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G |
ABCA1 |
ATP binding cassette subfamily A member 1 |
decreases expression increases expression multiple interactions |
EXP ISO |
Lithocholic Acid results in decreased expression of ABCA1 mRNA; Lithocholic Acid results in decreased expression of ABCA1 protein Lithocholic Acid results in increased expression of ABCA1 mRNA NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCA1 mRNA] |
CTD |
PMID:15883047 PMID:20977460 |
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NCBI chr 9:104,781,006...104,928,155
Ensembl chr 9:104,781,006...104,928,155
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G |
ABCB1 |
ATP binding cassette subfamily B member 1 |
increases expression multiple interactions |
EXP |
Lithocholic Acid results in increased expression of ABCB1 mRNA VDR protein promotes the reaction [Lithocholic Acid results in increased expression of ABCB1 mRNA] |
CTD |
PMID:19460946 |
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NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
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G |
ABCB11 |
ATP binding cassette subfamily B member 11 |
increases expression decreases expression multiple interactions |
ISO EXP |
Lithocholic Acid results in increased expression of ABCB11 mRNA Lithocholic Acid results in decreased expression of ABCB11 mRNA Lithocholic Acid promotes the reaction [NR1H3 protein results in increased expression of ABCB11 mRNA] [Lithocholic Acid analog binds to and results in increased activity of NR1H4 protein] which results in increased expression of ABCB11 mRNA; [Lithocholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of ABCB11 mRNA |
CTD |
PMID:17256725 PMID:17963371 PMID:20359477 PMID:20977460 PMID:23034213 PMID:25055961 PMID:25582706 More...
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NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324
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G |
ABCB4 |
ATP binding cassette subfamily B member 4 |
increases expression |
ISO |
Lithocholic Acid results in increased expression of ABCB4 mRNA |
CTD |
PMID:20359477 PMID:25582706 |
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NCBI chr 7:87,365,896...87,476,027
Ensembl chr 7:87,401,696...87,480,435
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G |
ABCC1 |
ATP binding cassette subfamily C member 1 (ABCC1 blood group) |
increases expression multiple interactions |
ISO EXP |
Lithocholic Acid results in increased expression of ABCC1 mRNA; Lithocholic Acid results in increased expression of ABCC1 protein Lithocholic Acid inhibits the reaction [ABCC1 protein results in increased export of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein] [Lithocholic Acid co-treated with oltipraz] results in increased expression of ABCC1 protein; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC1 mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC1 mRNA] |
CTD |
PMID:16101123 PMID:18032408 PMID:20977460 PMID:23034213 |
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NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257
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G |
ABCC2 |
ATP binding cassette subfamily C member 2 |
increases expression affects localization multiple interactions |
EXP ISO |
Lithocholic Acid results in increased expression of ABCC2 mRNA Lithocholic Acid results in increased expression of ABCC2 mRNA; Lithocholic Acid results in increased expression of ABCC2 protein Lithocholic Acid affects the localization of ABCC2 protein [Cyclosporine results in decreased activity of ABCC2 protein] which results in increased abundance of Lithocholic Acid; [Lithocholic Acid results in increased activity of NR1I2 protein] which results in increased expression of ABCC2 mRNA [Lithocholic Acid binds to and results in increased activity of NR1I2 protein] which results in increased expression of ABCC2 mRNA [Lithocholic Acid co-treated with oltipraz] results in increased expression of ABCC2 protein; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC2 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC2 protein] |
CTD |
PMID:14570758 PMID:16436656 PMID:18032408 PMID:20888898 PMID:20977460 PMID:21311750 PMID:25582706 PMID:26198044 More...
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NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594
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G |
ABCC3 |
ATP binding cassette subfamily C member 3 |
multiple interactions decreases expression increases expression increases activity |
ISO EXP |
[Lithocholic Acid co-treated with 1,4-bis(2-(3,5-dichloropyridyloxy))benzene] results in increased expression of ABCC3 mRNA; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC3 mRNA]; NR1I3 protein affects the reaction [Lithocholic Acid results in increased expression of ABCC3 mRNA] Lithocholic Acid results in decreased expression of ABCC3 mRNA Lithocholic Acid results in increased activity of ABCC3 protein [Lithocholic Acid results in increased activity of NR1I2 protein] which results in increased expression of ABCC3 mRNA Lithocholic Acid results in increased expression of ABCC3 mRNA; Lithocholic Acid results in increased expression of ABCC3 protein |
CTD |
PMID:14570758 PMID:15358766 PMID:15824121 PMID:16436656 PMID:18032408 PMID:20888898 PMID:20977460 PMID:25055961 PMID:25582706 More...
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NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,777...50,692,253
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G |
ABCC4 |
ATP binding cassette subfamily C member 4 (PEL blood group) |
increases expression decreases expression multiple interactions |
ISO |
Lithocholic Acid results in increased expression of ABCC4 mRNA Lithocholic Acid results in decreased expression of ABCC4 mRNA 1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [Lithocholic Acid results in increased expression of ABCC4 mRNA]; [Lithocholic Acid co-treated with 1,4-bis(2-(3,5-dichloropyridyloxy))benzene] results in increased expression of ABCC4 protein; [Lithocholic Acid co-treated with oltipraz] results in increased expression of ABCC4 protein; Lithocholic Acid promotes the reaction [NR1H3 protein results in increased expression of ABCC4 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC4 mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC4 mRNA] |
CTD |
PMID:17256725 PMID:18032408 PMID:20977460 PMID:23034213 |
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NCBI chr13:95,019,835...95,301,451
Ensembl chr13:95,019,835...95,301,475
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G |
ABCC5 |
ATP binding cassette subfamily C member 5 |
multiple interactions increases expression |
ISO |
[Lithocholic Acid co-treated with oltipraz] results in increased expression of ABCC5 protein; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC5 mRNA] Lithocholic Acid results in increased expression of ABCC5 mRNA; Lithocholic Acid results in increased expression of ABCC5 protein |
CTD |
PMID:18032408 PMID:20977460 PMID:23034213 |
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NCBI chr 3:183,919,934...184,017,884
Ensembl chr 3:183,919,934...184,017,939
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G |
ABCC6 |
ATP binding cassette subfamily C member 6 |
decreases expression |
ISO |
Lithocholic Acid results in decreased expression of ABCC6 protein |
CTD |
PMID:18032408 |
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NCBI chr16:16,149,565...16,223,494
Ensembl chr16:16,149,565...16,223,522
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G |
ABCG2 |
ATP binding cassette subfamily G member 2 (JR blood group) |
multiple interactions increases expression |
ISO |
NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCG2 mRNA] |
CTD |
PMID:20977460 |
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NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628
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G |
ABCG5 |
ATP binding cassette subfamily G member 5 |
multiple interactions increases expression |
ISO EXP |
[Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in increased expression of ABCG5 mRNA Lithocholic Acid results in increased expression of ABCG5 mRNA |
CTD |
PMID:20359477 PMID:25055961 PMID:25582706 |
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NCBI chr 2:43,806,211...43,839,231
Ensembl chr 2:43,812,472...43,838,865
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G |
ABCG8 |
ATP binding cassette subfamily G member 8 |
decreases expression increases expression |
ISO |
Lithocholic Acid results in decreased expression of ABCG8 mRNA Lithocholic Acid results in increased expression of ABCG8 mRNA |
CTD |
PMID:20359477 PMID:25582706 |
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NCBI chr 2:43,838,971...43,882,988
Ensembl chr 2:43,831,942...43,882,988
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G |
ACACA |
acetyl-CoA carboxylase alpha |
multiple interactions decreases expression |
ISO |
Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of ACACA mRNA] |
CTD |
PMID:20359477 |
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NCBI chr17:37,084,992...37,406,836
Ensembl chr17:37,084,992...37,406,836
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G |
ACADVL |
acyl-CoA dehydrogenase very long chain |
decreases expression |
ISO |
Lithocholic Acid results in decreased expression of ACADVL mRNA |
CTD |
PMID:20359477 |
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NCBI chr17:7,217,125...7,225,266
Ensembl chr17:7,217,125...7,225,266
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G |
ACSL1 |
acyl-CoA synthetase long chain family member 1 |
decreases expression multiple interactions |
ISO |
Lithocholic Acid results in decreased expression of ACSL1 mRNA Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of ACSL1 mRNA] |
CTD |
PMID:20359477 |
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NCBI chr 4:184,755,595...184,826,594
Ensembl chr 4:184,755,595...184,826,818
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G |
AHR |
aryl hydrocarbon receptor |
multiple interactions decreases abundance increases secretion |
ISO |
AHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in decreased secretion of Lithocholic Acid] AHR gene mutant form results in decreased abundance of Lithocholic Acid AHR gene mutant form results in increased secretion of Lithocholic Acid |
CTD |
PMID:29452137 PMID:32679164 |
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NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
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G |
AKR1C1 |
aldo-keto reductase family 1 member C1 |
affects binding decreases activity |
EXP |
AKR1C1 protein binds to Lithocholic Acid Lithocholic Acid results in decreased activity of AKR1C1 protein |
CTD |
PMID:8573067 PMID:12604236 |
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NCBI chr10:4,963,415...4,983,283
Ensembl chr10:4,963,253...4,983,283
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G |
AKR1C2 |
aldo-keto reductase family 1 member C2 |
affects binding decreases activity |
EXP |
AKR1C2 protein binds to Lithocholic Acid; Lithocholic Acid binds to AKR1C2 protein Lithocholic Acid results in decreased activity of AKR1C2 protein |
CTD |
PMID:8486699 PMID:8573067 PMID:12604236 |
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NCBI chr10:4,987,775...5,018,000
Ensembl chr10:4,987,775...5,018,031
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G |
AKR1C3 |
aldo-keto reductase family 1 member C3 |
decreases activity |
EXP |
Lithocholic Acid results in decreased activity of AKR1C3 protein |
CTD |
PMID:12604236 PMID:21851338 |
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NCBI chr10:5,048,781...5,107,686
Ensembl chr10:5,035,354...5,107,686
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G |
ALB |
albumin |
affects binding |
EXP |
Lithocholic Acid analog binds to ALB protein |
CTD |
PMID:19900495 |
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NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
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G |
ALPL |
alkaline phosphatase, biomineralization associated |
multiple interactions |
EXP |
[Lithocholic Acid co-treated with lysophosphatidic acid] results in increased activity of ALPL protein; EGF protein promotes the reaction [Lithocholic Acid results in increased activity of ALPL protein] |
CTD |
PMID:19646460 |
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NCBI chr 1:21,508,984...21,578,410
Ensembl chr 1:21,509,397...21,578,410
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G |
ANXA1 |
annexin A1 |
increases expression |
ISO |
Lithocholic Acid results in increased expression of ANXA1 mRNA |
CTD |
PMID:20359477 |
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NCBI chr 9:73,151,865...73,170,393
Ensembl chr 9:73,151,865...73,170,393
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G |
ANXA2 |
annexin A2 |
multiple interactions increases expression |
ISO |
Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in increased expression of ANXA2 mRNA] |
CTD |
PMID:20359477 |
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NCBI chr15:60,347,151...60,397,986
Ensembl chr15:60,347,134...60,402,883
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G |
ANXA3 |
annexin A3 |
increases expression multiple interactions |
ISO |
Lithocholic Acid results in increased expression of ANXA3 mRNA Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in increased expression of ANXA3 mRNA] |
CTD |
PMID:20359477 |
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NCBI chr 4:78,551,770...78,610,447
Ensembl chr 4:78,551,747...78,610,451
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G |
ANXA4 |
annexin A4 |
multiple interactions increases expression |
ISO |
Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in increased expression of ANXA4 mRNA] |
CTD |
PMID:20359477 |
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NCBI chr 2:69,643,808...69,827,112
Ensembl chr 2:69,644,425...69,827,112
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G |
ANXA5 |
annexin A5 |
increases expression multiple interactions |
ISO |
Lithocholic Acid results in increased expression of ANXA5 mRNA Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in increased expression of ANXA5 mRNA] |
CTD |
PMID:20359477 |
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NCBI chr 4:121,667,946...121,696,980
Ensembl chr 4:121,667,946...121,696,995
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G |
APOA4 |
apolipoprotein A4 |
increases expression |
ISO |
Lithocholic Acid results in increased expression of APOA4 mRNA |
CTD |
PMID:20359477 |
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NCBI chr11:116,820,700...116,823,304
Ensembl chr11:116,820,700...116,823,304
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G |
APOC1 |
apolipoprotein C1 |
decreases expression |
ISO |
Lithocholic Acid results in decreased expression of APOC1 mRNA |
CTD |
PMID:20359477 |
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NCBI chr19:44,914,325...44,919,346
Ensembl chr19:44,914,247...44,919,349
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G |
APOC2 |
apolipoprotein C2 |
increases expression |
ISO |
Lithocholic Acid results in increased expression of APOC2 mRNA |
CTD |
PMID:20359477 |
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NCBI chr19:44,946,051...44,949,565
Ensembl chr19:44,946,035...44,949,565
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G |
APOC4 |
apolipoprotein C4 |
decreases expression |
ISO |
Lithocholic Acid results in decreased expression of APOC4 mRNA |
CTD |
PMID:20359477 |
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NCBI chr19:44,942,237...44,945,496
Ensembl chr19:44,942,237...44,945,496
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G |
AR |
androgen receptor |
multiple interactions affects binding |
EXP |
Lithocholic Acid inhibits the reaction [Dihydrotestosterone binds to AR protein] Lithocholic Acid binds to AR protein |
CTD |
PMID:15206167 |
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NCBI chr X:67,544,021...67,730,619
Ensembl chr X:67,544,021...67,730,619
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G |
BAAT |
bile acid-CoA:amino acid N-acyltransferase |
decreases expression multiple interactions |
ISO |
Lithocholic Acid results in decreased expression of BAAT mRNA 1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of BAAT mRNA]; NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of BAAT mRNA]]; NR1I3 protein promotes the reaction [Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of BAAT mRNA]]; Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of BAAT mRNA] |
CTD |
PMID:19196849 |
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NCBI chr 9:101,360,417...101,385,006
Ensembl chr 9:101,354,182...101,385,400
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G |
BAK1 |
BCL2 antagonist/killer 1 |
multiple interactions |
ISO |
[Lithocholic Acid co-treated with 1,4-bis(2-(3,5-dichloropyridyloxy))benzene] results in decreased expression of BAK1 protein; [Lithocholic Acid co-treated with Phenobarbital] results in decreased expression of BAK1 protein; [Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in decreased expression of BAK1 protein |
CTD |
PMID:19433268 |
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NCBI chr 6:33,572,552...33,580,276
Ensembl chr 6:33,572,547...33,580,293
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G |
BAX |
BCL2 associated X, apoptosis regulator |
increases expression multiple interactions |
ISO |
Lithocholic Acid results in increased expression of BAX mRNA [Lithocholic Acid co-treated with 1,4-bis(2-(3,5-dichloropyridyloxy))benzene] results in decreased expression of BAX protein; [Lithocholic Acid co-treated with 1,4-bis(2-(3,5-dichloropyridyloxy))benzene] results in increased expression of BAX mRNA; [Lithocholic Acid co-treated with oltipraz] results in increased expression of BAX mRNA; [Lithocholic Acid co-treated with Phenobarbital] results in decreased expression of BAX protein; [Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in decreased expression of BAX protein; Phenobarbital inhibits the reaction [Lithocholic Acid results in increased expression of BAX mRNA] |
CTD |
PMID:17881359 PMID:19433268 |
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NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798
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G |
BCL2L1 |
BCL2 like 1 |
multiple interactions increases expression |
ISO |
1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in increased expression of BCL2L1 mRNA]; [Lithocholic Acid co-treated with oltipraz] results in increased expression of BCL2L1 mRNA; Phenobarbital inhibits the reaction [Lithocholic Acid results in increased expression of BCL2L1 mRNA]; Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in increased expression of BCL2L1 mRNA] |
CTD |
PMID:19433268 |
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NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
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G |
BGLAP |
bone gamma-carboxyglutamate protein |
multiple interactions increases expression |
EXP |
Lithocholic Acid inhibits the reaction [Vitamin D results in increased expression of BGLAP mRNA] Lithocholic Acid results in increased expression of BGLAP mRNA |
CTD |
PMID:20055894 |
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NCBI chr 1:156,242,184...156,243,317
Ensembl chr 1:156,242,184...156,243,317
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G |
BID |
BH3 interacting domain death agonist |
multiple interactions increases cleavage |
EXP |
[[[[[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein] which results in increased cleavage of BID protein] which results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein; [[[[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein] which results in increased cleavage of BID protein] which results in increased activity of CASP9 protein; [[[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein] which results in increased cleavage of BID protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Lithocholic Acid results in increased cleavage of and results in increased activity of BID protein] Lithocholic Acid results in increased cleavage of BID protein |
CTD |
PMID:19054763 |
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NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770
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G |
BRCA2 |
BRCA2 DNA repair associated |
decreases response to substance |
EXP |
BRCA2 protein results in decreased susceptibility to Lithocholic Acid |
CTD |
PMID:20028873 |
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NCBI chr13:32,315,508...32,400,268
Ensembl chr13:32,315,086...32,400,268
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G |
CALR |
calreticulin |
affects expression |
ISO |
Lithocholic Acid affects the expression of CALR mRNA |
CTD |
PMID:18246545 |
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NCBI chr19:12,938,609...12,944,489
Ensembl chr19:12,938,578...12,944,489
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G |
CAMP |
cathelicidin antimicrobial peptide |
multiple interactions increases expression |
EXP |
[Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of CAMP mRNA; HR protein promotes the reaction [Lithocholic Acid results in increased expression of CAMP mRNA] Lithocholic Acid analog results in increased expression of CAMP mRNA; Lithocholic Acid results in increased expression of CAMP mRNA; Lithocholic Acid results in increased expression of CAMP protein |
CTD |
PMID:18180267 PMID:19733911 PMID:22466564 |
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NCBI chr 3:48,223,495...48,225,485
Ensembl chr 3:48,223,347...48,225,491
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G |
CASP1 |
caspase 1 |
increases expression multiple interactions |
ISO |
Lithocholic Acid results in increased expression of CASP1 mRNA; Lithocholic Acid results in increased expression of CASP1 protein Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in increased expression of CASP1 mRNA]; Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in increased expression of CASP1 protein] |
CTD |
PMID:29794447 |
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NCBI chr11:105,025,443...105,036,686
Ensembl chr11:105,025,397...105,035,250
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G |
CASP2 |
caspase 2 |
multiple interactions |
EXP |
benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Lithocholic Acid results in increased cleavage of and results in increased activity of CASP2 protein]; Lithocholic Acid results in increased cleavage of and results in increased activity of CASP2 protein |
CTD |
PMID:19054763 |
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NCBI chr 7:143,288,351...143,307,696
Ensembl chr 7:143,288,215...143,307,696
