GCG (glucagon) - Rat Genome Database

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Gene: GCG (glucagon) Homo sapiens
Analyze
Symbol: GCG
Name: glucagon
RGD ID: 68970
HGNC Page HGNC:4191
Description: Enables gastric inhibitory polypeptide receptor binding activity and identical protein binding activity. Predicted to be involved in several processes, including positive regulation of bicellular tight junction assembly; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and protein kinase A signaling. Predicted to act upstream of or within negative regulation of execution phase of apoptosis and positive regulation of gluconeogenesis. Predicted to be located in endoplasmic reticulum lumen; extracellular region; and secretory granule lumen. Predicted to be active in extracellular space and plasma membrane. Implicated in Alzheimer's disease and prediabetes syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: glicentin-related polypeptide; GLP-1; GLP1; GLP2; glucagon-like peptide 1; glucagon-like peptide 2; GRPP; preproglucagon; pro-glucagon
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382162,142,882 - 162,152,247 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2162,142,882 - 162,152,404 (-)EnsemblGRCh38hg38GRCh38
GRCh372162,999,392 - 163,008,757 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362162,707,634 - 162,717,003 (-)NCBINCBI36Build 36hg18NCBI36
Build 342162,824,894 - 162,834,264NCBI
Celera2156,609,679 - 156,619,210 (-)NCBICelera
Cytogenetic Map2q24.2NCBI
HuRef2154,881,734 - 154,891,273 (-)NCBIHuRef
CHM1_12163,005,267 - 163,014,802 (-)NCBICHM1_1
T2T-CHM13v2.02162,599,534 - 162,608,895 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
2-deoxy-D-glucose  (ISO)
3',5'-cyclic AMP  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
9-(tetrahydrofuryl)adenine  (EXP)
9-phenanthrol  (ISO)
acetate ester  (ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP)
all-trans-retinol  (ISO)
aminophylline  (ISO)
amitraz  (ISO)
ammonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
bicalutamide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
budesonide  (ISO)
butyric acid  (ISO)
cadmium dichloride  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
candesartan  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbachol  (ISO)
CGP 52608  (EXP)
chitosan  (EXP)
chlorogenic acid  (ISO)
chlorpyrifos  (ISO)
citronellal  (EXP)
clofibrate  (EXP)
colforsin daropate hydrochloride  (ISO)
D-glucose  (EXP,ISO)
Deoxycorticosterone acetate  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dexloxiglumide  (EXP)
diazoxide  (EXP)
dibutyl phthalate  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
fipronil  (ISO)
fructose  (ISO)
gatifloxacin  (EXP,ISO)
geraniol  (EXP,ISO)
glucose  (EXP,ISO)
hexadecanoic acid  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
Isosteviol  (ISO)
linoleic acid  (ISO)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
lithocholic acid  (ISO)
mangiferin  (ISO)
metformin  (ISO)
metoclopramide  (EXP)
N'-(2,4-dimethylphenyl)-N-methylformamidine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
niclosamide  (ISO)
nicotinamide  (ISO)
nicotinic acid  (EXP)
nitrendipine  (ISO)
oleic acid  (ISO)
orlistat  (EXP)
paraquat  (ISO)
PCB138  (ISO)
pentetrazol  (ISO)
pirinixic acid  (ISO)
potassium chloride  (ISO)
prednisone  (ISO)
pyruvic acid  (ISO)
rotenone  (ISO)
SB 203580  (EXP)
Sodium oleate  (EXP)
streptozocin  (ISO)
tacrolimus hydrate  (ISO)
tadalafil  (ISO)
terbutaline  (ISO)
tetrachloromethane  (ISO)
tolbutamide  (ISO)
tributylstannane  (ISO)
triphenylphosphane oxide  (ISO)
troglitazone  (ISO)
U-73122  (ISO)
valproic acid  (EXP)
vinclozolin  (ISO)
Voglibose  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Novel fusion of GLP-1 with a domain antibody to serum albumin prolongs protection against myocardial ischemia/reperfusion injury in the rat. Bao W, etal., Cardiovasc Diabetol. 2013 Oct 14;12:148. doi: 10.1186/1475-2840-12-148.
