Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17beta-estradiol | increases expression | ISO | AMOTL2 (Homo sapiens) | 6480464 | Estradiol results in increased expression of AMOTL2 mRNA | CTD | PMID:23019147 | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of AMOTL2 mRNA | CTD | PMID:32145629 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Amotl2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of AMOTL2 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of AMOTL2 mRNA | CTD | PMID:33387578 and PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Amotl2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of AMOTL2 mRNA | CTD | PMID:15034205 | 3,3',5,5'-tetrabromobisphenol A | decreases expression | ISO | Amotl2 (Mus musculus) | 6480464 | tetrabromobisphenol A results in decreased expression of AMOTL2 mRNA | CTD | PMID:25172293 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | AMOTL2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of AMOTL2 mRNA | CTD | PMID:28628672 | 4,4'-sulfonyldiphenol | affects methylation | ISO | Amotl2 (Mus musculus) | 6480464 | bisphenol S affects the methylation of AMOTL2 gene | CTD | PMID:31683443 | 4-hydroxyphenyl retinamide | decreases expression | ISO | Amotl2 (Mus musculus) | 6480464 | Fenretinide results in decreased expression of AMOTL2 mRNA | CTD | PMID:28973697 | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of AMOTL2 mRNA | CTD | PMID:30047161 | acrolein | multiple interactions | ISO | AMOTL2 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of AMOTL2 mRNA more ... | CTD | PMID:32699268 and PMID:32845096 | acrylamide | increases expression | EXP | | 6480464 | Acrylamide results in increased expression of AMOTL2 mRNA | CTD | PMID:28959563 | acrylamide | increases expression | ISO | AMOTL2 (Homo sapiens) | 6480464 | Acrylamide results in increased expression of AMOTL2 mRNA | CTD | PMID:32763439 | aflatoxin B1 | decreases methylation | ISO | AMOTL2 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of AMOTL2 gene | CTD | PMID:27153756 | aflatoxin B1 | increases expression | ISO | AMOTL2 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased expression of AMOTL2 mRNA | CTD | PMID:27153756 | alpha-pinene | multiple interactions | ISO | AMOTL2 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of AMOTL2 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased expression of AMOTL2 mRNA | CTD | PMID:32699268 | amitrole | decreases expression | EXP | | 6480464 | Amitrole results in decreased expression of AMOTL2 mRNA | CTD | PMID:30047161 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of AMOTL2 mRNA | CTD | PMID:16483693 | amphetamine | increases expression | EXP | | 6480464 | Amphetamine results in increased expression of AMOTL2 mRNA | CTD | PMID:30779732 | aristolochic acid A | decreases expression | ISO | AMOTL2 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of AMOTL2 mRNA | CTD | PMID:33212167 | arsenite(3-) | multiple interactions | ISO | AMOTL2 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to AMOTL2 mRNA] | CTD | PMID:32406909 | benzo[a]pyrene | decreases expression | ISO | Amotl2 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of AMOTL2 mRNA | CTD | PMID:15034205 | benzo[a]pyrene | affects methylation | ISO | AMOTL2 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of AMOTL2 3' UTR more ... | CTD | PMID:27901495 and PMID:30157460 | benzo[e]pyrene | increases methylation | ISO | AMOTL2 (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of AMOTL2 intron | CTD | PMID:30157460 | bexarotene | decreases expression | ISO | AMOTL2 (Homo sapiens) | 6480464 | bexarotene results in decreased expression of AMOTL2 mRNA | CTD | PMID:17178900 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of AMOTL2 mRNA | CTD | PMID:25181051 | bisphenol A | increases expression | ISO | Amotl2 (Mus musculus) | 6480464 | bisphenol A results in increased expression of AMOTL2 mRNA | CTD | PMID:32156529 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of AMOTL2 mRNA | CTD | PMID:32145629 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of AMOTL2 mRNA | CTD | PMID:33296240 | bisphenol A | multiple interactions | ISO | AMOTL2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of AMOTL2 mRNA | CTD | PMID:28628672 | bisphenol F | multiple interactions | ISO | AMOTL2 (Homo sapiens) | 6480464 | [bisphenol F co-treated with Fulvestrant] results in decreased methylation of AMOTL2 gene | CTD | PMID:31601247 | cadmium atom | increases expression | ISO | AMOTL2 (Homo sapiens) | 6480464 | Cadmium results in increased expression of AMOTL2 mRNA | CTD | PMID:24284285 | cadmium atom | multiple interactions | ISO | AMOTL2 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of AMOTL2 mRNA | CTD | PMID:35301059 | cadmium dichloride | multiple interactions | ISO | AMOTL2 (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of AMOTL2 mRNA | CTD | PMID:35301059 | caffeine | affects phosphorylation | ISO | AMOTL2 (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of AMOTL2 protein | CTD | PMID:35688186 | carbamazepine | affects expression | ISO | AMOTL2 (Homo sapiens) | 6480464 | Carbamazepine affects the expression of AMOTL2 mRNA | CTD | PMID:25979313 | carbon nanotube | increases expression | ISO | Amotl2 (Mus musculus) | 6480464 | Nanotubes and Carbon results in increased expression of AMOTL2 mRNA | CTD | PMID:25554681 | CGP 52608 | multiple interactions | ISO | AMOTL2 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to AMOTL2 gene] | CTD | PMID:28238834 | cisplatin | multiple interactions | ISO | AMOTL2 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in decreased expression of AMOTL2 mRNA | CTD | PMID:27392435 | copper atom | multiple interactions | ISO | AMOTL2 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of AMOTL2 mRNA | CTD | PMID:20971185 | copper(0) | multiple interactions | ISO | AMOTL2 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of AMOTL2 mRNA | CTD | PMID:20971185 | copper(II) sulfate | increases expression | ISO | AMOTL2 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of AMOTL2 mRNA | CTD | PMID:19549813 | coumarin | affects phosphorylation | ISO | AMOTL2 (Homo sapiens) | 6480464 | coumarin affects the phosphorylation of AMOTL2 protein | CTD | PMID:35688186 | coumestrol | decreases expression | ISO | AMOTL2 (Homo sapiens) | 6480464 | Coumestrol results in decreased expression of AMOTL2 mRNA | CTD | PMID:19167446 | coumestrol | multiple interactions | ISO | AMOTL2 (Homo sapiens) | 6480464 | [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of AMOTL2 mRNA | CTD | PMID:19167446 | crocidolite asbestos | decreases expression | ISO | AMOTL2 (Homo sapiens) | 6480464 | Asbestos and Crocidolite results in decreased expression of AMOTL2 mRNA | CTD | PMID:29523930 | Cuprizon | increases expression | EXP | | 6480464 | Cuprizone results in increased expression of AMOTL2 mRNA | CTD | PMID:26577399 | cyclosporin A | increases expression | ISO | AMOTL2 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of AMOTL2 mRNA | CTD | PMID:25562108 | dexamethasone | multiple interactions | ISO | AMOTL2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of AMOTL2 mRNA | CTD | PMID:28628672 | dibutyl phthalate | increases expression | ISO | Amotl2 (Mus musculus) | 6480464 | Dibutyl Phthalate results in increased expression of AMOTL2 mRNA | CTD | PMID:17361019 and PMID:21266533 | diclofenac | decreases expression | ISO | Amotl2 (Mus musculus) | 6480464 | Diclofenac results in decreased expression of AMOTL2 mRNA | CTD | PMID:35537566 | diuron | decreases expression | EXP | | 6480464 | Diuron results in decreased expression of AMOTL2 mRNA | CTD | PMID:21551480 | dorsomorphin | multiple interactions | ISO | AMOTL2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AMOTL2 mRNA | CTD | PMID:27188386 | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of AMOTL2 mRNA | CTD | PMID:29391264 | Enterolactone | multiple interactions | ISO | AMOTL2 (Homo sapiens) | 6480464 | [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of AMOTL2 mRNA | CTD | PMID:19167446 | fenamidone | increases expression | ISO | Amotl2 (Mus musculus) | 6480464 | fenamidone results in increased expression of AMOTL2 mRNA | CTD | PMID:27029645 | FR900359 | increases phosphorylation | ISO | AMOTL2 (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of AMOTL2 protein | CTD | PMID:37730182 | fulvestrant | increases methylation | ISO | AMOTL2 (Homo sapiens) | 6480464 | Fulvestrant results in increased methylation of AMOTL2 gene | CTD | PMID:31601247 | fulvestrant | multiple interactions | ISO | AMOTL2 (Homo sapiens) | 6480464 | [bisphenol F co-treated with Fulvestrant] results in decreased methylation of AMOTL2 gene | CTD | PMID:31601247 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of AMOTL2 mRNA | CTD | PMID:33387578 | hydrogen peroxide | affects expression | ISO | AMOTL2 (Homo sapiens) | 6480464 | Hydrogen Peroxide affects the expression of AMOTL2 mRNA | CTD | PMID:20044591 | indometacin | multiple interactions | ISO | AMOTL2 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of AMOTL2 mRNA | CTD | PMID:28628672 | leflunomide | increases expression | ISO | AMOTL2 (Homo sapiens) | 6480464 | leflunomide results in increased expression of AMOTL2 mRNA | CTD | PMID:28988120 | lipopolysaccharide | increases expression | EXP | | 6480464 | Lipopolysaccharides results in increased expression of AMOTL2 mRNA | CTD | PMID:16415329 | lipopolysaccharide | multiple interactions | ISO | AMOTL2 (Homo sapiens) | 6480464 | [S-(1 more ... | CTD | PMID:35811015 | lipopolysaccharide | multiple interactions | EXP | | 6480464 | Ranitidine inhibits the reaction [Lipopolysaccharides results in increased expression of AMOTL2 mRNA] | CTD | PMID:16415329 | menadione | affects expression | ISO | AMOTL2 (Homo sapiens) | 6480464 | Vitamin K 3 affects the expression of AMOTL2 mRNA | CTD | PMID:20044591 | methapyrilene | increases methylation | ISO | AMOTL2 (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of AMOTL2 intron | CTD | PMID:30157460 | methylmercury chloride | increases expression | ISO | AMOTL2 (Homo sapiens) | 6480464 | methylmercuric chloride results in increased expression of AMOTL2 mRNA | CTD | PMID:23179753 and PMID:28001369 | N-methyl-4-phenylpyridinium | decreases expression | ISO | AMOTL2 (Homo sapiens) | 6480464 | 1-Methyl-4-phenylpyridinium results in decreased expression of AMOTL2 mRNA | CTD | PMID:24810058 | N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine | multiple interactions | EXP | | 6480464 | Ranitidine inhibits the reaction [Lipopolysaccharides results in increased expression of AMOTL2 mRNA] | CTD | PMID:16415329 | ochratoxin A | decreases expression | ISO | AMOTL2 (Homo sapiens) | 6480464 | ochratoxin A results in decreased expression of AMOTL2 mRNA | CTD | PMID:30763683 | orphenadrine | affects expression | EXP | | 6480464 | Orphenadrine affects the expression of AMOTL2 mRNA | CTD | PMID:23665939 | oxaliplatin | increases expression | EXP | | 6480464 | oxaliplatin results in increased expression of AMOTL2 mRNA | CTD | PMID:25729387 | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of AMOTL2 mRNA and [Topotecan co-treated with oxaliplatin] results in increased expression of AMOTL2 mRNA | CTD | PMID:25729387 | ozone | multiple interactions | ISO | AMOTL2 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of AMOTL2 mRNA more ... | CTD | PMID:32699268 and PMID:32845096 | paracetamol | affects expression | ISO | Amotl2 (Mus musculus) | 6480464 | Acetaminophen affects the expression of AMOTL2 mRNA | CTD | PMID:17562736 | paracetamol | increases expression | ISO | Amotl2 (Mus musculus) | 6480464 | Acetaminophen results in increased expression of AMOTL2 mRNA | CTD | PMID:34546377 | paracetamol | decreases expression | ISO | AMOTL2 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of AMOTL2 mRNA | CTD | PMID:21420995 | paraquat | decreases expression | EXP | | 6480464 | Paraquat results in decreased expression of AMOTL2 mRNA | CTD | PMID:32680482 | perfluorooctanoic acid | increases expression | ISO | Amotl2 (Mus musculus) | 6480464 | perfluorooctanoic acid results in increased expression of AMOTL2 mRNA | CTD | PMID:36152675 | phenylmercury acetate | increases expression | ISO | AMOTL2 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in increased expression of AMOTL2 mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | AMOTL2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AMOTL2 mRNA | CTD | PMID:27188386 | pioglitazone | multiple interactions | ISO | AMOTL2 (Homo sapiens) | 6480464 | [pioglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of AMOTL2 mRNA | CTD | PMID:20847119 | pirinixic acid | increases expression | ISO | Amotl2 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of