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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (S)-amphetamine | affects response to substance | EXP | | 6480464 | TACR1 protein affects the susceptibility to Dextroamphetamine | CTD | PMID:11897087 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:731009 | 6480464 | Tetrachlorodibenzodioxin affects the expression of TACR1 mRNA | CTD | PMID:21570461 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of TACR1 mRNA | CTD | PMID:16483693 | arsenite(3-) | multiple interactions | ISO | RGD:731009 | 6480464 | [arsenite co-treated with Benzo(a)pyrene] results in decreased expression of TACR1 mRNA | CTD | PMID:15894712 | arsenite(3-) | decreases expression | ISO | RGD:731009 | 6480464 | arsenite results in decreased expression of TACR1 mRNA | CTD | PMID:15894712 | benzo[a]pyrene | multiple interactions | ISO | RGD:731009 | 6480464 | [arsenite co-treated with Benzo(a)pyrene] results in decreased expression of TACR1 mRNA | CTD | PMID:15894712 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of TACR1 mRNA | CTD | PMID:22374506 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of TACR1 mRNA | CTD | PMID:21839799 | benzo[a]pyrene | decreases expression | ISO | RGD:731009 | 6480464 | Benzo(a)pyrene results in decreased expression of TACR1 mRNA | CTD | PMID:15894712 | beta-amyrin | multiple interactions | ISO | RGD:731009 | 6480464 | amyrin inhibits the reaction [Cyclophosphamide results in increased expression of TACR1 protein] | CTD | PMID:18210232 | bis(2-ethylhexyl) phthalate | increases expression | EXP | | 6480464 | Diethylhexyl Phthalate results in increased expression of TACR1 mRNA | CTD | PMID:15620428 | C60 fullerene | decreases expression | EXP | | 6480464 | fullerene C60 results in decreased expression of TACR1 mRNA | CTD | PMID:19167457 | cadmium atom | increases expression | ISO | RGD:731008 | 6480464 | Cadmium results in increased expression of TACR1 mRNA | CTD | PMID:21694771 | capsaicin | increases expression | ISO | RGD:731009 | 6480464 | Capsaicin results in increased expression of TACR1 protein | CTD | PMID:21294877 | capsaicin | multiple interactions | EXP | | 6480464 | Capsaicin inhibits the reaction [[1,2-naphthoquinone co-treated with Vehicle Emissions] results in increased expression of TACR1 mRNA] | CTD | PMID:19399481 | capsaicin | increases response to substance | ISO | RGD:731009 | 6480464 | TACR1 results in increased susceptibility to Capsaicin | CTD | PMID:11166975 PMID:10360863 | capsaicin | multiple interactions | EXP | | 6480464 | Capsaicin affects the reaction [Vehicle Emissions affects the expression of TACR1 mRNA]; more ... | CTD | PMID:13680092 | capsaicin | affects expression | EXP | | 6480464 | Capsaicin affects the expression of TACR1 mRNA | CTD | PMID:13680092 | capsaicin | increases response to substance | ISO | RGD:731009 | 6480464 | TACR1 results in increased susceptibility to Capsaicin | CTD | PMID:10360863 PMID:11166975 | capsaicin | decreases expression | ISO | RGD:731009 | 6480464 | Capsaicin results in decreased expression of TACR1 mRNA; more ... | CTD | PMID:18441096 | cocaine | multiple interactions | ISO | RGD:731009 | 6480464 | HDAC5 affects the reaction [Cocaine affects the expression of TACR1 mRNA] | CTD | PMID:17988634 | cyclophosphamide | multiple interactions | ISO | RGD:731009 | 6480464 | amyrin inhibits the reaction [Cyclophosphamide results in increased expression of TACR1 protein] | CTD | PMID:18210232 | cyclophosphamide | decreases response to substance | ISO | RGD:731009 | 6480464 | TACR1 gene mutant form results in decreased susceptibility to Cyclophosphamide | CTD | PMID:10854767 | cyclophosphamide | increases expression | ISO | RGD:731009 | 6480464 | Cyclophosphamide results in increased expression of TACR1 protein | CTD | PMID:18210232 | dioxygen | increases response to substance | ISO | RGD:731009 | 6480464 | TACR1 protein results in increased susceptibility to Oxygen | CTD | PMID:11463606 | dobutamine | multiple interactions | ISO | RGD:731008 | 6480464 | Dobutamine promotes the reaction [TAC1 protein binds to and results in increased activity of TACR1 protein] | CTD | PMID:8994422 | dydrogesterone | decreases expression | ISO | RGD:731009 | 6480464 | Dydrogesterone results in decreased expression of TACR1 protein | CTD | PMID:16389545 | famotidine | multiple interactions | ISO | RGD:731009 | 6480464 | Famotidine inhibits the reaction [Acids affects the localization of TACR1 protein] | CTD | PMID:16091555 | hydrogen chloride | affects response to substance | EXP | | 6480464 | TACR1 protein affects the susceptibility to Hydrochloric Acid | CTD | PMID:11730984 | manganese atom | decreases expression | ISO | RGD:731008 | 6480464 | Manganese results in decreased expression of TACR1 mRNA | CTD | PMID:17175027 | manganese(0) | decreases expression | ISO | RGD:731008 | 6480464 | Manganese results in decreased expression of TACR1 mRNA | CTD | PMID:17175027 | manganese(II) chloride | decreases expression | ISO | RGD:731008 | 6480464 | manganese chloride results in decreased expression of TACR1 mRNA | CTD | PMID:17175027 | morphine | multiple interactions | EXP | | 6480464 | substance P-saporin inhibits the reaction [Morphine results in increased expression of TACR1 protein] | CTD | PMID:17123731 | morphine | decreases expression | EXP | | 6480464 | Morphine results in decreased expression of TACR1 protein | CTD | PMID:19428329 | morphine | increases expression | EXP | | 6480464 | Morphine results in increased expression of TACR1 protein | CTD | PMID:15964684 PMID:17123731 | morphine | increases expression | EXP | | 6480464 | Morphine results in increased expression of TACR1 protein | CTD | PMID:17123731 PMID:15964684 | morphine | multiple interactions | EXP | | 6480464 | [SR 140333 binds to and results in decreased activity of TACR1 protein] which results in increased susceptibility to Morphine | CTD | PMID:14511336 | nitroprusside | increases response to substance | EXP | | 6480464 | TACR1 protein results in increased susceptibility to Nitroprusside | CTD | PMID:16982039 | omeprazole | multiple