Gene: CCNB1 (cyclin B1)  Homo sapiens Symbol: CCNB1 Name: cyclin B1 Description: The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites. [provided by RefSeq, Jul 2008] Type: protein-coding RefSeq Status: REVIEWED Also known as: CCNB; G2/mitotic-specific cyclin B1; G2/mitotic-specific cyclin-B1; OTTHUMP00000123478; OTTHUMP00000221981; OTTHUMP00000223023 Orthologs: Mus musculus : Ccnb1 (cyclin B1)  MGI Rattus norvegicus : Ccnb1 (cyclin B1) Latest Assembly: Human Genome Assembly GRCh37 Position: Map Chr Position Strand Source Human Alternate Assembly CHM1_1 5 68,382,314 - 68,393,549 + NCBI Human Genome Assembly HuRef 5 65,418,249 - 65,429,485 + NCBI Human Genome Assembly GRCh37 5 68,462,837 - 68,474,072 + NCBI Human Genome Assembly Build 36 5 68,498,669 - 68,509,828 + NCBI Human Cytogenetic Map 5 q12   NCBI Human Genome Assembly 5 68,498,668 - 68,509,824   NCBI Model Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19) Annotation    (Toggle Detail/Summary View) Disease Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) Breast Neoplasms   IED   2315937   RGD   Breast Neoplasms Disease_progression IEP   2315934   RGD   Carcinoma in Situ   IEP   2296040 associated with Vulvar Neoplasms;protein:increased expression:vulva RGD   Carcinoma, Renal Cell Disease_progression IEP   2315941 protein:increased expression:kidney RGD   Diabetes Mellitus, Experimental   ISS RGD:2291 2316310 mRNA:decreased expression:liver (rat) RGD   Endometrial Neoplasms   IEP   2289230   RGD   Hyperplasia   ISS RGD:2291 2314685 mRNA, protein:increased expression:thyroid gland RGD   Liver Neoplasms, Experimental   ISS RGD:2291 2315991 mRNA:increased expression:liver RGD   Lymphoma   ISS RGD:735742 2315935   RGD   Mammary Neoplasms, Experimental   ISS RGD:735742 2315939   RGD   Ovarian Neoplasms   IEP   2315936 protein:increased expression:ovary RGD   Prostatic Hyperplasia   ISS RGD:735742 2315046   RGD   Prostatic Neoplasms   IED   2293596   RGD   Prostatic Neoplasms Severity IEP   2315940   RGD   Reperfusion Injury   ISS RGD:2291 2315990 protein;altered expression:cerebral cortex, hippocampus CA1, neuron RGD   Seizures   ISS RGD:2291 2315994 protein:increased expression:hippocampus CA1, neuron RGD   Uterine Cervical Neoplasms   IEP   2315938 mRNA, protein:increased expression:uterine cervix RGD   Gene-Chemical Interaction Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) (-)-epigallocatechin 3-gallate multiple interactions EXP   6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CCNB1 mRNA CTD PMID:22079256 (S)-colchicine increases expression EXP   6480464 Colchicine results in increased expression of CCNB1 mRNA CTD PMID:21472861 (S)-nicotine increases expression EXP   6480464 Nicotine results in increased expression of CCNB1 protein CTD PMID:20106947 (S)-nicotine multiple interactions ISO RGD:735742 6480464 Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CCNB1 mRNA]; more ... CTD PMID:20230807 1,4-dioxane increases expression ISO RGD:735742 6480464 1,4-dioxane results in increased expression of CCNB1 protein CTD PMID:20025956 1-chloro-2,4-dinitrobenzene affects expression ISO RGD:735742 6480464 Dinitrochlorobenzene affects the expression of CCNB1 mRNA CTD PMID:22302311 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine increases expression ISO RGD:735742 6480464 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CCNB1 mRNA CTD PMID:20230807 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactions ISO RGD:735742 6480464 [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of CCNB1 mRNA; more ... CTD PMID:20230807 17alpha-ethynylestradiol affects expression ISO RGD:2291 6480464 Ethinyl Estradiol affects the expression of CCNB1 mRNA CTD PMID:17351261 17beta-estradiol multiple interactions ISO RGD:735742 6480464 Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CCNB1 mRNA] CTD PMID:11861973 17beta-estradiol increases expression EXP   6480464 Estradiol results in increased expression of CCNB1 mRNA CTD PMID:17445807 PMID:19167446 17beta-estradiol affects expression EXP   6480464 Estradiol affects the expression of CCNB1 mRNA CTD PMID:21826169 17beta-estradiol increases expression ISO RGD:735742 6480464 Estradiol results in increased expression of CCNB1 mRNA CTD PMID:11861973 17beta-estradiol multiple interactions EXP   6480464 fulvestrant inhibits the reaction [Estradiol results in increased expression of CCNB1 mRNA] CTD PMID:17445807 17beta-estradiol increases expression EXP   6480464 Estradiol results in increased expression of CCNB1 protein; more ... CTD PMID:17445807 17beta-hydroxy-5alpha-androstan-3-one increases expression ISO RGD:735742 6480464 Dihydrotestosterone results in increased expression of CCNB1 mRNA CTD PMID:17023530 2,2',4,4',5,5'-hexachlorobiphenyl affects expression ISO RGD:735742 6480464 2,4,5,2',4',5'-hexachlorobiphenyl affects the expression of CCNB1 mRNA CTD PMID:15201435 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:735742 6480464 Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CCNB1 mRNA] CTD PMID:11861973 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:735742 6480464 Tetrachlorodibenzodioxin affects the expression of CCNB1 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:735742 6480464 Tetrachlorodibenzodioxin results in increased expression of CCNB1 mRNA CTD PMID:19465110 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:735742 6480464 Tetrachlorodibenzodioxin results in decreased expression of CCNB1 mRNA CTD PMID:16102516 2,4,6-trinitrobenzenesulfonic acid increases expression ISO RGD:735742 6480464 Trinitrobenzenesulfonic Acid results in increased expression of CCNB1 mRNA CTD PMID:17982090 2,6-di-tert-butyl-4-methylphenol increases expression ISO RGD:735742 6480464 Butylated Hydroxytoluene results in increased expression of CCNB1 mRNA; more ... CTD PMID:12867420 2,6-di-tert-butyl-4-methylphenol increases expression ISO RGD:735742 6480464 Butylated Hydroxytoluene results in increased expression of CCNB1 mRNA CTD PMID:12867420 PMID:19000923 2-acetamidofluorene decreases expression ISO RGD:2291 6480464 2-Acetylaminofluorene results in decreased expression of CCNB1 protein CTD PMID:15158336 2-acetamidofluorene increases expression ISO RGD:2291 6480464 2-Acetylaminofluorene results in increased expression of CCNB1 mRNA CTD PMID:22584684 2-amino-2-deoxy-D-glucopyranose decreases expression ISO RGD:2291 6480464 Glucosamine results in decreased expression of CCNB1 mRNA CTD PMID:17109745 2-methoxy-17beta-estradiol multiple interactions EXP   6480464 2-methoxyestradiol results in increased expression of and results in increased activity of CCNB1 protein CTD PMID:16356831 2-nitrofluorene increases expression ISO RGD:2291 6480464 2-nitrofluorene results in increased expression of CCNB1 mRNA CTD PMID:15890375 3,3'-diindolylmethane decreases expression EXP   6480464 3,3'-diindolylmethane results in decreased expression of CCNB1 CTD PMID:22290291 3-methylcholanthrene increases expression ISO RGD:735742 6480464 Methylcholanthrene results in increased expression of CCNB1 mRNA CTD PMID:20713471 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one decreases expression ISO RGD:2291 6480464 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of CCNB1 mRNA CTD PMID:15890375 4-hydroxynon-2-enal decreases expression ISO RGD:735742 6480464 4-hydroxy-2-nonenal results in decreased expression of CCNB1 mRNA CTD PMID:19191707 4-nitroquinoline N-oxide decreases expression ISO RGD:735742 6480464 4-Nitroquinoline-1-oxide results in decreased expression of CCNB1 mRNA CTD PMID:22561872 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide multiple interactions EXP   6480464 AICA ribonucleotide inhibits the reaction [ELAVL1 protein binds to CCNB1 3' UTR] CTD PMID:12730239 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide decreases expression EXP   6480464 AICA ribonucleotide results in decreased expression of CCNB1 mRNA; more ... CTD PMID:12730239 5-aza-2'-deoxycytidine affects methylation EXP   6480464 decitabine affects the methylation of CCNB1 gene CTD PMID:17630775 5-azacytidine multiple interactions EXP   6480464 [Azacitidine co-treated with Thalidomide] affects the expression of CCNB1 mRNA CTD PMID:18720364 5-azacytidine increases expression EXP   6480464 Azacitidine results in increased expression of CCNB1 protein CTD PMID:20607034 5-azacytidine multiple interactions EXP   6480464 pifithrin inhibits the reaction [Azacitidine results in decreased expression of CCNB1 protein] CTD PMID:15547111 5-azacytidine decreases expression EXP   6480464 Azacitidine results in decreased expression of CCNB1 protein CTD PMID:15547111 5-fluorouracil multiple interactions EXP   6480464 N(1),N(11)-diethylnorspermine promotes the reaction [Fluorouracil results in decreased expression of CCNB1 protein]; more ... CTD PMID:15546879 5-fluorouracil decreases expression EXP   6480464 Fluorouracil results in decreased expression of CCNB1 mRNA CTD PMID:15205334 more ... 5-fluorouracil decreases expression EXP   6480464 Fluorouracil results in decreased expression of CCNB1 mRNA CTD PMID:17982676 more ... 5-fluorouracil decreases expression EXP   6480464 Fluorouracil results in decreased expression of CCNB1 mRNA CTD PMID:15205334 more ... 5-fluorouracil decreases expression EXP   6480464 Fluorouracil results in decreased expression of CCNB1 mRNA CTD PMID:17982676 more ... 5-fluorouracil multiple interactions EXP   6480464 TP53 protein inhibits the reaction [Fluorouracil results in decreased expression of CCNB1 mRNA] CTD PMID:17982676 5-fluorouracil multiple interactions EXP   6480464 TP53 protein affects the reaction [Fluorouracil results in decreased expression of CCNB1 mRNA] CTD PMID:15016801 5-fluorouracil decreases expression EXP   6480464 Fluorouracil results in decreased expression of CCNB1 protein CTD PMID:15546879 5-fluorouracil decreases expression EXP   6480464 Fluorouracil results in decreased expression of CCNB1 mRNA CTD PMID:16557594 more ... 