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G |
CASP3 |
caspase 3 |
increases cleavage multiple interactions increases expression |
ISO EXP |
Lithocholic Acid results in increased cleavage of CASP3 protein [[[[[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein] which results in increased cleavage of BID protein] which results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Lithocholic Acid results in increased cleavage of and results in increased activity of CASP3 protein]; Lithocholic Acid results in increased cleavage of and results in increased activity of CASP3 protein; TNF protein promotes the reaction [Lithocholic Acid results in increased expression of CASP3 protein] 1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in increased cleavage of CASP3 protein]; Phenobarbital inhibits the reaction [Lithocholic Acid results in increased cleavage of CASP3 protein]; Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in increased cleavage of CASP3 protein] |
CTD |
PMID:19054763 PMID:19433268 PMID:23627780 |
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NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
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G |
CASP8 |
caspase 8 |
multiple interactions |
EXP |
[[[[[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein] which results in increased cleavage of BID protein] which results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein; [[[[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein] which results in increased cleavage of BID protein] which results in increased activity of CASP9 protein; [[[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein] which results in increased cleavage of BID protein; [[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Lithocholic Acid results in increased cleavage of and results in increased activity of CASP8 protein]; Lithocholic Acid results in increased cleavage of and results in increased activity of CASP8 protein |
CTD |
PMID:19054763 |
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NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836
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G |
CASP9 |
caspase 9 |
multiple interactions |
EXP |
[[[[[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein] which results in increased cleavage of BID protein] which results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein; [[[[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein] which results in increased cleavage of BID protein] which results in increased activity of CASP9 protein; benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [Lithocholic Acid results in increased cleavage of and results in increased activity of CASP9 protein]; Lithocholic Acid results in increased cleavage of and results in increased activity of CASP9 protein |
CTD |
PMID:19054763 |
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NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
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G |
CAV1 |
caveolin 1 |
multiple interactions |
EXP |
Lithocholic Acid results in increased localization of [VDR protein co-treated with CAV1 protein] |
CTD |
PMID:20371703 |
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NCBI chr 7:116,525,009...116,561,185
Ensembl chr 7:116,524,994...116,561,179
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G |
CCNB1 |
cyclin B1 |
increases expression |
ISO |
Lithocholic Acid results in increased expression of CCNB1 mRNA |
CTD |
PMID:19000923 |
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NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245
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G |
CCT6A |
chaperonin containing TCP1 subunit 6A |
decreases expression |
EXP |
Lithocholic Acid results in decreased expression of CCT6A protein |
CTD |
PMID:21224350 |
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NCBI chr 7:56,051,765...56,063,989
Ensembl chr 7:56,051,685...56,063,989
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G |
CD14 |
CD14 molecule |
increases expression multiple interactions |
EXP |
Lithocholic Acid analog results in increased expression of CD14 mRNA; Lithocholic Acid results in increased expression of CD14 mRNA Benzo(a)pyrene promotes the reaction [Lithocholic Acid results in increased expression of CD14 mRNA] |
CTD |
PMID:18180267 PMID:19244278 |
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NCBI chr 5:140,631,732...140,633,701
Ensembl chr 5:140,631,728...140,633,700
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G |
CDH1 |
cadherin 1 |
multiple interactions |
EXP |
[Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of CDH1 mRNA; Lithocholic Acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [TNF protein results in decreased expression of and affects the localization of CDH1 protein]]; Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of and affects the localization of CDH1 protein]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of CDH1 protein]] |
CTD |
PMID:15489543 PMID:31472180 |
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NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,537
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G |
CERS1 |
ceramide synthase 1 |
increases expression |
ISO |
Lithocholic Acid results in increased expression of CERS1 mRNA |
CTD |
PMID:21480330 |
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NCBI chr19:18,868,545...18,896,982
Ensembl chr19:18,868,545...18,896,727
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G |
CERS2 |
ceramide synthase 2 |
increases expression |
ISO |
Lithocholic Acid results in increased expression of CERS2 mRNA |
CTD |
PMID:21480330 |
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NCBI chr 1:150,965,186...150,974,835
Ensembl chr 1:150,960,583...150,975,003
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G |
CES1 |
carboxylesterase 1 |
decreases expression multiple interactions |
ISO |
Lithocholic Acid results in decreased expression of CES1D mRNA Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of CES1D mRNA] |
CTD |
PMID:20359477 |
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NCBI chr16:55,802,851...55,833,096
Ensembl chr16:55,802,851...55,833,337
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G |
CFL1 |
cofilin 1 |
increases expression |
EXP |
Lithocholic Acid results in increased expression of CFL1 protein |
CTD |
PMID:21224350 |
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NCBI chr11:65,854,673...65,858,180
Ensembl chr11:65,823,022...65,862,026
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G |
CHKA |
choline kinase alpha |
increases expression multiple interactions |
ISO |
Lithocholic Acid results in increased expression of CHKA mRNA SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of CHKA mRNA] |
CTD |
PMID:21480330 PMID:23034213 |
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NCBI chr11:68,052,859...68,121,388
Ensembl chr11:68,052,859...68,121,444
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G |
CHPT1 |
choline phosphotransferase 1 |
multiple interactions decreases expression |
ISO |
[Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in decreased expression of CHPT1 mRNA Lithocholic Acid results in decreased expression of CHPT1 mRNA |
CTD |
PMID:20359477 PMID:21480330 |
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NCBI chr12:101,697,640...101,729,074
Ensembl chr12:101,696,947...101,744,140
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G |
CLDN1 |
claudin 1 |
multiple interactions |
EXP |
Lithocholic Acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [TNF protein results in decreased expression of and affects the localization of CLDN1 protein]]; Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of and affects the localization of CLDN1 protein]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of CLDN1 protein]] |
CTD |
PMID:31472180 |
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NCBI chr 3:190,305,707...190,322,446
Ensembl chr 3:190,305,707...190,322,446
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G |
COL1A1 |
collagen type I alpha 1 chain |
increases expression |
ISO |
Lithocholic Acid results in increased expression of COL1A1 mRNA |
CTD |
PMID:16436656 |
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NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632
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G |
CPT2 |
carnitine palmitoyltransferase 2 |
decreases expression |
ISO |
Lithocholic Acid results in decreased expression of CPT2 mRNA |
CTD |
PMID:20359477 |
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NCBI chr 1:53,196,824...53,214,197
Ensembl chr 1:53,196,792...53,214,197
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G |
CREB1 |
cAMP responsive element binding protein 1 |
multiple interactions |
EXP |
[PPARA protein co-treated with CREB1 protein] promotes the reaction [Lithocholic Acid results in increased expression of PTGS2 mRNA] |
CTD |
PMID:18648741 |
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NCBI chr 2:207,529,962...207,605,988
Ensembl chr 2:207,529,737...207,605,988
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G |
CROT |
carnitine O-octanoyltransferase |
multiple interactions decreases expression |
ISO |
Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of CROT mRNA] |
CTD |
PMID:20359477 |
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NCBI chr 7:87,345,664...87,399,794
Ensembl chr 7:87,345,664...87,399,794
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G |
CTNNB1 |
catenin beta 1 |
multiple interactions |
EXP |
[Lithocholic Acid binds to VDR protein] which results in decreased activity of CTNNB1 mRNA |
CTD |
PMID:20043299 |
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NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096
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G |
CXCL2 |
C-X-C motif chemokine ligand 2 |
increases expression |
ISO |
Lithocholic Acid results in increased expression of CXCL2 mRNA |
CTD |
PMID:24742700 |
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NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196
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G |
CXCL8 |
C-X-C motif chemokine ligand 8 |
multiple interactions |
EXP |
Lithocholic Acid inhibits the reaction [IL1B protein results in increased expression of CXCL8 protein] |
CTD |
PMID:18515093 |
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NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716
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G |
CYP1A1 |
cytochrome P450 family 1 subfamily A member 1 |
decreases activity |
ISO |
Lithocholic Acid results in decreased activity of CYP1A1 protein |
CTD |
PMID:18420780 |
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NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
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G |
CYP1A2 |
cytochrome P450 family 1 subfamily A member 2 |
decreases activity increases metabolic processing multiple interactions |
ISO |
Lithocholic Acid results in decreased activity of CYP1A2 protein CYP1A2 protein results in increased metabolism of Lithocholic Acid [CYP1A2 protein results in increased metabolism of Lithocholic Acid] which results in increased chemical synthesis of Lithocholic Acid analog |
CTD |
PMID:18039809 PMID:18420780 |
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NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
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G |
CYP1B1 |
cytochrome P450 family 1 subfamily B member 1 |
decreases activity |
ISO |
Lithocholic Acid results in decreased activity of CYP1B1 protein |
CTD |
PMID:18420780 |
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NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902
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G |
CYP24A1 |
cytochrome P450 family 24 subfamily A member 1 |
multiple interactions increases expression |
EXP ISO |
[Lithocholic Acid analog binds to and results in increased activity of VDR protein] which results in increased expression of CYP24A1 mRNA; [Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of CYP24A1 mRNA; Benzo(a)pyrene promotes the reaction [Lithocholic Acid results in increased expression of CYP24A1 mRNA]; HR protein inhibits the reaction [Lithocholic Acid results in increased expression of CYP24A1 mRNA]; Lithocholic Acid inhibits the reaction [NCOR2 protein binds to CYP24A1 promoter]; Lithocholic Acid inhibits the reaction [Vitamin D results in increased expression of CYP24A1 mRNA]; Lithocholic Acid promotes the reaction [VDR protein binds to CYP24A1 promoter] Lithocholic Acid analog results in increased expression of CYP24A1 mRNA; Lithocholic Acid results in increased expression of CYP24A1 mRNA [Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of CYP24A1 mRNA; Vitamin D inhibits the reaction [Lithocholic Acid results in increased expression of CYP24A1 mRNA] |
CTD |
PMID:15489543 PMID:17535892 PMID:18180267 PMID:19244278 PMID:20055894 PMID:21311750 PMID:21917910 PMID:22466564 More...
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NCBI chr20:54,143,538...54,173,986
Ensembl chr20:54,153,446...54,173,986
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G |
CYP26A1 |
cytochrome P450 family 26 subfamily A member 1 |
increases expression multiple interactions |
EXP |
Lithocholic Acid results in increased expression of CYP26A1 mRNA Lithocholic Acid promotes the reaction [Tretinoin results in increased expression of CYP26A1 mRNA] |
CTD |
PMID:18059332 |
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NCBI chr10:93,073,475...93,077,885
Ensembl chr10:93,073,475...93,077,885
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G |
CYP27A1 |
cytochrome P450 family 27 subfamily A member 1 |
multiple interactions decreases expression |
ISO |
1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP27A1 mRNA]; NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP27A1 mRNA]]; NR1I3 protein promotes the reaction [Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of CYP27A1 mRNA]]; Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of CYP27A1 mRNA] |
CTD |
PMID:19196849 PMID:20359477 |
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NCBI chr 2:218,782,147...218,815,293
Ensembl chr 2:218,781,749...218,815,293
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G |
CYP2A13 |
cytochrome P450 family 2 subfamily A member 13 |
decreases activity |
ISO |
Lithocholic Acid results in decreased activity of CYP2A1 protein |
CTD |
PMID:8889968 |
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NCBI chr19:41,088,451...41,096,195
Ensembl chr19:41,088,451...41,096,195
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G |
CYP2A7 |
cytochrome P450 family 2 subfamily A member 7 |
decreases activity |
ISO |
Lithocholic Acid results in decreased activity of CYP2A4 protein |
CTD |
PMID:18420780 |
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NCBI chr19:40,875,439...40,882,231
Ensembl chr19:40,875,439...40,882,752
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G |
CYP2B6 |
cytochrome P450 family 2 subfamily B member 6 |
decreases activity increases expression multiple interactions |
ISO |
Lithocholic Acid results in decreased activity of CYP2B10 protein Lithocholic Acid results in increased expression of CYP2B10 mRNA [1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Lithocholic Acid] results in increased expression of CYP2B10 mRNA; [Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in increased expression of CYP2B10 mRNA; [Pregnenolone Carbonitrile co-treated with Lithocholic Acid] results in increased expression of CYP2B10 mRNA; NR1I3 protein affects the reaction [Lithocholic Acid results in increased expression of CYP2B10 mRNA]; NR1I3 protein promotes the reaction [[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Lithocholic Acid] results in increased expression of CYP2B10 mRNA]; NR1I3 protein promotes the reaction [[Pregnenolone Carbonitrile co-treated with Lithocholic Acid] results in increased expression of CYP2B10 mRNA] |
CTD |
PMID:15358766 PMID:18420780 PMID:19433268 PMID:20359477 |
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NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398
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G |
CYP2C18 |
cytochrome P450 family 2 subfamily C member 18 |
increases metabolic processing multiple interactions decreases activity |
ISO |
CYP2C11 protein results in increased metabolism of Lithocholic Acid [CYP2C11 protein results in increased metabolism of Lithocholic Acid] which results in increased chemical synthesis of 3-oxocholan-24-oic acid Lithocholic Acid results in decreased activity of CYP2C11 protein |
CTD |
PMID:8889968 PMID:18039809 |
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NCBI chr10:94,683,729...94,736,190
Ensembl chr10:94,683,729...94,736,190
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G |
CYP2C19 |
cytochrome P450 family 2 subfamily C member 19 |
increases metabolic processing multiple interactions |
ISO |
CYP2C6 protein results in increased metabolism of Lithocholic Acid [CYP2C6 protein results in increased metabolism of Lithocholic Acid] which results in increased chemical synthesis of Lithocholic Acid analog |
CTD |
PMID:18039809 |
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NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547
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G |
CYP2C8 |
cytochrome P450 family 2 subfamily C member 8 |
decreases activity |
ISO |
Lithocholic Acid results in decreased activity of CYP2C29 protein |
CTD |
PMID:18420780 |
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NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497
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G |
CYP2C9 |
cytochrome P450 family 2 subfamily C member 9 |
decreases activity |
ISO |
Lithocholic Acid results in decreased activity of CYP2C9 protein |
CTD |
PMID:18420780 |
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NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
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G |
CYP2D6 |
cytochrome P450 family 2 subfamily D member 6 |
increases metabolic processing decreases activity multiple interactions |
ISO |
CYP2D6 protein results in increased metabolism of Lithocholic Acid Lithocholic Acid results in decreased activity of CYP2D22 protein [CYP2D6 protein results in increased metabolism of Lithocholic Acid] which results in increased chemical synthesis of hyodeoxycholic acid |
CTD |
PMID:18039809 PMID:18420780 |
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NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865
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G |
CYP2D7 |
cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene) |
multiple interactions increases metabolic processing |
ISO |
[CYP2D1 protein results in increased metabolism of Lithocholic Acid] which results in increased chemical synthesis of Lithocholic Acid analog |
CTD |
PMID:18039809 |
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NCBI chr22:42,139,576...42,144,483
Ensembl chr22:42,140,203...42,149,455
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G |
CYP2E1 |
cytochrome P450 family 2 subfamily E member 1 |
decreases activity |
ISO |
Lithocholic Acid results in decreased activity of CYP2E1 protein |
CTD |
PMID:18420780 |
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NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
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G |
CYP39A1 |
cytochrome P450 family 39 subfamily A member 1 |
multiple interactions |
ISO |
[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Lithocholic Acid] results in increased expression of CYP39A1 mRNA; [Phenobarbital co-treated with Lithocholic Acid] results in increased expression of CYP39A1 mRNA; NR1I3 protein promotes the reaction [[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Lithocholic Acid] results in increased expression of CYP39A1 mRNA]; NR1I3 protein promotes the reaction [[Phenobarbital co-treated with Lithocholic Acid] results in increased expression of CYP39A1 mRNA] |
CTD |
PMID:19196849 |
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NCBI chr 6:46,549,580...46,652,818
Ensembl chr 6:46,549,580...46,652,830
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G |
CYP3A4 |
cytochrome P450 family 3 subfamily A member 4 |
affects metabolic processing increases hydroxylation decreases activity multiple interactions increases metabolic processing increases expression increases oxidation increases activity |
EXP ISO |
CYP3A4 protein affects the metabolism of Lithocholic Acid CYP3A4 protein results in increased hydroxylation of Lithocholic Acid Lithocholic Acid results in decreased activity of CYP3A2 protein [CYP3A2 protein results in increased metabolism of Lithocholic Acid] which results in increased chemical synthesis of 3-oxocholan-24-oic acid; [CYP3A2 protein results in increased metabolism of Lithocholic Acid] which results in increased chemical synthesis of Lithocholic Acid analog; [CYP3A23-3A1 gene mutant form co-treated with CYP3A2 gene mutant form] affects the abundance of Lithocholic Acid Lithocholic Acid results in increased expression of CYP3A2 mRNA CYP3A4 protein results in increased oxidation of Lithocholic Acid Lithocholic Acid results in increased expression of CYP3A4 mRNA Lithocholic Acid results in increased activity of CYP3A4 protein mutant form [CYP3A4 protein results in increased hydroxylation of Lithocholic Acid] which results in increased abundance of hyodeoxycholic acid; [CYP3A4 protein results in increased metabolism of Lithocholic Acid] which results in increased abundance of 3-ketocholanoic acid; [CYP3A4 protein results in increased metabolism of Lithocholic Acid] which results in increased abundance of hyodeoxycholic acid; [CYP3A4 protein results in increased metabolism of Lithocholic Acid] which results in increased abundance of Ursodeoxycholic Acid; [CYP3A4 protein results in increased oxidation of Lithocholic Acid] which results in increased chemical synthesis of 3-ketocholanoic acid; [Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of CYP3A4 mRNA; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of Lithocholic Acid]; Lithocholic Acid promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]; tocotrienol, alpha inhibits the reaction [CYP3A4 protein results in increased oxidation of Lithocholic Acid]; tocotrienol, delta inhibits the reaction [CYP3A4 protein results in increased oxidation of Lithocholic Acid]; Tocotrienols inhibits the reaction [CYP3A4 protein results in increased oxidation of Lithocholic Acid]; VDR protein promotes the reaction [Lithocholic Acid results in increased expression of CYP3A4 mRNA] |
CTD |
PMID:8889968 PMID:15489543 PMID:15578590 PMID:15708356 PMID:17965521 PMID:18039809 PMID:18645036 PMID:19299527 PMID:19487251 PMID:19562681 PMID:20006981 PMID:20888898 PMID:31102695 PMID:34461081 PMID:36473578 More...