interactions | ISO | RGD:731009 | 6480464 | Omeprazole inhibits the reaction [Acids affects the localization of TACR1 protein] | CTD | PMID:16091555 | phenylephrine | increases response to substance | EXP | | 6480464 | TACR1 protein results in increased susceptibility to Phenylephrine | CTD | PMID:16982039 | sodium cyanide | increases response to substance | EXP | | 6480464 | TACR1 protein results in increased susceptibility to Sodium Cyanide | CTD | PMID:16982039 | sucrose | multiple interactions | EXP | | 6480464 | Sucrose inhibits the reaction [TAC1 protein affects the localization of TACR1 protein] | CTD | PMID:7524481 | taurine | decreases expression | ISO | RGD:731008 | 6480464 | Taurine results in decreased expression of TACR1 mRNA | CTD | PMID:16579726 | valproic acid | decreases expression | ISO | RGD:731008 | 6480464 | Valproic Acid results in decreased expression of TACR1 mRNA | CTD | PMID:12807426 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Calcium signaling pathway |
| Measles | |
| Neuroactive ligand-receptor interaction | |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Calcium signaling pathway |
| Measles | |
| Neuroactive ligand-receptor interaction | |
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RGD Disease Portals| Tacr1 has been annotated in the following RGD Disease Portals. |
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Candidate Gene StatusComparative Map Data| Tacr1 (Rattus norvegicus) |
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| TACR1 (Homo sapiens) |
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| Tacr1 (Mus musculus) |
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Position Markers| D4Mgh17 |
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| D4Wox19 |
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| D4Mit23 |
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| D4Arb39 |
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| D0Got964 |
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| RH138512 |
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| UniSTS:480302 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_012667 | (Get FASTA) | Search GEO for Microarray Profiles |
| XM_003749783 | (Get FASTA) | Search GEO for Microarray Profiles | |
| XM_003753911 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AABR06031992 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06032000 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06032001 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06032002 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06032003 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01031220 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01031221 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01031222 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01031223 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01031224 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473957 | (Get FASTA) | Search GEO for Microarray Profiles | |
| J05097 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M31477 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M64232 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M64233 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M64234 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M64235 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M64236 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_012667 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_036799 | ||||||||||||||||||||
| Position: |
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| RefSeq Acc Id: | XM_003749783 | ||||||||||
| RefSeq Status: | |||||||||||
| Type: | CODING | ||||||||||
| Protein Acc Id: | XP_003749831 | ||||||||||
| Position: |
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| RefSeq Acc Id: | XM_003753911 |
| RefSeq Status: | |
| Type: | CODING |
| Protein Acc Id: | XP_003753959 |
| Position: | No map positions available. |
Protein Sequences| Protein RefSeqs | NP_036799 | (Get FASTA) |
| XP_003749831 | (Get FASTA) | |
| XP_003753959 | (Get FASTA) | |
| GenBank Protein | AAA42175 | (Get FASTA) |
| AAA42176 | (Get FASTA) | |
| AAB59726 | (Get FASTA) | |
| EDL91094 | (Get FASTA) | |
| EDL91095 | (Get FASTA) | |
| P14600 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000005853 | UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000007984 | UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000007984 | UniProtKB/Swiss-Prot |
| Entrez Gene | 24807 | ENTREZGENE |
| Germonline | ENSRNOG00000005853 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 20288 | ENTREZGENE |
| InterPro | 7TM_GPCR_Rhodpsn | UniProtKB/Swiss-Prot |
| GPCR_Rhodpsn_supfam | UniProtKB/Swiss-Prot | |
| Neurokn_rcpt | UniProtKB/Swiss-Prot | |
| NK1_rcpt | UniProtKB/Swiss-Prot | |
| IPI | IPI00207210 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:24807 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Pfam | 7tm_1 | UniProtKB/Swiss-Prot |
| PRINTS | GPCRRHODOPSN | UniProtKB/Swiss-Prot |
| NEUROKININ1R | UniProtKB/Swiss-Prot | |
| NEUROKININR | UniProtKB/Swiss-Prot | |
| PROSITE | G_PROTEIN_RECEP_F1_1 | UniProtKB/Swiss-Prot |
| G_PROTEIN_RECEP_F1_2 | UniProtKB/Swiss-Prot | |
| TIGR | TC233578 | |
| UniGene | Rn.89609 | ENTREZGENE |
| UniProt | NK1R_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2001-06-20 | Tacr1 | Tachykinin 1 receptor | Name updated | 461 | APPROVED | ||
| 2001-06-20 | Tac1r | Tachykinin 1 receptor (substance P receptor, neurokinin 1 receptor) | Symbol withdrawn, duplicate of Tacr1 (RGD:3811) | 461 | WITHDRAWN |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_expression | mRNA is stable and expressed in low levels in the lungs | 625601 |
| gene_expression | expression declined with age in the lungs of pathogen free rats | 625601 |
| gene_process | mediates the respiratory stimulant effect of substance P | 625695 |
| More on Tacr1 | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 3811 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-05-14 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.