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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:loxtidine
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Accession:CHEBI:6550 term browser browse the term
Definition:A triazole that consists of 1,2,4-triazole bearing a methyl substituent at position 1, a hydroxymethyl substituent at position 3 and a {3-[3-(piperidin-1-ylmethyl)phenoxy]propyl}amino group at position 5. A highly potent and selective H2-receptor antagonist.
Synonyms:exact_synonym: [1-methyl-5-({3-[3-(piperidin-1-ylmethyl)phenoxy]propyl}amino)-1H-1,2,4-triazol-3-yl]methanol
 related_synonym: Formula=C19H29N5O2;   InChI=1S/C19H29N5O2/c1-23-19(21-18(15-25)22-23)20-9-6-12-26-17-8-5-7-16(13-17)14-24-10-3-2-4-11-24/h5,7-8,13,25H,2-4,6,9-12,14-15H2,1H3,(H,20,21,22);   InChIKey=VTLNPNNUIJHJQB-UHFFFAOYSA-N;   Lavoltidine;   Loxtidina;   Loxtidinum;   SMILES=Cn1nc(CO)nc1NCCCOc1cccc(CN2CCCCC2)c1;   lavoltidina;   lavoltidinum
 xref: CAS:76956-02-0;   KEGG:C11805
 xref_mesh: MESH:C039993
 xref: PMID:10219966;   PMID:11025361;   PMID:15940630;   PMID:1600050;   PMID:2038267;   PMID:2568467;   PMID:2883848;   PMID:2895888;   PMID:4041682;   PMID:6145595;   PMID:7605857;   PMID:8026255;   PMID:9131722;   Reaxys:6876968;   Wikipedia:Loxtidine


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loxtidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Areg amphiregulin multiple interactions
decreases expression		 ISO [YF 476 co-treated with loxtidine] results in decreased expression of AREG mRNA
loxtidine results in decreased expression of AREG mRNA		 CTD PMID:15940630 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535 		JBrowse link
G Reg1a regenerating family member 1 alpha decreases expression
multiple interactions		 ISO loxtidine results in decreased expression of REG1 mRNA
[YF 476 co-treated with loxtidine] results in decreased expression of REG1 mRNA		 CTD PMID:15940630 NCBI chr 4:110,892,451...110,895,115
Ensembl chr 4:110,892,453...110,895,570 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19834
    role 19810
      biological role 19808
        pharmacological role 19055
          antagonist 17244
            histamine antagonist 4893
              H2-receptor antagonist 212
                loxtidine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19834
    subatomic particle 19832
      composite particle 19832
        hadron 19832
          baryon 19832
            nucleon 19832
              atomic nucleus 19832
                atom 19832
                  main group element atom 19782
                    p-block element atom 19782
                      carbon group element atom 19731
                        carbon atom 19727
                          organic molecular entity 19727
                            organic molecule 19680
                              organic cyclic compound 19493
                                organic heterocyclic compound 18871
                                  heteroarene 17142
                                    monocyclic heteroarene 14874
                                      azole 14379
                                        triazoles 8146
                                          loxtidine 2
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