PRKACA (protein kinase, cAMP-dependent, catalytic, alpha)

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Keyword

Gene: PRKACA (protein kinase, cAMP-dependent, catalytic, alpha) Homo sapiens

Symbol:

PRKACA

Name:

protein kinase, cAMP-dependent, catalytic, alpha

Description:

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

cAMP-dependent protein kinase catalytic subunit alpha; cAMP-dependent protein kinase catalytic subunit alpha, isoform 1; MGC102831; MGC48865; PKA C-alpha; PKACA; protein kinase A catalytic subunit

Orthologs:

Mus musculus : Prkaca (protein kinase, cAMP dependent, catalytic, alpha) MGI
Rattus norvegicus : Prkaca (protein kinase, cAMP-dependent, catalytic, alpha)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	19	14,138,403 - 14,164,287	-	NCBI
Human Genome Assembly HuRef	19	13,774,379 - 13,800,126	-	NCBI
Human Genome Assembly GRCh37	19	14,202,500 - 14,228,559	-	NCBI
Human Genome Assembly Build 36	19	14,063,500 - 14,089,559	-	NCBI
Human Cytogenetic Map	19	p13.1		NCBI
Human Genome Assembly	19	14,063,508 - 14,085,992		NCBI