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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | RGD:1344203 | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of NEDD4L mRNA | CTD | PMID:22079256 | 17alpha-ethynylestradiol | increases expression | ISO | RGD:1551161 | 6480464 | Ethinyl Estradiol results in increased expression of NEDD4L mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:1551161 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NEDD4L mRNA | CTD | PMID:17942748 | 17beta-estradiol | affects expression | ISO | RGD:1551161 | 6480464 | Estradiol affects the expression of NEDD4L mRNA | CTD | PMID:15598610 | 17beta-estradiol | decreases expression | ISO | RGD:1344203 | 6480464 | Estradiol results in decreased expression of NEDD4L mRNA | CTD | PMID:19167446 | 17beta-estradiol | affects expression | ISO | RGD:1344203 | 6480464 | Estradiol affects the expression of NEDD4L mRNA | CTD | PMID:22574217 | 17beta-estradiol | increases expression | ISO | RGD:1344203 | 6480464 | Estradiol results in increased expression of NEDD4L mRNA | CTD | PMID:19619570 | 17beta-estradiol | multiple interactions | ISO | RGD:1344203 | 6480464 | [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of NEDD4L mRNA | CTD | PMID:19619570 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1344203 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of NEDD4L mRNA | CTD | PMID:19619570 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of NEDD4L mRNA | CTD | PMID:21724226 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1551161 | 6480464 | Tetrachlorodibenzodioxin affects the expression of NEDD4L mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of NEDD4L mRNA | CTD | PMID:22298810 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1344203 | 6480464 | Tetrachlorodibenzodioxin affects the expression of NEDD4L mRNA | CTD | PMID:22298810 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1551161 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of NEDD4L mRNA | CTD | PMID:18691609 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1344203 | 6480464 | [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of NEDD4L mRNA | CTD | PMID:19619570 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1551161 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of NEDD4L mRNA | CTD | PMID:17942748 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2,6-dinitrotoluene affects the expression of NEDD4L mRNA | CTD | PMID:21346803 | 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine | decreases expression | EXP | | 6480464 | Puromycin Aminonucleoside results in decreased expression of NEDD4L protein | CTD | PMID:16020936 | 5-aza-2'-deoxycytidine | decreases expression | ISO | RGD:1344203 | 6480464 | decitabine results in decreased expression of NEDD4L mRNA | CTD | PMID:19363521 | 5-aza-2'-deoxycytidine | multiple interactions | ISO | RGD:1344203 | 6480464 | TP53 protein affects the reaction [decitabine results in decreased expression of NEDD4L mRNA] | CTD | PMID:19363521 | aflatoxin B1 | decreases expression | ISO | RGD:1344203 | 6480464 | Aflatoxin B1 results in decreased expression of NEDD4L mRNA | CTD | PMID:21641981 | aflatoxin B1 | decreases expression | ISO | RGD:1344203 | 6480464 | Aflatoxin B1 results in decreased expression of NEDD4L mRNA | CTD | PMID:21641981 PMID:22100608 | benzo[a]pyrene | decreases expression | ISO | RGD:1344203 | 6480464 | Benzo(a)pyrene results in decreased expression of NEDD4L mRNA | CTD | PMID:20106945 | benzo[a]pyrene | decreases expression | ISO | RGD:1344203 | 6480464 | Benzo(a)pyrene results in decreased expression of NEDD4L mRNA | CTD | PMID:20106945 PMID:21632981 | benzo[a]pyrene | increases expression | ISO | RGD:1551161 | 6480464 | Benzo(a)pyrene results in increased expression of NEDD4L mRNA | CTD | PMID:22228805 | benzo[a]pyrene | decreases expression | ISO | RGD:1551161 | 6480464 | Benzo(a)pyrene results in decreased expression of NEDD4L mRNA | CTD | PMID:19770486 | benzo[a]pyrene | multiple interactions | ISO | RGD:1551161 | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of NEDD4L mRNA | CTD | PMID:21715664 | cadmium dichloride | increases expression | ISO | RGD:1551161 | 6480464 | Cadmium Chloride results in increased