2. Biologic actions and therapeutic potential of the proglucagon-derived peptides. Drucker DJ Nat Clin Pract Endocrinol Metab. 2005 Nov;1(1):22-31.
3. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
4. Pre-germinated brown rice extract ameliorates high-fat diet-induced metabolic syndrome. Hao CL, etal., J Food Biochem. 2019 Mar;43(3):e12769. doi: 10.1111/jfbc.12769. Epub 2019 Jan 13.
5. Berberine promotes glucagon-like peptide-1 (7-36) amide secretion in streptozotocin-induced diabetic rats. Lu SS, etal., J Endocrinol. 2009 Feb;200(2):159-65. doi: 10.1677/JOE-08-0419. Epub 2008 Nov 7.
6. Glucagon-like peptide-1 cleavage product GLP-1(9-36) amide rescues synaptic plasticity and memory deficits in Alzheimer's disease model mice. Ma T, etal., J Neurosci. 2012 Oct 3;32(40):13701-8. doi: 10.1523/JNEUROSCI.2107-12.2012.
7. Pancreatic function of spontaneously diabetic torii rats in pre-diabetic stage. Matsui K, etal., Exp Anim. 2009 Jul;58(4):363-74.
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2753890   PMID:2901414   PMID:3569278   PMID:3725587   PMID:6546710   PMID:6877358   PMID:7340337   PMID:7929237   PMID:8382034   PMID:8482423   PMID:8538742   PMID:9287128  
PMID:9667960   PMID:9990065   PMID:10322410   PMID:10605628   PMID:10990079   PMID:11116211   PMID:11278902   PMID:11375130   PMID:11738243   PMID:11943215   PMID:11946536   PMID:11961492  
PMID:11972291   PMID:12036966   PMID:12174892   PMID:12387900   PMID:12436337   PMID:12459036   PMID:12477932   PMID:12519856   PMID:12524435   PMID:12540594   PMID:12554744   PMID:12626323  
PMID:12627948   PMID:12651102   PMID:12736145   PMID:12810581   PMID:12960095   PMID:14517773   PMID:14522730   PMID:14557443   PMID:14608103   PMID:14632334   PMID:14719035   PMID:14988249  
PMID:15002062   PMID:15111524   PMID:15289644   PMID:15489334   PMID:15533774   PMID:15616022   PMID:15664668   PMID:15671479   PMID:15815621   PMID:15821104   PMID:15897480   PMID:15899957  
PMID:15983224   PMID:16125528   PMID:16131602   PMID:16132964   PMID:16142014   PMID:16153418   PMID:16201096   PMID:16202636   PMID:16362283   PMID:16401467   PMID:16563563   PMID:16736556  
PMID:16754659   PMID:16787987   PMID:16828127   PMID:16988001   PMID:17051221   PMID:17141269   PMID:17160672   PMID:17164779   PMID:17290009   PMID:17324423   PMID:17344652   PMID:17609256  
PMID:17688385   PMID:17715056   PMID:17724330   PMID:17846745   PMID:17901057   PMID:17944883   PMID:18080106   PMID:18180317   PMID:18198306   PMID:18223636   PMID:18240029   PMID:18248821  
PMID:18298441   PMID:18413175   PMID:18445652   PMID:18499738   PMID:18534636   PMID:18575785   PMID:18577758   PMID:18596108   PMID:18695009   PMID:18760331   PMID:18770489   PMID:18832087  
PMID:18996102   PMID:19051206   PMID:19077438   PMID:19229515   PMID:19351867   PMID:19556358   PMID:19631991   PMID:19664300   PMID:19703531   PMID:19737911   PMID:19808921   PMID:19819966  
PMID:19837920   PMID:19881250   PMID:19913121   PMID:19924023   PMID:19936703   PMID:19948975   PMID:20001917   PMID:20008019   PMID:20040695   PMID:20100914   PMID:20188316   PMID:20194524  
PMID:20305008   PMID:20460948   PMID:20470376   PMID:20580750   PMID:20628086   PMID:20682687   PMID:20816021   PMID:20871975   PMID:20939591   PMID:21048796   PMID:21167157   PMID:21314817  
PMID:21324568   PMID:21384500   PMID:21419173   PMID:21454562   PMID:21454584   PMID:21623172   PMID:21666414   PMID:21677044   PMID:21707949   PMID:21722955   PMID:21744074   PMID:21798957  