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NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
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G |
CYP3A5 |
cytochrome P450 family 3 subfamily A member 5 |
increases expression multiple interactions increases oxidation |
ISO EXP |
Lithocholic Acid results in increased expression of CYP3A9 mRNA [CYP3A5 protein results in increased oxidation of Lithocholic Acid] which results in increased chemical synthesis of 3-ketocholanoic acid; CYP3A5 gene polymorphism affects the reaction [CYP3A5 gene results in increased oxidation of Lithocholic Acid]; Ketoconazole inhibits the reaction [CYP3A5 protein results in increased oxidation of Lithocholic Acid]; plastochromanol 8 inhibits the reaction [CYP3A5 protein results in increased oxidation of Lithocholic Acid]; tocotrienol, alpha inhibits the reaction [CYP3A5 protein results in increased oxidation of Lithocholic Acid]; tocotrienol, delta inhibits the reaction [CYP3A5 protein results in increased oxidation of Lithocholic Acid]; Tocotrienols inhibits the reaction [CYP3A5 protein results in increased oxidation of Lithocholic Acid] |
CTD |
PMID:20888898 PMID:31102695 |
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NCBI chr 7:99,648,194...99,679,996
Ensembl chr 7:99,648,194...99,679,996
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G |
CYP3A7 |
cytochrome P450 family 3 subfamily A member 7 |
multiple interactions |
EXP |
[Lithocholic Acid results in increased activity of NR1I2 protein] which results in increased expression of CYP3A11 mRNA |
CTD |
PMID:14570758 |
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NCBI chr 7:99,705,036...99,735,196
Ensembl chr 7:99,705,036...99,735,196
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G |
CYP4F12 |
cytochrome P450 family 4 subfamily F member 12 |
decreases expression multiple interactions |
ISO |
Lithocholic Acid results in decreased expression of CYP4F14 mRNA Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of CYP4F14 mRNA] |
CTD |
PMID:20359477 |
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NCBI chr19:15,673,087...15,697,174
Ensembl chr19:15,673,018...15,697,174
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G |
CYP51A1 |
cytochrome P450 family 51 subfamily A member 1 |
decreases expression |
ISO |
Lithocholic Acid results in decreased expression of CYP51 mRNA |
CTD |
PMID:20359477 |
|
NCBI chr 7:92,112,153...92,134,803
Ensembl chr 7:92,084,987...92,134,803
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G |
CYP7A1 |
cytochrome P450 family 7 subfamily A member 1 |
decreases expression multiple interactions decreases activity |
ISO EXP |
Lithocholic Acid results in decreased expression of CYP7A1 mRNA [Lithocholic Acid analog binds to and results in increased activity of NR1H4 protein] which results in decreased expression of CYP7A1 mRNA; [Lithocholic Acid binds to and results in increased activity of NR1H4 protein] which results in decreased expression of CYP7A1 mRNA 1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP7A1 mRNA]; [Lithocholic Acid results in increased activity of NR1H4 protein] which results in increased expression of CYP7A1 mRNA; NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP7A1 mRNA]]; Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of CYP7A1 mRNA] Lithocholic Acid results in decreased activity of CYP7A1 protein |
CTD |
PMID:1175606 PMID:16436656 PMID:17963371 PMID:19196849 PMID:20359477 PMID:20671298 PMID:20888898 PMID:22531947 PMID:22982774 PMID:23034213 PMID:25055961 PMID:25582706 More...
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NCBI chr 8:58,490,178...58,500,163
Ensembl chr 8:58,490,178...58,500,163
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G |
CYP7B1 |
cytochrome P450 family 7 subfamily B member 1 |
decreases expression multiple interactions |
ISO |
Lithocholic Acid results in decreased expression of CYP7B1 mRNA 1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP7B1 mRNA]; NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP7B1 mRNA]]; NR1I3 protein promotes the reaction [Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of CYP7B1 mRNA]]; Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of CYP7B1 mRNA] |
CTD |
PMID:19196849 |
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NCBI chr 8:64,586,575...64,798,737
Ensembl chr 8:64,587,763...64,798,737
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G |
CYP8B1 |
cytochrome P450 family 8 subfamily B member 1 |
multiple interactions decreases expression |
ISO |
1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP8B1 mRNA]; NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP8B1 mRNA]]; NR1I3 protein promotes the reaction [Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of CYP8B1 mRNA]]; Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of CYP8B1 mRNA]; Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of CYP8B1 mRNA] |
CTD |
PMID:16436656 PMID:19196849 PMID:20359477 PMID:25582706 |
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NCBI chr 3:42,872,192...42,875,879
Ensembl chr 3:42,856,005...42,875,898
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G |
DEGS1 |
delta 4-desaturase, sphingolipid 1 |
increases expression |
ISO |
Lithocholic Acid results in increased expression of DEGS1 mRNA |
CTD |
PMID:21480330 |
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NCBI chr 1:224,183,240...224,193,441
Ensembl chr 1:224,175,756...224,193,441
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G |
DHRS11 |
dehydrogenase/reductase 11 |
increases oxidation |
EXP |
DHRS11 protein results in increased oxidation of Lithocholic Acid |
CTD |
PMID:30926317 |
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NCBI chr17:36,591,879...36,600,804
Ensembl chr17:36,591,879...36,600,804
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G |
DIO2 |
iodothyronine deiodinase 2 |
increases expression multiple interactions increases activity |
ISO |
Lithocholic Acid results in increased expression of DIO2 mRNA N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Lithocholic Acid results in increased activity of DIO2 protein] |
CTD |
PMID:19036883 |
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NCBI chr14:80,197,526...80,231,057
Ensembl chr14:80,197,526...80,387,757
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G |
DIO3 |
iodothyronine deiodinase 3 |
increases activity |
ISO |
Lithocholic Acid results in increased activity of DIO3 protein |
CTD |
PMID:19036883 |
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NCBI chr14:101,561,495...101,563,452
Ensembl chr14:101,560,139...101,563,452
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G |
DMP1 |
dentin matrix acidic phosphoprotein 1 |
increases expression |
ISO |
Lithocholic Acid results in increased expression of DMP1 mRNA |
CTD |
PMID:19000923 |
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NCBI chr 4:87,650,280...87,664,357
Ensembl chr 4:87,650,280...87,664,361
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G |
EFNA1 |
ephrin A1 |
multiple interactions |
EXP |
Lithocholic Acid analog inhibits the reaction [EPHA2 protein binds to EFNA1 protein]; Lithocholic Acid inhibits the reaction [[EPHA2 protein binds to EFNA1 protein] which results in increased phosphorylation of EPHA2 protein]; Lithocholic Acid inhibits the reaction [EFNA1 protein binds to EPHA2 protein]; Lithocholic Acid inhibits the reaction [EPHA2 protein binds to EFNA1 protein] |
CTD |
PMID:21479221 PMID:22529030 PMID:23489211 |
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NCBI chr 1:155,127,876...155,134,899
Ensembl chr 1:155,127,876...155,134,899
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G |
EFNB2 |
ephrin B2 |
multiple interactions |
EXP |
Lithocholic Acid inhibits the reaction [[EPHB4 protein binds to EFNB2 protein] which results in increased phosphorylation of EPHB4 protein] |
CTD |
PMID:21479221 |
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NCBI chr13:106,489,745...106,535,662
Ensembl chr13:106,489,745...106,535,662
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G |
EGF |
epidermal growth factor |
multiple interactions |
EXP |
EGF protein promotes the reaction [Lithocholic Acid results in increased activity of ALPL protein]; EGF protein promotes the reaction [Lithocholic Acid results in increased activity of TGFB1 protein] |
CTD |
PMID:19646460 |
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NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766
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G |
EPHA2 |
EPH receptor A2 |
multiple interactions increases expression |
EXP ISO |
Lithocholic Acid analog binds to and results in decreased phosphorylation of and results in decreased activity of EPHA2 protein; Lithocholic Acid analog inhibits the reaction [EPHA2 protein binds to EFNA1 protein]; Lithocholic Acid binds to and results in decreased activity of EPHA2 protein; Lithocholic Acid inhibits the reaction [[EPHA2 protein binds to EFNA1 protein] which results in increased phosphorylation of EPHA2 protein]; Lithocholic Acid inhibits the reaction [EFNA1 protein binds to EPHA2 protein]; Lithocholic Acid inhibits the reaction [EPHA2 protein binds to EFNA1 protein] Lithocholic Acid results in increased expression of EPHA2 protein Lithocholic Acid inhibits the reaction [Doxazosin results in increased phosphorylation of and results in increased activity of EPHA2 protein] |
CTD |
PMID:21479221 PMID:22529030 PMID:22845314 PMID:23489211 |
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NCBI chr 1:16,124,337...16,156,069
Ensembl chr 1:16,124,337...16,156,069
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G |
EPHB4 |
EPH receptor B4 |
multiple interactions |
EXP |
Lithocholic Acid inhibits the reaction [[EPHB4 protein binds to EFNB2 protein] which results in increased phosphorylation of EPHB4 protein] |
CTD |
PMID:21479221 |
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NCBI chr 7:100,802,565...100,827,523
Ensembl chr 7:100,802,565...100,827,523
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G |
EPHX1 |
epoxide hydrolase 1 |
multiple interactions |
ISO |
[Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in increased expression of EPHX1 mRNA |
CTD |
PMID:20359477 |
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NCBI chr 1:225,810,124...225,845,563
Ensembl chr 1:225,810,124...225,845,563
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G |
FABP6 |
fatty acid binding protein 6 |
increases expression |
EXP ISO |
Lithocholic Acid results in increased expression of FABP6 mRNA |
CTD |
PMID:15821044 PMID:25582706 |
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NCBI chr 5:160,187,381...160,238,722
Ensembl chr 5:160,187,367...160,238,735
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G |
FADS1 |
fatty acid desaturase 1 |
decreases expression |
ISO |
Lithocholic Acid results in decreased expression of FADS1 mRNA |
CTD |
PMID:20359477 |
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NCBI chr11:61,799,627...61,817,003
Ensembl chr11:61,799,627...61,829,318
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G |
FADS2 |
fatty acid desaturase 2 |
decreases expression |
ISO |
Lithocholic Acid results in decreased expression of FADS2 mRNA |
CTD |
PMID:20359477 |
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NCBI chr11:61,816,203...61,867,354
Ensembl chr11:61,792,980...61,867,354
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G |
FADS6 |
fatty acid desaturase 6 |
decreases expression |
ISO |
Lithocholic Acid results in decreased expression of FADS6 mRNA |
CTD |
PMID:20359477 |
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NCBI chr17:74,874,787...74,893,633
Ensembl chr17:74,877,302...74,893,781
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G |
FAS |
Fas cell surface death receptor |
multiple interactions |
EXP |
[[[[[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein] which results in increased cleavage of BID protein] which results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein; [[[[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein] which results in increased cleavage of BID protein] which results in increased activity of CASP9 protein; [[[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein] which results in increased cleavage of BID protein; [[Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein] which results in increased activity of CASP8 protein; [Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased activity of FAS protein; [Lithocholic Acid results in increased abundance of Reactive Oxygen Species] which results in increased localization of and results in increased activity of FAS protein; Lithocholic Acid results in increased localization of and results in increased activity of FAS protein |
CTD |
PMID:19054763 |
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NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605
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G |
FASN |
fatty acid synthase |
multiple interactions decreases expression |
ISO |
Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of FASN mRNA] |
CTD |
PMID:20359477 |
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NCBI chr17:82,078,338...82,098,236
Ensembl chr17:82,078,338...82,098,294
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G |
FGB |
fibrinogen beta chain |
multiple interactions |
ISO |
[Lithocholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of FGB mRNA |
CTD |
PMID:21311750 |
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NCBI chr 4:154,562,980...154,572,807
Ensembl chr 4:154,563,011...154,572,807
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G |
FGF19 |
fibroblast growth factor 19 |
multiple interactions increases expression |
EXP ISO |
[Lithocholic Acid results in increased activity of NR1H4 protein] which results in increased expression of FGF19 mRNA; [Lithocholic Acid results in increased activity of NR1I2 protein] which results in increased expression of FGF19 mRNA; NR1I2 protein promotes the reaction [Lithocholic Acid results in increased expression of FGF19 mRNA] Lithocholic Acid results in increased expression of FGF15 mRNA |
CTD |
PMID:17696253 PMID:22561792 PMID:25055961 PMID:25582706 |
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NCBI chr11:69,698,238...69,704,022
Ensembl chr11:69,698,238...69,704,022
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G |
FTL |
ferritin light chain |
multiple interactions |
EXP |
[Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of FTL mRNA |
CTD |
PMID:17724089 |
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NCBI chr19:48,965,309...48,966,879
Ensembl chr19:48,965,309...48,966,879
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G |
GCG |
glucagon |
multiple interactions increases secretion |
ISO |
GNAT3 protein promotes the reaction [Lithocholic Acid results in increased secretion of GCG protein] |
CTD |
PMID:23341498 |
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NCBI chr 2:162,142,882...162,152,247
Ensembl chr 2:162,142,882...162,152,404
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G |
GCLC |
glutamate-cysteine ligase catalytic subunit |
increases expression decreases expression multiple interactions affects expression |
ISO EXP |
Lithocholic Acid results in increased expression of GCLC mRNA; Lithocholic Acid results in increased expression of GCLC protein Lithocholic Acid results in decreased expression of GCLC mRNA [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of GCLC mRNA; [Lithocholic Acid results in increased expression of GCLC protein] which results in increased abundance of Glutathione; Buthionine Sulfoximine inhibits the reaction [[Lithocholic Acid results in increased expression of GCLC protein] which results in increased abundance of Glutathione]; S-Adenosylmethionine inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA]]; Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GCLC mRNA] Lithocholic Acid affects the expression of GCLC mRNA; Lithocholic Acid affects the expression of GCLC protein [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of GCLC mRNA; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of GCLC mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of GCLC protein]; Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in decreased expression of GCLC mRNA] |
CTD |
PMID:17724089 PMID:20146260 PMID:20977460 PMID:29794447 |
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NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
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G |
GCLM |
glutamate-cysteine ligase modifier subunit |
affects expression decreases expression multiple interactions increases expression |
EXP ISO |
Lithocholic Acid affects the expression of GCLM mRNA; Lithocholic Acid affects the expression of GCLM protein Lithocholic Acid results in decreased expression of GCLM mRNA [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of GCLM mRNA; Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in decreased expression of GCLM mRNA] Lithocholic Acid results in increased expression of GCLM protein [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of GCLM mRNA; [Lithocholic Acid results in increased expression of GCLM protein] which results in increased abundance of Glutathione; Buthionine Sulfoximine inhibits the reaction [[Lithocholic Acid results in increased expression of GCLM protein] which results in increased abundance of Glutathione] |
CTD |
PMID:17724089 PMID:20146260 PMID:29794447 |
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NCBI chr 1:93,885,199...93,909,430
Ensembl chr 1:93,885,199...93,909,456
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G |
GNAT3 |
G protein subunit alpha transducin 3 |
multiple interactions |
ISO |
GNAT3 protein promotes the reaction [Lithocholic Acid results in increased secretion of GCG protein] |
CTD |
PMID:23341498 |
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NCBI chr 7:80,458,635...80,512,064
Ensembl chr 7:80,458,635...80,512,064
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G |
GOT1 |
glutamic-oxaloacetic transaminase 1 |
multiple interactions increases expression |
EXP |
cucurbitacin B inhibits the reaction [Lithocholic Acid results in increased expression of GOT1 protein] |
CTD |
PMID:38104874 |
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NCBI chr10:99,396,870...99,430,624
Ensembl chr10:99,396,870...99,430,624
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G |
GPBAR1 |
G protein-coupled bile acid receptor 1 |
affects binding increases expression multiple interactions increases response to substance |
EXP ISO |
Lithocholic Acid binds to GPBAR1 protein Lithocholic Acid results in increased expression of GPBAR1 mRNA [Lithocholic Acid binds to and results in increased activity of GPBAR1 protein] which results in increased abundance of Cyclic AMP; Lithocholic Acid analog binds to and results in increased activity of GPBAR1 protein; Lithocholic Acid binds to and results in increased activity of GPBAR1 protein GPBAR1 protein results in increased susceptibility to Lithocholic Acid |
CTD |
PMID:17963371 PMID:18180267 PMID:20023205 PMID:21454404 PMID:23041323 PMID:23566200 PMID:25055961 More...
