ONTOLOGY REPORT - ANNOTATIONS

Term:cimetidine
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Accession:CHEBI:3699 term browser browse the term
Definition:An alkyl sulfide that has formula C10H16N6S.
Synonyms:exact_synonym: 2-cyano-1-methyl-3-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl)guanidine
 related_synonym: 1-Cyano-2-methyl-3-(2-(((5-methyl-4-imidazolyl)methyl)thio)ethyl)guanidine;   2-cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine;   C10H16N6S;   CN\\C(NCCSCc1nc[nH]c1C)=N\\C#N;   Cimetag;   InChI=1S/C10H16N6S/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14);   InChIKey=AQIXAKUUQRKLND-UHFFFAOYSA-N;   N''-cyano-N-methyl-N'-(2-{[(5-methyl-1H-imidazol-4-yl)methyl]thio}ethyl)guanidine;   N-cyano-N'-methyl-N''-(2-([(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl)ethyl)guanidine;   Tagamet HB 200;   Ulcerfen;   cimetidina;   cimetidinum
 xref_casrn: 51481-61-9
 xref: ChEMBL:101620 "ChEMBL COMPOUND";   ChemIDplus:51481-61-9 "CAS Registry Number";   DrugBank:DB00501 "DrugBank";   KEGG COMPOUND:51481-61-9 "CAS Registry Number";   KEGG DRUG:D00295 "KEGG DRUG"
 xref_mesh: MESH:D002927
 xref: NIST Chemistry WebBook:51481-61-9 "CAS Registry Number";   Patent:BE804144 "Patent";   Patent:US3950333 "Patent";   Reaxys:6516325 "Reaxys Registry Number";   Wikipedia:Cimetidine "Wikipedia"

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cimetidine term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 GBrowse link affects transport ISO 4 87,502,584 87,560,017 RGD:6480464 CTD
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 GBrowse link affects transport ISO 4 87,502,584 87,560,017 RGD:6480464 CTD
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 GBrowse link affects transport ISO 4 87,502,584 87,560,017 RGD:6480464 CTD
G Adipoq adiponectin, C1Q and collagen domain containing GBrowse link multiple interactions ISO 11 79,908,291 79,911,065 RGD:6480464 CTD
G Ahr aryl hydrocarbon receptor GBrowse link affects expression ISO 6 54,205,104 54,240,268 RGD:6480464 CTD
G Ahr aryl hydrocarbon receptor GBrowse link multiple interactions ISO 6 54,205,104 54,240,268 RGD:6480464 CTD
G Apaf1 apoptotic peptidase activating factor 1 GBrowse link increases activity ISO 7 27,932,908 28,020,533 RGD:6480464 CTD
G Ar androgen receptor GBrowse link multiple interactions ISO X 85,949,507 86,119,199 RGD:6480464 CTD
G Ar androgen receptor GBrowse link multiple interactions EXP X 85,949,507 86,119,199 RGD:6480464 CTD
G Bax Bcl2-associated X protein GBrowse link increases expression ISO 1 95,933,023 95,938,176 RGD:6480464 CTD
G Bcl2 B-cell CLL/lymphoma 2 GBrowse link decreases expression ISO 13 12,730,736 12,905,108 RGD:6480464 CTD
G Casp1 caspase 1 GBrowse link increases activity ISO 8 2,027,976 2,036,872 RGD:6480464 CTD
G Casp1 caspase 1 GBrowse link multiple interactions ISO 8 2,027,976 2,036,872 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link increases activity ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link increases activity ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp7 caspase 7 GBrowse link increases activity ISO 1 262,689,300 262,721,591 RGD:6480464 CTD
G Casp8 caspase 8 GBrowse link increases activity ISO 9 57,389,353 57,437,803 RGD:6480464 CTD
G Casp8 caspase 8 GBrowse link increases activity ISO 9 57,389,353 57,437,803 RGD:6480464 CTD
G Casp9 caspase 9, apoptosis-related cysteine peptidase GBrowse link increases activity ISO 5 160,704,234 160,721,796 RGD:6480464 CTD
G Casp9 caspase 9, apoptosis-related cysteine peptidase GBrowse link increases activity ISO 5 160,704,234 160,721,796 RGD:6480464 CTD
G Ccl2 chemokine (C-C motif) ligand 2 GBrowse link multiple interactions ISO 10 70,256,263 70,258,061 RGD:6480464 CTD
G Cd14 CD14 molecule GBrowse link decreases expression ISO 18 29,374,593 29,376,190 RGD:6480464 CTD
G Cst3 cystatin C GBrowse link multiple interactions ISO 3 137,650,903 137,654,776 RGD:6480464 CTD