PMID:21813805   PMID:21822931   PMID:21873635   PMID:21915820   PMID:22037645   PMID:22100593   PMID:22147710   PMID:22186413   PMID:22212535   PMID:22319034   PMID:22349073   PMID:22422137  
PMID:22516009   PMID:22534628   PMID:22564875   PMID:22750392   PMID:22806360   PMID:22807616   PMID:22809889   PMID:22893257   PMID:22901716   PMID:22914550   PMID:22929437   PMID:23020846  
PMID:23031433   PMID:23064014   PMID:23077074   PMID:23110179   PMID:23213228   PMID:23231933   PMID:23239758   PMID:23244065   PMID:23266825   PMID:23269670   PMID:23314196   PMID:23377698  
PMID:23485142   PMID:23509106   PMID:23519462   PMID:23548652   PMID:23579541   PMID:23684008   PMID:23820621   PMID:23864340   PMID:23937086   PMID:23953602   PMID:23956349   PMID:24089513  
PMID:24167603   PMID:24185078   PMID:24236650   PMID:24296715   PMID:24443715   PMID:24464714   PMID:24489924   PMID:24507870   PMID:24510283   PMID:24525020   PMID:24648662   PMID:24854384  
PMID:24875097   PMID:25005458   PMID:25008428   PMID:25218018   PMID:25361054   PMID:25427660   PMID:25437458   PMID:25445712   PMID:25447053   PMID:25452475   PMID:25458830   PMID:25543251  
PMID:25560206   PMID:25561730   PMID:25595459   PMID:25601282   PMID:25661189   PMID:25670826   PMID:25673670   PMID:25781355   PMID:25814364   PMID:25823991   PMID:25863010   PMID:25865948  
PMID:25957006   PMID:25984632   PMID:26270730   PMID:26294429   PMID:26315270   PMID:26571400   PMID:26672094   PMID:26684862   PMID:26718419   PMID:26739974   PMID:26752550   PMID:26762368  
PMID:26769912   PMID:26842302   PMID:27022941   PMID:27134062   PMID:27322465   PMID:27562916   PMID:27664588   PMID:27721013   PMID:27875537   PMID:27974199   PMID:27998387   PMID:28008585  
PMID:28174344   PMID:28202805   PMID:28288852   PMID:28321905   PMID:28363795   PMID:28374974   PMID:28466587   PMID:28508109   PMID:28566304   PMID:28609362   PMID:28624122   PMID:28655715  
PMID:28746825   PMID:28750074   PMID:28851219   PMID:28855269   PMID:28920919   PMID:29024725   PMID:29040429   PMID:29061224   PMID:29097626   PMID:29271910   PMID:29409356   PMID:29453982  
PMID:29535183   PMID:29627317   PMID:29859856   PMID:29877701   PMID:29883799   PMID:29947441   PMID:30447282   PMID:30513370   PMID:30586575   PMID:30713523   PMID:30991633   PMID:31042670  
PMID:31229924   PMID:31235909   PMID:31268979   PMID:31307484   PMID:31311066   PMID:31405212   PMID:31426028   PMID:31964806   PMID:31985487   PMID:32090124   PMID:32457219   PMID:32522585  
PMID:32598193   PMID:33082272   PMID:33367814   PMID:33397977   PMID:33921209   PMID:33940644   PMID:33961781   PMID:34220721   PMID:34296287   PMID:34341424   PMID:34383800   PMID:34402720  
PMID:34676939   PMID:35784565   PMID:35904939   PMID:36539382   PMID:36626940   PMID:36639733   PMID:36740132   PMID:36744850   PMID:36799940   PMID:36825397   PMID:36917279   PMID:36932176  
PMID:37014924   PMID:37052948   PMID:37138517   PMID:37185461   PMID:37266425   PMID:37367959   PMID:37439960   PMID:37629010   PMID:37762628   PMID:37980723   PMID:38055342   PMID:38199777  
PMID:38616646  


Genomics

Comparative Map Data
GCG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382162,142,882 - 162,152,247 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2162,142,882 - 162,152,404 (-)EnsemblGRCh38hg38GRCh38
GRCh372162,999,392 - 163,008,757 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362162,707,634 - 162,717,003 (-)NCBINCBI36Build 36hg18NCBI36
Build 342162,824,894 - 162,834,264NCBI
Celera2156,609,679 - 156,619,210 (-)NCBICelera
Cytogenetic Map2q24.2NCBI
HuRef2154,881,734 - 154,891,273 (-)NCBIHuRef
CHM1_12163,005,267 - 163,014,802 (-)NCBICHM1_1