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NCBI chr 2:218,259,496...218,263,861
Ensembl chr 2:218,259,496...218,263,861
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G |
GPT |
glutamic--pyruvic transaminase |
increases expression multiple interactions |
ISO EXP |
Lithocholic Acid results in increased expression of GPT protein cucurbitacin B inhibits the reaction [Lithocholic Acid results in increased expression of GPT protein] cryptotanshinone inhibits the reaction [Lithocholic Acid results in increased expression of GPT protein]; dihydrotanshinone I inhibits the reaction [Lithocholic Acid results in increased expression of GPT protein]; Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in increased expression of GPT protein]; tanshinone inhibits the reaction [Lithocholic Acid results in increased expression of GPT protein] |
CTD |
PMID:24742700 PMID:36804361 PMID:38104874 |
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NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174
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G |
GSK3B |
glycogen synthase kinase 3 beta |
multiple interactions |
ISO |
Lithocholic Acid results in increased phosphorylation of and results in decreased activity of GSK3B protein |
CTD |
PMID:20512997 |
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NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994
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G |
GSS |
glutathione synthetase |
affects expression multiple interactions |
EXP |
Lithocholic Acid affects the expression of GSS mRNA; Lithocholic Acid affects the expression of GSS protein S-Adenosylmethionine inhibits the reaction [Lithocholic Acid affects the expression of GSS mRNA]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GSS mRNA]]; Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GSS mRNA] |
CTD |
PMID:20146260 |
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NCBI chr20:34,928,432...34,956,027
Ensembl chr20:34,928,432...34,956,027
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G |
GSTA1 |
glutathione S-transferase alpha 1 |
multiple interactions |
EXP ISO |
Lithocholic Acid binds to and results in decreased activity of GSTA1 protein Lithocholic Acid binds to [GSTA1 protein co-treated with GSTA1 protein]; Lithocholic Acid binds to [GSTA3 protein co-treated with GSTA1 protein] |
CTD |
PMID:3783048 PMID:12206662 |
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NCBI chr 6:52,791,371...52,803,816
Ensembl chr 6:52,791,371...52,803,860
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G |
GSTA2 |
glutathione S-transferase alpha 2 |
increases expression |
ISO |
Lithocholic Acid results in increased expression of GSTA2 mRNA |
CTD |
PMID:21311750 |
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NCBI chr 6:52,750,087...52,763,475
Ensembl chr 6:52,750,087...52,763,475
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G |
GSTA4 |
glutathione S-transferase alpha 4 |
multiple interactions increases expression |
ISO |
Lithocholic Acid binds to and results in decreased activity of GSTA4 protein Lithocholic Acid results in increased expression of GSTA4 mRNA |
CTD |
PMID:3954743 PMID:21311750 |
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NCBI chr 6:52,977,953...52,995,284
Ensembl chr 6:52,977,948...52,995,304
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G |
GSTM1 |
glutathione S-transferase mu 1 |
increases expression multiple interactions |
ISO |
Lithocholic Acid results in increased expression of GSTM1 mRNA NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of GSTM1 mRNA] Lithocholic Acid binds to and results in decreased activity of GSTM1 protein |
CTD |
PMID:3954743 PMID:20977460 |
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NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039
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G |
GSTM2 |
glutathione S-transferase mu 2 |
multiple interactions increases expression |
ISO |
Lithocholic Acid binds to and results in decreased activity of GSTM2 protein Lithocholic Acid results in increased expression of GSTM2 mRNA |
CTD |
PMID:3954743 PMID:21311750 |
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NCBI chr 1:109,668,057...109,683,997
Ensembl chr 1:109,668,022...109,709,551
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G |
HIF1A |
hypoxia inducible factor 1 subunit alpha |
increases expression multiple interactions |
EXP |
Lithocholic Acid results in increased expression of HIF1A mRNA; Lithocholic Acid results in increased expression of HIF1A protein cucurbitacin B inhibits the reaction [Lithocholic Acid results in increased expression of HIF1A mRNA]; cucurbitacin B inhibits the reaction [Lithocholic Acid results in increased expression of HIF1A protein] |
CTD |
PMID:38104874 |
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NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259
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G |
HLA-B |
major histocompatibility complex, class I, B |
decreases expression |
EXP |
Lithocholic Acid results in decreased expression of HLA-B mRNA |
CTD |
PMID:8196671 |
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NCBI chr 6:31,353,875...31,357,179
Ensembl chr 6:31,353,872...31,367,067
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G |
HLA-C |
major histocompatibility complex, class I, C |
decreases expression |
EXP |
Lithocholic Acid results in decreased expression of HLA-C mRNA |
CTD |
PMID:8196671 |
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NCBI chr 6:31,268,749...31,272,092
Ensembl chr 6:31,268,749...31,272,130
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G |
HMGCR |
3-hydroxy-3-methylglutaryl-CoA reductase |
multiple interactions |
ISO |
[Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in increased expression of HMGCR mRNA |
CTD |
PMID:20359477 |
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NCBI chr 5:75,336,529...75,362,116
Ensembl chr 5:75,336,329...75,364,001
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G |
HMGCS2 |
3-hydroxy-3-methylglutaryl-CoA synthase 2 |
multiple interactions decreases expression |
ISO |
Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of HMGCS2 mRNA] |
CTD |
PMID:20359477 |
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NCBI chr 1:119,747,996...119,768,932
Ensembl chr 1:119,748,002...119,768,905
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G |
HMOX1 |
heme oxygenase 1 |
multiple interactions decreases expression increases expression |
ISO EXP |
NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of HMOX1 protein]; Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in decreased expression of HMOX1 mRNA] Lithocholic Acid results in increased expression of HMOX1 mRNA; Lithocholic Acid results in increased expression of HMOX1 protein [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 mRNA; Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of HMOX1 protein]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of HMOX1 protein]] |
CTD |
PMID:17724089 PMID:20977460 PMID:24742700 PMID:29794447 PMID:31472180 |
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NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
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G |
HNF1A |
HNF1 homeobox A |
decreases expression |
ISO |
Lithocholic Acid results in decreased expression of HNF1A mRNA |
CTD |
PMID:20888898 |
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NCBI chr12:120,978,543...121,002,512
Ensembl chr12:120,978,543...121,002,512
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G |
HNF4A |
hepatocyte nuclear factor 4 alpha |
decreases expression multiple interactions |
ISO |
Lithocholic Acid results in decreased expression of HNF4A mRNA [Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in decreased expression of HNF4A mRNA |
CTD |
PMID:20359477 PMID:20888898 |
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NCBI chr20:44,355,699...44,434,596
Ensembl chr20:44,355,699...44,432,845
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G |
HR |
HR lysine demethylase and nuclear receptor corepressor |
multiple interactions |
EXP |
HR protein inhibits the reaction [Lithocholic Acid results in increased activity of VDR protein]; HR protein inhibits the reaction [Lithocholic Acid results in increased expression of CYP24A1 mRNA]; HR protein promotes the reaction [Lithocholic Acid results in increased expression of CAMP mRNA]; Lithocholic Acid promotes the reaction [VDR protein binds to HR protein]; trichostatin A inhibits the reaction [HR protein inhibits the reaction [Lithocholic Acid results in increased activity of VDR protein]] |
CTD |
PMID:22466564 |
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NCBI chr 8:22,114,419...22,131,052
Ensembl chr 8:22,114,419...22,133,384
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G |
HSPB1 |
heat shock protein family B (small) member 1 |
increases phosphorylation |
EXP |
Lithocholic Acid results in increased phosphorylation of HSPB1 protein |
CTD |
PMID:21224350 |
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NCBI chr 7:76,302,673...76,304,292
Ensembl chr 7:76,302,673...76,304,295
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G |
ICAM1 |
intercellular adhesion molecule 1 |
increases expression |
EXP ISO |
Lithocholic Acid results in increased expression of ICAM1 mRNA; Lithocholic Acid results in increased expression of ICAM1 protein |
CTD |
PMID:16582018 PMID:24742700 |
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NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615
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G |
IDH1 |
isocitrate dehydrogenase (NADP(+)) 1 |
decreases expression |
ISO |
Lithocholic Acid results in decreased expression of IDH1 mRNA |
CTD |
PMID:20359477 |
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NCBI chr 2:208,236,227...208,255,071
Ensembl chr 2:208,236,229...208,266,074
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G |
IL10 |
interleukin 10 |
increases expression decreases abundance |
ISO |
Lithocholic Acid results in increased expression of IL10 mRNA IL10 gene mutant form results in decreased abundance of Lithocholic Acid |
CTD |
PMID:24742700 PMID:27580383 |
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NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
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G |
IL1B |
interleukin 1 beta |
multiple interactions increases expression |
EXP ISO |
cucurbitacin B inhibits the reaction [Lithocholic Acid results in increased expression of IL1B mRNA]; Lithocholic Acid inhibits the reaction [IL1B protein results in increased degradation of NFKBIA protein]; Lithocholic Acid inhibits the reaction [IL1B protein results in increased expression of CXCL8 protein]; Lithocholic Acid inhibits the reaction [IL1B protein results in increased phosphorylation of RELA protein] Lithocholic Acid results in increased expression of and results in increased secretion of IL1B protein; Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in increased expression of and results in increased secretion of IL1B protein]; Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in increased expression of IL1B mRNA] |
CTD |
PMID:18515093 PMID:24742700 PMID:29794447 PMID:38104874 |
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NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
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G |
IL6 |
interleukin 6 |
increases expression multiple interactions |
ISO EXP |
Lithocholic Acid results in increased expression of IL6 mRNA; Lithocholic Acid results in increased expression of IL6 protein cucurbitacin B inhibits the reaction [Lithocholic Acid results in increased expression of IL6 mRNA]; cucurbitacin B inhibits the reaction [Lithocholic Acid results in increased expression of IL6 protein] Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in increased expression of IL6 protein] |
CTD |
PMID:24742700 PMID:29794447 PMID:38104874 |
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NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
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G |
INS |
insulin |
multiple interactions |
EXP |
[Lithocholic Acid co-treated with Glucose] results in increased secretion of INS protein |
CTD |
PMID:23022524 |
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NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,221
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G |
ITGAM |
integrin subunit alpha M |
increases expression |
EXP |
Lithocholic Acid analog results in increased expression of ITGAM mRNA |
CTD |
PMID:18180267 |
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NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892
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G |
ITGB1 |
integrin subunit beta 1 |
decreases metabolic processing |
EXP |
Lithocholic Acid results in decreased metabolism of ITGB1 protein |
CTD |
PMID:21224350 |
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NCBI chr10:32,900,318...32,958,230
Ensembl chr10:32,887,273...33,005,792
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G |
JUN |
Jun proto-oncogene, AP-1 transcription factor subunit |
increases expression |
ISO |
Lithocholic Acid results in increased expression of JUN mRNA |
CTD |
PMID:19000923 |
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NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048
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G |
JUNB |
JunB proto-oncogene, AP-1 transcription factor subunit |
increases expression |
ISO |
Lithocholic Acid results in increased expression of JUNB mRNA |
CTD |
PMID:19000923 |
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NCBI chr19:12,791,486...12,793,315
Ensembl chr19:12,791,486...12,793,315
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G |
KCNMA1 |
potassium calcium-activated channel subfamily M alpha 1 |
multiple interactions increases response to substance |
EXP ISO |
[KCNMB1 protein co-treated with KCNMA1 protein] results in increased susceptibility to Lithocholic Acid; Lithocholic Acid promotes the reaction [[KCNMB1 protein co-treated with KCNMA1 protein] results in increased transport of Calcium]; Lithocholic Acid results in increased activity of [KCNMB1 protein co-treated with KCNMA1 protein] KCNMA1 mRNA alternative form results in increased susceptibility to Lithocholic Acid KCNMA1 mRNA alternative form results in increased susceptibility to Lithocholic Acid; KCNMA1 protein results in increased susceptibility to Lithocholic Acid Lithocholic Acid analog results in increased activity of [KCNMB1 protein co-treated with KCNMA1 protein]; Lithocholic Acid results in increased activity of [KCNMB1 protein co-treated with KCNMA1 protein] |
CTD |
PMID:18242174 PMID:18650555 PMID:22123969 PMID:28090300 |
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NCBI chr10:76,869,602...77,637,808
Ensembl chr10:76,869,601...77,638,369
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G |
KCNMB1 |
potassium calcium-activated channel subfamily M regulatory beta subunit 1 |
multiple interactions increases response to substance affects binding increases activity |
EXP ISO |
[KCNMB1 protein co-treated with KCNMA1 protein] results in increased susceptibility to Lithocholic Acid; Lithocholic Acid promotes the reaction [[KCNMB1 protein co-treated with KCNMA1 protein] results in increased transport of Calcium]; Lithocholic Acid results in increased activity of [KCNMB1 protein co-treated with KCNMA1 protein] KCNMB1 protein results in increased susceptibility to Lithocholic Acid Lithocholic Acid analog results in increased activity of [KCNMB1 protein co-treated with KCNMA1 protein]; Lithocholic Acid results in increased activity of [KCNMB1 protein co-treated with KCNMA1 protein] Lithocholic Acid binds to KCNMB1 protein Lithocholic Acid analog results in increased activity of KCNMB1 protein; Lithocholic Acid results in increased activity of KCNMB1 protein |
CTD |
PMID:17468198 PMID:18650555 PMID:19852931 PMID:22123969 PMID:22945504 |
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NCBI chr 5:170,374,671...170,389,367
Ensembl chr 5:170,374,671...170,389,634
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G |
KLK6 |
kallikrein related peptidase 6 |
multiple interactions |
ISO |
[Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of KLK6 mRNA |
CTD |
PMID:21311750 |
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NCBI chr19:50,958,631...50,969,591
Ensembl chr19:50,958,631...50,969,673
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G |
LCAT |
lecithin-cholesterol acyltransferase |
decreases expression multiple interactions |
ISO |
Lithocholic Acid results in decreased expression of LCAT mRNA [Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in decreased expression of LCAT mRNA |
CTD |
PMID:20359477 |
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NCBI chr16:67,939,750...67,944,120
Ensembl chr16:67,939,750...67,944,131
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G |
LDLR |
low density lipoprotein receptor |
decreases expression |
ISO |
Lithocholic Acid results in decreased expression of LDLR mRNA |
CTD |
PMID:20359477 |
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NCBI chr19:11,089,463...11,133,820
Ensembl chr19:11,089,418...11,133,820
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G |
LPCAT1 |
lysophosphatidylcholine acyltransferase 1 |
increases expression multiple interactions |
ISO |
Lithocholic Acid results in increased expression of LPCAT1 mRNA NR1H4 protein promotes the reaction [Lithocholic Acid results in increased expression of LPCAT1 mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of LPCAT1 mRNA] |
CTD |
PMID:21480330 PMID:23034213 |
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NCBI chr 5:1,461,427...1,523,960
Ensembl chr 5:1,456,480...1,523,962
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G |
LPCAT2 |
lysophosphatidylcholine acyltransferase 2 |
increases expression multiple interactions |
ISO |
Lithocholic Acid results in increased expression of LPCAT2 mRNA NR1H4 protein promotes the reaction [Lithocholic Acid results in increased expression of LPCAT2 mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of LPCAT2 mRNA] |
CTD |
PMID:21480330 PMID:23034213 |
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NCBI chr16:55,509,072...55,586,666
Ensembl chr16:55,509,072...55,586,666
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G |
LPCAT3 |
lysophosphatidylcholine acyltransferase 3 |
decreases expression |
ISO |
Lithocholic Acid results in decreased expression of LPCAT3 mRNA |
CTD |
PMID:21480330 |
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NCBI chr12:6,976,185...7,018,476
Ensembl chr12:6,976,185...7,018,477
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G |
LPCAT4 |
lysophosphatidylcholine acyltransferase 4 |
increases expression multiple interactions |
ISO |
Lithocholic Acid results in increased expression of LPCAT4 mRNA NR1H4 protein promotes the reaction [Lithocholic Acid results in increased expression of LPCAT4 mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of LPCAT4 mRNA] |
CTD |
PMID:21480330 PMID:23034213 |
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NCBI chr15:34,358,633...34,367,196
Ensembl chr15:34,358,633...34,367,196
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G |
LPL |
lipoprotein lipase |
increases expression |
ISO |
Lithocholic Acid results in increased expression of LPL mRNA |
CTD |
PMID:20359477 |
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NCBI chr 8:19,939,253...19,967,259
Ensembl chr 8:19,901,717...19,967,259
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G |
LRP2 |
LDL receptor related protein 2 |
decreases expression |
ISO |
Lithocholic Acid results in decreased expression of LRP2 protein |
CTD |
PMID:15375181 |
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NCBI chr 2:169,127,109...169,362,534
Ensembl chr 2:169,127,109...169,362,534
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G |
LYPLA1 |
lysophospholipase 1 |
multiple interactions decreases expression |
ISO |
[Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in decreased expression of LYPLA1 mRNA Lithocholic Acid results in decreased expression of LYPLA1 mRNA |