G Ctsd cathepsin D GBrowse link decreases activity EXP 1 202,619,669 202,631,545 RGD:6480464 CTD
G Ctsl1 cathepsin L1 GBrowse link decreases activity EXP 17 6,288,013 6,294,174 RGD:6480464 CTD
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 GBrowse link multiple interactions ISO 8 61,462,207 61,468,237 RGD:6480464 CTD
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 GBrowse link decreases activity ISO 8 61,462,207 61,468,237 RGD:6480464 CTD
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 GBrowse link multiple interactions ISO 8 61,462,207 61,468,237 RGD:6480464 CTD
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 GBrowse link decreases expression ISO 8 61,462,207 61,468,237 RGD:6480464 CTD
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 GBrowse link decreases activity ISO 8 61,439,062 61,447,861 RGD:6480464 CTD
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 GBrowse link multiple interactions ISO 8 61,439,062 61,447,861 RGD:6480464 CTD
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 GBrowse link multiple interactions EXP 1 243,281,320 243,320,945 RGD:6480464 CTD
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 GBrowse link multiple interactions ISO 1 243,281,320 243,320,945 RGD:6480464 CTD
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 GBrowse link decreases activity ISO 1 243,281,320 243,320,945 RGD:6480464 CTD
G Cyp2d3 cytochrome P450, family 2, subfamily d, polypeptide 3 GBrowse link decreases activity ISO 7 120,778,783 120,783,140 RGD:6480464 CTD
G Cyp2d3 cytochrome P450, family 2, subfamily d, polypeptide 3 GBrowse link multiple interactions ISO 7 120,778,783 120,783,140 RGD:6480464 CTD
G Cyp2d3 cytochrome P450, family 2, subfamily d, polypeptide 3 GBrowse link decreases activity EXP 7 120,778,783 120,783,140 RGD:6480464 CTD
G Cyp2d3 cytochrome P450, family 2, subfamily d, polypeptide 3 GBrowse link multiple interactions EXP 7 120,778,783 120,783,140 RGD:6480464 CTD
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 GBrowse link multiple interactions EXP 7 120,742,273 120,752,274 RGD:6480464 CTD
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 GBrowse link decreases activity EXP 7 120,742,273 120,752,274 RGD:6480464 CTD
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 GBrowse link decreases activity ISO 7 120,742,273 120,752,274 RGD:6480464 CTD
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 GBrowse link multiple interactions ISO 7 120,742,273 120,752,274 RGD:6480464 CTD
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 GBrowse link multiple interactions ISO 1 200,918,521 200,928,919 RGD:6480464 CTD
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 GBrowse link decreases expression ISO 1 200,918,521 200,928,919 RGD:6480464 CTD
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 GBrowse link multiple interactions ISO 5 116,702,370 116,729,722 RGD:6480464 CTD
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 GBrowse link decreases activity ISO 12 9,517,016 9,541,000 RGD:6480464 CTD
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 GBrowse link decreases activity ISO 12 9,517,016 9,541,000 RGD:6480464 CTD
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 GBrowse link multiple interactions ISO 12 9,517,016 9,541,000 RGD:6480464 CTD
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 GBrowse link decreases expression ISO 12 9,517,016 9,541,000 RGD:6480464 CTD
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 GBrowse link decreases activity ISO 12 9,517,016 9,541,000 RGD:6480464 CTD
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 GBrowse link multiple interactions ISO 12 9,517,016 9,541,000 RGD:6480464 CTD
G Egfr epidermal growth factor receptor GBrowse link multiple interactions ISO 14 97,617,358 97,788,211 RGD:6480464 CTD
G Egfr epidermal growth factor receptor GBrowse link multiple interactions ISO 14 97,617,358 97,788,211 RGD:6480464 CTD