7,12-dimethyltetraphene increases expression ISO RGD:735742 6480464 9,10-Dimethyl-1,2-benzanthracene results in increased expression of CCNB1 protein CTD PMID:20025956 acetylleucyl-leucyl-norleucinal multiple interactions EXP   6480464 acetylleucyl-leucyl-norleucinal inhibits the reaction [arsenite results in increased degradation of CCNB1 protein] CTD PMID:17373649 acetylsalicylic acid multiple interactions EXP   6480464 Aspirin inhibits the reaction [troglitazone results in decreased expression of CCNB1 protein] CTD PMID:19908241 acetylsalicylic acid increases expression EXP   6480464 Aspirin results in increased expression of CCNB1 mRNA CTD PMID:11906190 acrylamide increases expression ISO RGD:735742 6480464 Acrylamide results in increased expression of CCNB1 protein CTD PMID:20025956 aflatoxin B1 affects expression EXP   6480464 Aflatoxin B1 affects the expression of CCNB1 protein CTD PMID:20106945 aflatoxin B1 decreases expression ISO RGD:735742 6480464 Aflatoxin B1 results in decreased expression of CCNB1 mRNA CTD PMID:19770486 aflatoxin B1 increases expression ISO RGD:2291 6480464 Aflatoxin B1 results in increased expression of CCNB1 mRNA CTD PMID:15890375 alachlor increases expression ISO RGD:2291 6480464 alachlor results in increased expression of CCNB1 mRNA CTD PMID:12419858 aldehydo-D-glucosamine decreases expression ISO RGD:2291 6480464 Glucosamine results in decreased expression of CCNB1 mRNA CTD PMID:17109745 all-trans-retinoic acid decreases expression EXP   6480464 Tretinoin results in decreased expression of CCNB1 protein CTD PMID:16517207 all-trans-retinoic acid decreases expression ISO RGD:735742 6480464 Tretinoin results in decreased expression of CCNB1 protein; more ... CTD PMID:22498432 all-trans-retinoic acid increases expression ISO RGD:735742 6480464 Tretinoin results in increased expression of CCNB1 protein CTD PMID:20025956 alpha-hexylcinnamaldehyde affects expression ISO RGD:735742 6480464 hexyl cinnamic aldehyde affects the expression of CCNB1 mRNA CTD PMID:22302311 amiloride decreases expression EXP   6480464 Amiloride results in decreased expression of CCNB1 protein CTD PMID:9458082 ammonium chloride affects expression ISO RGD:2291 6480464 Ammonium Chloride affects the expression of CCNB1 mRNA; more ... CTD PMID:16483693 amsacrine multiple interactions EXP   6480464 Amsacrine results in increased degradation of and results in decreased expression of CCNB1 protein CTD PMID:11774253 anthracene-1,8,9-triol increases expression ISO RGD:735742 6480464 Anthralin results in increased expression of CCNB1 protein CTD PMID:20025956 antimycin A multiple interactions EXP   6480464 Antimycin A inhibits the reaction [ELAVL1 protein binds to CCNB1 3' UTR] CTD PMID:12730239 antimycin A decreases expression EXP   6480464 Antimycin A results in decreased expression of CCNB1 mRNA; more ... CTD PMID:12730239 apigenin decreases expression EXP   6480464 Apigenin results in decreased expression of CCNB1 mRNA; more ... CTD PMID:19397994 aristolochic acid decreases expression ISO RGD:2291 6480464 aristolochic acid I results in decreased expression of CCNB1 mRNA CTD PMID:17483316 arsenite(3-) decreases expression EXP   6480464 arsenite results in decreased expression of CCNB1 protein CTD PMID:20083129 arsenite(3-) increases ubiquitination EXP   6480464 arsenite results in increased ubiquitination of CCNB1 protein CTD PMID:17373649 arsenite(3-) multiple interactions EXP   6480464 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [arsenite results in increased ubiquitination of and results in increased degradation of CCNB1 protein]; more ... CTD PMID:17373649 arsenite(3-) decreases expression ISO RGD:735742 6480464 arsenite results in decreased expression of CCNB1 mRNA CTD PMID:18929588 atrazine multiple interactions EXP   6480464 [Atrazine co-treated with Arsenates] results in increased expression of CCNB1 mRNA CTD PMID:18585445 benomyl increases response to substance EXP   6480464 CCNB1 protein results in increased susceptibility to Benomyl CTD PMID:11960377 benzene multiple interactions ISO RGD:735742 6480464 TRP53 protein promotes the reaction [Benzene results in decreased expression of CCNB1] CTD PMID:15935813 benzene increases expression EXP   6480464 Benzene analog results in increased expression of CCNB1 protein CTD PMID:15826604 benzo[a]pyrene decreases expression EXP   6480464 Benzo(a)pyrene results in decreased expression of CCNB1 mRNA CTD PMID:20064835 benzo[a]pyrene decreases expression EXP   6480464 Benzo(a)pyrene results in decreased expression of CCNB1 mRNA CTD PMID:16120219 more ... benzo[a]pyrene decreases expression EXP   6480464 Benzo(a)pyrene results in decreased expression of CCNB1 protein CTD PMID:16120219 benzo[a]pyrene decreases expression EXP   6480464 Benzo(a)pyrene results in decreased expression of CCNB1 mRNA CTD PMID:20064835 PMID:21632981 benzo[a]pyrene decreases expression ISO RGD:735742 6480464 Benzo(a)pyrene results in decreased expression of CCNB1 mRNA CTD PMID:17942131 PMID:22228805 benzo[a]pyrene decreases expression ISO RGD:735742 6480464 Benzo(a)pyrene results in decreased expression of CCNB1 mRNA CTD PMID:17942131 benzophenone increases expression ISO RGD:2291 6480464 benzophenone results in increased expression of CCNB1 mRNA CTD PMID:22584684 beta-D-glucosamine decreases expression ISO RGD:2291 6480464 Glucosamine results in decreased expression of CCNB1 mRNA CTD PMID:17109745 bezafibrate increases expression ISO RGD:735742 6480464 Bezafibrate results in increased expression of CCNB1 mRNA CTD PMID:15447978 bicalutamide decreases expression EXP   6480464 bicalutamide results in decreased expression of CCNB1 mRNA CTD PMID:15887248 bis(2-ethylhexyl) phthalate increases expression ISO RGD:735742 6480464 Diethylhexyl Phthalate results in increased expression of CCNB1 mRNA CTD PMID:19000923 bis(2-ethylhexyl) phthalate increases expression ISO RGD:2291 6480464 Diethylhexyl Phthalate results in increased expression of CCNB1 mRNA CTD PMID:22584684 bisphenol A affects expression EXP   6480464 bisphenol A affects the expression of CCNB1 mRNA CTD PMID:21826169 brassinolide decreases expression EXP   6480464 brassinolide results in decreased expression of CCNB1 protein CTD PMID:20833159 cadmium atom decreases expression ISO RGD:2291 6480464 Cadmium results in decreased expression of CCNB1 protein CTD PMID:16730872 cadmium dichloride decreases expression ISO RGD:735742 6480464 Cadmium Chloride results in decreased expression of CCNB1 mRNA CTD PMID:20061341 cadmium dichloride decreases expression ISO RGD:735742 6480464 Cadmium Chloride results in decreased expression of CCNB1 mRNA CTD PMID:15501611 PMID:20061341 cadmium dichloride multiple interactions ISO RGD:735742 6480464 [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of CCNB1 mRNA CTD PMID:12135628 cadmium dichloride decreases expression ISO RGD:2291 6480464 Cadmium Chloride results in decreased expression of CCNB1 protein CTD PMID:16730872 caffeine multiple interactions ISO RGD:735742 6480464 Caffeine inhibits the reaction [Cisplatin results in increased expression of CCNB1 protein] CTD PMID:9098629 caffeine multiple interactions EXP   6480464 Caffeine inhibits the reaction [Genistein results in increased expression of CCNB1 protein] CTD PMID:19038232 caffeine increases expression ISO RGD:735742 6480464 Caffeine results in increased expression of CCNB1 protein CTD PMID:20025956 calcitriol decreases expression EXP   6480464 Calcitriol results in decreased expression of CCNB1 mRNA CTD PMID:21592394 calcitriol multiple interactions EXP   6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of CCNB1 mRNA CTD PMID:21592394 camptothecin multiple interactions EXP   6480464 [Butyrates co-treated with Camptothecin] results in decreased expression of CCNB1 protein CTD PMID:16061681 capsaicin decreases expression EXP   6480464 Capsaicin results in decreased expression of CCNB1 protein CTD PMID:19939880 cefaloridine decreases expression ISO RGD:2291 6480464 Cephaloridine results in decreased expression of CCNB1 mRNA CTD PMID:18500788 celecoxib affects expression EXP   6480464 celecoxib affects the expression of CCNB1 CTD PMID:19846907 chloramphenicol multiple interactions ISO RGD:735742 6480464 [enterotoxin B, staphylococcal co-treated with Chloramphenicol] results in increased expression of CCNB1 CTD PMID:18559535 chloroethene increases expression ISO RGD:735742 6480464 Vinyl Chloride results in increased expression of CCNB1 mRNA CTD PMID:18579281 chloroprene increases expression ISO RGD:735742 6480464 Chloroprene results in increased expression of CCNB1 mRNA CTD PMID:23125180 chlorpyrifos decreases expression ISO RGD:2291 6480464 Chlorpyrifos results in decreased expression of CCNB1 mRNA CTD PMID:20691718 choline multiple interactions ISO RGD:735742 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CCNB1 mRNA CTD PMID:20938992 chromium(6+) multiple interactions ISO RGD:2291 6480464 Ascorbic Acid inhibits the reaction [chromium hexavalent ion results in decreased expression of CCNB1 protein] CTD PMID:21621607 chromium(6+) decreases expression ISO RGD:2291 6480464 chromium hexavalent ion results in decreased expression of CCNB1 protein CTD PMID:21621607 ciprofloxacin decreases expression EXP   6480464 Ciprofloxacin results in decreased expression of CCNB1 protein CTD PMID:10741713 ciprofloxacin increases expression ISO RGD:2291 6480464 Ciprofloxacin results in increased expression of CCNB1 mRNA; more ... CTD PMID:18512786 cisplatin multiple interactions EXP   6480464 [Cisplatin co-treated with fisetin] results in decreased expression of CCNB1 protein CTD PMID:21216935 cisplatin increases expression EXP   6480464 Cisplatin results in increased expression of CCNB1 protein CTD PMID:20195699 cisplatin multiple interactions EXP   6480464 (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane inhibits the reaction [Cisplatin results in increased expression of CCNB1 protein] CTD PMID:20195699 cisplatin increases expression ISO RGD:735742 6480464 Cisplatin results in increased expression of CCNB1 protein CTD PMID:9098629 cisplatin decreases expression ISO RGD:2291 6480464 Cisplatin results in decreased expression of CCNB1 mRNA CTD PMID:22023808 cisplatin increases expression ISO RGD:735742 6480464 Cisplatin results in increased expression of CCNB1 mRNA CTD PMID:21151649 cisplatin multiple interactions EXP   6480464 [Piroxicam co-treated with Cisplatin] results in decreased expression of CCNB1 mRNA CTD PMID:21858171 cisplatin multiple interactions ISO RGD:735742 6480464 Caffeine inhibits the reaction [Cisplatin results in increased expression of CCNB1 protein] CTD PMID:9098629 cisplatin multiple interactions EXP   6480464 Cisplatin results in decreased activity of [CCNB1 protein binds to CDK1 protein] CTD PMID:21592546 cisplatin decreases activity EXP   6480464 Cisplatin results in decreased activity of CCNB1 protein CTD PMID:21592546 clofibrate decreases expression ISO RGD:2291 6480464 Clofibrate results in decreased expression of CCNB1 mRNA CTD PMID:22008536 cobalt dichloride decreases expression EXP   6480464 cobaltous chloride results in decreased expression of CCNB1 mRNA CTD PMID:19320972 PMID:19376846 copper atom decreases expression ISO RGD:2291 6480464 Copper deficiency results in decreased expression of CCNB1 mRNA CTD PMID:19497425 copper atom multiple interactions EXP   6480464 [NSC 689534 binds to Copper] which results in decreased expression of CCNB1 mRNA CTD PMID:20971185 copper atom increases expression ISO RGD:2291 6480464 Copper results in increased expression of CCNB1 mRNA CTD PMID:22465980 copper(0) decreases expression ISO RGD:2291 6480464 Copper deficiency results in decreased expression of CCNB1 mRNA CTD PMID:19497425 copper(0) multiple interactions EXP   6480464 [NSC 689534 binds to Copper] which results in decreased expression of CCNB1 mRNA CTD PMID:20971185 copper(0) increases expression ISO RGD:2291 6480464 Copper results in increased expression of CCNB1 mRNA CTD PMID:22465980 copper(2+) sulfate decreases expression EXP   6480464 Copper Sulfate results in decreased expression of CCNB1 mRNA CTD PMID:19549813 corticosterone decreases expression ISO RGD:2291 6480464 Corticosterone results in decreased expression of CCNB1 mRNA; more ... CTD PMID:15755911 coumestrol multiple interactions EXP   6480464 [Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of CCNB1 mRNA; more ... CTD PMID:19167446 coumestrol increases expression EXP   6480464 Coumestrol results in increased expression of CCNB1 mRNA CTD PMID:19167446 curcumin decreases expression EXP   6480464 Curcumin results in decreased expression of CCNB1 mRNA CTD PMID:18719366 curcumin decreases expression EXP   6480464 Curcumin results in decreased expression of CCNB1 protein CTD PMID:17148446 PMID:19401701 curcumin