GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Klf4 | affects response to substance | EXP | | 6480464 | CTD | KLF4 protein affects the susceptibility to Estradiol | PMID:21484412 | Klf4 | increases expression | EXP | | 6480464 | CTD | Estradiol results in increased expression of KLF4 protein | PMID:21484412 | Klf4 | multiple interactions | EXP | | 6480464 | CTD | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased expression of KLF4 protein]; [bisphenol A co-treated with Estradiol] results in increased expression of KLF4 mRNA; [Estradiol binds to ESR1 protein] which affects the localization of KLF4 protein; [Estradiol binds to ESR1 protein] which results in increased expression of KLF4; fulvestrant inhibits the reaction [Estradiol results in increased expression of KLF4 protein]; KLF4 protein affects the reaction [Estradiol results in increased expression of SOD2]; wortmannin inhibits the reaction [Estradiol results in increased expression of KLF4 protein] | PMID:21484412 PMID:26496021 | Klf4 | increases expression | ISO | KLF4 (Homo sapiens) | 6480464 | CTD | Estradiol results in increased expression of KLF4 mRNA | PMID:19619570 PMID:21185374 PMID:21795739 PMID:31614463 PMID:33728745 | Klf4 | multiple interactions | ISO | KLF4 (Homo sapiens) | 6480464 | CTD | [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of KLF4 mRNA; Progesterone promotes the reaction [Estradiol results in increased expression of KLF4 mRNA] | PMID:19619570 PMID:21795739 | | ||||||||||||||||||||||
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