G Fshb follicle stimulating hormone, beta polypeptide GBrowse link affects expression ISO 3 92,569,344 92,571,254 RGD:6480464 CTD
G Gast gastrin GBrowse link affects expression ISO 10 89,273,628 89,276,192 RGD:6480464 CTD
G Gstp1 glutathione S-transferase pi 1 GBrowse link affects expression ISO 1 206,627,398 206,629,866 RGD:6480464 CTD
G Gstp1 glutathione S-transferase pi 1 GBrowse link multiple interactions ISO 1 206,627,398 206,629,866 RGD:6480464 CTD
G Hmox1 heme oxygenase (decycling) 1 GBrowse link multiple interactions EXP 19 13,963,139 13,969,960 RGD:6480464 CTD
G Hrh1 histamine receptor H 1 GBrowse link multiple interactions ISO 4 150,431,239 150,432,699 RGD:6480464 CTD
G Hrh2 histamine receptor H 2 GBrowse link multiple interactions ISO 17 16,497,967 16,499,043 RGD:6480464 CTD
G Hrh2 histamine receptor H 2 GBrowse link multiple interactions ISO 17 16,497,967 16,499,043 RGD:6480464 CTD
G Hrh2 histamine receptor H 2 GBrowse link multiple interactions ISO 17 16,497,967 16,499,043 RGD:6480464 CTD
G Hrh2 histamine receptor H 2 GBrowse link multiple interactions ISO 17 16,497,967 16,499,043 RGD:6480464 CTD
G Hrh2 histamine receptor H 2 GBrowse link multiple interactions ISO 17 16,497,967 16,499,043 RGD:6480464 CTD
G Hrh2 histamine receptor H 2 GBrowse link increases expression ISO 17 16,497,967 16,499,043 RGD:6480464 CTD
G Hrh2 histamine receptor H 2 GBrowse link multiple interactions ISO 17 16,497,967 16,499,043 RGD:6480464 CTD
G Hrh2 histamine receptor H 2 GBrowse link multiple interactions ISO 17 16,497,967 16,499,043 RGD:6480464 CTD
G Hrh2 histamine receptor H 2 GBrowse link multiple interactions ISO 17 16,497,967 16,499,043 RGD:6480464 CTD
G Hrh2 histamine receptor H 2 GBrowse link multiple interactions EXP 17 16,497,967 16,499,043 RGD:6480464 CTD
G Hrh2 histamine receptor H 2 GBrowse link multiple interactions EXP 17 16,497,967 16,499,043 RGD:6480464 CTD
G Hrh2 histamine receptor H 2 GBrowse link multiple interactions ISO 17 16,497,967 16,499,043 RGD:6480464 CTD
G Hrh2 histamine receptor H 2 GBrowse link multiple interactions ISO 17 16,497,967 16,499,043 RGD:6480464 CTD
G Hrh2 histamine receptor H 2 GBrowse link multiple interactions ISO 17 16,497,967 16,499,043 RGD:6480464 CTD
G Hrh2 histamine receptor H 2 GBrowse link decreases activity EXP 17 16,497,967 16,499,043 RGD:6480464 CTD
G Hrh2 histamine receptor H 2 GBrowse link multiple interactions ISO 17 16,497,967 16,499,043 RGD:6480464 CTD
G Icam1 intercellular adhesion molecule 1 GBrowse link decreases expression ISO 8 20,040,177 20,051,939 RGD:6480464 CTD
G Ifng interferon gamma GBrowse link multiple interactions ISO 7 57,621,756 57,625,792 RGD:6480464 CTD
G Ifng interferon gamma GBrowse link increases expression ISO 7 57,621,756 57,625,792 RGD:6480464 CTD
G Il16 interleukin 16 GBrowse link multiple interactions ISO 1 139,908,061 140,000,146 RGD:6480464 CTD
G Il18 interleukin 18 GBrowse link multiple interactions ISO 8 53,936,584 53,943,228 RGD:6480464 CTD
G Il18 interleukin 18 GBrowse link increases expression ISO 8 53,936,584 53,943,228 RGD:6480464 CTD
G Il18 interleukin 18 GBrowse link increases expression ISO 8 53,936,584 53,943,228 RGD:6480464 CTD
G Il18 interleukin 18 GBrowse link multiple interactions ISO 8 53,936,584 53,943,228 RGD:6480464 CTD
G Il1b interleukin 1 beta GBrowse link multiple interactions ISO 3 116,964,422 116,970,867 RGD:6480464 CTD
G Itga4 integrin, alpha 4 GBrowse link decreases expression ISO 3 62,024,747 62,097,456 RGD:6480464 CTD
G Itgax integrin, alpha X GBrowse link decreases expression ISO 1 187,396,184 187,416,273 RGD:6480464 CTD
G Lrp1 low density lipoprotein receptor-related protein 1 GBrowse link decreases expression ISO 7 67,520,575 67,601,549 RGD:6480464 CTD
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 GBrowse link multiple interactions ISO 2 233,091,013 233,187,501 RGD:6480464 CTD
