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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:integrin mediated signaling pathway
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Accession:PW:0000286 term browser browse the term
Definition:Integrins signal bi-directionally across the plasma membrane and provide an example of mechanotransduction. Inside-out signaling modulates their interaction with ligands to regulate cell adhesion and ECM organization. Ligand binding initiates and shapes many signaling events and links to the cytoskeleton. Via protein clustering and ECM organization integrins synergize with and/or modulate various growth factor pathways. Integrin signaling regulates multiple processes including gene expression, cell proliferation, differentiation and survival.
Synonyms:related_synonym: Integrin signaling;   integrin-mediated signaling pathway
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integrin mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apbb1ip amyloid beta precursor protein binding family B member 1 interacting protein ISO RGD PMID:18363565 RGD:2300340 NCBI chr17:89,849,474...89,941,099
Ensembl chr17:89,671,716...89,941,089 		JBrowse link
G Fabp3 fatty acid binding protein 3 ISO RGD PMID:23719537 RGD:7364738 NCBI chr 5:147,936,027...147,942,870
Ensembl chr 5:147,936,119...147,942,881 		JBrowse link
G Fblim1 filamin binding LIM protein 1 ISO RGD PMID:23860236 RGD:7349373 NCBI chr 5:159,167,004...159,198,578
Ensembl chr 5:159,167,004...159,196,853 		JBrowse link
G Fermt1 FERM domain containing kindlin 1 ISO RGD PMID:23860236 RGD:7349373 NCBI chr 3:140,624,434...140,666,419
Ensembl chr 3:140,624,434...140,666,419 		JBrowse link
G Fermt2 FERM domain containing kindlin 2 ISO RGD PMID:23860236 RGD:7349373 NCBI chr15:21,162,603...21,257,995
Ensembl chr15:21,162,605...21,258,115 		JBrowse link
G Fermt3 FERM domain containing kindlin 3 ISO RGD PMID:23860236 RGD:7349373 NCBI chr 1:213,618,691...213,636,889
Ensembl chr 1:213,618,208...213,636,273 		JBrowse link
G Flna filamin A ISO RGD PMID:23719537 RGD:7364738 NCBI chr  X:157,159,051...157,185,559
Ensembl chr  X:157,159,051...157,182,343 		JBrowse link
G Flnb filamin B ISO RGD PMID:23719537 RGD:7364738 NCBI chr15:19,392,212...19,525,278
Ensembl chr15:19,392,216...19,525,209 		JBrowse link
G Flnc filamin C ISO RGD PMID:23719537 RGD:7364738 NCBI chr 4:58,999,445...59,027,240
Ensembl chr 4:58,999,547...59,027,240 		JBrowse link
G Ilk integrin-linked kinase ISO
IMP 		RGD PMID:16493410 PMID:8538749 PMID:12629168 RGD:2300344, RGD:40924646, RGD:2302091 NCBI chr 1:169,500,716...169,506,972
Ensembl chr 1:169,498,681...169,506,964 		JBrowse link
G Ilkap ILK associated serine/threonine phosphatase ISO RGD PMID:16493410 RGD:2300344 NCBI chr 9:99,413,981...99,436,262
Ensembl chr 9:99,413,978...99,436,418 		JBrowse link
G Itga1 integrin subunit alpha 1 ISS