decreases expression EXP   6480464 Curcumin results in decreased expression of CCNB1 protein CTD PMID:19401701 PMID:17148446 cyclosporin A decreases expression EXP   6480464 Cyclosporine results in decreased expression of CCNB1 mRNA CTD PMID:20106945 cyclosporin A decreases expression EXP   6480464 Cyclosporine results in decreased expression of CCNB1 mRNA CTD PMID:20106945 PMID:21632981 cyclosporin A decreases expression ISO RGD:735742 6480464 Cyclosporine results in decreased expression of CCNB1 mRNA CTD PMID:17942131 desferrioxamine B decreases expression EXP   6480464 Deferoxamine results in decreased expression of CCNB1 protein CTD PMID:11468187 dexamethasone decreases expression ISO RGD:2291 6480464 Dexamethasone results in decreased expression of CCNB1 mRNA CTD PMID:20032058 dexamethasone multiple interactions ISO RGD:2291 6480464 Testosterone inhibits the reaction [Dexamethasone results in decreased expression of CCNB1 mRNA] CTD PMID:20032058 diallyl disulfide decreases expression EXP   6480464 diallyl disulfide results in decreased expression of CCNB1 protein CTD PMID:16691315 diallyl disulfide increases expression EXP   6480464 diallyl disulfide results in increased expression of CCNB1 protein CTD PMID:19202565 diarsenic trioxide increases expression EXP   6480464 arsenic trioxide results in increased expression of CCNB1 mRNA CTD PMID:12783709 PMID:20458559 diarsenic trioxide decreases expression EXP   6480464 arsenic trioxide results in decreased expression of CCNB1 mRNA CTD PMID:19825857 PMID:17530438 diarsenic trioxide increases expression EXP   6480464 arsenic trioxide results in increased expression of CCNB1 protein CTD PMID:12181429 diarsenic trioxide decreases expression EXP   6480464 arsenic trioxide results in decreased expression of CCNB1 protein CTD PMID:12883267 PMID:19825857 diarsenic trioxide decreases expression EXP   6480464 arsenic trioxide results in decreased expression of CCNB1 mRNA CTD PMID:17530438 PMID:19825857 diarsenic trioxide increases expression EXP   6480464 arsenic trioxide results in increased expression of CCNB1 mRNA CTD PMID:20458559 PMID:12783709 diarsenic trioxide multiple interactions EXP   6480464 [arsenic trioxide co-treated with Oxygen deficiency] results in decreased expression of CCNB1 mRNA; more ... CTD PMID:19825857 dibenzofuran decreases expression ISO RGD:2291 6480464 dibenzofuran analog results in decreased expression of CCNB1 mRNA CTD PMID:20566336 dibutyl phthalate decreases expression ISO RGD:735742 6480464 Dibutyl Phthalate results in decreased expression of CCNB1 mRNA CTD PMID:17361019 diethylstilbestrol increases expression ISO RGD:2291 6480464 Diethylstilbestrol results in increased expression of CCNB1 mRNA CTD PMID:15890375 digitoxin multiple interactions EXP   6480464 Digitoxin analog results in decreased expression of [CCNB1 protein binds to CDK1 protein]; more ... CTD PMID:22037315 digitoxin decreases expression EXP   6480464 Digitoxin analog results in decreased expression of CCNB1 protein; more ... CTD PMID:22037315 dioxygen multiple interactions EXP   6480464 [arsenic trioxide co-treated with Oxygen deficiency] results in decreased expression of CCNB1 protein; more ... CTD PMID:19825857 docetaxel anhydrous multiple interactions EXP   6480464 docetaxel results in increased expression of and results in increased activity of CCNB1 protein CTD PMID:16731754 doxorubicin affects response to substance EXP   6480464 CCNB1 protein affects the susceptibility to Doxorubicin CTD PMID:16928833 doxorubicin increases expression EXP   6480464 Doxorubicin results in increased expression of CCNB1 protein CTD PMID:17320279 PMID:20826841 doxorubicin multiple interactions EXP   6480464 [2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine co-treated with Doxorubicin] results in decreased expression of CCNB1 protein CTD PMID:20826841 doxorubicin multiple interactions ISO RGD:735742 6480464 Doxorubicin promotes the reaction [AZD 6244 results in decreased expression of CCNB1 protein] CTD PMID:17876044 doxorubicin multiple interactions ISO RGD:735742 6480464 [zoledronic acid co-treated with Doxorubicin] results in decreased expression of CCNB1 protein CTD PMID:19789217 doxorubicin multiple interactions EXP   6480464 Go 6976 inhibits the reaction [Doxorubicin results in increased expression of CCNB1 protein] CTD PMID:17320279 doxorubicin increases expression EXP   6480464 Doxorubicin results in increased expression of CCNB1 protein CTD PMID:17320279 doxorubicin decreases expression EXP   6480464 Doxorubicin results in decreased expression of CCNB1 protein CTD PMID:15141020 doxorubicin decreases expression EXP   6480464 Doxorubicin results in decreased expression of CCNB1 mRNA CTD PMID:15205334 doxorubicin decreases expression EXP   6480464 Doxorubicin results in decreased expression of CCNB1 CTD PMID:20222868 doxorubicin multiple interactions EXP   6480464 Doxorubicin promotes the reaction [RBL2 protein binds to CCNB1 promoter] CTD PMID:16537896 doxorubicin affects expression EXP   6480464 Doxorubicin affects the expression of CCNB1 protein CTD PMID:17893511 elemental selenium decreases expression EXP   6480464 Selenium deficiency results in decreased expression of CCNB1 mRNA CTD PMID:11925459 etoposide decreases expression EXP   6480464 Etoposide results in decreased expression of CCNB1 mRNA; more ... CTD PMID:16120219 eugenol multiple interactions ISO RGD:2291 6480464 Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of CCNB1 mRNA] CTD PMID:19851710 fisetin multiple interactions EXP   6480464 [Cisplatin co-treated with fisetin] results in decreased expression of CCNB1 protein CTD PMID:21216935 fisetin decreases expression EXP   6480464 fisetin results in decreased expression of CCNB1 protein CTD PMID:21216935 fluoxetine decreases expression ISO RGD:735742 6480464 Fluoxetine results in decreased expression of CCNB1 mRNA CTD PMID:21497159 flurbiprofen decreases expression EXP   6480464 Flurbiprofen results in decreased expression of CCNB1 protein CTD PMID:11687965 folic acid multiple interactions ISO RGD:735742 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CCNB1 mRNA CTD PMID:20938992 fulvestrant multiple interactions EXP   6480464 fulvestrant inhibits the reaction [Estradiol results in increased expression of CCNB1 mRNA] CTD PMID:17445807 fulvestrant increases expression EXP   6480464 fulvestrant results in increased expression of CCNB1 mRNA CTD PMID:12154049 furan increases expression ISO RGD:2291 6480464 furan results in increased expression of CCNB1 mRNA CTD PMID:22079235 genistein affects expression EXP   6480464 Genistein affects the expression of CCNB1 mRNA CTD PMID:18847459 genistein multiple interactions ISO RGD:2291 6480464 [Genistein co-treated with vinclozolin] results in decreased expression of CCNB1 mRNA CTD PMID:23160963 genistein increases expression EXP   6480464 Genistein results in increased expression of CCNB1 protein CTD PMID:19038232 genistein multiple interactions EXP   6480464 Caffeine inhibits the reaction [Genistein results in increased expression of CCNB1 protein]; more ... CTD PMID:19038232 genistein affects expression EXP   6480464 Genistein affects the expression of CCNB1 protein CTD PMID:10601582 Goe 6976 multiple interactions EXP   6480464 Go 6976 inhibits the reaction [Doxorubicin results in increased expression of CCNB1 protein] CTD PMID:17320279 hydrazine decreases expression ISO RGD:735742 6480464 hydrazine results in decreased expression of CCNB1 mRNA CTD PMID:15282401 hydrogen peroxide affects expression EXP   6480464 Hydrogen Peroxide affects the expression of CCNB1 mRNA CTD PMID:20044591 hydrogen peroxide affects expression EXP   6480464 Hydrogen Peroxide affects the expression of CCNB1 protein CTD PMID:21179406 hydroxyurea increases expression EXP   6480464 Hydroxyurea results in increased expression of CCNB1 protein CTD PMID:11468187 hydroxyurea decreases expression ISO RGD:735742 6480464 Hydroxyurea results in decreased expression of CCNB1 protein CTD PMID:16356682 indole-3-methanol affects expression ISO RGD:2291 6480464 indole-3-carbinol affects the expression of CCNB1 mRNA CTD PMID:21396975 indole-3-methanol multiple interactions ISO RGD:2291 6480464 [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of CCNB1 mRNA CTD PMID:22129741 indomethacin decreases expression EXP   6480464 Indomethacin results in decreased expression of CCNB1 protein CTD PMID:11504793 iron dichloride increases expression ISO RGD:735742 6480464 ferrous chloride results in increased expression of CCNB1 protein CTD PMID:20025956 iron trichloride increases expression ISO RGD:735742 6480464 ferric chloride results in increased expression of CCNB1 protein CTD PMID:20025956 kaempferol decreases expression EXP   6480464 kaempferol results in decreased expression of CCNB1 mRNA; more ... CTD PMID:18331776 PMID:19397994 kaempferol decreases expression EXP   6480464 kaempferol results in decreased expression of CCNB1 mRNA; more ... CTD PMID:19397994 PMID:18331776 kojic acid increases expression ISO RGD:735742 6480464 kojic acid results in increased expression of CCNB1 mRNA CTD PMID:19000923 L-ascorbic acid multiple interactions ISO RGD:2291 6480464 Ascorbic Acid inhibits the reaction [chromium hexavalent ion results in decreased expression of CCNB1 protein] CTD PMID:21621607 L-methionine multiple interactions ISO RGD:735742 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CCNB1 mRNA CTD PMID:20938992 lidocaine affects expression ISO RGD:735742 6480464 Lidocaine affects the expression of CCNB1 mRNA CTD PMID:18931217 lithocholic acid increases expression ISO RGD:735742 6480464 Lithocholic Acid results in increased expression of CCNB1 mRNA CTD PMID:19000923 lucanthone decreases expression EXP   6480464 Lucanthone results in decreased expression of CCNB1 mRNA CTD PMID:21148553 luteolin decreases expression EXP   6480464 Luteolin results in decreased expression of CCNB1 mRNA; more ... CTD PMID:19397994 PMID:18331776 luteolin decreases expression EXP   6480464 Luteolin results in decreased expression of CCNB1 protein CTD PMID:18331776 more ... luteolin decreases expression EXP   6480464 Luteolin results in decreased expression of CCNB1 protein; more ... CTD PMID:18331776 PMID:19397994 malachite green cation multiple interactions ISO RGD:2291 6480464 [Diethylnitrosamine co-treated with malachite green] results in increased expression of CCNB1 protein; more ... CTD PMID:12616621 mangiferin increases expression EXP   6480464 mangiferin results in increased expression of CCNB1 mRNA CTD PMID:20518311 mechlorethamine decreases activity EXP   6480464 Mechlorethamine results in decreased activity of CCNB1 protein CTD PMID:8463339 mechlorethamine multiple interactions EXP   6480464 Pentoxifylline inhibits the reaction [Mechlorethamine results in decreased activity of [CCNB1 protein binds to CDK1 protein]] CTD PMID:8463339 melatonin decreases expression EXP   6480464 Melatonin results in decreased expression of CCNB1 protein; more ... CTD PMID:21108658 methapyrilene increases expression ISO RGD:2291 6480464 Methapyrilene results in increased expression of CCNB1 mRNA CTD PMID:15890375 methapyrilene increases expression ISO RGD:2291 6480464 Methapyrilene results in increased expression of CCNB1 mRNA CTD PMID:15890375 PMID:22584684 methyl salicylate affects expression ISO RGD:735742 6480464 methyl salicylate affects