
cellular response to retinoic acid  (IEP)
defense response to tumor cell  (IEA,ISO)
DNA-templated transcription  (IEA,ISO)
epidermal cell differentiation  (ISO)
epidermis development  (IEA,ISO)
epidermis morphogenesis  (ISO)
establishment of skin barrier  (IEA,ISO)
fat cell differentiation  (IEA,ISO)
gene expression  (IEA,ISO)
negative regulation of angiogenesis  (IEA,ISO)
negative regulation of canonical NF-kappaB signal transduction  (IEA,ISO)
negative regulation of cell migration  (IEA,ISO)
negative regulation of cell migration involved in sprouting angiogenesis  (IEA,ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of chemokine (C-X-C motif) ligand 2 production  (IEA,ISO)
negative regulation of DNA-templated transcription  (IEA,IMP,ISO,ISS)
negative regulation of ERK1 and ERK2 cascade  (IMP)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (IEA,ISO)
negative regulation of G1/S transition of mitotic cell cycle  (IEA,ISO)
negative regulation of gene expression  (IEA,ISO)
negative regulation of heterotypic cell-cell adhesion  (IEA,ISO)
negative regulation of interleukin-8 production  (IEA,ISO)
negative regulation of leukocyte adhesion to arterial endothelial cell  (IEA,ISO)
negative regulation of muscle hyperplasia  (IMP)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IMP)
negative regulation of response to cytokine stimulus  (IEA,ISO)
negative regulation of smooth muscle cell proliferation  (IDA,IMP)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of hemoglobin biosynthetic process  (IEA,ISO)
positive regulation of miRNA transcription  (IEA,ISO)
positive regulation of nitric oxide biosynthetic process  (IEA,ISO)
positive regulation of protein metabolic process  (IEA,ISO)
positive regulation of sprouting angiogenesis  (IEA,ISO)
positive regulation of telomere maintenance  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IEA,ISO)
post-embryonic camera-type eye development  (ISO)
post-embryonic hemopoiesis  (IEA,ISO)
regulation of axon regeneration  (ISO)
regulation of blastocyst development  (ISO)
regulation of cell differentiation  (IEA,ISO)
regulation of cell population proliferation  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
response to retinoic acid  (ISO)
stem cell population maintenance  (IEA,ISO)