CTD |
PMID:20359477 PMID:21480330 |
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NCBI chr 8:54,046,367...54,101,947
Ensembl chr 8:54,046,367...54,102,017
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G |
MAF |
MAF bZIP transcription factor |
multiple interactions |
EXP |
Lithocholic Acid results in increased expression of and results in increased activity of MAF protein; S-Adenosylmethionine inhibits the reaction [Lithocholic Acid results in increased expression of MAF protein]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAF protein]]; Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAF protein] |
CTD |
PMID:20146260 |
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NCBI chr16:79,202,622...79,600,737
Ensembl chr16:79,585,843...79,600,737
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G |
MAFG |
MAF bZIP transcription factor G |
multiple interactions |
EXP |
Lithocholic Acid results in increased expression of and results in increased activity of MAFG protein; S-Adenosylmethionine inhibits the reaction [Lithocholic Acid results in increased expression of MAFG protein]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAFG protein]]; Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in increased expression of MAFG protein] |
CTD |
PMID:20146260 |
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NCBI chr17:81,918,270...81,931,244
Ensembl chr17:81,918,270...81,927,735
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G |
MAP2K1 |
mitogen-activated protein kinase kinase 1 |
multiple interactions |
EXP |
MAP2K1 protein promotes the reaction [Lithocholic Acid results in increased expression of PLAUR mRNA] |
CTD |
PMID:19782465 |
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NCBI chr15:66,386,912...66,491,544
Ensembl chr15:66,386,837...66,491,656
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G |
MAPK1 |
mitogen-activated protein kinase 1 |
multiple interactions increases activity |
EXP |
[Lithocholic Acid results in increased activity of MAPK1 protein] which results in increased expression of PLAUR mRNA; MAPK1 protein promotes the reaction [Lithocholic Acid results in increased expression of PLAUR mRNA] |
CTD |
PMID:19782465 |
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NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
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G |
MAPK3 |
mitogen-activated protein kinase 3 |
multiple interactions increases activity |
EXP |
[Lithocholic Acid results in increased activity of MAPK3 protein] which results in increased expression of PLAUR mRNA |
CTD |
PMID:19782465 |
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NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
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G |
MCL1 |
MCL1 apoptosis regulator, BCL2 family member |
affects localization multiple interactions increases expression |
ISO |
Lithocholic Acid affects the localization of MCL1 protein 1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid affects the localization of MCL1 protein]; [Lithocholic Acid co-treated with oltipraz] results in increased expression of MCL1 mRNA; Phenobarbital inhibits the reaction [Lithocholic Acid affects the localization of MCL1 protein]; Phenobarbital inhibits the reaction [Lithocholic Acid results in increased expression of MCL1 mRNA]; Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid affects the localization of MCL1 protein] |
CTD |
PMID:19433268 |
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NCBI chr 1:150,574,558...150,579,610
Ensembl chr 1:150,560,895...150,579,738
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G |
MMP2 |
matrix metallopeptidase 2 |
decreases expression increases expression |
EXP ISO |
Lithocholic Acid results in decreased expression of MMP2 protein Lithocholic Acid results in increased expression of MMP2 mRNA |
CTD |
PMID:16436656 PMID:21224350 |
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NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
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G |
MMP9 |
matrix metallopeptidase 9 |
decreases expression |
EXP |
Lithocholic Acid results in decreased expression of MMP9 protein |
CTD |
PMID:21224350 |
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NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
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G |
MRAS |
muscle RAS oncogene homolog |
affects binding |
ISO |
Lithocholic Acid binds to MRAS protein |
CTD |
PMID:18641422 |
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NCBI chr 3:138,347,648...138,405,535
Ensembl chr 3:138,347,648...138,405,534
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G |
MT1A |
metallothionein 1A |
increases expression |
ISO |
Lithocholic Acid results in increased expression of MT1A mRNA |
CTD |
PMID:21311750 |
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NCBI chr16:56,638,666...56,640,087
Ensembl chr16:56,638,666...56,640,087
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G |
MT1X |
metallothionein 1X |
increases expression |
ISO |
Lithocholic Acid results in increased expression of MT1 mRNA |
CTD |
PMID:24742700 |
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NCBI chr16:56,682,470...56,684,196
Ensembl chr16:56,682,470...56,684,196
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G |
MT2A |
metallothionein 2A |
increases expression |
ISO |
Lithocholic Acid results in increased expression of MT2A mRNA |
CTD |
PMID:21311750 |
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NCBI chr16:56,608,584...56,609,497
Ensembl chr16:56,608,584...56,609,497
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G |
NCOA1 |
nuclear receptor coactivator 1 |
multiple interactions |
ISO EXP |
Lithocholic Acid inhibits the reaction [NR1I3 protein binds to NCOA1 protein] Lithocholic Acid promotes the reaction [VDR protein binds to NCOA1 protein] |
CTD |
PMID:15489543 PMID:21917910 PMID:22466564 PMID:23015691 |
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NCBI chr 2:24,491,254...24,770,702
Ensembl chr 2:24,491,254...24,770,702
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G |
NCOR1 |
nuclear receptor corepressor 1 |
multiple interactions |
EXP |
Lithocholic Acid inhibits the reaction [VDR protein binds to NCOR1 protein] |
CTD |
PMID:22466564 |
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NCBI chr17:16,029,157...16,215,534
Ensembl chr17:16,029,065...16,218,185
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G |
NCOR2 |
nuclear receptor corepressor 2 |
multiple interactions |
EXP |
Lithocholic Acid inhibits the reaction [NCOR2 protein binds to CYP24A1 promoter]; Lithocholic Acid inhibits the reaction [VDR protein binds to NCOR2 protein]; Lithocholic Acid promotes the reaction [VDR protein binds to NCOR2 protein] |
CTD |
PMID:21917910 PMID:22466564 |
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NCBI chr12:124,324,415...124,567,612
Ensembl chr12:124,324,415...124,567,612
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G |
NFE2L2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions decreases expression decreases response to substance |
ISO EXP |
[Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of GCLC mRNA; [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of GCLM mRNA; [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of NQO1 mRNA; [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of TXN1 mRNA; Lithocholic Acid results in increased localization of and results in increased activity of NFE2L2 protein; NFE2L2 protein inhibits the reaction [Lithocholic Acid results in increased expression of GSTA4 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCA1 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC1 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC2 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC2 protein]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC3 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC4 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC5 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCG2 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of GCLC mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of GCLC protein]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of GSTM1 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of HMOX1 protein]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of NQO1 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of TXNRD1 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of TXNRD1 protein]; Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in decreased expression of NFE2L2 mRNA]; Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in decreased expression of NFE2L2 protein] Lithocholic Acid results in decreased expression of NFE2L2 mRNA; Lithocholic Acid results in decreased expression of NFE2L2 protein NFE2L2 protein results in decreased susceptibility to Lithocholic Acid [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of FTL mRNA; [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of GCLC mRNA; [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of GCLM mRNA; [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 mRNA; [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of NQO1 mRNA; [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of TXN mRNA; [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of TXNRD1 mRNA; Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of and affects the localization of NFE2L2 protein]; Lithocholic Acid results in decreased expression of and results in decreased activity of NFE2L2 protein; Lithocholic Acid results in increased expression of and results in increased localization of and results in increased activity of NFE2L2 protein; S-Adenosylmethionine inhibits the reaction [Lithocholic Acid results in decreased expression of NFE2L2 protein]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in decreased expression of NFE2L2 protein]]; Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in decreased expression of NFE2L2 protein]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of NFE2L2 protein]] |
CTD |
PMID:17724089 PMID:20146260 PMID:20977460 PMID:29794447 PMID:31472180 |
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NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756
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G |
NFKBIA |
NFKB inhibitor alpha |
multiple interactions |
EXP |
Lithocholic Acid inhibits the reaction [IL1B protein results in increased degradation of NFKBIA protein]; Lithocholic Acid inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Lithocholic Acid inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]]; VDR protein promotes the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]] |
CTD |
PMID:18515093 PMID:31472180 |
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NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749
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G |
NLRP3 |
NLR family pyrin domain containing 3 |
multiple interactions increases expression |
ISO |
Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in increased expression of NLRP3 mRNA]; Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in increased expression of NLRP3 protein] Lithocholic Acid results in increased expression of NLRP3 mRNA; Lithocholic Acid results in increased expression of NLRP3 protein |
CTD |
PMID:29794447 |
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NCBI chr 1:247,416,077...247,448,817
Ensembl chr 1:247,332,331...247,449,108
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G |
NQO1 |
NAD(P)H quinone dehydrogenase 1 |
increases expression decreases expression multiple interactions |
ISO EXP |
Lithocholic Acid results in increased expression of NQO1 mRNA Lithocholic Acid results in decreased expression of NQO1 mRNA [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of NQO1 mRNA [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of NQO1 mRNA; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of NQO1 mRNA]; Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in decreased expression of NQO1 mRNA] |
CTD |
PMID:17724089 PMID:20977460 PMID:29794447 |
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NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
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G |
NR0B2 |
nuclear receptor subfamily 0 group B member 2 |
increases expression multiple interactions decreases expression |
ISO EXP |
Lithocholic Acid results in increased expression of NR0B2 mRNA Lithocholic Acid results in increased expression of NR0B2 mRNA; Lithocholic Acid results in increased expression of NR0B2 protein [Lithocholic Acid analog binds to and results in increased activity of NR1H4 protein] which results in increased expression of NR0B2 mRNA; [Lithocholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of NR0B2 mRNA [Lithocholic Acid binds to VDR protein] which results in increased expression of NR0B2 mRNA Lithocholic Acid results in decreased expression of NR0B2 mRNA [Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in decreased expression of NR0B2 mRNA |
CTD |
PMID:17963371 PMID:19562681 PMID:20359477 PMID:20888898 PMID:22540009 PMID:22982774 PMID:25055961 PMID:25582706 PMID:30419252 More...
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NCBI chr 1:26,911,489...26,913,975
Ensembl chr 1:26,911,489...26,913,975
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G |
NR1H3 |
nuclear receptor subfamily 1 group H member 3 |
decreases expression decreases response to substance multiple interactions |
ISO |
Lithocholic Acid results in decreased expression of NR1H3 mRNA NR1H3 protein results in decreased susceptibility to Lithocholic Acid Lithocholic Acid inhibits the reaction [NR1H3 protein results in increased expression of SLC51A mRNA]; Lithocholic Acid inhibits the reaction [NR1H3 protein results in increased expression of SLCO1B2 mRNA]; Lithocholic Acid promotes the reaction [NR1H3 protein results in increased expression of ABCB11 mRNA]; Lithocholic Acid promotes the reaction [NR1H3 protein results in increased expression of ABCC4 mRNA]; NR1H3 protein inhibits the reaction [Lithocholic Acid results in decreased expression of SLC10A1 mRNA]; NR1H3 protein inhibits the reaction [Lithocholic Acid results in increased expression of SLC10A2 mRNA]; NR1H3 protein inhibits the reaction [Lithocholic Acid results in increased expression of SLC51B mRNA] |
CTD |
PMID:17256725 PMID:20359477 PMID:20888898 |
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NCBI chr11:47,248,300...47,269,033
Ensembl chr11:47,248,300...47,269,033
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G |
NR1H4 |
nuclear receptor subfamily 1 group H member 4 |
multiple interactions increases expression increases activity increases response to substance decreases expression |
ISO EXP |
[Lithocholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of FGB mRNA; [Lithocholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of UGT2B15 mRNA; Lithocholic Acid binds to and results in increased activity of NR1H4 protein; NR1H4 protein inhibits the reaction [Lithocholic Acid results in increased expression of CYP3A11 mRNA] [Lithocholic Acid analog binds to and results in increased activity of NR1H4 protein] which results in decreased expression of CYP7A1 mRNA; [Lithocholic Acid analog binds to and results in increased activity of NR1H4 protein] which results in increased expression of ABCB11 mRNA; [Lithocholic Acid analog binds to and results in increased activity of NR1H4 protein] which results in increased expression of NR0B2 mRNA; [Lithocholic Acid binds to and results in increased activity of NR1H4 protein] which results in decreased expression of CYP7A1 mRNA; [Lithocholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of ABCB11 mRNA; [Lithocholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of NR0B2 mRNA; [Lithocholic Acid promotes the reaction [NR1H4 protein binds to UGT2B7 promoter]] which results in decreased expression of UGT2B7 mRNA; [Lithocholic Acid results in increased activity of NR1H4 protein] which results in increased expression of FGF19 mRNA; Lithocholic Acid analog binds to and results in increased activity of NR1H4 protein; Lithocholic Acid binds to and results in decreased activity of NR1H4 protein; Lithocholic Acid binds to and results in increased activity of NR1H4 protein; Lithocholic Acid inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; Lithocholic Acid inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]; Lithocholic Acid promotes the reaction [NR1H4 protein binds to UGT2B7 promoter] Lithocholic Acid results in increased expression of NR1H4 mRNA NR1H4 protein results in increased susceptibility to Lithocholic Acid; NR1H4 results in increased susceptibility to Lithocholic Acid 1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid inhibits the reaction [NR1I3 protein results in increased expression of NR1H4 mRNA]]; [Lithocholic Acid results in increased activity of NR1H4 protein] which results in increased expression of CYP7A1 mRNA; Lithocholic Acid inhibits the reaction [NR1I3 protein results in increased expression of NR1H4 mRNA]; NR1H4 protein promotes the reaction [Lithocholic Acid results in increased expression of LPCAT1 mRNA]; NR1H4 protein promotes the reaction [Lithocholic Acid results in increased expression of LPCAT2 mRNA]; NR1H4 protein promotes the reaction [Lithocholic Acid results in increased expression of LPCAT4 mRNA]; NR1H4 protein promotes the reaction [Lithocholic Acid results in increased expression of TGFB1 mRNA]; Phenobarbital inhibits the reaction [Lithocholic Acid inhibits the reaction [NR1I3 protein results in increased expression of NR1H4 mRNA]] Lithocholic Acid results in decreased expression of NR1H4 mRNA |
CTD |
PMID:12875239 PMID:14684751 PMID:15489543 PMID:15821044 PMID:17963371 PMID:18180267 PMID:19196849 PMID:19965603 PMID:20359477 PMID:20888898 PMID:21291553 PMID:21311750 PMID:21480330 PMID:21543282 PMID:22531947 PMID:22561792 PMID:25055961 PMID:25257666 PMID:27871908 More...
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NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414
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G |
NR1I2 |
nuclear receptor subfamily 1 group I member 2 |
decreases response to substance increases response to substance decreases expression multiple interactions increases localization increases activity |
ISO EXP |
NR1I2 protein results in decreased susceptibility to Lithocholic Acid NR1I2 results in increased susceptibility to Lithocholic Acid Lithocholic Acid results in decreased expression of NR1I2 mRNA; Lithocholic Acid results in decreased expression of NR1I2 protein [Lithocholic Acid binds to and results in increased activity of NR1I2 protein] which results in increased expression of ABCC2 mRNA; [Lithocholic Acid binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP3A23-3A1 mRNA; [NR1I2 protein co-treated with RXRA protein] promotes the reaction [Lithocholic Acid results in increased expression of SULT2A1 mRNA]; Lithocholic Acid binds to and results in increased activity of NR1I2 protein Lithocholic Acid results in increased localization of NR1I2 protein [Lithocholic Acid results in increased activity of NR1I2 protein] which results in increased expression of ABCC2 mRNA; [Lithocholic Acid results in increased activity of NR1I2 protein] which results in increased expression of ABCC3 mRNA; [Lithocholic Acid results in increased activity of NR1I2 protein] which results in increased expression of CYP3A11 mRNA; [Lithocholic Acid results in increased activity of NR1I2 protein] which results in increased expression of FGF19 mRNA; Lithocholic Acid analog binds to and results in increased activity of NR1I2 protein; Lithocholic Acid binds to and results in increased activity of NR1I2 protein; NR1I2 protein promotes the reaction [Lithocholic Acid results in increased expression of FGF19 mRNA] |
CTD |
PMID:12370413 PMID:14570758 PMID:15358766 PMID:15883047 PMID:16054614 PMID:17696253 PMID:17963371 PMID:19797606 PMID:20888898 PMID:21311750 PMID:21977915 PMID:22561792 PMID:27871908 More...