the expression of CCNB1 mRNA CTD PMID:22302311 methylmercury chloride decreases expression ISO RGD:735742 6480464 methylmercuric chloride results in decreased expression of CCNB1 mRNA CTD PMID:20061341 mitomycin C multiple interactions EXP   6480464 Mitomycin promotes the reaction [TP53 protein results in increased expression of CCNB1 mRNA] CTD PMID:18647660 mitomycin C increases expression EXP   6480464 Mitomycin results in increased expression of CCNB1 mRNA CTD PMID:18647660 PMID:12760830 mitomycin C increases expression EXP   6480464 Mitomycin results in increased expression of CCNB1 mRNA CTD PMID:12760830 PMID:18647660 myricetin decreases expression EXP   6480464 myricetin results in decreased expression of CCNB1 mRNA; more ... CTD PMID:19397994 N-methyl-N'-nitro-N-nitrosoguanidine multiple interactions ISO RGD:2291 6480464 Eugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of CCNB1 mRNA] CTD PMID:19851710 N-methyl-N'-nitro-N-nitrosoguanidine multiple interactions ISO RGD:735742 6480464 [Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of CCNB1 mRNA CTD PMID:12135628 N-methyl-N'-nitro-N-nitrosoguanidine decreases expression ISO RGD:735742 6480464 Methylnitronitrosoguanidine results in decreased expression of CCNB1 mRNA CTD PMID:11516527 N-methyl-N'-nitro-N-nitrosoguanidine increases expression ISO RGD:2291 6480464 Methylnitronitrosoguanidine results in increased expression of CCNB1 mRNA CTD PMID:19851710 N-nitrosodiethylamine increases expression ISO RGD:735742 6480464 Diethylnitrosamine results in increased expression of CCNB1 mRNA CTD PMID:17854601 PMID:19996281 N-nitrosodiethylamine multiple interactions ISO RGD:2291 6480464 [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of CCNB1 mRNA CTD PMID:22129741 N-nitrosodiethylamine increases expression ISO RGD:735742 6480464 Diethylnitrosamine results in increased expression of CCNB1 mRNA CTD PMID:19996281 PMID:17854601 N-nitrosodiethylamine multiple interactions ISO RGD:2291 6480464 [Diethylnitrosamine co-treated with malachite green] results in increased expression of CCNB1 protein; more ... CTD PMID:12616621 N-nitrosodiethylamine multiple interactions ISO RGD:2291 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CCNB1 mRNA CTD PMID:18164116 N-nitrosodiethylamine multiple interactions ISO RGD:735742 6480464 RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CCNB1 mRNA] CTD PMID:17854601 N-nitrosodimethylamine increases expression ISO RGD:2291 6480464 Dimethylnitrosamine results in increased expression of CCNB1 mRNA CTD PMID:15890375 nonanoic acid affects expression ISO RGD:735742 6480464 pelargonic acid affects the expression of CCNB1 mRNA CTD PMID:22302311 ochratoxin A multiple interactions EXP   6480464 ochratoxin A inhibits the reaction [CCNB1 protein binds to CDC2 protein]; more ... CTD PMID:20060447 ochratoxin A increases expression ISO RGD:2291 6480464 ochratoxin A results in increased expression of CCNB1 mRNA CTD PMID:19237604 more ... ochratoxin A decreases expression EXP   6480464 ochratoxin A results in decreased expression of CCNB1 protein CTD PMID:20060447 PMID:22230261 ochratoxin A multiple interactions EXP   6480464 MAPK14 protein promotes the reaction [ochratoxin A inhibits the reaction [CDK1 protein binds to CCNB1 protein]]; more ... CTD PMID:22230261 ochratoxin A increases expression ISO RGD:2291 6480464 ochratoxin A results in increased expression of CCNB1 mRNA CTD PMID:19237604 PMID:19717638 ochratoxin A increases expression ISO RGD:2291 6480464 ochratoxin A results in increased expression of CCNB1 mRNA CTD PMID:19717638 PMID:19237604 ochratoxin A increases expression ISO RGD:2291 6480464 ochratoxin A results in increased expression of CCNB1 mRNA CTD PMID:19717638 ochratoxin A decreases expression EXP   6480464 ochratoxin A results in decreased expression of CCNB1 mRNA; more ... CTD PMID:20060447 oxaliplatin decreases expression EXP   6480464 oxaliplatin results in decreased expression of CCNB1 protein CTD PMID:19735649 oxaliplatin increases expression EXP   6480464 oxaliplatin results in increased expression of CCNB1 protein CTD PMID:15204521 ozone decreases expression ISO RGD:735742 6480464 Ozone results in decreased expression of CCNB1 protein; more ... CTD PMID:16183385 ozone multiple interactions ISO RGD:735742 6480464 TTPA protein affects the reaction [Ozone results in increased expression of CCNB1 mRNA] CTD PMID:19555225 paclitaxel increases response to substance EXP   6480464 CCNB1 protein results in increased susceptibility to Paclitaxel CTD PMID:16849574 paclitaxel multiple interactions EXP   6480464 [pifithrin co-treated with Paclitaxel] results in increased expression of CCNB1 protein CTD PMID:18516295 paclitaxel increases expression EXP   6480464 Paclitaxel results in increased expression of CCNB1 protein CTD PMID:10430095 paclitaxel multiple interactions EXP   6480464 Paclitaxel results in increased expression of and results in increased activity of CCNB1 protein CTD PMID:16356831 paclitaxel multiple interactions EXP   6480464 flavopiridol inhibits the reaction [Paclitaxel results in increased expression of CCNB1 protein]; more ... CTD PMID:10430095 paclitaxel multiple interactions EXP   6480464 CDK7 protein affects the reaction [Paclitaxel results in increased activity of [CDK2 protein binds to CCNB1 protein]] CTD PMID:14646529 paracetamol affects expression ISO RGD:735742 6480464 Acetaminophen affects the expression of CCNB1 mRNA CTD PMID:17562736 paracetamol increases expression EXP   6480464 Acetaminophen results in increased expression of CCNB1 mRNA CTD PMID:22230336 paracetamol increases expression ISO RGD:735742 6480464 Acetaminophen results in increased expression of CCNB1 protein CTD PMID:20025956 paracetamol decreases expression ISO RGD:735742 6480464 Acetaminophen results in decreased expression of CCNB1 mRNA CTD PMID:17942131 phenobarbital increases expression ISO RGD:2291 6480464 Phenobarbital results in increased expression of CCNB1 mRNA CTD PMID:19162173 phenobarbital increases expression ISO RGD:735742 6480464 Phenobarbital results in increased expression of CCNB1 mRNA CTD PMID:19482888 PMID:23091169 phenobarbital increases expression ISO RGD:2291 6480464 Phenobarbital results in increased expression of CCNB1 mRNA CTD PMID:19162173 PMID:22584684 phenobarbital decreases expression ISO RGD:2291 6480464 Phenobarbital results in decreased expression of CCNB1 mRNA CTD PMID:22008536 phenobarbital increases expression ISO RGD:735742 6480464 Phenobarbital results in increased expression of CCNB1 mRNA CTD PMID:19482888 phenobarbital multiple interactions ISO RGD:735742 6480464 NR1I3 protein affects the reaction [Phenobarbital results in increased expression of CCNB1 mRNA] CTD PMID:19482888 phorbol 13-acetate 12-myristate increases expression ISO RGD:735742 6480464 Tetradecanoylphorbol Acetate results in increased expression of CCNB1 mRNA CTD PMID:10866668 phorbol 13-acetate 12-myristate increases expression ISO RGD:735742 6480464 Tetradecanoylphorbol Acetate results in increased expression of CCNB1 mRNA CTD PMID:10866668 PMID:19000923 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:735742 6480464 PPARD protein affects the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCNB1 mRNA] CTD PMID:10866668 phthalaldehyde affects expression ISO RGD:735742 6480464 o-Phthalaldehyde affects the expression of CCNB1 mRNA CTD PMID:22302311 pioglitazone decreases expression EXP   6480464 pioglitazone results in decreased expression of CCNB1 protein CTD PMID:15729575 piperonyl butoxide increases expression ISO RGD:2291 6480464 Piperonyl Butoxide results in increased expression of CCNB1 mRNA CTD PMID:15890375 piperonyl butoxide increases expression ISO RGD:2291 6480464 Piperonyl Butoxide results in increased expression of CCNB1 mRNA CTD PMID:15890375 PMID:22484513 pirinixic acid multiple interactions ISO RGD:735742 6480464 RXRA protein promotes the reaction [pirinixic acid results in increased expression of CCNB1 mRNA] CTD PMID:19176532 pirinixic acid increases expression ISO RGD:2291 6480464 pirinixic acid results in increased expression of CCNB1 mRNA CTD PMID:12832660 more ... pirinixic acid increases expression ISO RGD:735742 6480464 pirinixic acid results in increased expression of CCNB1 protein CTD PMID:17483499 PMID:19748123 pirinixic acid multiple interactions ISO RGD:735742 6480464 NCF1 protein affects the reaction [pirinixic acid results in increased expression of CCNB1 protein]; more ... CTD PMID:17483499 pirinixic acid increases expression ISO RGD:2291 6480464 pirinixic acid results in increased expression of CCNB1 mRNA CTD PMID:19162173 more ... pirinixic acid increases expression ISO RGD:735742 6480464 pirinixic acid results in increased expression of CCNB1 mRNA CTD PMID:19748123 more ... pirinixic acid increases expression ISO RGD:2291 6480464 pirinixic acid results in increased expression of CCNB1 mRNA CTD PMID:12832660 more ... pirinixic acid increases expression ISO RGD:735742 6480464 pirinixic acid results in increased expression of CCNB1 mRNA CTD PMID:19176532 more ... pirinixic acid increases expression ISO RGD:2291 6480464 pirinixic acid results in increased expression of CCNB1 mRNA CTD PMID:15890375 more ... pirinixic acid increases expression ISO RGD:735742 6480464 pirinixic acid results in increased expression of CCNB1 mRNA CTD PMID:18301758 more ... pirinixic acid multiple interactions EXP   6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CCNB1 mRNA CTD PMID:19710929 pirinixic acid increases expression ISO RGD:735742 6480464 pirinixic acid results in increased expression of CCNB1 protein CTD PMID:19748123 pirinixic acid increases expression ISO RGD:735742 6480464 pirinixic acid results in increased expression of CCNB1 mRNA CTD PMID:18301758 more ... pirinixic acid increases expression ISO RGD:2291 6480464 pirinixic acid results in increased expression of CCNB1 mRNA CTD PMID:19162173 more ... piroxicam multiple interactions EXP   6480464 [Piroxicam co-treated with Cisplatin] results in decreased expression of CCNB1 mRNA CTD PMID:21858171 potassium bromate increases expression EXP   6480464 potassium bromate results in increased expression of CCNB1 protein CTD PMID:20067818 potassium bromate multiple interactions EXP   6480464 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [potassium bromate results in increased expression of CCNB1 protein] CTD PMID:20067818 pregnenolone 16alpha-carbonitrile increases expression ISO RGD:2291 6480464 Pregnenolone Carbonitrile results in increased expression of CCNB1 mRNA CTD PMID:19162173 progesterone decreases expression EXP   6480464 Progesterone results in decreased expression of CCNB1 mRNA CTD PMID:18037150 progesterone increases expression ISO RGD:735742 6480464 Progesterone results in increased expression of CCNB1 mRNA CTD PMID:19000923 progesterone increases expression EXP   6480464 Progesterone results in increased expression of CCNB1 mRNA CTD PMID:18070364 quercetin multiple interactions EXP   6480464 Quercetin inhibits the reaction [NFYA protein binds to CCNB1 promoter] CTD PMID:19009557 quercetin decreases expression EXP   6480464 Quercetin results in decreased expression of CCNB1 mRNA CTD PMID:18331776 more ... quercetin decreases expression EXP   6480464 Quercetin results in decreased expression of CCNB1 protein CTD PMID:10601582 more ... quercetin decreases expression EXP   6480464 