HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase)

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Keyword

Gene: HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase) Homo sapiens

Symbol:

HMGCR

Name:

3-hydroxy-3-methylglutaryl-CoA reductase

Description:

HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

3-hydroxy-3-methylglutaryl CoA reductase (NADPH); 3-hydroxy-3-methylglutaryl-Coenzyme A reductase; HMG-CoA reductase; hydroxymethylglutaryl-CoA reductase; LDLCQ3; OTTHUMP00000128250; OTTHUMP00000222062; OTTHUMP00000222063

Orthologs:

Mus musculus : Hmgcr (3-hydroxy-3-methylglutaryl-Coenzyme A reductase) MGI
Rattus norvegicus : Hmgcr (3-hydroxy-3-methylglutaryl-CoA reductase)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	5	74,925,992 - 74,950,924	+	NCBI
Human Genome Assembly HuRef	5	69,838,165 - 69,863,098	+	NCBI
Human Genome Assembly GRCh37	5	74,632,993 - 74,657,926	+	NCBI
Human Genome Assembly Build 36	5	74,668,855 - 74,693,681	+	NCBI
Human Cytogenetic Map	5	q13.3-q14		NCBI
Human Genome Assembly	5	74,668,854 - 74,693,681		NCBI