ISO 		RGD PMID:2380249 PMID:17543136 RGD:729264, RGD:5135538 NCBI chr 2:48,379,181...48,545,336
Ensembl chr 2:48,386,249...48,545,284 		JBrowse link
G Itga10 integrin subunit alpha 10 ISO RGD PMID:12297042 PMID:17543136 RGD:1358329, RGD:5135538 NCBI chr 2:186,871,711...186,891,012
Ensembl chr 2:186,871,711...186,891,012 		JBrowse link
G Itga11 integrin subunit alpha 11 ISO RGD PMID:12297042 PMID:17543136 RGD:1358329, RGD:5135538 NCBI chr 8:72,041,432...72,150,137
Ensembl chr 8:72,016,652...72,150,137 		JBrowse link
G Itga2 integrin subunit alpha 2 TAS
ISO 		RGD PMID:12941079 PMID:17543136 RGD:1302878, RGD:5135538 NCBI chr 2:48,253,412...48,354,509
Ensembl chr 2:48,253,412...48,354,509 		JBrowse link
G Itga2b integrin subunit alpha 2b ISO based on Entrez HomoloGene, BLAST RGD PMID:17543136 RGD:5135538 NCBI chr10:87,908,697...87,926,225
Ensembl chr10:87,908,697...87,925,833 		JBrowse link
G Itga3 integrin subunit alpha 3 ISO RGD PMID:12297042 PMID:17543136 RGD:1358329, RGD:5135538 NCBI chr10:80,486,998...80,522,548
Ensembl chr10:80,486,999...80,518,901 		JBrowse link
G Itga4 integrin subunit alpha 4 TAS
ISO 		RGD PMID:11782963 PMID:17543136 RGD:1302879, RGD:5135538 NCBI chr 3:84,569,487...84,646,276
Ensembl chr 3:84,560,369...84,641,039 		JBrowse link
G Itga5 integrin subunit alpha 5 IDA
ISO 		RGD PMID:12821041 PMID:17543136 RGD:1300196, RGD:5135538 NCBI chr 7:136,358,097...136,381,305
Ensembl chr 7:136,358,097...136,381,305 		JBrowse link
G Itga6 integrin subunit alpha 6 ISS
ISO 		RGD PMID:12297042 PMID:17543136 RGD:1358329, RGD:5135538 NCBI chr 3:77,012,168...77,097,076
Ensembl chr 3:77,017,766...77,097,076 		JBrowse link
G Itga7 integrin subunit alpha 7 IDA
ISO 		RGD PMID:1315319 PMID:17543136 RGD:70774, RGD:5135538 NCBI chr 7:1,944,447...1,973,347
Ensembl chr 7:1,944,460...1,973,339 		JBrowse link
G Itga8 integrin subunit alpha 8 ISO RGD PMID:17543136 PMID:9054500 RGD:5135538, RGD:40903006 NCBI chr17:80,213,139...80,410,633
Ensembl chr17:80,213,143...80,410,633 		JBrowse link
G Itga9 integrin subunit alpha 9 ISO RGD PMID:12297042 PMID:17543136 RGD:1358329, RGD:5135538 NCBI chr 8:127,185,244...127,493,296
Ensembl chr 8:127,169,226...127,493,296 		JBrowse link
G Itgad integrin subunit alpha D ISS
ISO 		RGD PMID:12297042 PMID:17543136 RGD:1358329, RGD:5135538 NCBI chr 1:192,190,204...192,218,864
Ensembl chr 1:192,190,204...192,218,864 		JBrowse link
G Itgae integrin subunit alpha E TAS
ISO 		RGD PMID:9394838 PMID:17543136 RGD:633077, RGD:5135538 NCBI chr10:58,203,331...58,262,606
Ensembl chr10:58,203,364...58,262,606 		JBrowse link
G Itgal integrin subunit alpha L ISS
ISO 		RGD PMID:12297042 PMID:17543136 RGD:1358329, RGD:5135538 NCBI chr 1:191,348,424...191,386,228
Ensembl chr 1:191,348,542...191,386,225 		JBrowse link
G Itgam integrin subunit alpha M ISO RGD PMID:34630381 PMID:17543136 RGD:329849126, RGD:5135538 NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943 		JBrowse link