Quercetin results in decreased expression of CCNB1 mRNA CTD PMID:18331776 more ... quercetin decreases expression EXP   6480464 Quercetin results in decreased expression of CCNB1 protein CTD PMID:19397994 more ... quercetin decreases expression EXP   6480464 Quercetin results in decreased expression of CCNB1 protein CTD PMID:10601582 more ... quercetin decreases expression EXP   6480464 Quercetin results in decreased expression of CCNB1 mRNA CTD PMID:18331776 more ... quercetin decreases expression EXP   6480464 Quercetin results in decreased expression of CCNB1 protein CTD PMID:16049707 more ... quercetin decreases expression EXP   6480464 Quercetin results in decreased expression of CCNB1 protein CTD PMID:18331776 more ... quercetin decreases expression EXP   6480464 Quercetin results in decreased expression of CCNB1 protein CTD PMID:16049707 more ... quercetin decreases expression EXP   6480464 Quercetin results in decreased expression of CCNB1 mRNA CTD PMID:19009557 more ... quercetin affects phosphorylation ISO RGD:735742 6480464 Quercetin affects the phosphorylation of CCNB1 protein CTD PMID:15067354 quercetin affects expression ISO RGD:735742 6480464 Quercetin affects the expression of CCNB1 CTD PMID:15067354 quercetin decreases expression EXP   6480464 Quercetin results in decreased expression of CCNB1 protein CTD PMID:19397994 more ... quercetin decreases expression EXP   6480464 Quercetin results in decreased expression of CCNB1 mRNA CTD PMID:19009557 more ... quinoline increases expression EXP   6480464 quinoline analog results in increased expression of CCNB1 protein CTD PMID:18645022 raloxifene increases expression EXP   6480464 Raloxifene results in increased expression of CCNB1 mRNA; more ... CTD PMID:17445807 raloxifene increases expression EXP   6480464 Raloxifene results in increased expression of CCNB1 mRNA CTD PMID:12154049 PMID:17445807 resveratrol multiple interactions EXP   6480464 resveratrol affects the activity of [CCNB1 protein co-treated with CDK1 protein] CTD PMID:12392819 resveratrol decreases expression EXP   6480464 resveratrol results in decreased expression of CCNB1 protein CTD PMID:17050787 more ... resveratrol multiple interactions EXP   6480464 [Coumestrol co-treated with resveratrol] results in increased expression of CCNB1 mRNA CTD PMID:19167446 resveratrol decreases expression EXP   6480464 resveratrol results in decreased expression of CCNB1 protein CTD PMID:17050787 PMID:18089832 resveratrol increases expression EXP   6480464 resveratrol results in increased expression of CCNB1 protein CTD PMID:11577002 resveratrol decreases expression EXP   6480464 resveratrol results in decreased expression of CCNB1 protein CTD PMID:17050787 resveratrol multiple interactions EXP   6480464 resveratrol results in decreased activity of [CCNB1 protein binds to CDK1 protein] CTD PMID:17050787 resveratrol decreases expression EXP   6480464 resveratrol results in decreased expression of CCNB1 protein CTD PMID:11895924 more ... resveratrol affects expression EXP   6480464 resveratrol affects the expression of CCNB1 protein CTD PMID:12392819 riboflavin affects expression EXP   6480464 Riboflavin affects the expression of CCNB1 CTD PMID:20848206 romidepsin decreases expression EXP   6480464 romidepsin results in decreased expression of CCNB1 protein CTD PMID:15014036 rosiglitazone decreases expression EXP   6480464 rosiglitazone results in decreased expression of CCNB1 protein CTD PMID:15729575 rosiglitazone decreases expression ISO RGD:735742 6480464 rosiglitazone results in decreased expression of CCNB1 protein CTD PMID:17077279 selenium atom decreases expression EXP   6480464 Selenium deficiency results in decreased expression of CCNB1 mRNA CTD PMID:11925459 silver atom decreases expression EXP   6480464 Silver results in decreased expression of CCNB1 protein CTD PMID:22546375 silver(0) decreases expression EXP   6480464 Silver results in decreased expression of CCNB1 protein CTD PMID:22546375 silver(1+) nitrate decreases expression EXP   6480464 Silver Nitrate results in decreased expression of CCNB1 mRNA; more ... CTD PMID:22831968 sodium azide multiple interactions EXP   6480464 Sodium Azide inhibits the reaction [ELAVL1 protein binds to CCNB1 3' UTR] CTD PMID:12730239 sodium azide decreases expression EXP   6480464 Sodium Azide results in decreased expression of CCNB1 mRNA; more ... CTD PMID:12730239 sodium dichromate increases expression ISO RGD:2291 6480464 sodium bichromate results in increased expression of CCNB1 mRNA CTD PMID:22561333 sulfadimethoxine increases expression ISO RGD:735742 6480464 Sulfadimethoxine results in increased expression of CCNB1 mRNA CTD PMID:19000923 sulforaphane increases expression EXP   6480464 sulforafan results in increased expression of CCNB1 protein CTD PMID:15231455 sulindac decreases expression EXP   6480464 Sulindac results in decreased expression of CCNB1 mRNA CTD PMID:11906190 tamoxifen increases expression ISO RGD:2291 6480464 Tamoxifen results in increased expression of CCNB1 mRNA CTD PMID:12841865 testosterone multiple interactions EXP   6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of CCNB1 mRNA CTD PMID:21592394 testosterone decreases expression EXP   6480464 Testosterone results in decreased expression of CCNB1 mRNA CTD PMID:21592394 testosterone multiple interactions ISO RGD:2291 6480464 Testosterone inhibits the reaction [Dexamethasone results in decreased expression of CCNB1 mRNA] CTD PMID:20032058 tetrachloromethane increases expression ISO RGD:735742 6480464 Carbon Tetrachloride results in increased expression of CCNB1 protein CTD PMID:19887370 tetrachloromethane multiple interactions ISO RGD:735742 6480464 PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of CCNB1 mRNA] CTD PMID:16006527 tetrachloromethane increases expression ISO RGD:735742 6480464 Carbon Tetrachloride results in increased expression of CCNB1 mRNA CTD PMID:17484886 thalidomide multiple interactions EXP   6480464 [Azacitidine co-treated with Thalidomide] affects the expression of CCNB1 mRNA CTD PMID:18720364 thimerosal multiple interactions EXP   6480464 Thimerosal results in increased expression of and results in increased activity of CCNB1 protein CTD PMID:16649253 thioacetamide increases expression ISO RGD:2291 6480464 Thioacetamide results in increased expression of CCNB1 mRNA CTD PMID:22659510 trans-resveratrol multiple interactions EXP   6480464 resveratrol affects the activity of [CCNB1 protein co-treated with CDK1 protein] CTD PMID:12392819 trans-resveratrol decreases expression EXP   6480464 resveratrol results in decreased expression of CCNB1 protein CTD PMID:17050787 more ... trans-resveratrol multiple interactions EXP   6480464 [Coumestrol co-treated with resveratrol] results in increased expression of CCNB1 mRNA CTD PMID:19167446 trans-resveratrol decreases expression EXP   6480464 resveratrol results in decreased expression of CCNB1 protein CTD PMID:17050787 PMID:18089832 trans-resveratrol increases expression EXP   6480464 resveratrol results in increased expression of CCNB1 protein CTD PMID:11577002 trans-resveratrol decreases expression EXP   6480464 resveratrol results in decreased expression of CCNB1 protein CTD PMID:17050787 trans-resveratrol multiple interactions EXP   6480464 resveratrol results in decreased activity of [CCNB1 protein binds to CDK1 protein] CTD PMID:17050787 trans-resveratrol decreases expression EXP   6480464 resveratrol results in decreased expression of CCNB1 protein CTD PMID:11895924 more ... trans-resveratrol affects expression EXP   6480464 resveratrol affects the expression of CCNB1 protein CTD PMID:12392819 trichostatin A decreases expression EXP   6480464 trichostatin A results in decreased expression of CCNB1 mRNA CTD PMID:19606018 trichostatin A decreases expression EXP   6480464 trichostatin A results in decreased expression of CCNB1 protein CTD PMID:16009488 trimellitic anhydride increases expression ISO RGD:735742 6480464 trimellitic anhydride results in increased expression of CCNB1 mRNA CTD PMID:19042947 trimellitic anhydride affects expression ISO RGD:735742 6480464 trimellitic anhydride affects the expression of CCNB1 mRNA CTD PMID:22302311 troglitazone multiple interactions EXP   6480464 Aspirin inhibits the reaction [troglitazone results in decreased expression of CCNB1 protein] CTD PMID:19908241 troglitazone decreases expression EXP   6480464 troglitazone results in decreased expression of CCNB1 protein CTD PMID:15729575 more ... troglitazone decreases expression EXP   6480464 troglitazone results in decreased expression of CCNB1 protein CTD PMID:20540935 more ... troglitazone decreases expression EXP   6480464 troglitazone results in decreased expression of CCNB1 protein CTD PMID:19908241 more ... troglitazone decreases expression EXP   6480464 troglitazone results in decreased expression of CCNB1 protein CTD PMID:20540935 more ... troglitazone decreases expression EXP   6480464 troglitazone results in decreased expression of CCNB1 mRNA CTD PMID:19140230 troglitazone decreases expression EXP   6480464 troglitazone results in decreased expression of CCNB1 protein CTD PMID:15729575 more ... troglitazone multiple interactions EXP   6480464 GSK3B protein affects the susceptibility to [troglitazone results in decreased expression of CCNB1 protein]; more ... CTD PMID:20540935 troglitazone decreases expression EXP   6480464 troglitazone results in decreased expression of CCNB1 protein CTD PMID:19908241 PMID:15729575 urethane multiple interactions ISO RGD:735742 6480464 [Urethane co-treated with Freund's Adjuvant] results in increased expression of CCNB1 mRNA CTD PMID:12400877 valproic acid decreases expression ISO RGD:735742 6480464 Valproic Acid results in decreased expression of CCNB1 mRNA CTD PMID:21427059 vincaleukoblastine affects response to substance EXP   6480464 CCNB1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 vincaleukoblastine increases response to substance EXP   6480464 CCNB1 protein results in increased susceptibility to Vinblastine CTD PMID:16849574 vincristine affects response to substance EXP   6480464 CCNB1 protein affects the susceptibility to Vincristine CTD PMID:22178383 zidovudine multiple interactions EXP   6480464 [Zidovudine co-treated with IFNA1 protein] results in increased expression of CCNB1 mRNA CTD PMID:20370541 zinc atom increases expression ISO RGD:2291 6480464 Zinc deficiency results in increased expression of CCNB1 mRNA; more ... CTD PMID:16140947 zinc atom multiple interactions ISO RGD:2291 6480464 Zinc inhibits the reaction [Zinc deficiency results in increased expression of CCNB1 mRNA]; more ... CTD PMID:16140947 zinc dichloride increases expression ISO RGD:735742 6480464 zinc chloride results in increased expression of CCNB1 mRNA CTD PMID:19000923 zinc(0) increases expression ISO RGD:2291 6480464 Zinc deficiency results in increased expression of CCNB1 mRNA; more ... CTD PMID:16140947 zinc(0) multiple interactions ISO RGD:2291 6480464 Zinc inhibits the reaction [Zinc deficiency results in increased expression of CCNB1 mRNA]; more ... CTD PMID:16140947 zoledronic acid decreases expression EXP   6480464 zoledronic acid results in decreased expression of CCNB1 mRNA CTD PMID:20977926 zoledronic acid multiple interactions ISO RGD:735742 6480464 [zoledronic acid co-treated with Doxorubicin] results in decreased expression