T2T-CHM13v2.02162,599,534 - 162,608,895 (-)NCBIT2T-CHM13v2.0
Gcg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39262,304,874 - 62,313,997 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl262,304,874 - 62,313,994 (-)EnsemblGRCm39 Ensembl
GRCm38262,474,530 - 62,483,653 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl262,474,530 - 62,483,650 (-)EnsemblGRCm38mm10GRCm38
MGSCv37262,312,587 - 62,321,710 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36262,275,369 - 62,284,492 (-)NCBIMGSCv36mm8
Celera264,164,668 - 64,173,806 (-)NCBICelera
Cytogenetic Map2C1.3NCBI
cM Map235.85NCBI
Gcg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8367,522,489 - 67,531,533 (-)NCBIGRCr8
mRatBN7.2347,113,914 - 47,122,958 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl347,113,914 - 47,122,929 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx350,468,582 - 50,477,739 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0359,052,116 - 59,061,273 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0356,825,210 - 56,834,365 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0348,442,635 - 48,451,650 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl348,442,635 - 48,451,650 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0355,108,272 - 55,117,287 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4344,433,180 - 44,438,004 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1344,329,550 - 44,334,376 (-)NCBI
Celera346,755,241 - 46,764,256 (-)NCBICelera
RH 3.4 Map3602.83RGD
Cytogenetic Map3q21NCBI
Gcg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544911,708,152 - 11,716,429 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544911,708,152 - 11,716,429 (+)NCBIChiLan1.0ChiLan1.0
GCG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21364,834,986 - 64,845,162 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B64,849,961 - 64,856,251 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B49,436,379 - 49,446,559 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B166,804,877 - 166,814,374 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B166,806,016 - 166,811,155 (-)Ensemblpanpan1.1panPan2
GCG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1367,544,637 - 7,554,171 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl367,544,637 - 7,554,021 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha367,688,385 - 7,697,769 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0367,676,373 - 7,685,875 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl367,676,373 - 7,685,757 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1367,695,095 - 7,704,477 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0367,736,177 - 7,745,567 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0367,843,487 - 7,852,871 (-)NCBIUU_Cfam_GSD_1.0
Gcg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303124,701,669 - 124,710,958 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646916,906,658 - 16,916,045 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646916,906,658 - 16,916,045 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GCG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1568,800,560 - 68,810,242 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11568,800,557 - 68,810,268 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21576,292,316 - 76,302,025 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GCG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11047,550,097 - 47,560,610 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666040151,966,064 - 151,975,601 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gcg