G Itgav integrin subunit alpha V ISO
IDA 		RGD PMID:12297042 PMID:17543136 PMID:12639933 RGD:1358329, RGD:5135538, RGD:1625134 NCBI chr 3:89,245,382...89,333,512
Ensembl chr 3:89,245,095...89,333,511 		JBrowse link
G Itgax integrin subunit alpha X ISO RGD PMID:17543136 RGD:5135538 NCBI chr 1:192,140,089...192,171,151
Ensembl chr 1:192,149,905...192,171,151 		JBrowse link
G Itgb1 integrin subunit beta 1 ISS
ISO
IDA 		RGD PMID:9633916 PMID:17543136 PMID:12639933 RGD:1302874, RGD:5135538, RGD:1625134 NCBI chr19:73,602,277...73,650,271
Ensembl chr19:73,602,126...73,650,269 		JBrowse link
G Itgb1bp1 integrin subunit beta 1 binding protein 1 ISO RGD PMID:23860236 PMID:23719537 RGD:7349373, RGD:7364738 NCBI chr 6:46,549,994...46,564,735
Ensembl chr 6:46,549,999...46,564,398 		JBrowse link
G Itgb2 integrin subunit beta 2 ISO RGD PMID:12297042 PMID:17543136 RGD:1358329, RGD:5135538 NCBI chr20:11,061,009...11,097,242
Ensembl chr20:11,058,492...11,097,182 		JBrowse link
G Itgb3 integrin subunit beta 3 ISO
IDA 		RGD PMID:7528107 PMID:17543136 PMID:12639933 RGD:597805935, RGD:5135538, RGD:1625134 NCBI chr10:90,009,927...90,067,787
Ensembl chr10:90,009,900...90,067,800 		JBrowse link
G Itgb4 integrin subunit beta 4 TAS
ISO 		RGD PMID:8026337 PMID:17543136 RGD:729025, RGD:5135538 NCBI chr10:101,705,592...101,741,933
Ensembl chr10:101,705,587...101,741,932 		JBrowse link
G Itgb5 integrin subunit beta 5 ISO RGD PMID:17543136 PMID:8799848 RGD:5135538, RGD:41410438 NCBI chr11:80,333,588...80,449,373
Ensembl chr11:80,333,590...80,449,373 		JBrowse link
G Itgb6 integrin subunit beta 6 ISS
ISO 		RGD PMID:12297042 PMID:17543136 RGD:1358329, RGD:5135538 NCBI chr 3:65,454,964...65,579,179
Ensembl chr 3:65,456,713...65,530,333 		JBrowse link
G Itgb7 integrin subunit beta 7 TAS
ISO 		RGD PMID:9233649 PMID:17543136 RGD:633040, RGD:5135538 NCBI chr 7:135,225,962...135,243,522
Ensembl chr 7:135,226,555...135,243,597 		JBrowse link
G Itgb8 integrin subunit beta 8 ISO RGD PMID:12297042 PMID:17543136 RGD:1358329, RGD:5135538 NCBI chr 6:146,267,982...146,351,245
Ensembl chr 6:146,165,484...146,351,245 		JBrowse link
G Krit1 KRIT1, ankyrin repeat containing ISO RGD PMID:23860236 PMID:23719537 RGD:7349373, RGD:7364738 NCBI chr 4:31,253,918...31,288,066
Ensembl chr 4:31,253,918...31,288,073 		JBrowse link
G Lims1 LIM zinc finger domain containing 1 ISO RGD PMID:16493410 RGD:2300344 NCBI chr20:26,851,364...26,961,607
Ensembl chr20:26,852,996...26,961,606 		JBrowse link
G Lims2 LIM zinc finger domain containing 2 ISO RGD PMID:16493410 RGD:2300344 NCBI chr18:23,828,164...23,866,363
Ensembl chr18:23,837,686...23,867,086 		JBrowse link
G Nck2 NCK adaptor protein 2 ISO RGD PMID:16493410 RGD:2300344 NCBI chr 9:53,206,006...53,332,417
Ensembl chr 9:53,231,381...53,332,394 		JBrowse link
