(-)-epigallocatechin 3-gallate increases expression EXP 6480464 epigallocatechin gallate results in increased expression of AKR1C1 mRNA CTD PMID:32512070 (1->4)-beta-D-glucan multiple interactions ISO Akr1c20 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of AKR1C20 mRNA CTD PMID:36331819 (1S)-bornane-2,3-dione increases metabolic processing ISO Akr1c20 (Mus musculus) 6480464 AKR1C20 protein results in increased metabolism of camphorquinone CTD PMID:16508162 (E)-cinnamyl alcohol increases expression EXP 6480464 cinnamyl alcohol results in increased expression of AKR1C1 mRNA CTD PMID:20566472 (S)-naringenin multiple interactions EXP 6480464 naringenin binds to and results in decreased activity of AKR1C1 protein CTD PMID:16962702 1,10-phenanthroline decreases activity EXP 6480464 1 and 10-phenanthroline results in decreased activity of AKR1C1 protein CTD PMID:12604236 and PMID:8573067 1,7-phenanthroline decreases activity EXP 6480464 1 and 7-phenanthroline results in decreased activity of AKR1C1 protein CTD PMID:8573067 1,8-Dinitropyrene multiple interactions EXP 6480464 [AKR1C1 protein results in increased degradation of 1 and 8-dinitropyrene] which results in increased abundance of 1-amino-8-nitropyrene CTD PMID:36399404 1-Aminopyrene multiple interactions EXP 6480464 [AKR1C1 protein results in increased degradation of 1-nitropyrene] which results in increased abundance of 1-aminopyrene CTD PMID:36399404 1-chloro-2,4-dinitrobenzene increases expression EXP 6480464 Dinitrochlorobenzene results in increased expression of AKR1C1 mRNA CTD PMID:20566472 1-naphthyl isothiocyanate decreases expression ISO Akr1c1 (Rattus norvegicus) 6480464 1-Naphthylisothiocyanate results in decreased expression of AKR1C1 mRNA CTD PMID:25380136 1-nitropyrene multiple interactions EXP 6480464 [AKR1C1 protein results in increased degradation of 1-nitropyrene] which results in increased abundance of 1-aminopyrene CTD PMID:36399404 16-Ketoestrone increases metabolic processing ISO Akr1c20 (Mus musculus) 6480464 AKR1C20 protein results in increased metabolism of 16-ketoestrone CTD PMID:16508162 17beta-estradiol multiple interactions EXP 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of AKR1C1 mRNA CTD PMID:19619570 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of AKR1C1 mRNA CTD PMID:19619570 17beta-hydroxy-5alpha-androstan-3-one multiple interactions EXP 6480464 Flufenamic Acid inhibits the reaction [AKR1C1 protein results in increased metabolism of Dihydrotestosterone] CTD PMID:14672942 17beta-hydroxy-5alpha-androstan-3-one increases metabolic processing ISO Akr1c20 (Mus musculus) 6480464 AKR1C20 protein results in increased metabolism of Dihydrotestosterone CTD PMID:16508162 17beta-hydroxy-5alpha-androstan-3-one increases metabolic processing EXP 6480464 AKR1C1 protein results in increased metabolism of Dihydrotestosterone CTD PMID:14672942 2,2',4,4',5,5'-hexachlorobiphenyl decreases expression ISO Akr1c20 (Mus musculus) 6480464 2 more ... CTD PMID:20005886 and PMID:21851831 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO Akr1c20 (Mus musculus) 6480464 2 more ... CTD PMID:21851831 and PMID:25510870 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO Akr1c20 (Mus musculus) 6480464 [2 more ... CTD PMID:25510870 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of AKR1C1 mRNA CTD PMID:19619570 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO Akr1c20 (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in decreased expression of AKR1C20 mRNA CTD PMID:20005886 more ... 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Akr1c1 (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin affects the expression of AKR1C1 mRNA CTD PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO Akr1c1 (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin results in decreased expression of AKR1C1 mRNA and Tetrachlorodibenzodioxin results in decreased expression of AKR1C6 mRNA CTD PMID:18796159 and PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Akr1c20 (Mus musculus) 6480464 2 more ... CTD PMID:21851831 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of AKR1C1 mRNA CTD PMID:19619570 2,3-dimethoxynaphthalene-1,4-dione increases expression EXP 6480464 2 more ... CTD PMID:9973208 2,6-dinitrotoluene affects expression ISO Akr1c1 (Rattus norvegicus) 6480464 2 and 6-dinitrotoluene affects the expression of AKR1C6 mRNA CTD PMID:21346803 2-hydroxypropanoic acid increases expression EXP 6480464 Lactic Acid results in increased expression of AKR1C1 mRNA CTD PMID:20566472 and PMID:30851411 2-tert-butylhydroquinone increases expression EXP 6480464 2-tert-butylhydroquinone results in increased expression of AKR1C1 mRNA CTD PMID:30806763 and PMID:9973208 3,3',4,4',5-pentachlorobiphenyl multiple interactions ISO Akr1c1 (Rattus norvegicus) 6480464 [3 more ... CTD PMID:30744511 3,3',5-triiodo-L-thyronine increases expression EXP 6480464 Triiodothyronine results in increased expression of AKR1C1 mRNA CTD PMID:15507505 3,4,5,3',4',5'-Hexachlorobiphenyl multiple interactions ISO Akr1c1 (Rattus norvegicus) 6480464 [3 more ... CTD PMID:30744511 3,4-dichloroaniline increases expression EXP 6480464 3 and 4-dichloroaniline results in increased expression of AKR1C1 mRNA CTD PMID:24172598 3-isobutyl-1-methyl-7H-xanthine multiple interactions EXP 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of AKR1C1 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of AKR1C1 mRNA CTD PMID:28628672 3-methylcholanthrene increases expression EXP 6480464 Methylcholanthrene results in increased expression of AKR1C1 mRNA CTD PMID:9973208 3-Nitrobenzanthrone increases reduction EXP 6480464 AKR1C1 protein results in increased reduction of 3-nitrobenzanthrone CTD PMID:30406992 3-Nitrobenzanthrone multiple interactions EXP 6480464 [AKR1C1 protein results in increased reduction of 3-nitrobenzanthrone] which results in increased chemical synthesis of 3-aminobenzanthrone and [AKR1C1 protein results in increased reduction of 3-nitrobenzanthrone] which results in increased chemical synthesis of N-hydroxy-3-aminobenzanthrone CTD PMID:30406992 3-phenylprop-2-enal increases expression EXP 6480464 cinnamaldehyde results in increased expression of AKR1C1 mRNA CTD PMID:19524605 3alpha-hydroxy-5beta-pregnan-20-one increases reduction EXP 6480464 AKR1C1 protein results in increased reduction of Pregnanolone CTD PMID:11995921 3alpha-hydroxy-5beta-pregnan-20-one affects metabolic processing EXP 6480464 AKR1C1 protein affects the