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247323,362,234 - 3,370,536 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247323,361,897 - 3,370,020 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in GCG
4 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 2q24.1-24.3(chr2:158382388-166605758)x1 copy number loss See cases [RCV000051003] Chr2:158382388..166605758 [GRCh38]
Chr2:159238900..167462268 [GRCh37]
Chr2:158947146..167170514 [NCBI36]
Chr2:2q24.1-24.3		 pathogenic
GRCh38/hg38 2q24.1-24.3(chr2:154366788-167048902)x3 copy number gain See cases [RCV000052950] Chr2:154366788..167048902 [GRCh38]
Chr2:155223300..167905412 [GRCh37]
Chr2:154931546..167613658 [NCBI36]
Chr2:2q24.1-24.3		 pathogenic
GRCh38/hg38 2q23.1-24.3(chr2:148917286-163204623)x1 copy number loss See cases [RCV000054093] Chr2:148917286..163204623 [GRCh38]
Chr2:149674855..164061133 [GRCh37]
Chr2:149391325..163769379 [NCBI36]
Chr2:2q23.1-24.3		 pathogenic
NM_002054.4(GCG):c.209G>A (p.Arg70His) single nucleotide variant Malignant melanoma [RCV000065139] Chr2:162147398 [GRCh38]
Chr2:163003908 [GRCh37]
Chr2:162712154 [NCBI36]
Chr2:2q24.2		 not provided
GRCh38/hg38 2q24.1-31.1(chr2:154294042-175989372)x3 copy number gain See cases [RCV000142286] Chr2:154294042..175989372 [GRCh38]
Chr2:155150555..176854100 [GRCh37]
Chr2:154858801..176562346 [NCBI36]
Chr2:2q24.1-31.1		 pathogenic
Single allele deletion not provided [RCV000768457] Chr2:162485583..168295583 [GRCh37]
Chr2:2q24.2-24.3		 pathogenic
GRCh37/hg19 2q24.1-31.3(chr2:156489430-182921298)x3 copy number gain See cases [RCV000239848] Chr2:156489430..182921298 [GRCh37]
Chr2:2q24.1-31.3		 pathogenic
GRCh37/hg19 2q24.2-24.3(chr2:161542325-164640864)x1 copy number loss See cases [RCV000240370] Chr2:161542325..164640864 [GRCh37]
Chr2:2q24.2-24.3		 pathogenic
Single allele deletion Autistic behavior [RCV000627115] Chr2:160075929..164666149 [GRCh37]
Chr2:2q24.2-24.3		 likely pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:15672-243101834)x3 copy number gain not provided [RCV000752804] Chr2:15672..243101834 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:14238-243048760)x3 copy number gain not provided [RCV000752802] Chr2:14238..243048760 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384) copy number gain See cases [RCV000512056] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)x3 copy number gain See cases [RCV000511212] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
Single allele deletion Autistic behavior [RCV000627116] Chr2:161561653..163178787 [GRCh37]
Chr2:2q24.2		 likely pathogenic
GRCh37/hg19 2q24.1-24.3(chr2:157970774-169270675)x1 copy number loss See cases [RCV000512264] Chr2:157970774..169270675 [GRCh37]
Chr2:2q24.1-24.3		 pathogenic
GRCh37/hg19 2q24.2(chr2:162307327-163030442)x3 copy number gain See cases [RCV000512459] Chr2:162307327..163030442 [GRCh37]
Chr2:2q24.2		 uncertain significance
GRCh37/hg19 2q12.1-24.3(chr2:104172062-168223828)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626436] Chr2:104172062..168223828 [GRCh37]
Chr2:2q12.1-24.3		 drug response
GRCh37/hg19 2q23.3-31.2(chr2:152409978-179325736)x3 copy number gain not provided [RCV000740654] Chr2:152409978..179325736 [GRCh37]
Chr2:2q23.3-31.2		 pathogenic
NM_002054.5(GCG):c.472A>G (p.Ile158Val) single nucleotide variant not provided [RCV000891673] Chr2:162144091 [GRCh38]
Chr2:163000601 [GRCh37]
Chr2:2q24.2		 benign
NM_002054.5(GCG):c.254+5G>A single nucleotide variant not provided [RCV000883617] Chr2:162147348 [GRCh38]
Chr2:163003858 [GRCh37]
Chr2:2q24.2		 benign