Cellular Component
chromatin  (IDA,IEA,ISO)
cytoplasm  (IEA,ISO)
euchromatin  (IEA,ISO)
nucleus  (IEA,ISO)
transcription regulator complex  (IDA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Differential regulation of Kruppel-like factor family transcription factor expression in neonatal rat cardiac myocytes: effects of endothelin-1, oxidative stress and cytokines. Cullingford TE, etal., Biochim Biophys Acta. 2008 Jun;1783(6):1229-36. Epub 2008 Mar 25.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Synergistic activation of the rat laminin gamma1 chain promoter by the gut-enriched Kruppel-like factor (GKLF/KLF4) and Sp1. Higaki Y, etal., Nucleic Acids Res 2002 Jun 1;30(11):2270-9.
4. Dysregulated Krüppel-like factor 4 and vitamin D receptor signaling contribute to progression of hepatocellular carcinoma. Li Q, etal., Gastroenterology. 2012 Sep;143(3):799-810.e2. doi: 10.1053/j.gastro.2012.05.043. Epub 2012 Jun 4.
5. Effects of flavonoids on MicroRNA 145 regulation through Klf4 and myocardin in neointimal formation in vitro and in vivo. Lin CM, etal., J Nutr Biochem. 2018 Feb;52:27-35. doi: 10.1016/j.jnutbio.2017.08.016. Epub 2017 Sep 14.
6. All-trans retinoic acid increases KLF4 acetylation by inducing HDAC2 phosphorylation and its dissociation from KLF4 in vascular smooth muscle cells. Meng F, etal., Biochem Biophys Res Commun. 2009 Sep 11;387(1):13-8. doi: 10.1016/j.bbrc.2009.05.112. Epub 2009 May 30.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Combinatorial control of the bradykinin B2 receptor promoter by p53, CREB, KLF-4, and CBP: implications for terminal nephron differentiation. Saifudeen Z, etal., Am J Physiol Renal Physiol. 2005 May;288(5):F899-909. Epub 2005 Jan 4.
11. Induction of p53 by GKLF is essential for inhibition of proliferation of vascular smooth muscle cells. Wassmann S, etal., J Mol Cell Cardiol. 2007 Sep;43(3):301-7. Epub 2007 Jun 16.
12. ATRA activates and PDGF-BB represses the SM22alpha promoter through KLF4 binding to, or dissociating from, its cis-DNA elements. Yu K, etal., Cardiovasc Res. 2011 Jun 1;90(3):464-74. doi: 10.1093/cvr/cvr017. Epub 2011 Jan 20.
13. Kruppel-like factor 4 inhibits proliferation by platelet-derived growth factor receptor beta-mediated, not by retinoic acid receptor alpha-mediated, phosphatidylinositol 3-kinase and ERK signaling in vascular smooth muscle cells. Zheng B, etal., J Biol Chem. 2009 Aug 21;284(34):22773-85. doi: 10.1074/jbc.M109.026989. Epub 2009 Jun 16.
Additional References at PubMed
PMID:8161377   PMID:8702718   PMID:8940147   PMID:9422764   PMID:10431239   PMID:12477932   PMID:12538588   PMID:12970361   PMID:15358627   PMID:15623517   PMID:16632465   PMID:16954384  
PMID:17060454   PMID:17130451   PMID:17671182   PMID:18396140   PMID:18400104   PMID:18511453   PMID:18768922   PMID:19041854   PMID:19168719   PMID:19618124   PMID:19796622   PMID:19816951  
PMID:20375011   PMID:20433848   PMID:20439489   PMID:20551324   PMID:20629177   PMID:20711222   PMID:21109779   PMID:21182892   PMID:21539536   PMID:22267480   PMID:22282354   PMID:22306741  
PMID:22337869   PMID:22405696   PMID:22430140   PMID:22491752   PMID:22679022   PMID:22723415   PMID:23013362   PMID:23287475   PMID:23372771   PMID:23726909   PMID:23828673   PMID:23867820  
PMID:23934449   PMID:24129709   PMID:24161396   PMID:24321547   PMID:25138274   PMID:25944743   PMID:26082460   PMID:26241060   PMID:26691508   PMID:26945917   PMID:27237094   PMID:27431648  
PMID:27740527   PMID:27907090   PMID:28262547   PMID:28720846   PMID:28851732   PMID:29593216   PMID:30076931   PMID:30520133   PMID:30939050   PMID:31030942   PMID:31486512   PMID:31829402  
PMID:32438059   PMID:32468029   PMID:32556726   PMID:33036290   PMID:33275236   PMID:33383116   PMID:33428060   PMID:34108361   PMID:35171385   PMID:37356737   PMID:37381993   PMID:37441941  
PMID:37952156   PMID:38084712   PMID:38085146   PMID:38774964   PMID:38866991  