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NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487
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G |
NR1I3 |
nuclear receptor subfamily 1 group I member 3 |
increases expression decreases response to substance decreases expression multiple interactions |
ISO |
Lithocholic Acid results in increased expression of NR1I3 mRNA NR1I3 protein results in decreased susceptibility to Lithocholic Acid Lithocholic Acid results in decreased expression of NR1I3 mRNA 1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid inhibits the reaction [NR1I3 protein results in increased expression of NR1H4 mRNA]]; 1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [Lithocholic Acid affects the localization of and results in increased activity of NR1I3 protein]; [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased activity of NR1I3 protein] which results in decreased susceptibility to Lithocholic Acid; [Phenobarbital results in increased activity of NR1I3 protein] which results in decreased susceptibility to Lithocholic Acid; Lithocholic Acid affects the localization of and results in increased activity of NR1I3 protein; Lithocholic Acid inhibits the reaction [NR1I3 protein binds to NCOA1 protein]; Lithocholic Acid inhibits the reaction [NR1I3 protein results in increased expression of NR1H4 mRNA]; NR1I3 protein affects the reaction [Lithocholic Acid results in increased expression of ABCC3 mRNA]; NR1I3 protein affects the reaction [Lithocholic Acid results in increased expression of CYP2B10 mRNA]; NR1I3 protein affects the reaction [Lithocholic Acid results in increased expression of CYP3A11 mRNA]; NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of BAAT mRNA]]; NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP27A1 mRNA]]; NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP7A1 mRNA]]; NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP7B1 mRNA]]; NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP8B1 mRNA]]; NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of UGT1A1 mRNA]]; NR1I3 protein promotes the reaction [[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Lithocholic Acid] results in increased expression of CYP2B10 mRNA]; NR1I3 protein promotes the reaction [[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Lithocholic Acid] results in increased expression of CYP39A1 mRNA]; NR1I3 protein promotes the reaction [[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Lithocholic Acid] results in increased expression of CYP3A11 mRNA]; NR1I3 protein promotes the reaction [[Phenobarbital co-treated with Lithocholic Acid] results in increased expression of CYP39A1 mRNA]; NR1I3 protein promotes the reaction [[Phenobarbital co-treated with Lithocholic Acid] results in increased expression of CYP3A11 mRNA]; NR1I3 protein promotes the reaction [[Pregnenolone Carbonitrile co-treated with Lithocholic Acid] results in increased expression of CYP2B10 mRNA]; NR1I3 protein promotes the reaction [Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of BAAT mRNA]]; NR1I3 protein promotes the reaction [Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of CYP27A1 mRNA]]; NR1I3 protein promotes the reaction [Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of CYP7B1 mRNA]]; NR1I3 protein promotes the reaction [Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of CYP8B1 mRNA]]; NR1I3 protein promotes the reaction [Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of UGT1A1 mRNA]]; NR1I3 protein promotes the reaction [Phenobarbital inhibits the reaction [Lithocholic Acid results in increased abundance of Bile Acids and Salts]]; oltipraz inhibits the reaction [Lithocholic Acid affects the localization of and results in increased activity of NR1I3 protein]; Phenobarbital inhibits the reaction [Lithocholic Acid inhibits the reaction [NR1I3 protein results in increased expression of NR1H4 mRNA]]; Phenobarbital promotes the reaction [Lithocholic Acid affects the localization of and results in increased activity of NR1I3 protein]; Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid affects the localization of and results in increased activity of NR1I3 protein] |
CTD |
PMID:14742670 PMID:15358766 PMID:16929008 PMID:19196849 PMID:19433268 PMID:20359477 PMID:23015691 More...
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NCBI chr 1:161,229,669...161,238,203
Ensembl chr 1:161,229,666...161,238,244
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NR5A2 |
nuclear receptor subfamily 5 group A member 2 |
decreases expression |
ISO |
Lithocholic Acid results in decreased expression of NR5A2 mRNA |
CTD |
PMID:20888898 |
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NCBI chr 1:200,027,710...200,177,415
Ensembl chr 1:200,027,614...200,177,420
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G |
OCLN |
occludin |
multiple interactions |
EXP |
Lithocholic Acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [TNF protein results in decreased expression of and affects the localization of OCLN protein]]; Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of and affects the localization of OCLN protein]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of OCLN protein]] |
CTD |
PMID:31472180 |
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NCBI chr 5:69,492,547...69,558,104
Ensembl chr 5:69,492,292...69,558,104
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ORM1 |
orosomucoid 1 |
increases expression |
ISO |
Lithocholic Acid results in increased expression of ORM1 mRNA |
CTD |
PMID:19000923 |
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NCBI chr 9:114,323,098...114,326,479
Ensembl chr 9:114,323,098...114,326,479
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ORM2 |
orosomucoid 2 |
increases expression |
ISO |
Lithocholic Acid results in increased expression of ORM2 mRNA |
CTD |
PMID:19000923 |
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NCBI chr 9:114,329,869...114,333,251
Ensembl chr 9:114,329,869...114,333,251
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G |
PARP1 |
poly(ADP-ribose) polymerase 1 |
multiple interactions increases activity |
EXP |
3-aminobenzamide inhibits the reaction [Lithocholic Acid analog results in increased activity of PARP1 protein] |
CTD |
PMID:2120135 |
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NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154
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PCTP |
phosphatidylcholine transfer protein |
decreases expression |
ISO |
Lithocholic Acid results in decreased expression of PCTP mRNA |
CTD |
PMID:20359477 |
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NCBI chr17:55,751,051...55,852,715
Ensembl chr17:55,751,051...55,842,830
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PCYT1B |
phosphate cytidylyltransferase 1B, choline |
increases expression multiple interactions |
ISO |
Lithocholic Acid results in increased expression of PCYT1B mRNA SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of PCYT1B mRNA] |
CTD |
PMID:21480330 PMID:23034213 |
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NCBI chr X:24,558,087...24,672,887
Ensembl chr X:24,558,087...24,672,677
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PGK1 |
phosphoglycerate kinase 1 |
increases expression |
EXP |
Lithocholic Acid results in increased expression of PGK1 protein |
CTD |
PMID:21224350 |
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NCBI chr X:78,104,248...78,129,295
Ensembl chr X:77,910,739...78,129,295
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PIK3R5 |
phosphoinositide-3-kinase regulatory subunit 5 |
increases expression |
ISO |
Lithocholic Acid results in increased expression of PIK3R5 mRNA |
CTD |
PMID:19000923 |
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NCBI chr17:8,878,916...8,965,707
Ensembl chr17:8,878,911...8,965,712
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PLAUR |
plasminogen activator, urokinase receptor |
multiple interactions increases expression |
EXP |
[Lithocholic Acid results in increased activity of MAPK1 protein] which results in increased expression of PLAUR mRNA; [Lithocholic Acid results in increased activity of MAPK3 protein] which results in increased expression of PLAUR mRNA; MAP2K1 protein promotes the reaction [Lithocholic Acid results in increased expression of PLAUR mRNA]; MAPK1 protein promotes the reaction [Lithocholic Acid results in increased expression of PLAUR mRNA] |
CTD |
PMID:19782465 |
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NCBI chr19:43,646,095...43,670,169
Ensembl chr19:43,646,095...43,670,547
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G |
PLD1 |
phospholipase D1 |
increases expression multiple interactions |
ISO |
Lithocholic Acid results in increased expression of PLD1 mRNA SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of PLD1 mRNA] |
CTD |
PMID:21480330 PMID:23034213 |
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NCBI chr 3:171,600,404...171,810,483
Ensembl chr 3:171,600,404...171,810,950
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G |
PLD2 |
phospholipase D2 |
increases expression multiple interactions |
ISO |
Lithocholic Acid results in increased expression of PLD2 mRNA SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of PLD2 mRNA] |
CTD |
PMID:21480330 PMID:23034213 |
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NCBI chr17:4,807,152...4,823,430
Ensembl chr17:4,807,152...4,823,434
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G |
PLPP1 |
phospholipid phosphatase 1 |
increases expression |
ISO |
Lithocholic Acid results in increased expression of PLPP1 mRNA |
CTD |
PMID:20359477 |
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NCBI chr 5:55,424,854...55,534,964
Ensembl chr 5:55,424,854...55,534,969
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G |
PLPP2 |
phospholipid phosphatase 2 |
increases expression |
ISO |
Lithocholic Acid results in increased expression of PLPP2 mRNA |
CTD |
PMID:20359477 |
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NCBI chr19:281,043...291,403
Ensembl chr19:281,040...291,403
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PLSCR1 |
phospholipid scramblase 1 |
multiple interactions increases expression |
ISO |
Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in increased expression of PLSCR1 mRNA] |
CTD |
PMID:20359477 |
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NCBI chr 3:146,515,180...146,544,607
Ensembl chr 3:146,515,180...146,544,856
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POLB |
DNA polymerase beta |
multiple interactions |
ISO |
Lithocholic Acid analog binds to and results in decreased activity of POLB protein; Lithocholic Acid binds to and results in decreased activity of POLB protein; Lithocholic Acid binds to and results in decreased activity of POLB protein mutant form |
CTD |
PMID:15311928 PMID:15656580 PMID:16996474 |
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NCBI chr 8:42,338,494...42,371,808
Ensembl chr 8:42,338,454...42,371,808
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POR |
cytochrome p450 oxidoreductase |
increases abundance |
ISO |
POR gene mutant form results in increased abundance of Lithocholic Acid |
CTD |
PMID:25034404 |
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NCBI chr 7:75,915,155...75,986,855
Ensembl chr 7:75,899,200...75,986,855
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PPARA |
peroxisome proliferator activated receptor alpha |
decreases expression multiple interactions |
ISO EXP |
Lithocholic Acid results in decreased expression of PPARA mRNA [PPARA protein co-treated with CREB1 protein] promotes the reaction [Lithocholic Acid results in increased expression of PTGS2 mRNA] [Lithocholic Acid co-treated with Pregnenolone Carbonitrile] results in decreased expression of PPARA mRNA |
CTD |
PMID:18648741 PMID:20359477 |
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NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,755
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PRKCB |
protein kinase C beta |
increases activity |
EXP |
Lithocholic Acid results in increased activity of PRKCB protein |
CTD |
PMID:7705931 |
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NCBI chr16:23,835,983...24,220,611
Ensembl chr16:23,835,983...24,220,611
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PSMB4 |
proteasome 20S subunit beta 4 |
decreases expression affects expression |
ISO |
Lithocholic Acid results in decreased expression of PSMB4 mRNA Lithocholic Acid affects the expression of PSMB4 mRNA |
CTD |
PMID:18246545 |
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NCBI chr 1:151,399,573...151,401,937
Ensembl chr 1:151,399,560...151,401,937
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PTGS2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions increases expression |
EXP |
[PPARA protein co-treated with CREB1 protein] promotes the reaction [Lithocholic Acid results in increased expression of PTGS2 mRNA]; [SLCO1B3 protein results in increased transport of Lithocholic Acid] which results in increased expression of PTGS2 mRNA |
CTD |
PMID:18648741 |
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NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
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G |
PTK2 |
protein tyrosine kinase 2 |
multiple interactions |
EXP |
Lithocholic Acid results in decreased phosphorylation of and results in decreased activity of PTK2 protein |
CTD |
PMID:21224350 |
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NCBI chr 8:140,657,900...141,002,079
Ensembl chr 8:140,657,900...141,002,216
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G |
PXN |
paxillin |
multiple interactions |
EXP |
Lithocholic Acid results in decreased phosphorylation of and results in decreased activity of PXN protein |
CTD |
PMID:21224350 |
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NCBI chr12:120,210,447...120,265,730
Ensembl chr12:120,210,439...120,265,771
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PYCARD |
PYD and CARD domain containing |
increases expression multiple interactions |
ISO |
Lithocholic Acid results in increased expression of PYCARD mRNA; Lithocholic Acid results in increased expression of PYCARD protein Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in increased expression of PYCARD mRNA]; Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in increased expression of PYCARD protein] |
CTD |
PMID:29794447 |
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NCBI chr16:31,201,486...31,202,760
Ensembl chr16:31,201,486...31,203,450
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RAB12 |
RAB12, member RAS oncogene family |
affects binding |
ISO |
Lithocholic Acid binds to RAB12 protein |
CTD |
PMID:18641422 |
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NCBI chr18:8,609,437...8,639,383
Ensembl chr18:8,609,437...8,639,383
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G |
RAB3A |
RAB3A, member RAS oncogene family |
affects binding |
ISO |
Lithocholic Acid binds to RAB3A protein |
CTD |
PMID:18641422 |
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NCBI chr19:18,196,784...18,204,042
Ensembl chr19:18,196,784...18,204,042
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G |
RAB3D |
RAB3D, member RAS oncogene family |
affects binding |
ISO |
Lithocholic Acid binds to RAB3D protein |
CTD |
PMID:18641422 |
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NCBI chr19:11,322,068...11,339,657
Ensembl chr19:11,322,068...11,346,270
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G |
RANGAP1 |
Ran GTPase activating protein 1 |
increases phosphorylation |
EXP |
Lithocholic Acid results in increased phosphorylation of RANGAP1 protein |
CTD |
PMID:21224350 |
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NCBI chr22:41,244,779...41,302,369
Ensembl chr22:41,244,779...41,286,187
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G |
RELA |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
EXP |
Lithocholic Acid inhibits the reaction [IL1B protein results in increased phosphorylation of RELA protein]; Lithocholic Acid inhibits the reaction [TNF protein results in increased phosphorylation of and affects the localization of RELA protein]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]] |
CTD |
PMID:18515093 PMID:31472180 |
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NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090
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G |
RNH1 |
ribonuclease/angiogenin inhibitor 1 |
increases expression |
EXP |
Lithocholic Acid results in increased expression of RNH1 protein |
CTD |
PMID:21224350 |
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NCBI chr11:494,515...507,242
Ensembl chr11:494,512...507,300
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G |
RXRA |
retinoid X receptor alpha |
multiple interactions |
ISO EXP |
Lithocholic Acid promotes the reaction [VDR protein binds to RXRA protein] [NR1I2 protein co-treated with RXRA protein] promotes the reaction [Lithocholic Acid results in increased expression of SULT2A1 mRNA] |
CTD |
PMID:12370413 PMID:15578590 PMID:15824121 PMID:20153625 PMID:21917910 |
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NCBI chr 9:134,326,455...134,440,585
Ensembl chr 9:134,317,098...134,440,585
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G |
RXRB |
retinoid X receptor beta |
affects binding |
EXP |
Lithocholic Acid binds to RXRB protein |
CTD |
PMID:11939783 |
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NCBI chr 6:33,193,588...33,200,853
Ensembl chr 6:33,193,588...33,200,665
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G |
S100G |
S100 calcium binding protein G |
increases expression |
ISO |
Lithocholic Acid results in increased expression of S100G mRNA |
CTD |
PMID:15824121 PMID:17535892 |
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NCBI chr X:16,650,158...16,654,670
Ensembl chr X:16,650,158...16,654,670
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G |
SCARB1 |
scavenger receptor class B member 1 |
decreases expression increases expression |
EXP ISO |
Lithocholic Acid results in decreased expression of SCARB1 mRNA; Lithocholic Acid results in decreased expression of SCARB1 protein Lithocholic Acid results in increased expression of SCARB1 mRNA |
CTD |
PMID:15883047 PMID:19000923 |
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NCBI chr12:124,776,856...124,863,864
Ensembl chr12:124,776,856...124,882,668
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G |
SGMS1 |
sphingomyelin synthase 1 |
increases expression |
ISO |
Lithocholic Acid results in increased expression of SGMS1 mRNA |
CTD |
PMID:21480330 |
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NCBI chr10:50,305,600...50,625,184
Ensembl chr10:50,305,586...50,625,163
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G |
SIRT1 |
sirtuin 1 |
multiple interactions |
EXP |
Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of SIRT1 protein]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of SIRT1 protein]] |
CTD |
PMID:31472180 |
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NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390
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G |
SLC10A1 |
solute carrier family 10 member 1 |
multiple interactions decreases expression |
ISO |
[Lithocholic Acid co-treated with 1,4-bis(2-(3,5-dichloropyridyloxy))benzene] results in increased expression of SLC10A1 mRNA; NR1H3 protein inhibits the reaction [Lithocholic Acid results in decreased expression of SLC10A1 mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in decreased expression of SLC10A1 mRNA] Lithocholic Acid results in decreased expression of SLC10A1 mRNA; Lithocholic Acid results in decreased expression of SLC10A1 protein |
CTD |
PMID:12637555 PMID:16436656 PMID:17256725 PMID:18032408 PMID:20977460 PMID:23034213 PMID:25582706 More...