GRCh37/hg19 2q24.2-24.3(chr2:160075929-164666149) copy number loss Autistic behavior [RCV001200909] Chr2:160075929..164666149 [GRCh37]
Chr2:2q24.2-24.3		 likely pathogenic
GRCh37/hg19 2q24.2(chr2:161561653-163178787) copy number loss Autistic behavior [RCV001200908] Chr2:161561653..163178787 [GRCh37]
Chr2:2q24.2		 likely pathogenic
GRCh37/hg19 2q24.2(chr2:162620633-163421321)x1 copy number loss not provided [RCV001259777] Chr2:162620633..163421321 [GRCh37]
Chr2:2q24.2		 uncertain significance
GRCh37/hg19 2p25.3-q37.3(chr2:1-243199373) copy number gain Mosaic trisomy 2 [RCV002280628] Chr2:1..243199373 [GRCh37]
Chr2:2p25.3-q37.3		 pathogenic
GRCh37/hg19 2q24.2-31.1(chr2:160347642-174075851)x1 copy number loss 2q24 microdeletion syndrome [RCV002271993] Chr2:160347642..174075851 [GRCh37]
Chr2:2q24.2-31.1		 pathogenic
GRCh37/hg19 2q24.1-24.3(chr2:158950827-164456735) copy number loss not specified [RCV002053256] Chr2:158950827..164456735 [GRCh37]
Chr2:2q24.1-24.3		 pathogenic
GRCh37/hg19 2q24.2-24.3(chr2:161551326-167762790) copy number loss not specified [RCV002053257] Chr2:161551326..167762790 [GRCh37]
Chr2:2q24.2-24.3		 pathogenic
NM_002054.5(GCG):c.62G>T (p.Arg21Leu) single nucleotide variant not specified [RCV004187367] Chr2:162149117 [GRCh38]
Chr2:163005627 [GRCh37]
Chr2:2q24.2		 uncertain significance
GRCh37/hg19 2q24.1-24.3(chr2:157718631-165360287)x1 copy number loss not specified [RCV003986232] Chr2:157718631..165360287 [GRCh37]
Chr2:2q24.1-24.3		 pathogenic
GRCh37/hg19 2q24.2-31.1(chr2:162692199-174452488)x1 copy number loss not specified [RCV003986346] Chr2:162692199..174452488 [GRCh37]
Chr2:2q24.2-31.1		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:479
Count of miRNA genes:327
Interacting mature miRNAs:354
Transcripts:ENST00000375497, ENST00000418842, ENST00000483769, ENST00000492913, ENST00000497568
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH68969  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372162,999,606 - 162,999,786UniSTSGRCh37
Build 362162,707,852 - 162,708,032RGDNCBI36
Celera2156,609,900 - 156,610,080RGD
Cytogenetic Map2q36-q37UniSTS
HuRef2154,881,961 - 154,882,141UniSTS
GeneMap99-GB4 RH Map2541.49UniSTS
WI-18974  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372162,999,485 - 162,999,769UniSTSGRCh37
Build 362162,707,731 - 162,708,015RGDNCBI36
Celera2156,609,779 - 156,610,063RGD
Cytogenetic Map2q36-q37UniSTS
HuRef2154,881,840 - 154,882,124UniSTS
GeneMap99-GB4 RH Map2542.19UniSTS
Whitehead-RH Map2817.5UniSTS
GCG  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372163,002,052 - 163,002,177UniSTSGRCh37
Build 362162,710,298 - 162,710,423RGDNCBI36
Celera2156,612,346 - 156,612,471RGD
HuRef2154,884,409 - 154,884,534UniSTS
GDB:181269  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372163,000,136 - 163,000,643UniSTSGRCh37
Build 362162,708,382 - 162,708,889RGDNCBI36
Celera2156,610,430 - 156,610,937RGD
Cytogenetic Map2q36-q37UniSTS
HuRef2154,882,491 - 154,882,998UniSTS
SHGC-89190  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372163,002,281 - 163,002,600UniSTSGRCh37
Build 362162,710,527 - 162,710,846RGDNCBI36
Celera2156,612,575 - 156,612,894RGD
Cytogenetic Map2q36-q37UniSTS
HuRef2154,884,638 - 154,884,957UniSTS
TNG Radiation Hybrid Map2109072.0UniSTS
D2S2553  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372162,999,606 - 162,999,851UniSTSGRCh37
Build 362162,707,852 - 162,708,097RGDNCBI36
Celera2156,609,900 - 156,610,145RGD
Cytogenetic Map2q36-q37UniSTS
HuRef2154,881,961 - 154,882,206UniSTS
Stanford-G3 RH Map26654.0UniSTS
NCBI RH Map21171.6UniSTS
