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Pathways
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Ontology Browser
Term:
Parent Terms Term With Siblings Child Terms
altered cell adhesion signaling pathway +   
altered mechanotransduction pathway +  
auditory mechanotransduction pathway +    
cell-cell signaling pathway +    
cell-extracellular matrix signaling pathway +   
integrin mediated signaling pathway +    
Integrins signal bi-directionally across the plasma membrane and provide an example of mechanotransduction. Inside-out signaling modulates their interaction with ligands to regulate cell adhesion and ECM organization. Ligand binding initiates and shapes many signaling events and links to the cytoskeleton. Via protein clustering and ECM organization integrins synergize with and/or modulate various growth factor pathways. Integrin signaling regulates multiple processes including gene expression, cell proliferation, differentiation and survival.
View Interactive Diagram

Synonyms
Related Synonyms: Integrin signaling ;   integrin-mediated signaling pathway
Definition Sources: GO:0007229, KEGG:map04510, PMID:11842240, PMID:14570568, PMID:15009204, PMID:15276463, Reactome:R-HSA-9006921

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