metabolism of Pregnanolone CTD PMID:12604236 4,4'-diaminodiphenylmethane decreases expression ISO Akr1c1 (Rattus norvegicus) 6480464 4 and 4'-diaminodiphenylmethane results in decreased expression of AKR1C1 mRNA CTD PMID:25380136 4,4'-diaminodiphenylmethane increases expression ISO Akr1c20 (Mus musculus) 6480464 4 and 4'-diaminodiphenylmethane results in increased expression of AKR1C20 mRNA CTD PMID:18648102 4,4'-sulfonyldiphenol multiple interactions EXP 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of AKR1C1 mRNA CTD PMID:28628672 4,4'-sulfonyldiphenol increases expression EXP 6480464 bisphenol S results in increased expression of AKR1C1 protein CTD PMID:34186270 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases metabolic processing EXP 6480464 AKR1C1 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone CTD PMID:11306090 4-hydroxybenzoic acid decreases activity EXP 6480464 4-hydroxybenzoic acid analog results in decreased activity of AKR1C1 protein CTD PMID:27163852 4-hydroxyphenyl retinamide increases expression EXP 6480464 Fenretinide results in increased expression of AKR1C1 mRNA CTD PMID:16671099 4-phenylbutyric acid increases expression EXP 6480464 4-phenylbutyric acid results in increased expression of AKR1C1 mRNA CTD PMID:14583596 5-alpha-THDOC affects oxidation EXP 6480464 AKR1C1 protein affects the oxidation of tetrahydrodeoxycorticosterone CTD PMID:12604236 5-fluorouracil affects response to substance EXP 6480464 AKR1C1 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 5-fluorouracil affects expression EXP 6480464 Fluorouracil affects the expression of AKR1C1 mRNA CTD PMID:16584549 5alpha-pregnane-3,20-dione affects reduction EXP 6480464 AKR1C1 protein affects the reduction of 5-alpha-Dihydroprogesterone CTD PMID:12604236 5alpha-pregnane-3,20-dione increases reduction EXP 6480464 AKR1C1 protein results in increased reduction of 5-alpha-Dihydroprogesterone CTD PMID:11995921 7-hydroxyflavone multiple interactions EXP 6480464 7-hydroxyflavone binds to and results in decreased activity of AKR1C1 protein CTD PMID:16962702 9,10-phenanthroquinone increases metabolic processing EXP 6480464 AKR1C1 protein results in increased metabolism of 9 and 10-phenanthrenequinone CTD PMID:17950253 9,10-phenanthroquinone increases metabolic processing ISO Akr1c20 (Mus musculus) 6480464 AKR1C20 protein results in increased metabolism of 9 and 10-phenanthrenequinone CTD PMID:16508162 9,10-phenanthroquinone increases reduction EXP 6480464 AKR1C1 protein results in increased reduction of 9 and 10-phenanthrenequinone CTD PMID:21851338 and PMID:23261716 9,10-phenanthroquinone multiple interactions EXP 6480464 AKR1C1 protein results in increased reduction of and affects the activity of 9 and 10-phenanthrenequinone CTD PMID:21910479 9-cis-retinal increases reduction EXP 6480464 AKR1C1 protein results in increased reduction of 9-cis-retinal CTD PMID:21851338 acenaphthoquinone increases metabolic processing ISO Akr1c20 (Mus musculus) 6480464 AKR1C20 protein results in increased metabolism of acenaphthenequinone CTD PMID:16508162 acetylsalicylic acid decreases activity EXP 6480464 Aspirin results in decreased activity of AKR1C1 protein CTD PMID:19010312 aflatoxin B1 decreases methylation EXP 6480464 Aflatoxin B1 results in decreased methylation of AKR1C1 gene CTD PMID:27153756 aflatoxin B1 decreases expression ISO Akr1c20 (Mus musculus) 6480464 Aflatoxin B1 results in decreased expression of AKR1C20 mRNA CTD PMID:19770486 aflatoxin B1 decreases expression ISO Akr1c1 (Rattus norvegicus) 6480464 Aflatoxin B1 results in decreased expression of AKR1C1 mRNA CTD PMID:22484513 alpha-hexylcinnamaldehyde increases expression EXP 6480464 hexyl cinnamic aldehyde results in increased expression of AKR1C1 mRNA CTD PMID:20566472 amiodarone increases expression EXP 6480464 Amiodarone results in increased expression of AKR1C1 mRNA CTD PMID:21163907 anthranilic acid decreases activity EXP 6480464 anthranilic acid analog results in decreased activity of AKR1C1 protein CTD PMID:19007763 arsane increases expression EXP 6480464 Arsenic results in increased expression of AKR1C1 mRNA CTD PMID:36861143 arsenic atom increases expression EXP 6480464 Arsenic results in increased expression of AKR1C1 mRNA CTD PMID:36861143 arsenite(3-) multiple interactions EXP 6480464 [sodium arsenite results in increased abundance of arsenite] which results in increased expression of AKR1C1 mRNA and SQSTM1 protein affects the reaction [[sodium arsenite results in increased abundance of arsenite] which results in increased expression of AKR1C1 mRNA] CTD PMID:31781319 arsenous acid decreases response to substance EXP 6480464 AKR1C1 protein results in decreased susceptibility to Arsenic Trioxide CTD PMID:20707922 arsenous acid multiple interactions EXP 6480464 [Arsenic Trioxide co-treated with Bortezomib] results in increased expression of AKR1C1 mRNA and Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to AKR1C1 protein] CTD PMID:25913414 and PMID:26598702 astilbin multiple interactions EXP 6480464 [astilbin co-treated with Cisplatin] results in increased expression of AKR1C1 mRNA CTD PMID:29471006 avobenzone increases expression EXP 6480464 avobenzone results in increased expression of AKR1C1 mRNA CTD PMID:31016361 azathioprine increases expression EXP 6480464 Azathioprine results in increased expression of AKR1C1 mRNA CTD PMID:22623647 Bandrowski's base increases expression EXP 6480464 Bandrowski's base results in increased expression of AKR1C1 mRNA CTD PMID:20566472 benzbromarone multiple interactions EXP 6480464 Benzbromarone binds to and results in decreased activity of AKR1C1 protein CTD PMID:12604236 Benzo[a]fluorene increases expression EXP 6480464 benzo(a)fluorene results in increased expression of AKR1C1 mRNA CTD PMID:17253728 benzo[a]pyrene affects response to substance EXP 6480464 AKR1C1 protein affects the susceptibility to Benzo(a)pyrene CTD PMID:19800895 benzo[a]pyrene decreases expression ISO Akr1c20 (Mus musculus) 6480464 Benzo(a)pyrene results in decreased expression of AKR1C20 mRNA CTD PMID:19770486 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of AKR1C1 mRNA CTD PMID:15735009 more ... benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of AKR1C1 mRNA CTD PMID:16545412 benzo[a]pyrene multiple interactions EXP 6480464 [Butyric Acid co-treated with Benzo(a)pyrene] results in increased expression of AKR1C1 mRNA more ... CTD PMID:17612574 more ... Benzo[a]pyrene-7,8-diol multiple interactions EXP 6480464 [AKR1C1 protein co-treated with NADP] results in increased oxidation of and affects the activity of benzo(a)pyrene 7 and 8-dihydrodiol CTD PMID:21910479 benzo[a]pyrene-7,8-dione multiple interactions EXP 6480464 [AKR1C1 protein co-treated with NADP] results in increased reduction of and affects the activity of benzo(a)pyrene-7 and 8-dione CTD PMID:21910479 benzo[a]pyrene-7,8-dione increases expression EXP 6480464 benzo(a)pyrene-7 and 8-dione results in increased expression of AKR1C1 mRNA CTD PMID:9973208 benzo[b]fluoranthene increases expression EXP 6480464 benzo(b)fluoranthene results in increased expression of AKR1C1 mRNA CTD PMID:17253728 Benzo[b]fluorene increases expression EXP 6480464 benzo(b)fluorene results in increased expression of AKR1C1 mRNA CTD PMID:17253728 Benzo[k]fluoranthene increases expression EXP 6480464 benzo(k)fluoranthene results in increased expression of AKR1C1 mRNA CTD PMID:17253728 benzoic acid increases expression EXP 6480464 Benzoic Acid results in increased expression of AKR1C1 mRNA CTD PMID:20566472 beta-naphthoflavone increases expression EXP 6480464 beta-Naphthoflavone results in increased expression of AKR1C1 mRNA CTD PMID:17253728 and PMID:32151702 bexarotene increases expression EXP 6480464 bexarotene results in increased expression of AKR1C1 mRNA CTD PMID:17178900 bis(2-ethylhexyl) phthalate increases expression EXP 6480464 Diethylhexyl Phthalate results in increased expression of AKR1C1 mRNA CTD PMID:28412506 bis(2-ethylhexyl) phthalate decreases expression ISO Akr1c20 (Mus musculus) 6480464 Diethylhexyl Phthalate results in decreased expression of AKR1C20 mRNA CTD PMID:28085963 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of AKR1C1 mRNA CTD PMID:30903817 bisphenol A increases expression ISO Akr1c20 (Mus musculus) 6480464 bisphenol A results in increased expression of AKR1C20 mRNA CTD PMID:30245210 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of AKR1C1 protein CTD PMID:34186270 bisphenol A decreases methylation EXP 6480464 bisphenol A results in decreased methylation of AKR1C1 gene CTD PMID:31601247 bisphenol A affects expression ISO Akr1c1 (Rattus norvegicus) 6480464 bisphenol A affects the expression of AKR1C1 mRNA CTD PMID:30903817 bisphenol A increases expression ISO Akr1c1 (Rattus norvegicus) 6480464 bisphenol A results in increased expression of AKR1C1 mRNA CTD PMID:32145629 Bisphenol B increases expression EXP 6480464 bisphenol B results in increased expression of AKR1C1 protein CTD PMID:34186270 bisphenol F increases expression EXP 6480464 bisphenol F results in increased expression of AKR1C1 protein CTD PMID:34186270 bortezomib multiple interactions EXP 6480464 [arsenic trioxide co-treated with Bortezomib] results in increased expression of AKR1C1 mRNA CTD PMID:25913414 bortezomib increases expression EXP 6480464 Bortezomib results in increased expression of AKR1C1 mRNA CTD PMID:21215737 bromosulfophthalein decreases activity ISO Akr1c20 (Mus musculus) 6480464 Sulfobromophthalein results in decreased activity of AKR1C20 protein CTD PMID:16508162 butyric acid multiple interactions EXP 6480464 [Butyric Acid co-treated with Benzo(a)pyrene] results in increased expression of AKR1C1 mRNA CTD PMID:30439556 cadmium atom increases expression EXP 6480464 Cadmium results in increased expression of AKR1C1 mRNA CTD PMID:21172416 cadmium atom multiple interactions EXP 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of AKR1C1 mRNA CTD PMID:29741670 and PMID:31738976 cadmium dichloride multiple interactions EXP 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of AKR1C1 mRNA CTD PMID:29741670 and PMID:31738976 cadmium dichloride decreases expression ISO Akr1c1 (Rattus norvegicus) 6480464 Cadmium Chloride results in decreased expression of AKR1C1 mRNA CTD PMID:25993096 cadmium sulfate multiple interactions EXP 6480464 [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of AKR1C1 mRNA CTD PMID:18654764 calcitriol multiple interactions EXP 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of AKR1C1 mRNA CTD PMID:21592394 calcitriol increases expression EXP 6480464 Calcitriol results in increased expression of AKR1C1 mRNA CTD PMID:12040012 and PMID:21592394 cantharidin increases expression ISO Akr1c20 (Mus musculus) 6480464 Cantharidin results in increased expression of AKR1C20 mRNA CTD PMID:36907384 carbon nanotube decreases expression ISO Akr1c20 (Mus musculus) 6480464 Nanotubes more ... CTD PMID:25620056 carmustine affects response to substance EXP 6480464 AKR1C1 mRNA affects the susceptibility to Carmustine CTD PMID:16365179 celastrol increases expression EXP 6480464 celastrol results in increased expression of AKR1C1 mRNA CTD PMID:17010675 CGP 52608 multiple interactions EXP 6480464 CGP 52608 promotes the reaction [RORA protein binds to AKR1C1 gene] CTD PMID:28238834 chenodeoxycholic acid decreases expression EXP 6480464 Chenodeoxycholic Acid results in decreased expression of AKR1C1 mRNA CTD PMID:27174168 chlorohydrocarbon multiple interactions ISO Akr1c1 (Rattus norvegicus) 6480464 [Hydrocarbons and Chlorinated co-treated with Polychlorinated Biphenyls co-treated with methylmercuric chloride] results in decreased expression of AKR1C1 mRNA CTD PMID:30744511 chrysene increases expression EXP 6480464 chrysene results in increased expression of AKR1C1 mRNA CTD PMID:17253728 ciglitazone multiple interactions EXP 6480464 [ciglitazone binds to PPARG protein alternative form] which results in increased expression of AKR1C1 mRNA and [ciglitazone binds to PPARG protein] which results in increased expression of AKR1C1 mRNA CTD PMID:16197558 cinnamyl alcohol increases expression EXP 6480464 cinnamyl alcohol results in increased expression of AKR1C1 mRNA CTD PMID:20566472 cisplatin multiple interactions EXP 6480464 [astilbin co-treated with Cisplatin] results in increased expression of AKR1C1 mRNA more ... CTD PMID:23165153 more ... cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of AKR1C1 mRNA CTD PMID:23165153 and PMID:27392435 cisplatin decreases response to substance EXP 6480464 AKR1C1 protein results in decreased susceptibility to Cisplatin CTD PMID:20953859 and PMID:23165153 Clofop increases reduction EXP 6480464 AKR1C1 protein results in increased reduction of fenofibric acid CTD PMID:27599626 cloxazolam decreases activity EXP 6480464 cloxazolam results in decreased activity of AKR1C1 protein CTD PMID:12604236 cobalt atom multiple interactions EXP 6480464 [tungsten carbide binds to Cobalt] which results in decreased