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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621445
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Klf4
Name: KLF transcription factor 4
Acc ID: CHEBI:5296
Term: gemfibrozil
Definition: An aromatic ether that has formula C15H22O3.
Chemical ID: MESH:D015248
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Klf4affects localizationISOKlf4 (Mus musculus)6480464CTDGemfibrozil affects the localization of KLF4 proteinPMID:22685291
Klf4affects response to substanceISOKlf4 (Mus musculus)6480464CTDKLF4 mRNA affects the susceptibility to GemfibrozilPMID:22685291
Klf4increases phosphorylationISOKlf4 (Mus musculus)6480464CTDGemfibrozil results in increased phosphorylation of KLF4 proteinPMID:22685291
Klf4multiple interactionsISOKlf4 (Mus musculus)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Gemfibrozil affects the localization of KLF4 protein]; KLF4 mRNA affects the reaction [Gemfibrozil results in increased expression of SOCS3 mRNA]PMID:22685291
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