Genomics

Comparative Map Data
Klf4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8575,074,107 - 75,079,182 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl575,074,236 - 75,078,592 (-)EnsemblGRCr8
mRatBN7.2570,278,843 - 70,283,751 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl570,278,972 - 70,283,602 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx572,152,882 - 72,157,243 (-)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0573,983,387 - 73,987,747 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0573,955,520 - 73,959,880 (-)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd575,107,047 - 75,111,408 (-)NCBI
Lyon_Normotensive576,773,666 - 76,778,027 (-)NCBI
Lyon_Hypertensive575,995,460 - 75,999,821 (-)NCBI
F344_StmMcwi569,876,359 - 69,880,719 (-)NCBI
Rnor_6.0572,283,311 - 72,287,669 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl572,283,313 - 72,287,669 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.0576,447,643 - 76,452,001 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4573,446,928 - 73,451,286 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera569,133,658 - 69,138,016 (-)NCBICelera
RGSC_v3.1573,452,042 - 73,456,399 (-)NCBI
Cytogenetic Map5q24NCBI
KLF4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389107,484,852 - 107,489,769 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9107,484,454 - 107,490,482 (-)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh379110,247,133 - 110,252,050 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369109,286,956 - 109,291,576 (-)NCBIBuild 36Build 36hg18NCBI36
Build 349107,326,689 - 107,331,310NCBI
Celera980,749,144 - 80,754,056 (-)NCBICelera
Cytogenetic Map9q31.2NCBI
HuRef979,848,720 - 79,853,633 (-)NCBIHuRef
CHM1_19110,393,822 - 110,398,611 (-)NCBICHM1_1
T2T-CHM13v2.09119,656,625 - 119,661,541 (-)NCBIT2T-CHM13v2.0
Klf4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39455,527,137 - 55,536,984 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl455,527,139 - 55,532,528 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38455,527,137 - 55,532,475 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl455,527,143 - 55,532,466 (-)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv37455,540,009 - 55,545,347 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36455,548,365 - 55,553,566 (-)NCBIMGSCv36mm8
Celera455,439,526 - 55,444,543 (-)NCBICelera
Cytogenetic Map4B3NCBI
cM Map429.76NCBI
Klf4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541919,280,235 - 19,285,174 (+)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_00495541919,280,311 - 19,284,097 (+)NCBIChiLan1.0ChiLan1.0
KLF4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21131,918,525 - 31,923,988 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1931,921,406 - 31,926,354 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0978,634,545 - 78,639,447 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19106,820,954 - 106,825,751 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9106,820,954 - 106,825,797 (-)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
KLF4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11162,881,840 - 62,886,676 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1162,882,767 - 62,928,251 (-)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1161,280,192 - 61,284,913 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01164,023,332 - 64,028,057 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1164,023,336 - 64,027,760 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11162,546,457 - 62,551,183 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01162,556,227 - 62,560,944 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01163,258,346 - 63,263,062 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Klf4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap14185,494,802 - 185,499,600 (-)NCBImIctTri1.hap1
HiC_Itri_2NW_024404947178,156,606 - 178,161,129 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365595,105,463 - 5,109,970 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365595,105,456 - 5,109,970 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLF4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1248,604,820 - 248,609,035 (-)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.11248,604,817 - 248,609,574 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21279,056,801 - 279,061,560 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1q28-q29NCBI
KLF4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap11277,410,744 - 77,415,597 (-)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_02366603510,633,003 - 10,637,951 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.11232,045,690 - 32,050,531 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1232,045,609 - 32,050,703 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Klf4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247584,047,217 - 4,052,257 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_0046247584,047,219 - 4,051,983 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl1226,354,252 - 26,359,525 (+)Ensembl
Klf4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1196,004,619 - 96,009,625 (+)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1

Variants

.
Variants in Klf4
57 total Variants
miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir146arno-miR-146a-5pMirtarbaseexternal_infoReporter assay;Western blot;OtherFunctional MTI21109779

Predicted Target Of
Summary Value
Count of predictions:133
Count of miRNA genes:101
Interacting mature miRNAs:121
Transcripts:ENSRNOT00000022255
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)53275164977751649Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53801167083011670Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)55266537294894052Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)573779642118779642Rat
6907115Mcs29Mammary carcinoma susceptibility QTL 29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)53800433183004331Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)573779642103472210Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)52367149379046465Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)565089051103648916Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (CMO:0000105)573779642118779642Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (CMO:0000105)573779642118779642Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53801167083011670Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53801167083011670Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
1331782Rf36Renal function QTL 363.296kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)539019942102105896Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)53331167378311673Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)53275164977751649Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)53998594884985948Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5692228281330203Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53331167378311673Rat
7394708Emca11Estrogen-induced mammary cancer QTL 11mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)573176602118176602Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)53952692484526924Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54852312391770353Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)569474415114474415Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906491770353Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)560511627105511627Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)564589016109589016Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)569835120114835120Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906487027358Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)570969494136328156Rat
2316954Rf57Renal function QTL 570kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)56458901693503770Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)556546393101546393Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)573779642118779642Rat
2316957Pur21Proteinuria QTL 216.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)56458901691762830Rat

Markers in Region
Klf4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2570,281,917 - 70,283,119 (+)MAPPERmRatBN7.2
mRatBN7.25155,921,461 - 155,922,013 (+)MAPPERmRatBN7.2
Rnor_6.0599,017,243 - 99,017,794NCBIRnor6.0
Rnor_6.0572,286,258 - 72,287,459NCBIRnor6.0
Rnor_5.0576,450,590 - 76,451,791UniSTSRnor5.0
Rnor_5.05103,050,485 - 103,051,036UniSTSRnor5.0
RGSC_v3.45162,463,654 - 162,464,205UniSTSRGSC3.4
RGSC_v3.4573,449,875 - 73,451,076UniSTSRGSC3.4
Celera569,136,605 - 69,137,806UniSTS
Celera5154,221,854 - 154,222,405UniSTS
Cytogenetic Map5q36UniSTS
Cytogenetic Map5q24UniSTS