expression of NEDD4L mRNA | CTD | PMID:20061341 | cadmium sulfate | increases expression | ISO | RGD:1344203 | 6480464 | cadmium sulfate results in increased expression of NEDD4L mRNA | CTD | PMID:21783983 | cisplatin | decreases expression | ISO | RGD:1344203 | 6480464 | Cisplatin results in decreased expression of NEDD4L mRNA | CTD | PMID:19561079 | clofibrate | decreases expression | ISO | RGD:1551161 | 6480464 | Clofibrate results in decreased expression of NEDD4L mRNA | CTD | PMID:17585979 | cocaine | increases expression | ISO | RGD:1344203 | 6480464 | Cocaine results in increased expression of NEDD4L mRNA | CTD | PMID:15009677 | copper(2+) sulfate | decreases expression | ISO | RGD:1344203 | 6480464 | Copper Sulfate results in decreased expression of NEDD4L mRNA | CTD | PMID:19549813 | coumestrol | multiple interactions | ISO | RGD:1344203 | 6480464 | [Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of NEDD4L mRNA | CTD | PMID:19167446 | coumestrol | decreases expression | ISO | RGD:1344203 | 6480464 | Coumestrol results in decreased expression of NEDD4L mRNA | CTD | PMID:19167446 | crocidolite asbestos | increases expression | ISO | RGD:1344203 | 6480464 | Asbestos, Crocidolite results in increased expression of NEDD4L mRNA | CTD | PMID:18687144 | cyclosporin A | increases expression | ISO | RGD:1344203 | 6480464 | Cyclosporine results in increased expression of NEDD4L mRNA | CTD | PMID:20106945 | diethylstilbestrol | decreases expression | ISO | RGD:1551161 | 6480464 | Diethylstilbestrol results in decreased expression of NEDD4L mRNA | CTD | PMID:15171707 | diuron | decreases expression | EXP | | 6480464 | Diuron results in decreased expression of NEDD4L mRNA | CTD | PMID:21551480 | manganese(II) chloride | increases expression | EXP | | 6480464 | manganese chloride results in increased expression of NEDD4L mRNA; more ... | CTD | PMID:20737472 | methyl methacrylate | increases expression | ISO | RGD:1551161 | 6480464 | Methylmethacrylate results in increased expression of NEDD4L mRNA | CTD | PMID:16916219 | methylmercury chloride | increases expression | ISO | RGD:1551161 | 6480464 | methylmercuric chloride results in increased expression of NEDD4L mRNA | CTD | PMID:20061341 | paracetamol | affects expression | ISO | RGD:1551161 | 6480464 | Acetaminophen affects the expression of NEDD4L mRNA | CTD | PMID:17562736 | paracetamol | increases expression | ISO | RGD:1344203 | 6480464 | Acetaminophen results in increased expression of NEDD4L mRNA | CTD | PMID:21420995 | phenobarbital | decreases expression | ISO | RGD:1551161 | 6480464 | Phenobarbital results in decreased expression of NEDD4L mRNA | CTD | PMID:19270015 | pirinixic acid | increases expression | ISO | RGD:1551161 | 6480464 | pirinixic acid results in increased expression of NEDD4L mRNA | CTD | PMID:18445702 PMID:18301758 | pirinixic acid | increases expression | ISO | RGD:1551161 | 6480464 | pirinixic acid results in increased expression of NEDD4L mRNA | CTD | PMID:18301758 PMID:18445702 | quercetin | decreases expression | ISO | RGD:1344203 | 6480464 | Quercetin results in decreased expression of NEDD4L mRNA | CTD | PMID:21632981 | ranitidine | multiple interactions | EXP | | 6480464 | [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of NEDD4L mRNA | CTD | PMID:16415329 | resveratrol | decreases expression | ISO | RGD:1551161 | 6480464 | resveratrol results in decreased expression of NEDD4L mRNA | CTD | PMID:22610192 | resveratrol | increases expression | EXP | | 6480464 | resveratrol results in increased expression of NEDD4L mRNA | CTD | PMID:19228061 | silicon dioxide | increases expression | ISO | RGD:1551161 | 6480464 | Silicon Dioxide results in increased expression of NEDD4L mRNA | CTD | PMID:19073995 | tert-butyl hydroperoxide | increases expression | ISO | RGD:1344203 | 6480464 | tert-Butylhydroperoxide results in increased expression of NEDD4L mRNA | CTD | PMID:15336504 | tetrachloromethane | affects expression | ISO | RGD:1551161 | 6480464 | Carbon Tetrachloride affects the expression of NEDD4L mRNA | CTD | PMID:17484886 | theophylline | increases expression | ISO | RGD:1344203 | 6480464 | Theophylline results in increased expression of NEDD4L mRNA | CTD | PMID:16083514 | trans-resveratrol | decreases