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 GBrowse link multiple interactions ISO 2 233,091,013 233,187,501 RGD:6480464 CTD
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 GBrowse link decreases expression ISO 11 64,239,918 64,276,702 RGD:6480464 CTD
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 GBrowse link multiple interactions ISO 11 64,239,918 64,276,702 RGD:6480464 CTD
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 GBrowse link multiple interactions ISO 13 87,104,241 87,108,563 RGD:6480464 CTD
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 GBrowse link decreases expression ISO 13 87,104,241 87,108,563 RGD:6480464 CTD
G Ntf3 neurotrophin 3 GBrowse link multiple interactions EXP 4 162,435,781 162,506,961 RGD:6480464 CTD
G Pde4b phosphodiesterase 4B, cAMP specific GBrowse link multiple interactions ISO 5 123,158,156 123,533,877 RGD:6480464 CTD
G Prl prolactin GBrowse link affects expression ISO 17 44,699,101 44,709,162 RGD:6480464 CTD
G Prl prolactin GBrowse link affects expression ISO 17 44,699,101 44,709,162 RGD:6480464 CTD
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) GBrowse link multiple interactions ISO 1 208,262,669 208,273,148 RGD:6480464 CTD
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) GBrowse link multiple interactions ISO 1 208,262,669 208,273,148 RGD:6480464 CTD
G Selp selectin P GBrowse link decreases expression ISO 13 79,886,614 79,922,180 RGD:6480464 CTD
G Slc22a1 solute carrier family 22 (organic cation transporter), member 1 GBrowse link increases uptake EXP 1 42,351,239 42,378,295 RGD:6480464 CTD
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 GBrowse link multiple interactions ISO 1 42,395,676 42,442,847 RGD:6480464 CTD
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 GBrowse link increases uptake ISO 1 42,395,676 42,442,847 RGD:6480464 CTD
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 GBrowse link increases uptake EXP 1 42,395,676 42,442,847 RGD:6480464 CTD
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 GBrowse link increases uptake ISO 1 42,395,676 42,442,847 RGD:6480464 CTD
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 GBrowse link decreases response to substance ISO 1 42,395,676 42,442,847 RGD:6480464 CTD
G Slc22a3 solute carrier family 22 (extraneuronal monoamine transporter), member 3 GBrowse link multiple interactions ISO 1 42,690,158 42,781,895 RGD:6480464 CTD
G Slc22a3 solute carrier family 22 (extraneuronal monoamine transporter), member 3 GBrowse link increases transport ISO 1 42,690,158 42,781,895 RGD:6480464 CTD
G Slc22a6 solute carrier family 22 (organic anion transporter), member 6 GBrowse link multiple interactions ISO 1 211,294,178 211,302,398 RGD:6480464 CTD
G Slc22a6 solute carrier family 22 (organic anion transporter), member 6 GBrowse link increases uptake ISO 1 211,294,178 211,302,398 RGD:6480464 CTD
G Slc22a6 solute carrier family 22 (organic anion transporter), member 6 GBrowse link increases uptake ISO 1 211,294,178 211,302,398 RGD:6480464 CTD
G Slc22a6 solute carrier family 22 (organic anion transporter), member 6 GBrowse link increases uptake ISO 1 211,294,178 211,302,398 RGD:6480464 CTD
G Slc22a6 solute carrier family 22 (organic anion transporter), member 6 GBrowse link increases uptake ISO 1 211,294,178 211,302,398 RGD:6480464 CTD
G Slc22a6 solute carrier family 22 (organic anion transporter), member 6 GBrowse link increases uptake ISO 1 211,294,178 211,302,398 RGD:6480464 CTD
G Slc22a7 solute carrier family 22 (organic anion transporter), member 7 GBrowse link increases uptake ISO 9 9,934,309 9,940,107 RGD:6480464 CTD
G Slc22a7 solute carrier family 22 (organic anion transporter), member 7 GBrowse link multiple interactions ISO 9 9,934,309 9,940,107 RGD:6480464 CTD
G Slc22a8 solute carrier family 22 (organic anion transporter), member 8 GBrowse link multiple interactions ISO 1 211,269,366 211,287,596 RGD:6480464 CTD