expression of AKR1C1 mRNA CTD PMID:20105288 cobalt dichloride increases expression EXP 6480464 cobaltous chloride results in increased expression of AKR1C1 mRNA CTD PMID:20105288 cobalt dichloride multiple interactions EXP 6480464 [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of AKR1C1 mRNA CTD PMID:18654764 coniferyl aldehyde multiple interactions EXP 6480464 NFE2L2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of AKR1C1 protein] CTD PMID:26275128 coniferyl aldehyde increases expression EXP 6480464 coniferaldehyde results in increased expression of AKR1C1 mRNA and coniferaldehyde results in increased expression of AKR1C1 protein CTD PMID:26275128 copper atom multiple interactions EXP 6480464 [NSC 689534 binds to Copper] which results in increased expression of AKR1C1 mRNA CTD PMID:20971185 copper(0) multiple interactions EXP 6480464 [NSC 689534 binds to Copper] which results in increased expression of AKR1C1 mRNA CTD PMID:20971185 copper(II) sulfate increases expression EXP 6480464 Copper Sulfate results in increased expression of AKR1C1 mRNA CTD PMID:19549813 coumarin decreases expression ISO Akr1c1 (Rattus norvegicus) 6480464 coumarin results in decreased expression of AKR1C6 mRNA CTD PMID:18480146 crotonaldehyde increases expression EXP 6480464 2-butenal results in increased expression of AKR1C1 mRNA CTD PMID:20471460 cyclopentanol increases oxidation EXP 6480464 AKR1C1 protein results in increased oxidation of cyclopentanol CTD PMID:23261716 cyclopentanone increases reduction EXP 6480464 AKR1C1 protein results in increased reduction of cyclopentanone CTD PMID:23261716 cyclopentanone multiple interactions EXP 6480464 NADP promotes the reaction [AKR1C1 protein results in increased reduction of cyclopentanone] CTD PMID:23261716 cyclosporin A increases expression EXP 6480464 Cyclosporine results in increased expression of AKR1C1 mRNA CTD PMID:25562108 cyclosporin A decreases expression ISO Akr1c20 (Mus musculus) 6480464 Cyclosporine results in decreased expression of AKR1C20 mRNA CTD PMID:19770486 dexamethasone increases expression EXP 6480464 Dexamethasone results in increased expression of AKR1C1 mRNA CTD PMID:25047013 dexamethasone multiple interactions EXP 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of AKR1C1 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of AKR1C1 mRNA CTD PMID:28628672 diallyl trisulfide increases expression EXP 6480464 diallyl trisulfide results in increased expression of AKR1C1 mRNA CTD PMID:34995734 diarsenic trioxide multiple interactions EXP 6480464 [Arsenic Trioxide co-treated with Bortezomib] results in increased expression of AKR1C1 mRNA and Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to AKR1C1 protein] CTD PMID:25913414 and PMID:26598702 diarsenic trioxide decreases response to substance EXP 6480464 AKR1C1 protein results in decreased susceptibility to Arsenic Trioxide CTD PMID:20707922 diazepam decreases activity EXP 6480464 Diazepam results in decreased activity of AKR1C1 protein CTD PMID:11995921 and PMID:12604236 Dibenz[a,c]anthracene increases expression EXP 6480464 benzotriphenylene results in increased expression of AKR1C1 mRNA CTD PMID:17253728 dibenz[a,h]anthracene increases expression EXP 6480464 1 more ... CTD PMID:17253728 dibenzo[a,l]pyrene multiple interactions EXP 6480464 [Particulate Matter co-treated with dibenzo(a more ... CTD PMID:17612574 dibutyl phthalate increases expression EXP 6480464 Dibutyl Phthalate results in increased expression of AKR1C1 mRNA CTD PMID:18214805 dicoumarol decreases activity ISO Akr1c1 (Rattus norvegicus) 6480464 Dicumarol results in decreased activity of AKR1C6 protein CTD PMID:16788056 dienogest decreases expression EXP 6480464 dienogest results in decreased expression of AKR1C1 mRNA CTD PMID:23183084 dimethylarsinous acid increases expression EXP 6480464 dimethylarsinous acid results in increased expression of AKR1C1 mRNA CTD PMID:23487506 diquat increases expression EXP 6480464 Diquat results in increased expression of AKR1C1 mRNA CTD PMID:21172416 disulfiram increases expression EXP 6480464 Disulfiram results in increased expression of AKR1C1 mRNA CTD PMID:20566472 diuron increases expression EXP 6480464 Diuron metabolite results in increased expression of AKR1C1 mRNA CTD PMID:24172598 dorsomorphin multiple interactions EXP 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 dutasteride increases expression EXP 6480464 Dutasteride results in increased expression of AKR1C1 mRNA CTD PMID:16806904 dydrogesterone increases metabolic processing EXP 6480464 AKR1C1 protein results in increased metabolism of Dydrogesterone CTD PMID:21182831 dydrogesterone increases expression EXP 6480464 Dydrogesterone results in increased expression of AKR1C1 mRNA CTD PMID:23183084 dydrogesterone decreases expression EXP 6480464 Dydrogesterone results in decreased expression of AKR1C1 mRNA CTD PMID:23183084 dydrogesterone decreases activity EXP 6480464 Dydrogesterone results in decreased activity of AKR1C1 protein CTD PMID:21182831 entinostat decreases expression EXP 6480464 entinostat results in decreased expression of AKR1C1 mRNA CTD PMID:27188386 estazolam decreases activity EXP 6480464 Estazolam results in decreased activity of AKR1C1 protein CTD PMID:11995921 etacrynic acid increases expression EXP 6480464 Ethacrynic Acid results in increased expression of AKR1C1 mRNA CTD PMID:9973208 ethyl methanesulfonate increases expression EXP 6480464 Ethyl Methanesulfonate results in increased expression of AKR1C1 mRNA CTD PMID:23649840 eugenol increases expression EXP 6480464 Eugenol results in increased expression of AKR1C1 mRNA CTD PMID:20566472 farnesol increases expression EXP 6480464 Farnesol results in increased expression of AKR1C1 mRNA CTD PMID:30806763 fenamic acid decreases activity EXP 6480464 fenamic acid analog results in decreased activity of AKR1C1 protein CTD PMID:19010312 flufenamic acid multiple interactions EXP 6480464 Flufenamic Acid inhibits the reaction [AKR1C1 protein affects the susceptibility to oxaliplatin] and Flufenamic Acid inhibits the reaction [AKR1C1 protein results in increased metabolism of Dihydrotestosterone] CTD PMID:14672942 and PMID:23933386 flufenamic acid decreases activity ISO Akr1c20 (Mus musculus) 6480464 Flufenamic Acid results in decreased activity of AKR1C20 protein CTD PMID:16508162 flufenamic acid decreases activity EXP 6480464 Flufenamic Acid results in decreased activity of AKR1C1 protein CTD PMID:12604236 and PMID:8573067 flunitrazepam