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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621445
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Klf4
Name: KLF transcription factor 4
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Klf4increases expressionEXP 6480464CTDbisphenol A results in increased expression of KLF4 mRNAPMID:12075121 PMID:25181051
Klf4multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Estradiol] results in increased expression of KLF4 mRNAPMID:26496021
Klf4affects expressionISOKLF4 (Homo sapiens)6480464CTDbisphenol A affects the expression of KLF4 mRNAPMID:20170705
Klf4affects methylationISOKlf4 (Mus musculus)6480464CTDbisphenol A affects the methylation of KLF4 promoterPMID:27334623
Klf4increases expressionISOKLF4 (Homo sapiens)6480464CTDbisphenol A results in increased expression of KLF4 mRNAPMID:37834465
Klf4increases expressionISOKlf4 (Mus musculus)6480464CTDbisphenol A results in increased expression of KLF4 mRNAPMID:32156529 PMID:36315628
Klf4multiple interactionsISOKLF4 (Homo sapiens)6480464CTD[bisphenol A co-treated with perfluorooctane sulfonic acid] results in increased expression of KLF4 mRNA; [bisphenol A co-treated with perfluorooctanoic acid co-treated with bisphenol S co-treated with perfluorooctane sulfonic acid] results in increased expression of KLF4 mRNA; [bisphenol A co-treated with perfluorooctanoic acid] results in increased expression of KLF4 mRNAPMID:37834465
Klf4multiple interactionsISOKlf4 (Mus musculus)6480464CTDAcetylcysteine inhibits the reaction [bisphenol A results in increased expression of KLF4 mRNA]PMID:36315628
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