Genetic Models
This gene Klf4 is modified in the following models/strains:
SS-Klf4m3Mcwi     SS-Klf4m2Mcwi     SS-Klf4m1Mcwi    


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
276 156 730 1591 4041 1007 1723 133 870 488 852 156 5380 2590 449 3954 38 1387 740 908 160 158

Sequence


Ensembl Acc Id: ENSRNOT00000022255   ⟹   ENSRNOP00000022255
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl575,074,236 - 75,078,592 (-)Ensembl
mRatBN7.2 Ensembl570,278,972 - 70,283,329 (-)Ensembl
Rnor_6.0 Ensembl572,283,313 - 72,287,669 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095509   ⟹   ENSRNOP00000083640
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl570,278,972 - 70,283,602 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116294   ⟹   ENSRNOP00000095641
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl570,278,972 - 70,283,239 (-)Ensembl
RefSeq Acc Id: NM_053713   ⟹   NP_446165
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8575,074,234 - 75,078,592 (-)NCBI
mRatBN7.2570,278,970 - 70,283,329 (-)NCBI
Dahl_SR_JrHsd575,107,047 - 75,111,408 (-)NCBI
Lyon_Normotensive576,773,666 - 76,778,027 (-)NCBI
Lyon_Hypertensive575,995,460 - 75,999,821 (-)NCBI
F344_StmMcwi569,876,359 - 69,880,719 (-)NCBI
Rnor_6.0572,283,311 - 72,287,669 (-)NCBI
Rnor_5.0576,447,643 - 76,452,001 (-)NCBI
RGSC_v3.4573,446,928 - 73,451,286 (-)RGD
Celera569,133,658 - 69,138,016 (-)RGD
Sequence:
RefSeq Acc Id: XM_039109121   ⟹   XP_038965049
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8575,074,107 - 75,079,182 (-)NCBI
mRatBN7.2570,278,843 - 70,283,751 (-)NCBI
Protein Sequences
Protein RefSeqs NP_446165 (Get FASTA)   NCBI Sequence Viewer  
  XP_038965049 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH85720 (Get FASTA)   NCBI Sequence Viewer  
  AAK73355 (Get FASTA)   NCBI Sequence Viewer  
  EDL91696 (Get FASTA)   NCBI Sequence Viewer  
  EDL91697 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000022255
  ENSRNOP00000022255.2
RefSeq Acc Id: NP_446165   ⟸   NM_053713
- UniProtKB: Q923V7 (UniProtKB/TrEMBL),   F7F8L9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022255   ⟸   ENSRNOT00000022255
RefSeq Acc Id: XP_038965049   ⟸   XM_039109121
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000095641   ⟸   ENSRNOT00000116294
Ensembl Acc Id: ENSRNOP00000083640   ⟸   ENSRNOT00000095509
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q923V7-F1-model_v2 AlphaFold Q923V7 1-482 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621445 AgrOrtholog
BioCyc Gene G2FUF-41239 BioCyc
Ensembl Genes ENSRNOG00000016299 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022255 ENTREZGENE
  ENSRNOT00000022255.5 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7190219 IMAGE-MGC_LOAD
InterPro Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:114505 UniProtKB/TrEMBL
MGC_CLONE MGC:93286 IMAGE-MGC_LOAD
NCBI Gene 114505 ENTREZGENE
PANTHER KRUEPPEL-LIKE FACTOR 4 UniProtKB/TrEMBL
  KRUEPPEL-LIKE TRANSCRIPTION FACTOR UniProtKB/TrEMBL
Pfam zf-C2H2 UniProtKB/TrEMBL
PhenoGen Klf4 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016299 RatGTEx
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt F7F8L9 ENTREZGENE, UniProtKB/TrEMBL
  Q923V7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-10-03 Klf4  KLF transcription factor 4  Klf4  Kruppel like factor 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-06-08 Klf4  Kruppel like factor 4  Klf4  Kruppel-like factor 4 (gut)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Klf4  Kruppel-like factor 4 (gut)      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Klf4  Kruppel-like factor 4 (gut)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction binds the bcn-1 element 619591