G Parva parvin, alpha ISO RGD PMID:16493410 RGD:2300344 NCBI chr 1:175,981,725...176,139,523
Ensembl chr 1:175,981,432...176,139,526 		JBrowse link
G Parvb parvin, beta ISO RGD PMID:16493410 RGD:2300344 NCBI chr 7:117,240,238...117,325,744
Ensembl chr 7:117,240,029...117,325,748 		JBrowse link
G Parvg parvin, gamma ISO RGD PMID:16493410 RGD:2300344 NCBI chr 7:117,336,160...117,366,341
Ensembl chr 7:117,336,187...117,362,155 		JBrowse link
G Ptk2 protein tyrosine kinase 2 ISO RGD PMID:15108811 RGD:2300402 NCBI chr 7:107,015,730...107,220,865
Ensembl chr 7:107,015,733...107,172,091 		JBrowse link
G Pxn paxillin ISO RGD PMID:16493410 RGD:2300344 NCBI chr12:46,721,546...46,768,706
Ensembl chr12:46,721,546...46,768,697 		JBrowse link
G Sharpin SHANK-associated RH domain interactor ISO RGD PMID:23860236 PMID:23719537 RGD:7349373, RGD:7364738 NCBI chr 7:109,951,336...109,955,552
Ensembl chr 7:109,950,345...109,955,552 		JBrowse link
G Tln1 talin 1 ISO RGD PMID:18363565 PMID:23860236 RGD:2300340, RGD:7349373 NCBI chr 5:62,583,730...62,613,687
Ensembl chr 5:62,583,731...62,613,687 		JBrowse link
G Tln2 talin 2 ISO RGD PMID:23860236 RGD:7349373 NCBI chr 8:76,712,112...77,133,361
Ensembl chr 8:76,712,112...77,133,361 		JBrowse link
altered integrin mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ilk integrin-linked kinase ISO RGD PMID:18772397 RGD:5490966 NCBI chr 1:169,500,716...169,506,972
Ensembl chr 1:169,498,681...169,506,964 		JBrowse link
G Itga1 integrin subunit alpha 1 IMP RGD PMID:10536667 RGD:1302875 NCBI chr 2:48,379,181...48,545,336
Ensembl chr 2:48,386,249...48,545,284 		JBrowse link
G Itga11 integrin subunit alpha 11 ISO RGD PMID:18772397 RGD:5490966 NCBI chr 8:72,041,432...72,150,137
Ensembl chr 8:72,016,652...72,150,137 		JBrowse link
G Itga4 integrin subunit alpha 4 IMP
ISO 		RGD PMID:11782963 PMID:18772397 RGD:1302879, RGD:5490966 NCBI chr 3:84,569,487...84,646,276
Ensembl chr 3:84,560,369...84,641,039 		JBrowse link
G Itga5 integrin subunit alpha 5 ISS RGD PMID:10536667 RGD:1302875 NCBI chr 7:136,358,097...136,381,305
Ensembl chr 7:136,358,097...136,381,305 		JBrowse link
G Itga8 integrin subunit alpha 8 ISO RGD PMID:9054500 RGD:40903006 NCBI chr17:80,213,139...80,410,633
Ensembl chr17:80,213,143...80,410,633 		JBrowse link
G Itga9 integrin subunit alpha 9 ISO RGD PMID:18772397 RGD:5490966 NCBI chr 8:127,185,244...127,493,296
Ensembl chr 8:127,169,226...127,493,296 		JBrowse link
G Itgb1 integrin subunit beta 1 ISS RGD PMID:9633916 RGD:1302874 NCBI chr19:73,602,277...73,650,271
Ensembl chr19:73,602,126...73,650,269 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2635
      mechanotransduction pathway 70
        integrin mediated signaling pathway 50
          altered integrin mediated signaling pathway 8
          integrin mediated cell-cell signaling pathway 0
          integrin mediated cell-extracellular matrix signaling pathway 0
paths to the root