expression | ISO | RGD:1551161 | 6480464 | resveratrol results in decreased expression of NEDD4L mRNA | CTD | PMID:22610192 | trans-resveratrol | increases expression | EXP | | 6480464 | resveratrol results in increased expression of NEDD4L mRNA | CTD | PMID:19228061 | valproic acid | affects expression | ISO | RGD:1551161 | 6480464 | Valproic Acid affects the expression of NEDD4L mRNA | CTD | PMID:17292431 | valproic acid | increases expression | ISO | RGD:1344203 | 6480464 | Valproic Acid results in increased expression of NEDD4L mRNA | CTD | PMID:19101580 | zinc atom | multiple interactions | ISO | RGD:1344203 | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of NEDD4L mRNA | CTD | PMID:18593933 | zinc(0) | multiple interactions | ISO | RGD:1344203 | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of NEDD4L mRNA | CTD | PMID:18593933 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Aldosterone-regulated sodium reabsorption |
| Endocytosis | |
| Ubiquitin mediated proteolysis | |
| Pathway Interaction Database | Neurotrophic factor-mediated Trk receptor signaling (PID:200150) |
| p73 transcription factor network (PID:200017) | |
| TGF-beta receptor signaling (PID:200227) | |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Aldosterone-regulated sodium reabsorption |
| Endocytosis | |
| Ubiquitin mediated proteolysis | |
| Pathway Interaction Database | Neurotrophic factor-mediated Trk receptor signaling (PID:200150) |
| p73 transcription factor network (PID:200017) | |
| TGF-beta receptor signaling (PID:200227) | |
References - curated| 1. |
Georgieva MV, etal., J Neurochem. 2011 May;117(3):479-93. doi: 10.1111/j.1471-4159.2011.07218.x. Epub 2011 Mar 15. |
| 2. |
Kabra R, etal., J Biol Chem. 2008 Mar 7;283(10):6033-9. Epub 2008 Jan 3. |
| 3. |
Kamynina E, etal., FASEB J 2001 Jan;15(1):204-214. |
| 4. |
Lackovic J, etal., Exp Neurol. 2012 May;235(1):326-35. Epub 2012 Mar 5. |
| 5. |
MGD data from the GO Consortium |
| 6. |
Persaud A, etal., Mol Syst Biol. 2009;5:333. Epub 2009 Dec 1. |
| 7. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 8. |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 9. |
RGD automated data pipeline |
| 10. |
RGD automated import pipeline for gene-chemical interactions |
| 11. |
RGD comprehensive gene curation |
References - uncurated
RGD Disease Portals| Nedd4l has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Nedd4l (Rattus norvegicus) |
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| NEDD4L (Homo sapiens) |
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| Nedd4l (Mus musculus) |
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Position Markers| D18Rat52 |
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| D18Rat91 |
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| D18Chm95 |
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| RH132932 |
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| BF411259 |
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| AU046785 |
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| RH140712 |
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| AU048729 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001008300 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06095528 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06095529 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06095530 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06095531 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06095532 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06095533 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06095534 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06095535 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06095536 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06095537 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06095538 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06095539 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06095540 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06095541 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06095542 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06095543 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06095544 