decreases activity EXP 6480464 Flunitrazepam results in decreased activity of AKR1C1 protein CTD PMID:11995921 flurbiprofen decreases activity EXP 6480464 Flurbiprofen results in decreased activity of AKR1C1 protein CTD PMID:19010312 flutamide decreases expression ISO Akr1c1 (Rattus norvegicus) 6480464 Flutamide results in decreased expression of AKR1C1 mRNA CTD PMID:24136188 folic acid increases expression ISO Akr1c20 (Mus musculus) 6480464 Folic Acid results in increased expression of AKR1C20 mRNA CTD PMID:25629700 furan decreases expression ISO Akr1c1 (Rattus norvegicus) 6480464 furan results in decreased expression of AKR1C1 mRNA CTD PMID:25539665 gamma-linolenic acid increases expression EXP 6480464 gamma-Linolenic Acid results in increased expression of AKR1C1 mRNA CTD PMID:20664735 gedunin increases expression EXP 6480464 gedunin results in increased expression of AKR1C1 mRNA CTD PMID:17010675 genistein decreases activity ISO Akr1c1 (Rattus norvegicus) 6480464 Genistein results in decreased activity of AKR1C6 protein CTD PMID:16788056 geraniol increases expression EXP 6480464 geraniol results in increased expression of AKR1C1 mRNA CTD PMID:30806763 glafenine decreases expression ISO Akr1c1 (Rattus norvegicus) 6480464 Glafenine results in decreased expression of AKR1C1 mRNA CTD PMID:24136188 glimepiride decreases activity EXP 6480464 glimepiride results in decreased activity of AKR1C1 protein CTD PMID:26362498 glipizide decreases activity EXP 6480464 Glipizide results in decreased activity of AKR1C1 protein CTD PMID:26362498 glyburide decreases activity EXP 6480464 Glyburide results in decreased activity of AKR1C1 protein CTD PMID:26362498 glycidyl methacrylate decreases expression EXP 6480464 glycidyl methacrylate results in decreased expression of AKR1C1 protein CTD PMID:36641056 glycyrrhetinate decreases activity EXP 6480464 Glycyrrhetinic Acid results in decreased activity of AKR1C1 protein CTD PMID:12604236 glycyrrhetinic acid decreases activity EXP 6480464 Glycyrrhetinic Acid results in decreased activity of AKR1C1 protein CTD PMID:12604236 hexane increases expression EXP 6480464 n-hexane results in increased expression of AKR1C1 mRNA CTD PMID:20566472 hexestrol decreases activity EXP 6480464 Hexestrol results in decreased activity of AKR1C1 protein CTD PMID:12604236 and PMID:8573067 hexestrol decreases activity ISO Akr1c20 (Mus musculus) 6480464 Hexestrol results in decreased activity of AKR1C20 protein CTD PMID:16508162 hydrogen peroxide increases expression EXP 6480464 Hydrogen Peroxide results in increased expression of AKR1C1 mRNA CTD PMID:9973208 hydrogen peroxide decreases expression EXP 6480464 Hydrogen Peroxide results in decreased expression of AKR1C1 protein CTD PMID:34581912 hydrogen peroxide multiple interactions EXP 6480464 [Hydrogen Peroxide results in increased abundance of Reactive Oxygen Species] which results in increased expression of AKR1C1 mRNA and [Hydrogen Peroxide results in increased abundance of Reactive Oxygen Species] which results in increased expression of AKR1C1 protein CTD PMID:19320734 ibuprofen decreases activity EXP 6480464 Ibuprofen results in decreased activity of AKR1C1 protein CTD PMID:19010312 Indeno[1,2,3-cd]pyrene increases expression EXP 6480464 indeno(1 more ... CTD PMID:17253728 indometacin decreases activity EXP 6480464 Indomethacin results in decreased activity of AKR1C1 protein CTD PMID:12604236 more ... indometacin decreases activity ISO Akr1c20 (Mus musculus) 6480464 Indomethacin results in decreased activity of AKR1C20 protein CTD PMID:16508162 indometacin multiple interactions EXP 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of AKR1C1 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of AKR1C1 mRNA CTD PMID:28628672 isoeugenol increases expression EXP 6480464 isoeugenol results in increased expression of AKR1C1 mRNA CTD PMID:20566472 ivermectin decreases expression EXP 6480464 Ivermectin results in decreased expression of AKR1C1 protein CTD PMID:32959892 lead diacetate increases expression EXP 6480464 lead acetate results in increased expression of AKR1C1 mRNA CTD PMID:22839698 lead(0) affects splicing EXP 6480464 Lead affects the splicing of AKR1C1 mRNA CTD PMID:28903495 lead(II) chloride increases expression EXP 6480464 lead chloride results in increased expression of AKR1C1 mRNA CTD PMID:18654764 lead(II) chloride multiple interactions EXP 6480464 [cadmium sulfate co-treated with cobaltous chloride co-treated with lead chloride] results in increased expression of AKR1C1 mRNA CTD PMID:18654764 leflunomide decreases expression EXP 6480464 leflunomide results in decreased expression of AKR1C1 mRNA CTD PMID:28988120 leflunomide decreases expression ISO Akr1c1 (Rattus norvegicus) 6480464 Leflunomide results in decreased expression of AKR1C1 mRNA CTD PMID:24136188 lipopolysaccharide multiple interactions EXP 6480464 [S-(1 more ... CTD PMID:35811015 lithocholic acid affects binding EXP 6480464 AKR1C1 protein binds to Lithocholic Acid CTD PMID:8573067 lithocholic acid decreases activity EXP 6480464 Lithocholic Acid results in decreased activity of AKR1C1 protein CTD PMID:12604236 and PMID:8573067 malathion increases expression EXP 6480464 Malathion results in increased expression of AKR1C1 mRNA CTD PMID:16079077 and PMID:18214805 meclofenamic acid decreases activity EXP 6480464 Meclofenamic Acid results in decreased activity of AKR1C1 protein CTD PMID:19010312 more ... Medazepam decreases activity EXP 6480464 Medazepam results in decreased activity of AKR1C1 protein CTD PMID:11995921 and PMID:12604236 medroxyprogesterone acetate decreases activity EXP 6480464 Medroxyprogesterone Acetate results in decreased activity of AKR1C1 protein CTD PMID:12604236 and PMID:21182831 medroxyprogesterone acetate increases expression EXP 6480464 Medroxyprogesterone Acetate results in increased expression of AKR1C1 mRNA CTD PMID:18497975 and PMID:23183084 medroxyprogesterone acetate decreases expression EXP 6480464 Medroxyprogesterone Acetate results in decreased expression of AKR1C1 mRNA CTD PMID:23183084 mefenamic acid decreases activity EXP 6480464 Mefenamic Acid analog results in decreased activity of AKR1C1 protein CTD PMID:19010312 menadione affects expression EXP 6480464 Vitamin K 3 affects the expression of AKR1C1 mRNA CTD PMID:20044591 mercury dibromide increases expression EXP 6480464 mercuric bromide results in increased expression of AKR1C1 mRNA CTD PMID:26272509 mercury dibromide multiple interactions EXP 