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NCBI chr14:69,775,416...69,797,241
Ensembl chr14:69,775,416...69,797,241
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SLC10A2 |
solute carrier family 10 member 2 |
multiple interactions increases expression |
ISO |
NR1H3 protein inhibits the reaction [Lithocholic Acid results in increased expression of SLC10A2 mRNA] |
CTD |
PMID:17256725 PMID:25582706 |
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NCBI chr13:103,043,998...103,066,417
Ensembl chr13:103,043,998...103,066,417
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G |
SLC2A1 |
solute carrier family 2 member 1 |
increases expression |
ISO |
Lithocholic Acid results in increased expression of SLC2A1 mRNA |
CTD |
PMID:19000923 |
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NCBI chr 1:42,925,353...42,958,868
Ensembl chr 1:42,925,353...42,958,893
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G |
SLC51A |
solute carrier family 51 member A |
multiple interactions increases expression |
ISO EXP |
[Lithocholic Acid binds to VDR protein] which affects the expression of SLC51A mRNA Lithocholic Acid results in increased expression of SLC51A mRNA Lithocholic Acid inhibits the reaction [NR1H3 protein results in increased expression of SLC51A mRNA] |
CTD |
PMID:17256725 PMID:19562681 PMID:25055961 PMID:25582706 |
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NCBI chr 3:196,216,534...196,233,427
Ensembl chr 3:196,211,487...196,243,178
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G |
SLC51B |
SLC51 subunit beta |
multiple interactions increases expression |
ISO EXP |
NR1H3 protein inhibits the reaction [Lithocholic Acid results in increased expression of SLC51B mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of SLC51B mRNA] [Lithocholic Acid binds to VDR protein] which affects the expression of SLC51B mRNA |
CTD |
PMID:17256725 PMID:19562681 PMID:23034213 PMID:25055961 |
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NCBI chr15:65,045,387...65,053,397
Ensembl chr15:65,045,387...65,053,397
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G |
SLCO1B1 |
solute carrier organic anion transporter family member 1B1 |
increases abundance increases uptake multiple interactions |
EXP |
SLCO1B1 SNP results in increased abundance of Lithocholic Acid SLCO1B1 protein results in increased uptake of Lithocholic Acid [SLCO1B1 SNP results in increased abundance of Lithocholic Acid] which results in increased susceptibility to Simvastatin |
CTD |
PMID:16534140 PMID:22022402 |
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NCBI chr12:21,131,194...21,239,796
Ensembl chr12:21,131,194...21,239,796
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G |
SLCO1B3 |
solute carrier organic anion transporter family member 1B3 |
increases transport increases expression multiple interactions decreases expression increases uptake |
EXP ISO |
SLCO1B3 protein results in increased transport of Lithocholic Acid Lithocholic Acid results in increased expression of SLCO1B2 mRNA Lithocholic Acid results in increased expression of SLCO1B3 mRNA Lithocholic Acid inhibits the reaction [NR1H3 protein results in increased expression of SLCO1B2 mRNA] Lithocholic Acid results in decreased expression of SLCO1B2 mRNA SLCO1B3 protein results in increased uptake of Lithocholic Acid [SLCO1B3 protein results in increased transport of Lithocholic Acid] which results in increased expression of PTGS2 mRNA |
CTD |
PMID:12637555 PMID:16534140 PMID:17256725 PMID:18648741 PMID:25055961 PMID:25582706 More...
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NCBI chr12:20,810,705...20,916,911
Ensembl chr12:20,810,702...20,916,911
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G |
SMAD3 |
SMAD family member 3 |
multiple interactions increases response to substance |
ISO |
SMAD3 protein promotes the reaction [Lithocholic Acid results in decreased expression of SLC10A1 mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC1 mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC4 mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of CHKA mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of LPCAT1 mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of LPCAT2 mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of LPCAT4 mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of PCYT1B mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of PLD1 mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of PLD2 mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of SLC51B mRNA] SMAD3 protein results in increased susceptibility to Lithocholic Acid |
CTD |
PMID:23034213 |
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NCBI chr15:67,065,602...67,195,169
Ensembl chr15:67,063,763...67,195,173
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G |
SMPD3 |
sphingomyelin phosphodiesterase 3 |
increases expression |
ISO |
Lithocholic Acid results in increased expression of SMPD3 mRNA |
CTD |
PMID:21480330 |
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NCBI chr16:68,358,327...68,448,508
Ensembl chr16:68,358,327...68,448,508
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G |
SOD1 |
superoxide dismutase 1 |
increases expression |
ISO |
Lithocholic Acid results in increased expression of SOD1 mRNA |
CTD |
PMID:21311750 |
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NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931
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G |
SPTLC1 |
serine palmitoyltransferase long chain base subunit 1 |
increases expression |
ISO |
Lithocholic Acid results in increased expression of SPTLC1 mRNA |
CTD |
PMID:21480330 |
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NCBI chr 9:92,031,147...92,115,413
Ensembl chr 9:92,000,087...92,115,413
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G |
SPTLC2 |
serine palmitoyltransferase long chain base subunit 2 |
increases expression |
ISO |
Lithocholic Acid results in increased expression of SPTLC2 mRNA |
CTD |
PMID:21480330 |
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NCBI chr14:77,505,997...77,616,637
Ensembl chr14:77,505,997...77,616,637
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G |
SREBF1 |
sterol regulatory element binding transcription factor 1 |
multiple interactions decreases expression |
ISO |
Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of SREBF1 mRNA] |
CTD |
PMID:20359477 |
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NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002
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G |
ST3GAL1 |
ST3 beta-galactoside alpha-2,3-sialyltransferase 1 |
multiple interactions |
EXP |
Lithocholic Acid analog results in decreased expression of and results in decreased activity of ST3GAL1 protein |
CTD |
PMID:21224350 |
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NCBI chr 8:133,454,848...133,571,887
Ensembl chr 8:133,454,848...133,571,926
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G |
ST3GAL3 |
ST3 beta-galactoside alpha-2,3-sialyltransferase 3 |
decreases activity |
EXP |
Lithocholic Acid analog results in decreased activity of ST3GAL3 protein |
CTD |
PMID:21224350 |
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NCBI chr 1:43,707,536...43,931,159
Ensembl chr 1:43,705,824...43,931,165
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G |
ST3GAL4 |
ST3 beta-galactoside alpha-2,3-sialyltransferase 4 |
increases phosphorylation |
EXP |
Lithocholic Acid results in increased phosphorylation of ST3GAL4 protein |
CTD |
PMID:21224350 |
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NCBI chr11:126,355,686...126,414,638
Ensembl chr11:126,355,640...126,440,344
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G |
ST6GAL1 |
ST6 beta-galactoside alpha-2,6-sialyltransferase 1 |
decreases activity |
EXP |
Lithocholic Acid analog results in decreased activity of ST6GAL1 protein |
CTD |
PMID:21224350 |
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NCBI chr 3:186,930,526...187,078,553
Ensembl chr 3:186,930,325...187,078,553
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G |
STAT3 |
signal transducer and activator of transcription 3 |
multiple interactions |
EXP |
cucurbitacin B inhibits the reaction [Lithocholic Acid results in increased expression of and results in increased phosphorylation of STAT3 mRNA]; Lithocholic Acid results in increased expression of and results in increased phosphorylation of STAT3 mRNA |
CTD |
PMID:38104874 |
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NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568
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G |
STIM1 |
stromal interaction molecule 1 |
affects localization |
ISO |
Lithocholic Acid affects the localization of STIM1 protein |
CTD |
PMID:18342630 |
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NCBI chr11:3,854,604...4,093,210
Ensembl chr11:3,854,527...4,093,210
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G |
STMN1 |
stathmin 1 |
increases expression |
ISO |
Lithocholic Acid results in increased expression of STMN1 mRNA |
CTD |
PMID:19000923 |
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NCBI chr 1:25,884,179...25,906,880
Ensembl chr 1:25,884,181...25,906,991
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G |
SULT2A1 |
sulfotransferase family 2A member 1 |
increases sulfation multiple interactions increases expression |
EXP ISO |
SULT2A1 protein results in increased sulfation of Lithocholic Acid [Cyclosporine results in decreased activity of SULT2A1 protein] which results in increased abundance of Lithocholic Acid [NR1I2 protein co-treated with RXRA protein] promotes the reaction [Lithocholic Acid results in increased expression of SULT2A1 mRNA] |
CTD |
PMID:12370413 PMID:20102295 PMID:21839837 PMID:26198044 PMID:36473578 |
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NCBI chr19:47,870,467...47,886,315
Ensembl chr19:47,870,467...47,886,315
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G |
TFRC |
transferrin receptor |
increases expression |
ISO |
Lithocholic Acid results in increased expression of TFRC mRNA |
CTD |
PMID:19000923 |
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NCBI chr 3:196,049,284...196,082,090
Ensembl chr 3:196,012,511...196,082,153
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G |
TGFB1 |
transforming growth factor beta 1 |
increases expression multiple interactions |
ISO EXP |
Lithocholic Acid results in increased expression of TGFB1 mRNA EGF protein promotes the reaction [Lithocholic Acid results in increased activity of TGFB1 protein] NR1H4 protein promotes the reaction [Lithocholic Acid results in increased expression of TGFB1 mRNA] |
CTD |
PMID:19646460 PMID:21480330 PMID:23034213 |
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NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
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G |
TGFBR1 |
transforming growth factor beta receptor 1 |
increases expression |
ISO |
Lithocholic Acid results in increased expression of TGFBR1 mRNA |
CTD |
PMID:23034213 |
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NCBI chr 9:99,103,647...99,154,192
Ensembl chr 9:99,104,038...99,154,192
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G |
TGFBR2 |
transforming growth factor beta receptor 2 |
increases expression |
ISO |
Lithocholic Acid results in increased expression of TGFBR2 mRNA |
CTD |
PMID:23034213 |
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NCBI chr 3:30,606,356...30,694,142
Ensembl chr 3:30,606,478...30,694,249
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G |
TIMP1 |
TIMP metallopeptidase inhibitor 1 |
increases expression |
ISO |
Lithocholic Acid results in increased expression of TIMP1 mRNA |
CTD |
PMID:16436656 |
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NCBI chr X:47,582,436...47,586,789
Ensembl chr X:47,582,408...47,586,789
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G |
TJP1 |
tight junction protein 1 |
multiple interactions |
EXP |
Lithocholic Acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [TNF protein results in decreased expression of and affects the localization of TJP1 protein]]; Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of and affects the localization of TJP1 protein]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of TJP1 protein]] |
CTD |
PMID:31472180 |
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NCBI chr15:29,699,367...29,969,049
Ensembl chr15:29,699,367...29,968,915
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G |
TNF |
tumor necrosis factor |
multiple interactions increases expression |
EXP ISO |
cucurbitacin B inhibits the reaction [Lithocholic Acid results in increased expression of TNF mRNA]; cucurbitacin B inhibits the reaction [Lithocholic Acid results in increased expression of TNF protein]; Lithocholic Acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [TNF protein results in decreased expression of and affects the localization of CDH1 protein]]; Lithocholic Acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [TNF protein results in decreased expression of and affects the localization of CLDN1 protein]]; Lithocholic Acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [TNF protein results in decreased expression of and affects the localization of OCLN protein]]; Lithocholic Acid inhibits the reaction [6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [TNF protein results in decreased expression of and affects the localization of TJP1 protein]]; Lithocholic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of and affects the localization of CDH1 protein]; Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of and affects the localization of CLDN1 protein]; Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of and affects the localization of NFE2L2 protein]; Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of and affects the localization of OCLN protein]; Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of and affects the localization of TJP1 protein]; Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of HMOX1 protein]; Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of SIRT1 protein]; Lithocholic Acid inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Lithocholic Acid inhibits the reaction [TNF protein results in increased phosphorylation of and affects the localization of RELA protein]; Lithocholic Acid inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; TNF protein promotes the reaction [Lithocholic Acid results in increased expression of CASP3 protein]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of CDH1 protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of CLDN1 protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of HMOX1 protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of NFE2L2 protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of OCLN protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of SIRT1 protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of TJP1 protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]]; VDR protein promotes the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]] Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in increased expression of TNF protein] Lithocholic Acid results in increased expression of TNF mRNA; Lithocholic Acid results in increased expression of TNF protein |
CTD |
PMID:18515093 PMID:21480330 PMID:23566200 PMID:23627780 PMID:29794447 PMID:31472180 PMID:38104874 More...
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NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
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G |
TNFSF11 |
TNF superfamily member 11 |
multiple interactions |
EXP |
Lithocholic Acid inhibits the reaction [Vitamin D results in increased expression of TNFSF11 mRNA] |
CTD |
PMID:20055894 |
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NCBI chr13:42,562,736...42,608,013
Ensembl chr13:42,562,736...42,608,013
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G |
TRAP1 |
TNF receptor associated protein 1 |
decreases expression |
EXP |
Lithocholic Acid results in decreased expression of TRAP1 protein |
CTD |
PMID:21224350 |
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NCBI chr16:3,658,037...3,717,524
Ensembl chr16:3,651,639...3,717,553
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G |
TRPV6 |
transient receptor potential cation channel subfamily V member 6 |
multiple interactions increases expression |
EXP ISO |
[Lithocholic Acid analog binds to and results in increased activity of VDR protein] which results in increased expression of TRPV6 mRNA; [Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of TRPV6 mRNA Lithocholic Acid results in increased expression of TRPV6 mRNA |
CTD |
PMID:15489543 PMID:17535892 PMID:18180267 |
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NCBI chr 7:142,871,208...142,885,745
Ensembl chr 7:142,871,208...142,885,745
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G |
TXN |
thioredoxin |
multiple interactions increases expression |
EXP ISO |
[Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of TXN mRNA [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of TXN1 mRNA Lithocholic Acid results in increased expression of TXN protein |
CTD |
PMID:17724089 |
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NCBI chr 9:110,243,810...110,256,507
Ensembl chr 9:110,243,810...110,256,507
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G |
TXNRD1 |
thioredoxin reductase 1 |
increases expression multiple interactions |
ISO EXP |
Lithocholic Acid results in increased expression of TXNRD1 mRNA; Lithocholic Acid results in increased expression of TXNRD1 protein [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of TXNRD1 mRNA NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of TXNRD1 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of TXNRD1 protein] |
CTD |
PMID:17724089 PMID:20977460 |
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NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307
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G |
UGT1A1 |
UDP glucuronosyltransferase family 1 member A1 |
multiple interactions decreases expression |
ISO |
1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of UGT1A1 mRNA]; NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of UGT1A1 mRNA]]; NR1I3 protein promotes the reaction [Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of UGT1A1 mRNA]]; Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of UGT1A1 mRNA] |
CTD |
PMID:19196849 |
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NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300
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G |
UGT1A3 |
UDP glucuronosyltransferase family 1 member A3 |
increases expression multiple interactions |
EXP |
Lithocholic Acid results in increased expression of UGT1A3 mRNA [Uridine Diphosphate Glucuronic Acid co-treated with UGT1A3 protein] results in increased metabolism of Lithocholic Acid |
CTD |
PMID:20189675 PMID:36473578 |
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NCBI chr 2:233,729,042...233,773,300
Ensembl chr 2:233,729,042...233,773,300
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G |
UGT2B17 |
UDP glucuronosyltransferase family 2 member B17 |
increases expression |
ISO |
Lithocholic Acid results in increased expression of UGT2B17 mRNA |
CTD |
PMID:21311750 |
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NCBI chr 4:68,537,173...68,576,322
Ensembl chr 4:68,537,173...68,576,413
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G |
UGT2B7 |
UDP glucuronosyltransferase family 2 member B7 |
multiple interactions |
EXP |
[Lithocholic Acid promotes the reaction [NR1H4 protein binds to UGT2B7 promoter]] which results in decreased expression of UGT2B7 mRNA; Lithocholic Acid promotes the reaction [NR1H4 protein binds to UGT2B7 promoter] |
CTD |
PMID:15821044 |
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NCBI chr 4:69,051,375...69,112,987
Ensembl chr 4:69,051,363...69,112,987
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G |
VCAM1 |
vascular cell adhesion molecule 1 |
increases expression |
EXP |
Lithocholic Acid results in increased expression of VCAM1 mRNA; Lithocholic Acid results in increased expression of VCAM1 protein |
CTD |
PMID:16582018 |
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NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045
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G |
VDR |
vitamin D receptor |
multiple interactions affects binding increases phosphorylation increases activity increases expression decreases expression |
ISO EXP |
Lithocholic Acid binds to and results in increased activity of VDR protein; Lithocholic Acid binds to and results in increased activity of VDR protein mutant form; Lithocholic Acid promotes the reaction [VDR protein binds to RXRA protein]; VDR protein promotes the reaction [Lithocholic Acid results in increased expression of CYP3A4 mRNA]; VDR protein promotes the reaction [Lithocholic Acid results in increased expression of CYP3A4 protein] Lithocholic Acid analog binds to VDR protein; Lithocholic Acid binds to VDR protein; Lithocholic Acid binds to VDR protein mutant form Lithocholic Acid results in increased phosphorylation of VDR protein [Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of CYP24A1 mRNA; [Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of KLK6 mRNA; [Lithocholic Acid binds to VDR protein] which affects the expression of SLC51A mRNA; [Lithocholic Acid binds to VDR protein] which affects the expression of SLC51B mRNA; [Lithocholic Acid binds to VDR protein] which results in increased expression of NR0B2 mRNA; Lithocholic Acid binds to and results in increased activity of VDR protein Lithocholic Acid metabolite results in increased activity of VDR protein; Lithocholic Acid results in increased activity of VDR protein [Lithocholic Acid analog binds to and results in increased activity of VDR protein] which results in increased expression of CYP24A1 mRNA; [Lithocholic Acid analog binds to and results in increased activity of VDR protein] which results in increased expression of TRPV6 mRNA; [Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of CAMP mRNA; [Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of CDH1 mRNA; [Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of CYP24A1 mRNA; [Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of CYP3A4 mRNA; [Lithocholic Acid binds to and results in increased activity of VDR protein] which results in increased expression of TRPV6 mRNA; [Lithocholic Acid binds to VDR protein] which results in decreased activity of CTNNB1 mRNA; HR protein inhibits the reaction [Lithocholic Acid results in increased activity of VDR protein]; Lithocholic Acid analog binds to and results in increased activity of VDR protein; Lithocholic Acid binds to and results in increased activity of and results in increased localization of VDR protein; Lithocholic Acid binds to and results in increased activity of VDR protein; Lithocholic Acid binds to and results in increased activity of VDR protein mutant form; Lithocholic Acid inhibits the reaction [1,25-dihydroxy-26,27-dimethylcholecalciferol binds to VDR protein]; Lithocholic Acid inhibits the reaction [VDR protein binds to NCOR1 protein]; Lithocholic Acid inhibits the reaction [VDR protein binds to NCOR2 protein]; Lithocholic Acid promotes the reaction [VDR protein binds to CYP24A1 promoter]; Lithocholic Acid promotes the reaction [VDR protein binds to HR protein]; Lithocholic Acid promotes the reaction [VDR protein binds to NCOA1 protein]; Lithocholic Acid promotes the reaction [VDR protein binds to NCOR2 protein]; Lithocholic Acid promotes the reaction [VDR protein binds to RXRA protein]; Lithocholic Acid results in increased expression of and results in increased activity of VDR protein; Lithocholic Acid results in increased localization of [VDR protein co-treated with CAV1 protein]; trichostatin A inhibits the reaction [HR protein inhibits the reaction [Lithocholic Acid results in increased activity of VDR protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of CDH1 protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of CLDN1 protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of HMOX1 protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of NFE2L2 protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of OCLN protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of SIRT1 protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of TJP1 protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]]; VDR protein promotes the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]; VDR protein promotes the reaction [Lithocholic Acid results in increased expression of ABCB1 mRNA]; VDR protein promotes the reaction [Lithocholic Acid results in increased expression of CYP3A4 mRNA] Lithocholic Acid results in increased expression of VDR mRNA; Lithocholic Acid results in increased expression of VDR protein Lithocholic Acid results in decreased expression of VDR mRNA |
CTD |
PMID:14525957 PMID:15489543 PMID:15578590 PMID:15824121 PMID:17963371 PMID:18180267 PMID:18515093 PMID:18645036 PMID:19460946 PMID:19562681 PMID:19646460 PMID:19733911 PMID:20006981 PMID:20043299 PMID:20153625 PMID:20371703 PMID:20435140 PMID:21291553 PMID:21311750 PMID:21397016 PMID:21543282 PMID:21917910 PMID:22466564 PMID:23723390 PMID:27871908 PMID:31472180 More...