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01095560 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01095561 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01095562 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01095563 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01095564 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01095565 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01095566 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01095567 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01095568 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01095569 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01095570 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01095571 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01095572 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01095573 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01095574 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC061798 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC086371 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473971 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GQ160815 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GQ160816 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_001008300 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001008301 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001008301 | (Get FASTA) |
| GenBank Protein | AAH61798 | (Get FASTA) |
| AAH86371 | (Get FASTA) | |
| ADD16471 | (Get FASTA) | |
| ADD16472 | (Get FASTA) | |
| EDM14676 | (Get FASTA) | |
| EDM14677 | (Get FASTA) | |
| EDM14678 | (Get FASTA) | |
| EDM14679 | (Get FASTA) | |
| EDM14680 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000017610 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000023890 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000023890 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 291553 | ENTREZGENE |
| HomoloGene Group ID | 86986 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:5598079 | IMAGE-MGC_LOAD |
| InterPro | C2_Ca-dep | UniProtKB/TrEMBL |
| C2_Ca/lipid-bd_dom_CaLB | UniProtKB/TrEMBL | |
| C2_membr_targeting | UniProtKB/TrEMBL | |
| E3_ub_ligase_SMURF1 | UniProtKB/TrEMBL | |
| HECT | UniProtKB/TrEMBL | |
| WW_Rsp5_WWP | UniProtKB/TrEMBL | |
| KEGG Report | rno:291553 | ENTREZGENE |
| MGC_CLONE | MGC:72524 | IMAGE-MGC_LOAD |
| Pfam | HECT | UniProtKB/TrEMBL |
| PF00168 | UniProtKB/TrEMBL | |
| PF00397 | UniProtKB/TrEMBL | |
| PIRSF | E3_ub_ligase_SMURF1 | UniProtKB/TrEMBL |
| PROSITE | HECT | UniProtKB/TrEMBL |
| PS50004 | UniProtKB/TrEMBL | |
| WW_DOMAIN_1 | UniProtKB/TrEMBL | |
| WW_DOMAIN_2 | UniProtKB/TrEMBL | |
| SMART | HECTc | UniProtKB/TrEMBL |
| SM00239 | UniProtKB/TrEMBL | |
| SM00456 | UniProtKB/TrEMBL | |
| Superfamily-SCOP | C2_CaLB | UniProtKB/TrEMBL |
| HECT | UniProtKB/TrEMBL | |
| WW_Rsp5_WWP | UniProtKB/TrEMBL | |
| UniGene | Rn.72824 | ENTREZGENE |
| UniProt | F1LRN8_RAT | UniProtKB/TrEMBL |
| Q6P778_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2012-10-05 | Nedd4l | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | Nedd4l | neural precursor cell expressed, developmentally down-regulated 4-like | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2008-09-25 | Nedd4l | neural precursor cell expressed, developmentally down-regulated 4-like | Nedd4l | neural precursor cell expressed, developmentally down-regulated gene 4-like | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2008-03-04 | Nedd4l | neural precursor cell expressed, developmentally down-regulated gene 4-like | Nedd4l | neural precursor cell expressed, developmentally down-regulated 4-like | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2005-07-08 | Nedd4l | neural precursor cell expressed, developmentally down-regulated 4-like | Symbol and Name status set to approved | 10779 | APPROVED |
| More on Nedd4l | |
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Entrez Gene |
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Ensembl Gene |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 735047 |
| Created: | 2004-02-05 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-05-28 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