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1C1 mRNA CTD PMID:27188386 methyl methanesulfonate increases expression EXP 6480464 Methyl Methanesulfonate results in increased expression of AKR1C1 mRNA CTD PMID:23649840 methyl salicylate increases expression EXP 6480464 methyl salicylate results in increased expression of AKR1C1 mRNA CTD PMID:20566472 methylmercury chloride increases expression EXP 6480464 methylmercuric chloride results in increased expression of AKR1C1 mRNA CTD PMID:28001369 methylmercury chloride multiple interactions ISO Akr1c1 (Rattus norvegicus) 6480464 [Hydrocarbons and Chlorinated co-treated with Polychlorinated Biphenyls co-treated with methylmercuric chloride] results in decreased expression of AKR1C1 mRNA CTD PMID:30744511 monosodium L-glutamate increases expression ISO Akr1c20 (Mus musculus) 6480464 Sodium Glutamate results in increased expression of AKR1C20 mRNA CTD PMID:25473020 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions EXP 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Salicylic Acid inhibits the reaction [AKR1C1 protein results in decreased susceptibility to Cisplatin]] CTD PMID:23165153 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal increases expression EXP 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of AKR1C1 mRNA CTD PMID:21215737 and PMID:23165153 N-nitrosodiethylamine multiple interactions ISO Akr1c1 (Rattus norvegicus) 6480464 [Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of AKR1C6 mRNA CTD PMID:28943392 N-nitrosodimethylamine decreases expression ISO Akr1c1 (Rattus norvegicus) 6480464 Dimethylnitrosamine results in decreased expression of AKR1C1 mRNA CTD PMID:25380136 NAD zwitterion multiple interactions EXP 6480464 [AKR1C1 protein co-treated with NAD] results in increased oxidation of acenaphthene-1-ol more ... CTD PMID:25446855 NAD(+) multiple interactions EXP 6480464 [AKR1C1 protein co-treated with NAD] results in increased oxidation of acenaphthene-1-ol more ... CTD PMID:25446855 NADP zwitterion multiple interactions EXP 6480464 [AKR1C1 protein co-treated with NADP] results in increased oxidation of and affects the activity of benzo(a)pyrene 7 more ... CTD PMID:21910479 and PMID:23261716 NADP(+) multiple interactions EXP 6480464 [AKR1C1 protein co-treated with NADP] results in increased oxidation of and affects the activity of benzo(a)pyrene 7 more ... CTD PMID:21910479 and PMID:23261716 naproxen decreases activity EXP 6480464 Naproxen results in decreased activity of AKR1C1 protein CTD PMID:19010312 nefazodone decreases expression ISO Akr1c1 (Rattus norvegicus) 6480464 nefazodone results in decreased expression of AKR1C1 mRNA CTD PMID:24136188 neoastilbin multiple interactions EXP 6480464 [astilbin co-treated with Cisplatin] results in increased expression of AKR1C1 mRNA CTD PMID:29471006 nickel sulfate increases expression EXP 6480464 nickel sulfate results in increased expression of AKR1C1 mRNA CTD PMID:20566472 nitrazepam decreases activity EXP 6480464 Nitrazepam results in decreased activity of AKR1C1 protein CTD PMID:11995921 norethisterone decreases activity EXP 6480464 Norethindrone results in decreased activity of AKR1C1 protein CTD PMID:21182831 ochratoxin A decreases expression EXP 6480464 ochratoxin A results in decreased expression of AKR1C1 mRNA CTD PMID:19287073 and PMID:32905824 octadecanoic acid increases expression EXP 6480464 stearic acid results in increased expression of AKR1C1 mRNA CTD PMID:32347412 octyl gallate decreases activity EXP 6480464 octyl gallate results in decreased activity of AKR1C1 protein CTD PMID:27163852 oxaliplatin multiple interactions EXP 6480464 alpha-methylcinnamic acid inhibits the reaction [AKR1C1 protein affects the susceptibility to oxaliplatin] more ... CTD PMID:23933386 oxaliplatin affects response to substance EXP 6480464 AKR1C1 protein affects the susceptibility to oxaliplatin CTD PMID:23933386 oxcarbazepine increases reduction EXP 6480464 AKR1C1 protein results in increased reduction of oxcarbazepine CTD PMID:25063510 p-chloromercuribenzoic acid increases expression EXP 6480464 p-Chloromercuribenzoic Acid results in increased expression of AKR1C1 mRNA CTD PMID:26272509 p-chloromercuribenzoic acid multiple interactions EXP 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1C1 mRNA CTD PMID:27188386 paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of AKR1C1 mRNA CTD PMID:26690555 paracetamol affects expression ISO Akr1c20 (Mus musculus) 6480464 Acetaminophen affects the expression of AKR1C20 mRNA CTD PMID:17562736 paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of AKR1C1 mRNA CTD PMID:21420995 Paraoxon-methyl increases expression EXP 6480464 methylparaoxon results in increased expression of AKR1C1 mRNA CTD PMID:19800895 Paraoxon-methyl multiple interactions EXP 6480464 AKR1C1 protein affects the susceptibility to [Benzo(a)pyrene co-treated with methylparaoxon] CTD PMID:19800895 parathion-methyl multiple interactions EXP 6480464 AKR1C1 protein affects the susceptibility to [Benzo(a)pyrene co-treated with Methyl Parathion] more ... CTD PMID:19800895 parathion-methyl increases expression EXP 6480464 Methyl Parathion results in increased expression of AKR1C1 mRNA CTD PMID:19800895 parathion-methyl increases activity EXP 6480464 Methyl Parathion results in increased activity of AKR1C1 protein CTD PMID:19800895 PCB138 multiple interactions ISO Akr1c20 (Mus musculus) 6480464 [2 more ... CTD PMID:25510870 pentachlorophenol increases expression ISO Akr1c20 (Mus musculus) 6480464 Pentachlorophenol results in increased expression of AKR1C20 mRNA CTD PMID:23892564 perfluorooctane-1-sulfonic acid multiple interactions ISO Akr1c20 (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of AKR1C20 mRNA and [perfluorooctane sulfonic acid co-treated with Pectins] results in decreased expression of AKR1C20 mRNA CTD PMID:36331819 perfluorooctanoic acid decreases expression EXP 6480464 perfluorooctanoic acid results in decreased expression of AKR1C1 mRNA CTD PMID:23978341 perfluorooctanoic acid affects expression ISO Akr1c20 (Mus musculus) 6480464 perfluorooctanoic acid affects the expression of AKR1C20 mRNA CTD PMID:18281256 phenethyl caffeate decreases activity EXP 6480464 caffeic acid phenethyl ester results in decreased activity of AKR1C1 protein CTD PMID:27163852 phenobarbital increases expression ISO Akr1c20 (Mus musculus) 6480464 Phenobarbital results in increased expression of AKR1C20 mRNA CTD PMID:19482888 phenobarbital multiple interactions ISO Akr1c20 (Mus musculus) 6480464 NR1I3 protein affects the reaction [Phenobarbital results in increased expression of AKR1C20 mRNA] CTD PMID:19482888 phenolphthalein multiple interactions EXP 6480464 Phenolphthalein inhibits the reaction [AKR1C1 protein affects the susceptibility to oxaliplatin] CTD PMID:23933386 phenolphthalein decreases activity EXP 6480464 Phenolphthalein results in decreased activity of AKR1C1 protein CTD PMID:12604236 phenylmercury acetate increases expression EXP 6480464 Phenylmercuric Acetate results in increased expression of AKR1C1 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions EXP 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1C1 mRNA CTD PMID:27188386 pirinixic acid multiple interactions EXP 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of AKR1C1 mRNA CTD PMID:19710929 pirinixic acid decreases expression ISO Akr1c20 (Mus musculus) 6480464 pirinixic acid results in decreased expression of AKR1C20 mRNA CTD PMID:18445702 and PMID:20813756 pirinixic acid multiple interactions ISO Akr1c20 (Mus musculus) 6480464 [pirinixic acid co-treated with PPARA] results in decreased expression of AKR1C20 mRNA CTD PMID:20813756 pirinixic acid decreases expression ISO Akr1c1 (Rattus norvegicus) 6480464 pirinixic acid results in decreased expression of AKR1C1 mRNA CTD PMID:22484513 potassium dichromate increases expression ISO Akr1c20 (Mus musculus) 6480464 Potassium Dichromate results in increased expression of AKR1C20 mRNA CTD PMID:23608068 pregnenolone 16alpha-carbonitrile decreases expression ISO Akr1c20 (Mus musculus) 6480464 Pregnenolone Carbonitrile results in decreased expression of AKR1C20 mRNA CTD PMID:28903501 progesterone multiple interactions EXP 6480464 AKR1C1 protein affects the metabolism of and results in decreased activity of Progesterone CTD PMID:16962702 progesterone decreases expression EXP 6480464 Progesterone results in decreased expression of AKR1C1 mRNA CTD PMID:23183084 progesterone increases reduction EXP 6480464 AKR1C1 protein results in increased reduction of Progesterone CTD PMID:11995921 and PMID:22245609 progesterone affects reduction EXP 6480464 AKR1C1 protein affects the reduction of Progesterone CTD PMID:12604236 and PMID:16338060 propan-2-ol increases expression EXP 6480464 2-Propanol results in increased expression of AKR1C1 mRNA CTD PMID:20566472 prostaglandin G2 increases metabolic processing EXP 6480464 AKR1C1 protein results in increased metabolism of prostaglandin G2 CTD PMID:8573067 pyrimidine decreases activity EXP 6480464 pyrimidine analog results in decreased activity of AKR1C1 protein CTD PMID:19007763 quercetin decreases activity ISO Akr1c1 (Rattus norvegicus) 6480464 Quercetin results in decreased activity of AKR1C6 protein CTD PMID:16788056 quinolin-8-ol increases expression EXP 6480464 Oxyquinoline results in increased expression of AKR1C1 mRNA CTD PMID:21632981 quinomethionate increases expression EXP 6480464 quinomethionate results in increased expression of AKR1C1 mRNA CTD PMID:18214805 quinomethionate affects expression EXP 6480464 quinomethionate affects the expression of AKR1C1 mRNA CTD PMID:15387888 rac-lactic acid increases expression EXP 6480464 Lactic Acid results in increased expression of AKR1C1 mRNA CTD PMID:20566472 and PMID:30851411 reactive oxygen species multiple interactions EXP 6480464 [Hydrogen Peroxide results in increased abundance of Reactive Oxygen Species] which results in increased expression of AKR1C1 mRNA and [Hydrogen Peroxide results in increased abundance of Reactive Oxygen Species] which results in increased expression of AKR1C1 protein CTD PMID:19320734 reactive oxygen species increases expression EXP 6480464 Reactive Oxygen Species results in increased expression of AKR1C1 mRNA CTD PMID:9973208 resorcinol increases expression EXP 6480464 resorcinol results in increased expression of AKR1C1 mRNA CTD PMID:30806763 rotenone decreases expression ISO Akr1c1 (Rattus norvegicus) 6480464 Rotenone results in decreased expression of AKR1C1 mRNA CTD PMID:28374803 S-(1,2-dichlorovinyl)-L-cysteine multiple interactions EXP 6480464 [S-(1 more ... CTD PMID:35811015 S-(1,2-dichlorovinyl)-L-cysteine increases expression EXP 6480464 S-(1 and 2-dichlorovinyl)cysteine results in increased expression of AKR1C1 mRNA CTD PMID:35811015 salicylic acid multiple interactions EXP 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Salicylic Acid inhibits the reaction [AKR1C1 protein results in decreased susceptibility to Cisplatin]] and Salicylic Acid inhibits the reaction [AKR1C1 protein results in decreased susceptibility to Cisplatin] CTD PMID:23165153 salicylic acid decreases activity EXP 6480464 Salicylic Acid results in decreased activity of AKR1C1 protein CTD PMID:19010312 and PMID:23165153 SB 431542 multiple interactions EXP 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 silicon dioxide decreases expression EXP 6480464 Silicon Dioxide analog results in decreased expression of AKR1C1 mRNA CTD PMID:25895662 silicon dioxide increases expression ISO Akr1c20 (Mus musculus) 6480464 Silicon Dioxide results in increased expression of AKR1C1 mRNA and Silicon Dioxide results in increased expression of AKR1C1 protein CTD PMID:30698894 silicon dioxide multiple interactions ISO Akr1c20 (Mus musculus) 6480464 [Silicon Dioxide co-treated with Vitamin D] results in increased expression of AKR1C1 mRNA and [Silicon Dioxide co-treated with Vitamin D] results in increased expression of AKR1C1 protein CTD PMID:30698894 silver atom increases expression EXP 6480464 Silver results in increased expression of AKR1C1 mRNA CTD PMID:22036727 silver atom multiple interactions EXP 6480464 NFE2L2 protein promotes the reaction [Silver results in increased expression of AKR1C1 mRNA] CTD PMID:22036727 silver(0) increases expression EXP 6480464 Silver results in increased expression of AKR1C1 mRNA CTD PMID:22036727 silver(0) multiple interactions EXP 6480464 NFE2L2 protein promotes the reaction [Silver results in increased expression of AKR1C1 mRNA] CTD PMID:22036727 simvastatin increases expression EXP 6480464 Simvastatin results in increased expression of AKR1C1 mRNA CTD PMID:17428261 sodium arsenate increases expression EXP 6480464 sodium arsenate results in increased expression of AKR1C1 mRNA CTD PMID:12727804 sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of AKR1C1 mRNA and sodium arsenite results in increased expression of AKR1C1 protein CTD PMID:19696165 more ... sodium arsenite multiple interactions EXP 