RGD Reference Report - Multiple connections link FAK to cell motility and invasion. - Rat Genome Database

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Multiple connections link FAK to cell motility and invasion.

Authors: Schlaepfer, DD  Mitra, SK 
Citation: Schlaepfer DD and Mitra SK, Curr Opin Genet Dev. 2004 Feb;14(1):92-101.
RGD ID: 2300402
Pubmed: PMID:15108811   (View Abstract at PubMed)
DOI: DOI:10.1016/j.gde.2003.12.002   (Journal Full-text)

The ability of intracellular signaling networks to orchestrate a complex biological response such as cell motility requires that individual signaling proteins must act as integrators, responding to multiple extracellular inputs and regulating multiple signaling pathway outputs. In this review, we highlight recent findings that place focal adhesion kinase (FAK) in an important receptor-proximal position in the regulation of growth factor and integrin-stimulated cell motility. Emphasis is placed on the molecular mechanisms of FAK activation, connections of FAK to focal contact formation as well as turnover, and the potential that FAK function in promoting cell invasion may be distinct from its role in cell motility.

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
integrin mediated signaling pathway   TAS 2300402 RGD 
integrin mediated signaling pathway   ISOPTK2 (Homo sapiens)2300402; 2300402 RGD 
Objects Annotated

Genes (Rattus norvegicus)
Ptk2  (protein tyrosine kinase 2)

Genes (Mus musculus)
Ptk2  (PTK2 protein tyrosine kinase 2)

Genes (Homo sapiens)
PTK2  (protein tyrosine kinase 2)


Additional Information