of CCNB1 protein CTD PMID:19789217 Gene Ontology Annotations Biological Process Term Qualifier Evidence With Reference Notes Source Original Reference(s) anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process   TAS   2290271 Reactome:REACT_6820 Reactome Reactome:REACT_6820 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process   TAS   2290271 Reactome:REACT_6828 Reactome Reactome:REACT_6828 cell cycle   IEA UniProtKB-KW:KW-0131 2290271 GO_REF:0000038 UniProtKB GO_REF:0000038 cell cycle checkpoint   TAS   2290271 Reactome:REACT_1538 Reactome Reactome:REACT_1538 cell division   IEA UniProtKB-KW:KW-0132 2290271 GO_REF:0000037 UniProtKB GO_REF:0000037 cell division   IEA UniProtKB-KW:KW-0132 2290271 GO_REF:0000038 UniProtKB GO_REF:0000038 cellular response to fatty acid   IEA Ensembl:ENSRNOP00000025297 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 cellular response to hypoxia   IEA Ensembl:ENSRNOP00000025297 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 cellular response to iron(III) ion   IEA Ensembl:ENSRNOP00000025297 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 cellular response to organic cyclic compound   IEA Ensembl:ENSRNOP00000025297 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 digestive tract development   IEA Ensembl:ENSRNOP00000025297 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 G1/S transition of mitotic cell cycle   TAS   2290271 Reactome:REACT_1783 Reactome Reactome:REACT_1783 G2/M transition of mitotic cell cycle   NAS   2290271 GO_REF:0000029 UniProtKB GO_REF:0000029 G2/M transition of mitotic cell cycle   TAS   2290271 Reactome:REACT_2203 Reactome Reactome:REACT_2203 in utero embryonic development   IEA Ensembl:ENSMUSP00000071989 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 M phase of mitotic cell cycle   TAS   2290271 Reactome:REACT_910 Reactome Reactome:REACT_910 mitotic cell cycle   TAS   2290271 Reactome:REACT_152 Reactome Reactome:REACT_152 mitotic metaphase plate congression   IMP   2290271 PMID:18195732 BHF-UCL PMID:18195732 mitotic nuclear envelope disassembly   TAS   2290271 Reactome:REACT_160255 Reactome Reactome:REACT_160255 mitotic prometaphase   IDA   2290271 PMID:18195732 BHF-UCL PMID:18195732 mitotic prometaphase   TAS   2290271 Reactome:REACT_682 Reactome Reactome:REACT_682 mitotic prophase   TAS   2290271 Reactome:REACT_765 Reactome Reactome:REACT_765 mitotic spindle checkpoint   IMP   2290271 PMID:18195732 BHF-UCL PMID:18195732 mitotic spindle stabilization   IMP   2290271 PMID:18195732 BHF-UCL PMID:18195732 negative regulation of gene expression   IEA Ensembl:ENSRNOP00000025297 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 negative regulation of protein phosphorylation   IEA Ensembl:ENSRNOP00000025297 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 oocyte maturation   IEA Ensembl:ENSRNOP00000025297 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of attachment of spindle microtubules to kinetochore   IMP   2290271 PMID:18195732 BHF-UCL PMID:18195732 positive regulation of cardiac muscle cell proliferation   IEA Ensembl:ENSRNOP00000025297 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of histone phosphorylation   IEA Ensembl:ENSRNOP00000025297 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of mitotic cell cycle   IMP   2290271 PMID:18195732 BHF-UCL PMID:18195732 positive regulation of mRNA 3'-end processing   IEA Ensembl:ENSRNOP00000025297 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle   TAS   2290271 Reactome:REACT_6904 Reactome Reactome:REACT_6904 protein complex assembly   IEA Ensembl:ENSRNOP00000025297 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 protein phosphorylation   IEA Ensembl:ENSMUSP00000071989 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 regulation of chromosome condensation   IEA Ensembl:ENSRNOP00000025297 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 regulation of cyclin-dependent protein serine/threonine kinase activity   IEA InterPro:IPR014400 2290271 GO_REF:0000002 InterPro GO_REF:0000002 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle   TAS   2290271 Reactome:REACT_6837 Reactome Reactome:REACT_6837 response to DDT   IEA Ensembl:ENSRNOP00000025297 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 response to drug   IEA Ensembl:ENSRNOP00000025297 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 response to mechanical stimulus   IEA Ensembl:ENSRNOP00000025297 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 spermatogenesis   IEA Ensembl:ENSRNOP00000025297 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 tissue regeneration   IEA Ensembl:ENSRNOP00000025297 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 ventricular cardiac muscle cell development   IEA Ensembl:ENSRNOP00000025297 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 Cellular Component Term Qualifier Evidence With Reference Notes Source Original Reference(s) centrosome   IDA   2290271 PMID:12524548 UniProtKB PMID:12524548 condensed nuclear chromosome outer kinetochore   IDA   2290271 PMID:18195732 BHF-UCL PMID:18195732 cytoplasm   IDA   2290271 PMID:11331587 BHF-UCL PMID:11331587 cytoplasm   IDA   2290271 PMID:17850284 UniProtKB PMID:17850284 cytosol   TAS   2290271 Reactome:REACT_6183 Reactome Reactome:REACT_6183 cytosol   TAS   2290271 Reactome:REACT_160217 Reactome Reactome:REACT_160217 cytosol   TAS   2290271 Reactome:REACT_150414 Reactome Reactome:REACT_150414 cytosol   TAS   2290271 Reactome:REACT_150454 Reactome Reactome:REACT_150454 cytosol   TAS   2290271 Reactome:REACT_147793 Reactome Reactome:REACT_147793 cytosol   TAS   2290271 Reactome:REACT_6766 Reactome Reactome:REACT_6766 cytosol   TAS   2290271 Reactome:REACT_6749 Reactome Reactome:REACT_6749 cytosol   TAS   2290271 Reactome:REACT_6735 Reactome Reactome:REACT_6735 cytosol   TAS   2290271 Reactome:REACT_6353 Reactome Reactome:REACT_6353 cytosol   TAS   2290271 Reactome:REACT_6345 Reactome Reactome:REACT_6345 cytosol   TAS   2290271 Reactome:REACT_6343 Reactome Reactome:REACT_6343 cytosol   TAS   2290271 Reactome:REACT_6257 Reactome Reactome:REACT_6257 cytosol   TAS   2290271 Reactome:REACT_6217 Reactome Reactome:REACT_6217 cytosol   TAS   2290271 Reactome:REACT_6216 Reactome Reactome:REACT_6216 membrane   IEA Ensembl:ENSMUSP00000071989 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 nucleoplasm   TAS   2290271 Reactome:REACT_1205 Reactome Reactome:REACT_1205 nucleoplasm   TAS   2290271 Reactome:REACT_150132 Reactome Reactome:REACT_150132 nucleoplasm   TAS   2290271 Reactome:REACT_6942 Reactome Reactome:REACT_6942 nucleoplasm   TAS   2290271 Reactome:REACT_6891 Reactome Reactome:REACT_6891 nucleoplasm   TAS   2290271 Reactome:REACT_6811 Reactome Reactome:REACT_6811 nucleoplasm   TAS   2290271 Reactome:REACT_6345 Reactome Reactome:REACT_6345 nucleoplasm   TAS   2290271 Reactome:REACT_6343 Reactome Reactome:REACT_6343 nucleoplasm   TAS   2290271 Reactome:REACT_6338 Reactome Reactome:REACT_6338 nucleoplasm   TAS   2290271 Reactome:REACT_6314 Reactome Reactome:REACT_6314 nucleoplasm   TAS   2290271 Reactome:REACT_6255 Reactome Reactome:REACT_6255 nucleoplasm   TAS   2290271 Reactome:REACT_6183 Reactome Reactome:REACT_6183 nucleoplasm   TAS   2290271 Reactome:REACT_6178 Reactome Reactome:REACT_6178 nucleoplasm   TAS   2290271 Reactome:REACT_15543 Reactome Reactome:REACT_15543 nucleus   IDA   2290271 PMID:11331587 BHF-UCL PMID:11331587 nucleus   IEA InterPro:IPR004367 2290271 GO_REF:0000002 InterPro GO_REF:0000002 nucleus   IDA   2290271 PMID:16109376 MGI PMID:16109376 spindle pole   IDA   2290271 PMID:18195732 BHF-UCL PMID:18195732 Molecular Function Term Qualifier Evidence With Reference Notes Source Original Reference(s) kinase activity   IEA Ensembl:ENSMUSP00000071989 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 patched binding   IPI UniProtKB:Q13635 2290271 PMID:11331587 BHF-UCL PMID:11331587 protein binding   IPI UniProtKB:Q99640 2290271 PMID:10373560 IntAct PMID:10373560 protein binding   IPI UniProtKB:P06493 2290271 PMID:23602568 IntAct PMID:23602568 protein binding   IPI UniProtKB:P06493 2290271 PMID:9001210 IntAct PMID:9001210 protein binding   IPI UniProtKB:Q96PU4 2290271 PMID:21952639 IntAct PMID:21952639 protein binding   IPI UniProtKB:P06493 2290271 PMID:19879842 IntAct PMID:19879842 protein binding   IPI UniProtKB:P06493 2290271 PMID:18408765 IntAct PMID:18408765 protein binding   IPI UniProtKB:Q9NPC3 2290271 PMID:12612082 IntAct PMID:12612082 protein binding   IPI UniProtKB:P06493 2290271 PMID:12612082 IntAct PMID:12612082 protein kinase binding   IPI UniProtKB:P53350 2290271 PMID:12524548 UniProtKB PMID:12524548 protein kinase binding   IEA InterPro:IPR014400 2290271 GO_REF:0000002 InterPro GO_REF:0000002 Molecular Pathway Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) cell cycle pathway, mitotic   IEA RGD:733179 6907045   KEGG hsa:04110 G1/S transition pathway   IEA   1358139   RGD   G2/M checkpoint pathway   IEA   1358139   RGD   G2/M DNA damage checkpoint pathway   IEA   1358139   RGD   G2/M DNA replication checkpoint pathway   IEA   1358139   RGD   G2/M transition pathway   IEA   1358139   RGD   p53 signaling pathway   IEA RGD:733179 6907045   KEGG hsa:04115 External Database Links KEGG Pathway Cell cycle Oocyte meiosis p53 signaling pathway Progesterone-mediated oocyte maturation Pathway Interaction Database C-MYB transcription factor network (PID:200153) Direct p53 effectors (PID:200120) FOXM1 transcription factor network (PID:200141) FoxO family signaling (PID:200108) p73 transcription factor network (PID:200017) PLK1 signaling events (PID:200103) Validated targets of C-MYC transcriptional activation (PID:200056) Disease Annotations Breast Neoplasms  (IED,IEP) Carcinoma in Situ  (IEP) Carcinoma, Renal Cell  (IEP) Diabetes Mellitus, Experimental  (ISS) Endometrial Neoplasms  (IEP) Hyperplasia  (ISS) Liver Neoplasms, Experimental  (ISS) Lymphoma  (ISS) Mammary Neoplasms, Experimental  (ISS) Ovarian Neoplasms  (IEP) Prostatic Hyperplasia  (ISS) Prostatic Neoplasms  (IED,IEP) Reperfusion Injury  (ISS) Seizures  (ISS) Uterine Cervical Neoplasms  (IEP) Gene-Chemical Interaction Annotations (-)-epigallocatechin 3-gallate  (EXP) (S)-colchicine  (EXP) (S)-nicotine  (EXP,ISO) 1,4-dioxane  (ISO) 1-chloro-2,4-dinitrobenzene  (ISO) 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO) 17alpha-ethynylestradiol  (ISO) 17beta-estradiol  (EXP,ISO) 17beta-hydroxy-5alpha-androstan-3-one  (ISO) 2,2',4,4',5,5'-hexachlorobiphenyl  (ISO) 2,3,7,8-tetrachlorodibenzodioxine  (ISO) 2,4,6-trinitrobenzenesulfonic acid  (ISO) 2,6-di-tert-butyl-4-methylphenol  (ISO) 2-acetamidofluorene  (ISO) 2-amino-2-deoxy-D-glucopyranose  (ISO) 2-methoxy-17beta-estradiol  (EXP) 2-nitrofluorene  (ISO) 3,3'-diindolylmethane  (EXP) 3-methylcholanthrene  (ISO) 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO) 4-hydroxynon-2-enal  (ISO) 4-nitroquinoline N-oxide  (ISO) 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide  (EXP) 5-aza-2'-deoxycytidine  (EXP) 5-azacytidine  (EXP) 5-fluorouracil  (EXP) 7,12-dimethyltetraphene  (ISO) acetylleucyl-leucyl-norleucinal  (EXP) acetylsalicylic acid  (EXP) acrylamide  (ISO) aflatoxin B1  (EXP,ISO) alachlor  (ISO) aldehydo-D-glucosamine  (ISO) all-trans-retinoic acid  (EXP,ISO) alpha-hexylcinnamaldehyde  (ISO) amiloride  (EXP) ammonium chloride  (ISO) amsacrine  (EXP) anthracene-1,8,9-triol  (ISO) antimycin A  (EXP) apigenin  (EXP) aristolochic acid  (ISO) arsenite(3-)  (EXP,ISO) atrazine  (EXP) benomyl  (EXP) benzene  (EXP,ISO) benzo[a]pyrene  (EXP,ISO) benzophenone  (ISO) beta-D-glucosamine  (ISO) bezafibrate  (ISO) bicalutamide  (EXP) bis(2-ethylhexyl) phthalate  (ISO) bisphenol A  (EXP) brassinolide  (EXP) cadmium atom  (ISO) cadmium dichloride  (ISO) caffeine  (EXP,ISO) calcitriol  (EXP) camptothecin  (EXP) capsaicin  (EXP) cefaloridine  (ISO) celecoxib  (EXP) chloramphenicol  (ISO) chloroethene  (ISO) chloroprene  (ISO) chlorpyrifos  (ISO) choline  (ISO) chromium(6+)  (ISO) ciprofloxacin  (EXP,ISO) cisplatin  (EXP,ISO) clofibrate  (ISO) cobalt dichloride  (EXP) copper atom  (EXP,ISO) copper(0)  (EXP,ISO) copper(2+) sulfate  (EXP) corticosterone  (ISO) coumestrol  (EXP) curcumin  (EXP) cyclosporin A  (EXP,ISO) desferrioxamine B  (EXP) dexamethasone  (ISO) diallyl disulfide  (EXP) diarsenic trioxide  (EXP) dibenzofuran  (ISO) dibutyl phthalate  (ISO) diethylstilbestrol  (ISO) digitoxin  (EXP) dioxygen  (EXP) docetaxel anhydrous  (EXP) doxorubicin  (EXP,ISO) elemental selenium  (EXP) etoposide  (EXP) eugenol  (ISO) fisetin  (EXP) fluoxetine  (ISO) flurbiprofen  (EXP) folic acid  (ISO) fulvestrant  (EXP) furan  (ISO) genistein  (EXP,ISO) Goe 6976  (EXP) hydrazine  (ISO) hydrogen peroxide  (EXP) hydroxyurea  (EXP,ISO) indole-3-methanol  (ISO) indomethacin  (EXP) iron dichloride  (ISO) iron trichloride  (ISO) kaempferol  (EXP) kojic acid  (ISO) L-ascorbic acid  (ISO) L-methionine  (ISO) lidocaine  (ISO) lithocholic acid  (ISO) lucanthone  (EXP) luteolin  (EXP) malachite green cation  (ISO) mangiferin  (EXP) mechlorethamine  (EXP) melatonin  (EXP) methapyrilene  (ISO) methyl salicylate  (ISO) methylmercury chloride  (ISO) mitomycin C  (EXP) myricetin  (EXP) N-methyl-N'-nitro-N-nitrosoguanidine  (ISO) N-nitrosodiethylamine  (ISO) N-nitrosodimethylamine  (ISO) nonanoic acid  (ISO) ochratoxin A  (EXP,ISO) oxaliplatin  (EXP) ozone  (ISO) paclitaxel  (EXP) paracetamol  (EXP,ISO) phenobarbital  (ISO) phorbol 13-acetate 12-myristate  (ISO) phthalaldehyde  (ISO) pioglitazone  (EXP) piperonyl butoxide  (ISO) pirinixic acid  (EXP,ISO) piroxicam  (EXP) potassium bromate  (EXP) pregnenolone 16alpha-carbonitrile  (ISO) progesterone  (EXP,ISO) quercetin  (EXP,ISO) quinoline  (EXP) raloxifene  (EXP) resveratrol  (EXP) riboflavin  (EXP) romidepsin  (EXP) rosiglitazone  (EXP,ISO) selenium atom  (EXP) silver atom  (EXP) silver(0)  (EXP) silver(1+) nitrate  (EXP) sodium azide  (EXP) sodium dichromate  (ISO) sulfadimethoxine  (ISO) sulforaphane  (EXP) sulindac  (EXP) tamoxifen  (ISO) testosterone  (EXP,ISO) tetrachloromethane  (ISO) thalidomide  (EXP) thimerosal  (EXP) thioacetamide  (ISO) trans-resveratrol  (EXP) trichostatin A  (EXP) trimellitic anhydride  (ISO) troglitazone  (EXP) urethane  (ISO) valproic acid  (ISO) vincaleukoblastine  (EXP) vincristine  (EXP) zidovudine  (EXP) zinc atom  (ISO) zinc dichloride  (ISO) zinc(0)  (ISO) zoledronic acid  (EXP,ISO) Gene Ontology Annotations Biological Process anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process  (TAS) cell cycle  (IEA) cell cycle checkpoint  (TAS) cell division  (IEA) cellular response to fatty acid  (IEA) cellular response to hypoxia  (IEA) cellular response to iron(III) ion  (IEA) cellular response to organic cyclic compound  (IEA) digestive tract development  (IEA) G1/S transition of mitotic cell cycle  (TAS) G2/M transition of mitotic cell cycle  (NAS,TAS) in utero embryonic development  (IEA) M phase of mitotic cell cycle  (TAS) mitotic cell cycle  (TAS) mitotic metaphase plate congression  (IMP) mitotic nuclear envelope disassembly  (TAS) mitotic prometaphase  (IDA,TAS) mitotic prophase  (TAS) mitotic spindle checkpoint  (IMP) mitotic spindle stabilization  (IMP) negative regulation of gene expression  (IEA) negative regulation of protein phosphorylation  (IEA) oocyte maturation  (IEA) positive regulation of attachment of spindle microtubules to kinetochore  (IMP) positive regulation of cardiac muscle cell proliferation  (IEA) positive regulation of histone phosphorylation  (IEA) positive regulation of mitotic cell cycle  (IMP) positive regulation of mRNA 3'-end processing  (IEA) positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  (TAS) protein complex assembly  (IEA) protein phosphorylation  (IEA) regulation of chromosome condensation  (IEA) regulation of cyclin-dependent protein serine/threonine kinase activity  (IEA) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  (TAS) response to DDT  (IEA) response to drug  (IEA) response to mechanical stimulus  (IEA) spermatogenesis  (IEA) tissue regeneration  (IEA) ventricular cardiac muscle cell development  (IEA) Cellular Component centrosome  (IDA) condensed nuclear chromosome outer kinetochore  (IDA) cytoplasm  (IDA) cytosol  (TAS) membrane  (IEA) nucleoplasm  (TAS) nucleus  (IDA,IEA) spindle pole  (IDA) Molecular Function kinase activity  (IEA) patched binding  (IPI) protein binding  (IPI) protein kinase binding  (IEA,IPI) Molecular Pathway Annotations cell cycle pathway, mitotic  (IEA) G1/S transition pathway  (IEA) G2/M checkpoint pathway  (IEA) G2/M DNA damage checkpoint pathway  (IEA) G2/M DNA replication checkpoint pathway  (IEA) G2/M transition pathway  (IEA) p53 signaling pathway  (IEA) External Database Links KEGG Pathway Cell cycle Oocyte meiosis p53 signaling pathway Progesterone-mediated oocyte maturation Pathway Interaction Database C-MYB transcription factor network (PID:200153) Direct p53 effectors (PID:200120) FOXM1 transcription factor network (PID:200141) FoxO family signaling (PID:200108) p73 transcription factor network (PID:200017) PLK1 signaling events (PID:200103) Validated targets of C-MYC transcriptional activation (PID:200056) References - curated 1. Chen B and Wang W, J Huazhong Univ Sci Technolog Med Sci. 2008 Feb;28(1):60-4. 2. Cui XS and Donehower LA, Oncogene. 2000 Dec 7;19(52):5988-96. 3. Davidson EJ, etal., Br J Cancer. 2003 Jan 27;88(2):257-62. 4. GOA_HUMAN data from the GO Consortium 5. Horree N, etal., J Clin Pathol. 2008 Jan;61(1):36-42. Epub 2007 May 4. 6. Ikuerowo SO, etal., Int J Cancer. 2006 Aug 15;119(4):867-74. 7. Kallakury BV, etal., Cancer. 1999 Apr 1;85(7):1569-76. 8. Kang JS, etal., Oncol Rep. 2007 Apr;17(4):747-52. 9. Nimeus-Malmstrom E, etal., Int J Cancer. 2009 Dec 2. 10. Pavlova T, etal., Neurosci Lett. 2006 Jan 9;392(1-2):154-8. Epub 2005 Oct 18. 11. Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology 12. Raina K, etal., Cancer Res. 2007 Nov 15;67(22):11083-91. 13. Reactome 14. RGD automated import pipeline for gene-chemical interactions 15. Shim EH, etal., Cancer Res. 2003 Apr 1;63(7):1583-8. 16. Sorensen RB, etal., Clin Cancer Res. 2009 Mar 1;15(5):1543-9. Epub 2009 Feb 17. 17. Tseng JH, etal., J Surg Res. 2009 Jul 30. 18. Vella LA, etal., Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14010-5. Epub 2009 Aug 3. 19. Woo GH, etal., Cancer Sci. 2009 Apr;100(4):617-25. Epub 2009 Feb 25. 20. Zhao M, etal., Exp Oncol. 2006 Mar;28(1):44-8. 21. Zheng H, etal., Am J Obstet Gynecol. 2009 Oct;201(4):367.e1-6. Epub 2009 Jul 15. References - uncurated PubMed 10339564   10362260   10373560   10395539   10421840   10581175   10716937   10793135   10799291   10864927   10958988   10973963   10995390   11242082   11260656   11278247   11285280   11310559   11331587   11444800   11531413   11559705   11562349   11572993   11598127   11642719   11691994   11732576   11751633   11779217   11809526   11836499   11878934   11960377   12009577   12054478   12068134   12097298   12115375   12124778   12200597   12379461   12397081   12424202   12447691   12468530   12477932   12483522   12515609   12524548   12586340   12612082   12684677   12738867   12775724   12791267   12839990   12865421   1384126   1386342   1387877   14645578   14701726   14760118   14993212   15016823   15024056   15181148   15215233   15256223   15265780   15489334   15541388   15623561   15635413   15654331   15710382   15749827   15767402   15790566   15916961   15931389   15989971   16009132   16082198   16109376   16142332   16159883   16221667   16226712   16237118   16273239   16275333   16322753   16407259   16474839   16478538   16479161   16751065   16784539   16799550   16880739   16921029   17098733   17167975   1717476   17242184   17242210   17274640   17327911   17359284   17359356   17360335   17373649   17386261   17388661   17389604   17408621   17431037   17445807   17466630   17472438   17495531   17495533   17513602   17533373   17586317   17598982   17655707   17668170   17679094   17850284   17881737   18048386   18059335   18195732   18281511   1828290   18337751   18353325   1836978   18372919   18408012   18414058   18445273   18471975   18491248   18591933   18593994   18652313   18671143   18692784   18799590   18820706   19028417   19134343   19275580   19275586   19293801   19344781   19369249   19458171   19470724   19475398   19505905   19609944   19614764   19724852   19738611   19763267   19786724   19820702   19825974   19826003   19855194   19968870   20080579   20095356   20097574   20103625   20160477   20169205   20171170   20228808   20334896   20360007   20360068   20367638   20368335   20383333   20404109   20412769   20453000   20508983   20526282   20660152   20661218   20733051   20733055   20808790   20810654   20890132   20927403   20937773   20956543   20965177   21120602   21139048   21145461   21148318   21174181   21241890   21264543   21276999   21336306   21379580   21488187   21489275   21504622   21525341   21569376   21596315   21628590   21871181   21890473   21900495   21900748   21906983   21925791   21952639   21963094   21965721   22014574   22024040   22024133   22071694   22137483   22157815   22158041   22163316   22193957   22253775   22266860   22286100   22391203   22482362   22508987   22529100   22532137   22552851   22580043   22682366   22726437   22905155   22939629   22965228   23007861   23091007   23239745   23253261   23383273   2570636   7474080   7474100   7494303   7666531   7737117   7769006   7799941   7843284   7876309   7903056   8070405   8101826   8397206   8397207   8402895   8463339   8475101   8524869   8662825   8756624   8889548   9001210   9053846   9094673   9244350   9247342   9499405   9515786   9520381   9560267   9679058   9813064   9885575   9891079   9926943 RGD Disease Portals CCNB1 has been annotated in the following RGD Disease Portals. Biological Process Cancer Diseases Cancer Pathways Biological Process Cardiovascular Diseases Cardiovascular Pathways Diabetes Diseases Diabetes Pathways Immune and Inflammatory Diseases Immune and Inflammatory Pathways Neurological Diseases Neurological Pathways Biological Process Obesity Diseases Obesity Pathways Respiratory Pathways Genomics Comparative Map Data CCNB1   (Homo sapiens) Map Chr Position Strand Source Human Alternate Assembly CHM1_1 5 68,382,314 - 68,393,549 + NCBI Human Genome Assembly HuRef 5 65,418,249 - 65,429,485 + NCBI Human Genome Assembly GRCh37 5 68,462,837 - 68,474,072 + NCBI Human Genome Assembly Build 36 5 68,498,669 - 68,509,828 + NCBI Human Cytogenetic Map 5 q12   NCBI Human Genome Assembly 5 68,498,668 - 68,509,824   NCBI Ccnb1   (Mus musculus) Map Chr Position Strand Source Mouse Genome Assembly GRCm38 13 100,778,739 - 100,786,486 - NCBI Mouse cM Map 13 53.23   