6480464 [sodium arsenite results in increased abundance of arsenite] which results in increased expression of AKR1C1 mRNA and SQSTM1 protein affects the reaction [[sodium arsenite results in increased abundance of arsenite] which results in increased expression of AKR1C1 mRNA] CTD PMID:31781319 sodium arsenite affects expression EXP 6480464 sodium arsenite affects the expression of AKR1C1 mRNA CTD PMID:29319823 sodium dichromate decreases expression ISO Akr1c1 (Rattus norvegicus) 6480464 sodium bichromate results in decreased expression of AKR1C1 mRNA CTD PMID:25993096 sodium dodecyl sulfate increases expression EXP 6480464 Sodium Dodecyl Sulfate results in increased expression of AKR1C1 mRNA CTD PMID:20566472 sulforaphane increases expression EXP 6480464 sulforaphane results in increased expression of AKR1C1 mRNA CTD PMID:24383545 more ... sulforaphane multiple interactions EXP 6480464 NFE2L2 protein affects the reaction [sulforaphane results in increased expression of AKR1C1 mRNA] CTD PMID:31518892 sulindac decreases activity EXP 6480464 Sulindac results in decreased activity of AKR1C1 protein CTD PMID:19010312 sulindac sulfide increases expression EXP 6480464 sulindac sulfide results in increased expression of AKR1C1 mRNA CTD PMID:16184548 sunitinib decreases expression EXP 6480464 Sunitinib results in decreased expression of AKR1C1 mRNA CTD PMID:31533062 tamoxifen decreases expression ISO Akr1c20 (Mus musculus) 6480464 Tamoxifen results in decreased expression of AKR1C20 mRNA CTD PMID:25123088 temozolomide affects response to substance EXP 6480464 AKR1C1 mRNA affects the susceptibility to temozolomide CTD PMID:16365179 tert-butyl hydroperoxide increases expression EXP 6480464 tert-Butylhydroperoxide results in increased expression of AKR1C1 mRNA CTD PMID:15336504 testosterone multiple interactions EXP 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of AKR1C1 mRNA CTD PMID:21592394 testosterone increases metabolic processing ISO Akr1c20 (Mus musculus) 6480464 AKR1C20 protein results in increased metabolism of Testosterone CTD PMID:16508162 testosterone increases oxidation ISO Akr1c1 (Rattus norvegicus) 6480464 AKR1C6 protein results in increased oxidation of Testosterone CTD PMID:16788056 testosterone increases expression EXP 6480464 Testosterone results in increased expression of AKR1C1 mRNA CTD PMID:21592394 testosterone enanthate affects expression EXP 6480464 testosterone enanthate affects the expression of AKR1C1 mRNA CTD PMID:17440010 tetrachloromethane decreases expression ISO Akr1c20 (Mus musculus) 6480464 Carbon Tetrachloride results in decreased expression of AKR1C20 mRNA CTD PMID:27339419 and PMID:31919559 tetraphene increases expression EXP 6480464 benz(a)anthracene results in increased expression of AKR1C1 mRNA CTD PMID:17253728 and PMID:22236718 thioacetamide multiple interactions ISO Akr1c1 (Rattus norvegicus) 6480464 [Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of AKR1C6 mRNA CTD PMID:28943392 thioacetamide decreases expression ISO Akr1c1 (Rattus norvegicus) 6480464 Thioacetamide results in decreased expression of AKR1C1 mRNA CTD PMID:23411599 more ... tofacitinib increases metabolic processing EXP 6480464 AKR1C1 protein results in increased metabolism of tofacitinib metabolite CTD PMID:27117606 tolcapone affects binding ISO Akr1c1 (Rattus norvegicus) 6480464 Tolcapone binds to AKR1C1 protein CTD PMID:19783845 trans-isoeugenol increases expression EXP 6480464 isoeugenol results in increased expression of AKR1C1 mRNA CTD PMID:20566472 trichloroethene increases methylation ISO Akr1c1 (Rattus norvegicus) 6480464 Trichloroethylene results in increased methylation of AKR1C1 gene CTD PMID:27618143 trichostatin A increases expression EXP 6480464 trichostatin A results in increased expression of AKR1C1 mRNA CTD PMID:24935251 and PMID:26272509 trichostatin A multiple interactions EXP 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1C1 mRNA CTD PMID:27188386 triclosan decreases expression EXP 6480464 Triclosan results in decreased expression of AKR1C1 mRNA CTD PMID:30510588 tris(2-butoxyethyl) phosphate decreases expression EXP 6480464 tris(2-butoxyethyl) phosphate results in decreased expression of AKR1C1 mRNA CTD PMID:29024780 Tungsten carbide decreases expression EXP 6480464 tungsten carbide results in decreased expression of AKR1C1 mRNA CTD PMID:20105288 Tungsten carbide multiple interactions EXP 6480464 [tungsten carbide binds to Cobalt] which results in decreased expression of AKR1C1 mRNA CTD PMID:20105288 urethane decreases expression EXP 6480464 Urethane results in decreased expression of AKR1C1 mRNA CTD PMID:28818685 ursodeoxycholic acid decreases activity EXP 6480464 Ursodeoxycholic Acid results in decreased activity of AKR1C1 protein CTD PMID:12604236 valdecoxib decreases expression ISO Akr1c1 (Rattus norvegicus) 6480464 valdecoxib results in decreased expression of AKR1C1 mRNA CTD PMID:24136188 valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of AKR1C1 mRNA CTD PMID:23179753 more ... valproic acid multiple interactions EXP 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1C1 mRNA CTD PMID:27188386 vancomycin increases expression ISO Akr1c20 (Mus musculus) 6480464 Vancomycin results in increased expression of AKR1C20 mRNA CTD PMID:18930951 vitamin D increases expression EXP 6480464 Vitamin D results in increased expression of AKR1C1 mRNA and Vitamin D results in increased expression of AKR1C1 protein CTD PMID:30698894 vitamin D increases expression ISO Akr1c20 (Mus musculus) 6480464 Vitamin D results in increased expression of AKR1C1 mRNA and Vitamin D results in increased expression of AKR1C1 protein CTD PMID:30698894 vitamin D multiple interactions ISO Akr1c20 (Mus musculus) 6480464 [Particulate Matter co-treated with Vitamin D] results in increased expression of AKR1C1 mRNA more ... CTD PMID:30698894 vorinostat multiple interactions EXP 6480464 [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AKR1C1 mRNA CTD PMID:27188386 vorinostat increases expression EXP 6480464 vorinostat results in increased expression of AKR1C1 mRNA CTD PMID:26272509 zinc atom multiple interactions EXP 6480464 [PCI 5002 co-treated with Zinc] results in decreased expression of AKR1C1 mRNA CTD PMID:18593933 zinc(0) multiple interactions EXP 6480464 [PCI 5002 co-treated with Zinc] results in decreased expression of AKR1C1 mRNA CTD PMID:18593933 zomepirac decreases activity EXP 6480464 zomepirac results in decreased activity of AKR1C1 protein CTD PMID:19010312