G Slc22a8 solute carrier family 22 (organic anion transporter), member 8 GBrowse link multiple interactions ISO 1 211,269,366 211,287,596 RGD:6480464 CTD
G Slc22a8 solute carrier family 22 (organic anion transporter), member 8 GBrowse link increases uptake ISO 1 211,269,366 211,287,596 RGD:6480464 CTD
G Slc22a8 solute carrier family 22 (organic anion transporter), member 8 GBrowse link multiple interactions EXP 1 211,269,366 211,287,596 RGD:6480464 CTD
G Slc22a8 solute carrier family 22 (organic anion transporter), member 8 GBrowse link multiple interactions ISO 1 211,269,366 211,287,596 RGD:6480464 CTD
G Slc22a8 solute carrier family 22 (organic anion transporter), member 8 GBrowse link multiple interactions EXP 1 211,269,366 211,287,596 RGD:6480464 CTD
G Slc22a8 solute carrier family 22 (organic anion transporter), member 8 GBrowse link increases uptake EXP 1 211,269,366 211,287,596 RGD:6480464 CTD
G Slc22a8 solute carrier family 22 (organic anion transporter), member 8 GBrowse link increases uptake EXP 1 211,269,366 211,287,596 RGD:6480464 CTD
G Slc22a8 solute carrier family 22 (organic anion transporter), member 8 GBrowse link increases uptake EXP 1 211,269,366 211,287,596 RGD:6480464 CTD
G Slc22a8 solute carrier family 22 (organic anion transporter), member 8 GBrowse link increases uptake ISO 1 211,269,366 211,287,596 RGD:6480464 CTD
G Slc22a8 solute carrier family 22 (organic anion transporter), member 8 GBrowse link affects transport ISO 1 211,269,366 211,287,596 RGD:6480464 CTD
G Slc22a8 solute carrier family 22 (organic anion transporter), member 8 GBrowse link increases uptake EXP 1 211,269,366 211,287,596 RGD:6480464 CTD
G Slc22a8 solute carrier family 22 (organic anion transporter), member 8 GBrowse link increases uptake EXP 1 211,269,366 211,287,596 RGD:6480464 CTD
G Slc47a1 solute carrier family 47, member 1 GBrowse link decreases activity ISO 10 47,514,258 47,548,353 RGD:6480464 CTD
G Slc47a1 solute carrier family 47, member 1 GBrowse link affects transport ISO 10 47,514,258 47,548,353 RGD:6480464 CTD
G Slc9a3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 GBrowse link multiple interactions EXP 1 29,930,908 29,973,686 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link multiple interactions ISO 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link multiple interactions ISO 20 3,661,000 3,663,618 RGD:6480464 CTD
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 492574
    role 482262
      biological role 480454
        pharmacological role 126923
          analgesic 22633
            cimetidine 132
              cimetidine S-oxide 0
              cimetidine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 492574
    subatomic particle 491537
      composite particle 491537
        hadron 491537
          baryon 491537
            nucleon 491537
              atomic nucleus 491537
                atom 491537
                  main group element atom 461203
                    p-block element atom 458699
                      carbon group element atom 410677
                        carbon atom 407233
                          organic molecular entity 407226
                            organic molecule 359465
                              organic cyclic compound 298342
                                organic heterocyclic compound 154273
                                  organic heteromonocyclic compound 58845
                                    mancude organic heteromonocyclic parent 8900
                                      azole 7417
                                        diazole 3604
                                          imidazoles 2794
                                            cimetidine 132
                                              cimetidine S-oxide 0
                                              cimetidine hydrochloride 0
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