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NCBI chr12:47,841,537...47,904,994
Ensembl chr12:47,841,537...47,943,048
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G |
VEGFA |
vascular endothelial growth factor A |
increases expression |
ISO |
Lithocholic Acid results in increased expression of VEGFA mRNA |
CTD |
PMID:19000923 |
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NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487
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G |
WDR1 |
WD repeat domain 1 |
decreases expression |
EXP |
Lithocholic Acid results in decreased expression of WDR1 protein |
CTD |
PMID:21224350 |
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NCBI chr 4:10,074,339...10,116,799
Ensembl chr 4:10,068,089...10,116,972
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G |
ZEB2 |
zinc finger E-box binding homeobox 2 |
increases expression |
ISO |
Lithocholic Acid results in increased expression of ZEB2 mRNA |
CTD |
PMID:19000923 |
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NCBI chr 2:144,384,081...144,520,119
Ensembl chr 2:144,364,364...144,521,057
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G |
HSD11B1 |
hydroxysteroid 11-beta dehydrogenase 1 |
increases reduction multiple interactions |
EXP |
HSD11B1 protein results in increased reduction of 7-ketolithocholic acid [HSD11B1 protein results in increased reduction of 7-ketolithocholic acid] which results in increased chemical synthesis of Chenodeoxycholic Acid; [HSD11B1 protein results in increased reduction of 7-ketolithocholic acid] which results in increased chemical synthesis of Ursodeoxycholic Acid |
CTD |
PMID:21453287 |
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NCBI chr 1:209,686,179...209,734,929
Ensembl chr 1:209,686,178...209,734,949
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G |
CYP3A4 |
cytochrome P450 family 3 subfamily A member 4 |
multiple interactions increases hydroxylation |
EXP |
[CYP3A4 protein results in increased hydroxylation of glycolithocholic acid] which results in increased abundance of glycohyodeoxycholic acid |
CTD |
PMID:36473578 |
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NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
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G |
HSD11B1 |
hydroxysteroid 11-beta dehydrogenase 1 |
decreases abundance |
ISO |
HSD11B1 gene mutant form results in decreased abundance of glycolithocholic acid |
CTD |
PMID:25061560 |
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NCBI chr 1:209,686,179...209,734,929
Ensembl chr 1:209,686,178...209,734,949
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G |
POR |
cytochrome p450 oxidoreductase |
increases abundance |
ISO |
POR gene mutant form results in increased abundance of glycolithocholic acid |
CTD |
PMID:25034404 |
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NCBI chr 7:75,915,155...75,986,855
Ensembl chr 7:75,899,200...75,986,855
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G |
SLCO1B1 |
solute carrier organic anion transporter family member 1B1 |
multiple interactions |
EXP |
SLCO1B1 protein binds to and results in increased transport of glycolithocholic acid analog |
CTD |
PMID:29933103 |
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NCBI chr12:21,131,194...21,239,796
Ensembl chr12:21,131,194...21,239,796
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G |
SULT2A1 |
sulfotransferase family 2A member 1 |
increases sulfation |
EXP |
SULT2A1 protein results in increased sulfation of glycolithocholic acid |
CTD |
PMID:36473578 |
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NCBI chr19:47,870,467...47,886,315
Ensembl chr19:47,870,467...47,886,315
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G |
ABCC1 |
ATP binding cassette subfamily C member 1 (ABCC1 blood group) |
multiple interactions |
EXP |
sulfolithocholic acid inhibits the reaction [ABCC1 protein results in increased export of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein] |
CTD |
PMID:16101123 |
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NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257
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G |
GSTA4 |
glutathione S-transferase alpha 4 |
multiple interactions |
ISO |
sulfolithocholic acid binds to and results in decreased activity of GSTA4 protein |
CTD |
PMID:3954743 |
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NCBI chr 6:52,977,953...52,995,284
Ensembl chr 6:52,977,948...52,995,304
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G |
GSTM1 |
glutathione S-transferase mu 1 |
multiple interactions |
ISO |
sulfolithocholic acid binds to and results in decreased activity of GSTM1 protein |
CTD |
PMID:3954743 |
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NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039
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G |
GSTM2 |
glutathione S-transferase mu 2 |
multiple interactions |
ISO |
sulfolithocholic acid binds to and results in decreased activity of GSTM2 protein |
CTD |
PMID:3954743 |
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NCBI chr 1:109,668,057...109,683,997
Ensembl chr 1:109,668,022...109,709,551
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G |
SLC10A1 |
solute carrier family 10 member 1 |
increases uptake |
EXP |
SLC10A1 protein results in increased uptake of sulfolithocholylglycine |
CTD |
PMID:29024779 |
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NCBI chr14:69,775,416...69,797,241
Ensembl chr14:69,775,416...69,797,241
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G |
ABCB11 |
ATP binding cassette subfamily B member 11 |
affects localization decreases activity multiple interactions |
ISO EXP |
Taurolithocholic Acid affects the localization of ABCB11 protein Taurolithocholic Acid results in decreased activity of ABCB11 protein Taurolithocholic Acid inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid] Taurolithocholic Acid affects the localization of and affects the activity of ABCB11 protein |
CTD |
PMID:12865277 PMID:15763547 PMID:24014644 |
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NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324
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G |
ABCC2 |
ATP binding cassette subfamily C member 2 |
multiple interactions affects localization |
ISO |
3-chloroacetylindole inhibits the reaction [Taurolithocholic Acid results in decreased activity of ABCC2 protein]; [Colchicine co-treated with JTE 013] inhibits the reaction [Taurolithocholic Acid results in decreased activity of ABCC2 protein]; CYM-5520 inhibits the reaction [Taurolithocholic Acid results in decreased activity of ABCC2 protein]; Dideoxyadenosine inhibits the reaction [Taurolithocholic Acid affects the localization of ABCC2 protein]; Dideoxyadenosine inhibits the reaction [Taurolithocholic Acid results in decreased activity of ABCC2 protein]; JTE 013 inhibits the reaction [Taurolithocholic Acid affects the localization of ABCC2 protein]; JTE 013 inhibits the reaction [Taurolithocholic Acid results in decreased activity of ABCC2 protein]; JTE 013 inhibits the reaction [Taurolithocholic Acid results in decreased activity of and affects the localization of ABCC2 protein]; KT 5720 inhibits the reaction [Taurolithocholic Acid results in decreased activity of and affects the localization of ABCC2 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Taurolithocholic Acid results in decreased activity of ABCC2 protein]; RMI 12330A inhibits the reaction [Taurolithocholic Acid results in decreased activity of and affects the localization of ABCC2 protein]; S1PR2 protein affects the reaction [Taurolithocholic Acid results in decreased activity of ABCC2 protein]; Taurolithocholic Acid results in decreased activity of and affects the localization of ABCC2 protein; Wortmannin inhibits the reaction [Taurolithocholic Acid results in decreased activity of and affects the localization of ABCC2 protein] |
CTD |
PMID:31300867 |
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NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594
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AKT1 |
AKT serine/threonine kinase 1 |
increases phosphorylation multiple interactions |
ISO |
Taurolithocholic Acid results in increased phosphorylation of AKT1 protein JTE 013 inhibits the reaction [Taurolithocholic Acid results in increased phosphorylation of AKT1 protein]; KT 5720 inhibits the reaction [Taurolithocholic Acid results in increased phosphorylation of AKT1 protein]; RMI 12330A inhibits the reaction [Taurolithocholic Acid results in increased phosphorylation of AKT1 protein]; S1PR2 protein affects the reaction [Taurolithocholic Acid results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Taurolithocholic Acid results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:31300867 |
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NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759
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G |
CHRM3 |
cholinergic receptor muscarinic 3 |
multiple interactions affects binding |
EXP |
[Taurolithocholic Acid binds to and affects the activity of CHRM3 protein] which results in increased abundance of Inositol Phosphates; Taurolithocholic Acid binds to and affects the activity of CHRM3 protein Taurolithocholic Acid binds to CHRM3 protein |
CTD |
PMID:12379313 PMID:12464352 |
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NCBI chr 1:239,386,568...239,915,450
Ensembl chr 1:239,386,565...239,915,452
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G |
CYP3A4 |
cytochrome P450 family 3 subfamily A member 4 |
increases hydroxylation |
EXP |
CYP3A4 protein results in increased hydroxylation of Taurolithocholic Acid |
CTD |
PMID:36473578 |
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NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
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G |
FOS |
Fos proto-oncogene, AP-1 transcription factor subunit |
increases expression multiple interactions |
EXP |
Taurolithocholic Acid results in increased expression of FOS mRNA ursodoxicoltaurine inhibits the reaction [Taurolithocholic Acid results in increased expression of FOS mRNA] |
CTD |
PMID:18164257 |
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NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
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G |
HSD11B1 |
hydroxysteroid 11-beta dehydrogenase 1 |
increases abundance |
ISO |
HSD11B1 gene mutant form results in increased abundance of Taurolithocholic Acid |
CTD |
PMID:25061560 |
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NCBI chr 1:209,686,179...209,734,929
Ensembl chr 1:209,686,178...209,734,949
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G |
JUN |
Jun proto-oncogene, AP-1 transcription factor subunit |
increases expression multiple interactions |
EXP |
Taurolithocholic Acid results in increased expression of JUN mRNA ursodoxicoltaurine inhibits the reaction [Taurolithocholic Acid results in increased expression of JUN mRNA] |
CTD |
PMID:18164257 |
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NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048
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G |
POR |
cytochrome p450 oxidoreductase |
increases abundance |
ISO |
POR gene mutant form results in increased abundance of Taurolithocholic Acid |
CTD |
PMID:25034404 |
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NCBI chr 7:75,915,155...75,986,855
Ensembl chr 7:75,899,200...75,986,855
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G |
PRKACA |
protein kinase cAMP-activated catalytic subunit alpha |
multiple interactions increases activity |
ISO |
JTE 013 inhibits the reaction [Taurolithocholic Acid results in increased activity of PRKACA protein]; KT 5720 inhibits the reaction [Taurolithocholic Acid results in increased activity of PRKACA protein]; RMI 12330A inhibits the reaction [Taurolithocholic Acid results in increased activity of PRKACA protein] |
CTD |
PMID:31300867 |
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NCBI chr19:14,091,688...14,117,762
Ensembl chr19:14,091,688...14,118,084
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G |
S1PR2 |
sphingosine-1-phosphate receptor 2 |
multiple interactions |
ISO |
S1PR2 protein affects the reaction [Taurolithocholic Acid results in decreased activity of ABCC2 protein]; S1PR2 protein affects the reaction [Taurolithocholic Acid results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:31300867 |
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NCBI chr19:10,221,433...10,231,331
Ensembl chr19:10,221,433...10,231,331
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G |
SLCO1B1 |
solute carrier organic anion transporter family member 1B1 |
increases abundance multiple interactions |
EXP |
SLCO1B1 SNP results in increased abundance of Taurolithocholic Acid [SLCO1B1 SNP results in increased abundance of Taurolithocholic Acid] which results in increased susceptibility to Simvastatin |
CTD |
PMID:22022402 |
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NCBI chr12:21,131,194...21,239,796
Ensembl chr12:21,131,194...21,239,796
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G |
SMAD3 |
SMAD family member 3 |
increases abundance |
ISO |
SMAD3 protein results in increased abundance of Taurolithocholic Acid |
CTD |
PMID:23034213 |
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NCBI chr15:67,065,602...67,195,169
Ensembl chr15:67,063,763...67,195,173
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G |
SULT2A1 |
sulfotransferase family 2A member 1 |
increases sulfation |
EXP |
SULT2A1 protein results in increased sulfation of Taurolithocholic Acid |
CTD |
PMID:36473578 |
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NCBI chr19:47,870,467...47,886,315
Ensembl chr19:47,870,467...47,886,315
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G |
AGT |
angiotensinogen |
multiple interactions decreases response to substance |
ISO |
AGT protein inhibits the reaction [taurolithocholic acid 3-sulfate results in increased activity of CASP3 protein] AGT protein results in decreased susceptibility to taurolithocholic acid 3-sulfate |
CTD |
PMID:23300732 |
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NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576
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G |
CASP3 |
caspase 3 |
multiple interactions increases activity |
ISO |
AGT protein inhibits the reaction [taurolithocholic acid 3-sulfate results in increased activity of CASP3 protein] |
CTD |
PMID:23300732 |
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NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
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G |
CFTR |
CF transmembrane conductance regulator |
decreases activity |
EXP |
taurolithocholic acid 3-sulfate results in decreased activity of CFTR protein |
CTD |
PMID:15634668 |
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NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971
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G |
CHRM1 |
cholinergic receptor muscarinic 1 |
affects binding |
EXP |
taurolithocholic acid 3-sulfate binds to CHRM1 protein |
CTD |
PMID:12464352 |
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NCBI chr11:62,908,679...62,921,878
Ensembl chr11:62,908,679...62,921,807
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G |
IFNG |
interferon gamma |
multiple interactions increases expression |
ISO |
Dantrolene inhibits the reaction [taurolithocholic acid 3-sulfate results in increased expression of IFNG mRNA] |
CTD |
PMID:22517774 |
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NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
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G |
IL6 |
interleukin 6 |
multiple interactions increases expression |
ISO |
Dantrolene inhibits the reaction [taurolithocholic acid 3-sulfate results in increased expression of IL6 mRNA] |
CTD |
PMID:22517774 |
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NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
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