AMOTL2 mRNA | CTD | PMID:18301758 and PMID:23811191 | pregnenolone 16alpha-carbonitrile | decreases expression | EXP | | 6480464 | Pregnenolone Carbonitrile results in decreased expression of AMOTL2 mRNA | CTD | PMID:30047161 | quercetin | decreases expression | ISO | AMOTL2 (Homo sapiens) | 6480464 | Quercetin results in decreased expression of AMOTL2 mRNA | CTD | PMID:21632981 | raloxifene | affects expression | ISO | AMOTL2 (Homo sapiens) | 6480464 | Raloxifene Hydrochloride affects the expression of AMOTL2 mRNA | CTD | PMID:14699072 | ranitidine | multiple interactions | EXP | | 6480464 | Ranitidine inhibits the reaction [Lipopolysaccharides results in increased expression of AMOTL2 mRNA] | CTD | PMID:16415329 | S-(1,2-dichlorovinyl)-L-cysteine | decreases expression | ISO | AMOTL2 (Homo sapiens) | 6480464 | S-(1 and 2-dichlorovinyl)cysteine results in decreased expression of AMOTL2 mRNA | CTD | PMID:35811015 | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | AMOTL2 (Homo sapiens) | 6480464 | [S-(1 more ... | CTD | PMID:35811015 | SB 431542 | multiple interactions | ISO | AMOTL2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AMOTL2 mRNA | CTD | PMID:27188386 | silicon dioxide | increases expression | ISO | AMOTL2 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in increased expression of AMOTL2 mRNA | CTD | PMID:25895662 | silver atom | increases expression | ISO | AMOTL2 (Homo sapiens) | 6480464 | Silver results in increased expression of AMOTL2 mRNA | CTD | PMID:26014281 | silver(0) | increases expression | ISO | AMOTL2 (Homo sapiens) | 6480464 | Silver results in increased expression of AMOTL2 mRNA | CTD | PMID:26014281 | sodium arsenite | decreases expression | ISO | AMOTL2 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of AMOTL2 mRNA | CTD | PMID:28595984 | sunitinib | increases expression | ISO | AMOTL2 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of AMOTL2 mRNA | CTD | PMID:31533062 | tert-butyl hydroperoxide | multiple interactions | ISO | AMOTL2 (Homo sapiens) | 6480464 | [pioglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of AMOTL2 mRNA more ... | CTD | PMID:20847119 | tert-butyl hydroperoxide | decreases expression | ISO | AMOTL2 (Homo sapiens) | 6480464 | tert-Butylhydroperoxide results in decreased expression of AMOTL2 mRNA | CTD | PMID:20847119 | tetrachloromethane | increases expression | ISO | Amotl2 (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of AMOTL2 mRNA | CTD | PMID:17484886 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of AMOTL2 mRNA | CTD | PMID:34492290 | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in increased expression of AMOTL2 mRNA and [Topotecan co-treated with oxaliplatin] results in increased expression of AMOTL2 mRNA | CTD | PMID:25729387 | topotecan | increases expression | EXP | | 6480464 | Topotecan results in increased expression of AMOTL2 mRNA | CTD | PMID:25729387 | triptonide | increases expression | ISO | Amotl2 (Mus musculus) | 6480464 | triptonide results in increased expression of AMOTL2 mRNA | CTD | PMID:33045310 | troglitazone | multiple interactions | ISO | AMOTL2 (Homo sapiens) | 6480464 | [troglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of AMOTL2 mRNA more ... | CTD | PMID:20847119 | troglitazone | increases expression | ISO | Amotl2 (Mus musculus) | 6480464 | troglitazone results in increased expression of AMOTL2 mRNA | CTD | PMID:28973697 | trovafloxacin | decreases expression | ISO | Amotl2 (Mus musculus) | 6480464 | trovafloxacin results in decreased expression of AMOTL2 mRNA | CTD | PMID:35537566 | valproic acid | affects expression | ISO | AMOTL2 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of AMOTL2 mRNA | CTD | PMID:25979313 | valproic acid | decreases expression | ISO | AMOTL2 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of AMOTL2 mRNA | CTD | PMID:29154799 | vinclozolin | affects expression | EXP | | 6480464 | vinclozolin affects the expression of AMOTL2 mRNA | CTD | PMID:19015723 | vorinostat | decreases expression | ISO | AMOTL2 (Homo sapiens) | 6480464 | vorinostat results in decreased expression of AMOTL2 mRNA | CTD | PMID:27188386 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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