GeneMap99-G3 RH Map27515.0UniSTS
GCG_3981  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372162,999,200 - 162,999,816UniSTSGRCh37
Build 362162,707,446 - 162,708,062RGDNCBI36
Celera2156,609,494 - 156,610,110RGD
HuRef2154,881,555 - 154,882,171UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High 1 1 7
Medium 302 2 2 1 144 1 6 4 3 4 1 2 3
Low 427 40 25 10 52 9 37 29 43 6 79 33 2 23 26
Below cutoff 758 858 566 198 404 133 1161 652 1133 46 599 429 64 431 758 2

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000375497   ⟹   ENSP00000364647
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2162,143,905 - 162,152,404 (-)Ensembl
RefSeq Acc Id: ENST00000418842   ⟹   ENSP00000387662
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2162,142,882 - 162,152,247 (-)Ensembl
RefSeq Acc Id: ENST00000483769
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2162,143,178 - 162,144,415 (-)Ensembl
RefSeq Acc Id: ENST00000492913
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2162,145,359 - 162,152,237 (-)Ensembl
RefSeq Acc Id: ENST00000497568
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2162,144,695 - 162,147,393 (-)Ensembl
RefSeq Acc Id: NM_002054   ⟹   NP_002045
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382162,142,882 - 162,152,247 (-)NCBI
GRCh372162,999,379 - 163,008,914 (-)NCBI
Build 362162,707,634 - 162,717,003 (-)NCBI Archive
HuRef2154,881,734 - 154,891,273 (-)NCBI
CHM1_12163,005,267 - 163,014,802 (-)NCBI
T2T-CHM13v2.02162,599,534 - 162,608,895 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_002045   ⟸   NM_002054
- Peptide Label: preproprotein
- UniProtKB: A6NN65 (UniProtKB/Swiss-Prot),   Q53TP6 (UniProtKB/Swiss-Prot),   P01275 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000364647   ⟸   ENST00000375497
RefSeq Acc Id: ENSP00000387662   ⟸   ENST00000418842

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P01275-F1-model_v2 AlphaFold P01275 1-180 view protein structure

Promoters
RGD ID:6861900
Promoter ID:EPDNEW_H4104
Type:multiple initiation site
Name:GCG_1
Description:glucagon
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382162,152,247 - 162,152,307EPDNEW
RGD ID:6849990
Promoter ID:EP17067
Type:single initiation site
Name:HS_GCG
Description:Glucagon, GCG gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 112; Mammalian glucagon.
Tissues & Cell Lines:pancreas, gut
Experiment Methods:Nuclease protection with homologous sequence ladder; experiments; performed with closely related gene
Position:
Human AssemblyChrPosition (strand)Source
Build 362162,717,009 - 162,717,069EPD

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:4191 AgrOrtholog
COSMIC GCG COSMIC
Ensembl Genes ENSG00000115263 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000375497.3 UniProtKB/Swiss-Prot
  ENST00000418842 ENTREZGENE
  ENST00000418842.7 UniProtKB/Swiss-Prot
Gene3D-CATH 6.10.250.590 UniProtKB/Swiss-Prot
GTEx ENSG00000115263 GTEx
HGNC ID HGNC:4191 ENTREZGENE
Human Proteome Map GCG Human Proteome Map
InterPro Glucagon UniProtKB/Swiss-Prot
  Glucagon_GIP_secretin_VIP UniProtKB/Swiss-Prot
KEGG Report hsa:2641 UniProtKB/Swiss-Prot
NCBI Gene 2641 ENTREZGENE
OMIM 138030 OMIM
PANTHER PRO-GLUCAGON UniProtKB/Swiss-Prot
  PTHR11418 UniProtKB/Swiss-Prot
Pfam Hormone_2 UniProtKB/Swiss-Prot
PharmGKB PA28606 PharmGKB
PRINTS GLUCAGON UniProtKB/Swiss-Prot
PROSITE GLUCAGON UniProtKB/Swiss-Prot
SMART GLUCA UniProtKB/Swiss-Prot
UniProt A6NN65 ENTREZGENE
  GLUC_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q53TP6 ENTREZGENE
UniProt Secondary A6NN65 UniProtKB/Swiss-Prot
  Q53TP6 UniProtKB/Swiss-Prot