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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621445
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Klf4
Name: KLF transcription factor 4
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Klf4decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of KLF4 mRNAPMID:34747641
Klf4increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of KLF4 mRNAPMID:32109520
Klf4affects expressionISOKlf4 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of KLF4 mRNAPMID:21570461 PMID:26377647
Klf4decreases expressionISOKLF4 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of KLF4 mRNAPMID:12377990 PMID:17101203 PMID:19619570
Klf4increases expressionISOKLF4 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of KLF4 mRNAPMID:23152189
Klf4increases expressionISOKlf4 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of KLF4 mRNAPMID:16054899 PMID:19770486 PMID:24058054
Klf4multiple interactionsISOKLF4 (Homo sapiens)6480464CTD[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of KLF4 mRNAPMID:19619570
Klf4multiple interactionsISOKlf4 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of KLF4 mRNA]; [Tetrachlorodibenzodioxin co-treated with EGF protein] results in increased expression of KLF4 mRNA; Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of KLF4 mRNA]PMID:16054899
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