NCBI Mouse Celera Assembly 13 104,387,574 - 104,395,322 - NCBI Mouse Genome Assembly Build 37 13 101,548,694 - 101,556,441 - NCBI Mouse Genome Assembly Build 36.1 13 101,548,694 - 101,556,441 - NCBI Mouse Cytogenetic Map 13 D1   NCBI Ccnb1   (Rattus norvegicus) Map Chr Position Strand Source Rat Cytogenetic Map 2 q12   NCBI RGSC Genome Assembly v5.0 2 49,941,586 - 49,948,770 - NCBI RGSC Genome Assembly v3.4 2 31,574,600 - 31,581,784 - NCBI Rat Celera Assembly 2 27,927,224 - 27,934,408 - NCBI Genome Assembly 3.1 2 31,493,947 - 31,502,123 - NCBI Position Markers csnpccnb1-pcr3-1   Map Chr Position Strand Source Human Genome Assembly HuRef 5 65,419,296 - 65,419,715   UniSTS Human Genome Assembly GRCh37 5 68,463,884 - 68,464,303   UniSTS Human Celera Assembly 5 65,463,137 - 65,463,556   RGD Human Genome Assembly Build 36 5 68,499,640 - 68,500,059   RGD Human Cytogenetic Map 5 q12   UniSTS csnpccnb1-pcr6-1   Map Chr Position Strand Source Human Genome Assembly HuRef 5 65,425,994 - 65,426,432   UniSTS Human Genome Assembly GRCh37 5 68,470,583 - 68,471,017   UniSTS Human Celera Assembly 5 65,469,835 - 65,470,273   RGD Human Genome Assembly Build 36 5 68,506,339 - 68,506,773   RGD Human Cytogenetic Map 5 q12   UniSTS csnpccnb1-pcr7-1   Map Chr Position Strand Source Human Genome Assembly HuRef 5 65,426,515 - 65,426,873   UniSTS Human Genome Assembly GRCh37 5 68,471,100 - 68,471,458   UniSTS Human Celera Assembly 5 65,470,356 - 65,470,714   RGD Human Genome Assembly Build 36 5 68,506,856 - 68,507,214   RGD Human Cytogenetic Map 5 q12   UniSTS csnpccnb1-pcr9-1   Map Chr Position Strand Source Human Genome Assembly HuRef 5 65,428,648 - 65,428,977   UniSTS Human Genome Assembly GRCh37 5 68,473,235 - 68,473,564   UniSTS Human Celera Assembly 5 65,472,491 - 65,472,820   RGD Human Genome Assembly Build 36 5 68,508,991 - 68,509,320   RGD Human Cytogenetic Map 5 q12   UniSTS PMC138289P1   Map Chr Position Strand Source Human Genome Assembly HuRef 5 65,418,261 - 65,418,501   UniSTS Human Genome Assembly GRCh37 5 68,462,849 - 68,463,089   UniSTS Human Celera Assembly 5 65,462,102 - 65,462,342   RGD Human Genome Assembly Build 36 5 68,498,605 - 68,498,845   RGD Human Cytogenetic Map 5 q12   UniSTS PMC31860P1   Map Chr Position Strand Source Human Genome Assembly HuRef 5 65,419,171 - 65,419,299   UniSTS Human Genome Assembly GRCh37 5 68,463,759 - 68,463,887   UniSTS Human Celera Assembly 5 65,463,012 - 65,463,140   RGD Human Genome Assembly Build 36 5 68,499,515 - 68,499,643   RGD Human Cytogenetic Map 5 q12   UniSTS PMC31860P2   Map Chr Position Strand Source Human Genome Assembly HuRef 5 65,419,207 - 65,419,299   UniSTS Human Genome Assembly GRCh37 5 68,463,795 - 68,463,887   UniSTS Human Celera Assembly 5 65,463,048 - 65,463,140   RGD Human Genome Assembly Build 36 5 68,499,551 - 68,499,643   RGD Human Cytogenetic Map 5 q12   UniSTS CCNB1_1683   Map Chr Position Strand Source Human Genome Assembly HuRef 5 65,428,827 - 65,429,678   UniSTS Human Genome Assembly GRCh37 5 68,473,414 - 68,474,265   UniSTS Human Celera Assembly 5 65,472,670 - 65,473,521   RGD Human Genome Assembly Build 36 5 68,509,170 - 68,510,021   RGD G31135   Map Chr Position Strand Source Human Genome Assembly HuRef 5 65,429,288 - 65,429,414   UniSTS Human Genome Assembly GRCh37 5 68,473,875 - 68,474,001   UniSTS Human Celera Assembly 5 65,473,131 - 65,473,257   RGD Human Genome Assembly Build 36 5 68,509,631 - 68,509,757   RGD Human Cytogenetic Map 5 q12   UniSTS CCNB1   Map Chr Position Strand Source Human Genome Assembly HuRef 5 65,425,508 - 65,426,211   UniSTS Human Genome Assembly GRCh37 5 68,470,097 - 68,470,796   UniSTS Human Celera Assembly 5 65,469,349 - 65,470,052   UniSTS QTLs in Region (Human Genome Assembly GRCh37) The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer RGD ID Symbol Name LOD P Value Trait Sub Trait Chr Start Stop Species 1559261 SAPOA3_H Serum apolipoprotein A level QTL 3 (human) 2.13 Apolipoprotein level apolipoprotein A -II level 5 1154429 101179152 Human 1357383 BW61_H Body weight QTL 61 (human) 2.4 .0004 Body weight BMI after exercise training 5 34952160 147315481 Human 2289442 BW407_H Body weight QTL 407 (human) 1.59 Body weight lean mass 5 42994831 68994831 Human 2289466 SLEP14_H Serum leptin level QTL 14 (human) 2.08 Hormone level leptin 5 42994831 68994831 Human 2301146 PRSTS372_H Prostate tumor susceptibility QTL 372 (human) 2.24 .0007 Prostate tumor susceptibility 5 42994831 68994831 Human 2301895 PRSTS339_H Prostate tumor susceptiblity QTL 339 (human) 1 Prostate tumor susceptibility 5 42994831 68994831 Human 1643506 BW288_H Body Weight QTL 288 (human) 1.7 Body weight BMI 5 45697268 71697268 Human 1559409 SCL114_H Serum cholesterol level QTL 114 (human) 2.09 Lipid level total cholesterol 5 49903260 75903260 Human 2292880 PRSTS81_H Prostate tumor susceptibility QTL 81 (human) 2.28 Prostate tumor susceptibility 5 50921153 76921153 Human 2300112 PRSTS335_H Prostate tumor susceptibility QTL 335 (human) Prostate tumor susceptibility 5 50921153 76921153 Human 2315773 GLUCO152_H Glucose level QTL 152 (human) 1.35 .0064 Glucose level 5 53247449 79247449 Human 2301140 PRSTS374_H Prostate tumor susceptibility QTL 374 (human) 2.34 Prostate tumor susceptibility 5 53247449 79247449 Human 2315819 GLUCO178_H Glucose level QTL 178 (human) 1.28 Glucose level 5 53247449 79247449 Human 2301180 PRSTS376_H Prostate tumor susceptibility QTL 376 (human) 2.17 Prostate tumor susceptibility lesions with ACI-type nuclei 5 63157987 89157987 Human 1578596 LDLPS12_H Low density lipoprotein particle size QTL 12 (human) 2.4 .000004 LDL particle size 5 65468508 91468508 Human 1578601 LDLPS11_H Low density lipoprotein particle size QTL 11 (human) 2.34 .000003 LDL particle size 5 65468508 91468508 Human 1578604 LDLPS10_H Low density lipoprotein particle size QTL 10 (human) 2.1 .000008 LDL particle size 5 65468508 91468508 Human 1643314 BW226_H Body weight QTL 226 (human) 1.04 Body weight body mass index 5 65468508 91468508 Human 2292888 MYI24_H Myocardial infarction susceptibility QTL 24 (human) Myocardial infarction susceptibility early-onset 5 65468508 91468508 Human Sequence Nucleotide Sequences Nucleotide RefSeqs NM_031966 (Get FASTA) Search GEO for Microarray Profiles GenBank Nucleotide ABBA01048284 (Get FASTA) Search GEO for Microarray Profiles   AC010273 (Get FASTA) Search GEO for Microarray Profiles   AC022107 (Get FASTA) Search GEO for Microarray Profiles   AI972071 (Get FASTA) Search GEO for Microarray Profiles   AK289431 (Get FASTA) Search GEO for Microarray Profiles   AM851053 (Get FASTA) Search GEO for Microarray Profiles   AMYH01015145 (Get FASTA) Search GEO for Microarray Profiles   AY027761 (Get FASTA) Search GEO for Microarray Profiles   AY027762 (Get FASTA) Search GEO for Microarray Profiles   AY027763 (Get FASTA) Search GEO for Microarray Profiles   AY027764 (Get FASTA) Search GEO for Microarray Profiles   AY027765 (Get FASTA) Search GEO for Microarray Profiles   AY027767 (Get FASTA) Search GEO for Microarray Profiles   AY027768 (Get FASTA) Search GEO for Microarray Profiles   AY027769 (Get FASTA) Search GEO for Microarray Profiles   AY027770 (Get FASTA) Search GEO for Microarray Profiles   AY338491 (Get FASTA) Search GEO for Microarray Profiles   BC006510 (Get FASTA) Search GEO for Microarray Profiles   BI253686 (Get FASTA) Search GEO for Microarray Profiles   BM979016 (Get FASTA) Search GEO for Microarray Profiles   BT020128 (Get FASTA) Search GEO for Microarray Profiles   CH471137 (Get FASTA) Search GEO for Microarray Profiles   HH771226 (Get FASTA) Search GEO for Microarray Profiles   M25753 (Get FASTA) Search GEO for Microarray Profiles   S74452 (Get FASTA) Search GEO for Microarray Profiles   U22364 (Get FASTA) Search GEO for Microarray Profiles Reference Sequences RefSeq Acc Id: NM_031966 RefSeq Status: REVIEWED Type: CODING Protein Acc Id: NP_114172 Position: Map Chr Position Strand Source Human Alternate Assembly CHM1_1 5 68,382,314 - 68,393,549 + NCBI Human Genome Assembly HuRef 5 65,418,249 - 65,429,485 + NCBI Human Genome Assembly GRCh37 5 68,462,837 - 68,474,072 + NCBI Human Genome Assembly Build 36 5 68,498,669 - 68,509,828 + NCBI Archive Protein Sequences Protein RefSeqs NP_114172 (Get FASTA) GenBank Protein AAD14154 (Get FASTA)   AAD14818 (Get FASTA)   AAH06510 (Get FASTA)   AAK27417 (Get FASTA)   AAK27418 (Get FASTA)   AAK27419 (Get FASTA)   AAK27420 (Get FASTA)   AAK27421 (Get FASTA)   AAK27422 (Get FASTA)   AAK27423 (Get FASTA)   AAK27424 (Get FASTA)   AAK27425 (Get FASTA)   AAP88038 (Get FASTA)   AAV38930 (Get FASTA)   ABM83901 (Get FASTA)   BAF82120 (Get FASTA)   CAO99273 (Get FASTA)   CBX86318 (Get FASTA)   EAW51306 (Get FASTA)   P14635 (Get FASTA) Promoters RGD ID: 6859148 Promoter ID: EPDNEW_H2738 Type: initiation region Name: TMEM18_2 Description: transmembrane protein 18 SO ACC ID: SO:0000170 Source: EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) Position: Map Chr Position Strand Source Human Genome Assembly Build 36 2 676,698 - 676,758   EPDNEW RGD ID: 6802940 Promoter ID: HG_KWN:50303 Type: CpG-Island SO ACC ID: SO:0000170 Source: MPROMDB Tissues & Cell Lines: CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4 Transcripts: OTTHUMT00000215084,   UC003JVL.1,   UC010IXB.1 Position: Map Chr Position Strand Source Human Genome Assembly Build 36 5 68,498,386 - 68,498,886 + MPROMDB RGD ID: 6852698 Promoter ID: EP74161 Type: initiation region Name: HS_CCNB1 Description: Cyclin B1. SO ACC ID: SO:0000170 Source: EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/) Experiment Methods: Mammalian gene collection (MGC) full-length cDNA cloning Position: Map Chr Position Strand Source Human Genome Assembly Build 36 5 68,498,765 - 68,498,825   EPD Additional Information External Database Links Database Acc Id Source(s) COSMIC CCNB1 COSMIC Ensembl Genes ENSG00000134057 ENTREZGENE Ensembl Protein ENSP00000256442 ENTREZGENE Ensembl Transcript ENST00000256442 ENTREZGENE Entrez Gene 891 ENTREZGENE Gene3D-CATH Cyclin_related UniProtKB/Swiss-Prot Germonline ENSG00000134057 HGNC ID 1579 ENTREZGENE HomoloGene Group ID 68982 ENTREZGENE HPRD ID 00454 ENTREZGENE InterPro Cyclin-like UniProtKB/Swiss-Prot   Cyclin_A/B/D/E UniProtKB/Swiss-Prot   Cyclin_C UniProtKB/Swiss-Prot   Cyclin_N UniProtKB/Swiss-Prot IPI IPI00294696 UniProtKB/TrEMBL   IPI00745793 UniProtKB/Swiss-Prot   IPI00966293 UniProtKB/TrEMBL   IPI00966971 UniProtKB/TrEMBL KEGG Report hsa:891 ENTREZGENE, UniProtKB/Swiss-Prot OMIM 123836 OMIM Pfam Cyclin_C UniProtKB/Swiss-Prot   Cyclin_N UniProtKB/Swiss-Prot PharmGKB CCNB1 RGD, PharmGKB PIRSF Cyclin_A_B_D_E UniProtKB/Swiss-Prot PROSITE CYCLINS UniProtKB/Swiss-Prot SMART CYCLIN UniProtKB/Swiss-Prot Superfamily-SCOP Cyclin_like UniProtKB/Swiss-Prot UniGene Hs.23960 ENTREZGENE UniProt CCNB1_HUMAN UniProtKB/Swiss-Prot   D6RHI0_HUMAN UniProtKB/TrEMBL   E9PC90_HUMAN UniProtKB/TrEMBL   H0Y9U8_HUMAN UniProtKB/TrEMBL   H0YA62_HUMAN UniProtKB/TrEMBL   Q5TZP9_HUMAN UniProtKB/TrEMBL Nomenclature History Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status 2011-08-16 CCNB1  cyclin B1  CCNB1  cyclin B1  Symbol and/or name change 39860 APPROVED

More on CCNB1 Entrez Gene Ensembl Gene Genome Browser: (hg18) (hg19) HGNC Report NCBI Map Viewer Vista Vista + UCSC RGD Object Information RGD ID: 733179 Created: 2004-01-12 Species: Homo sapiens Last Modified: 2013-04-09 Status: ACTIVE