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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:mechanotransduction pathway
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Accession:PW:0001502 term browser browse the term
Definition:The mechanostransduction pathway involves the conversion of a mechanical stimulus into an electrical signal whose processing underlies proprioception, hearing, balance and touch. Auditory and cytoskeleton mechanotransduction are examples.


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altered integrin mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ilk integrin-linked kinase ISO RGD PMID:18772397 RGD:5490966 NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140 		JBrowse link
G Itga1 integrin subunit alpha 1 IMP RGD PMID:10536667 RGD:1302875 NCBI chr 2:46,646,125...46,812,237
Ensembl chr 2:46,653,193...46,812,238 		JBrowse link
G Itga11 integrin subunit alpha 11 ISO RGD PMID:18772397 RGD:5490966 NCBI chr 8:63,145,998...63,254,714
Ensembl chr 8:63,146,001...63,254,407 		JBrowse link
G Itga4 integrin subunit alpha 4 IMP
ISO		 RGD PMID:11782963 PMID:18772397 RGD:1302879, RGD:5490966 NCBI chr 3:64,162,764...64,235,010
Ensembl chr 3:64,163,085...64,233,715 		JBrowse link
G Itga5 integrin subunit alpha 5 ISS RGD PMID:10536667 RGD:1302875 NCBI chr 7:134,478,963...134,502,837
Ensembl chr 7:134,478,968...134,502,837 		JBrowse link
G Itga8 integrin subunit alpha 8 ISO RGD PMID:9054500 RGD:40903006 NCBI chr17:75,304,004...75,501,510
Ensembl chr17:75,304,008...75,501,510 		JBrowse link
G Itga9 integrin subunit alpha 9 ISO RGD PMID:18772397 RGD:5490966 NCBI chr 8:118,307,424...118,615,527
Ensembl chr 8:118,307,381...118,613,754 		JBrowse link
G Itgb1 integrin subunit beta 1 ISS RGD PMID:9633916 RGD:1302874 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195 		JBrowse link
auditory mechanotransduction pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actb actin, beta ISO RGD PMID:20624897 RGD:8547669 NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877 		JBrowse link
G Actg1 actin, gamma 1 ISO RGD PMID:20624897 RGD:8547669 NCBI chr10:105,619,738...105,622,587
Ensembl chr10:105,619,737...105,624,232
Ensembl chr 3:105,619,737...105,624,232 		JBrowse link
G Adgrv1 adhesion G protein-coupled receptor V1 ISO RGD PMID:20624897 RGD:8547669 NCBI chr 2:11,331,434...11,911,713
Ensembl chr 2:11,331,442...11,911,688 		JBrowse link
G Cdh23 cadherin-related 23 ISO RGD PMID:19804752 PMID:22177415 RGD:8547667, RGD:8547671 NCBI chr20:28,240,643...28,622,490
Ensembl chr20:28,240,645...28,622,419 		JBrowse link
G Espn espin ISO RGD PMID:19804752 PMID:20624897 RGD:8547667, RGD:8547669 NCBI chr 5:162,626,560...162,660,439
Ensembl chr 5:162,626,560...162,660,256 		JBrowse link
G Myo15a myosin XVA ISO RGD PMID:19804752 RGD:8547667 NCBI chr10:45,277,619...45,335,953
Ensembl chr10:45,278,737...45,335,340 		JBrowse link
G Myo1c myosin 1C ISO RGD PMID:19804752 RGD:8547667 NCBI chr10:60,498,372...60,520,752
Ensembl chr10:60,498,280...60,520,752 		JBrowse link
G Myo3a myosin IIIA ISO RGD PMID:19804752 RGD:8547667 NCBI chr17:84,543,465...84,759,562
Ensembl chr17:84,543,552...84,759,042 		JBrowse link
G Myo6 myosin VI ISO RGD PMID:20624897 PMID:22715884 RGD:8547669, RGD:8547672 NCBI chr 8:81,087,157...81,242,022
Ensembl chr 8:81,087,139...81,239,292 		JBrowse link
G Myo7a myosin VIIA ISO RGD PMID:19804752 PMID:22177415 RGD:8547667, RGD:8547671 NCBI chr 1:152,342,611...152,414,171
Ensembl chr 1:152,344,448...152,414,157 		JBrowse link
G Otof otoferlin ISO RGD PMID:22715884 RGD:8547672 NCBI chr 6:25,928,018...26,024,631
Ensembl chr 6:25,928,055...26,024,631 		JBrowse link
G Pcdh15 protocadherin related 15 ISO RGD PMID:19804752 PMID:22177415 RGD:8547667, RGD:8547671 NCBI chr20:13,997,094...15,496,446
Ensembl chr20:13,963,565...15,494,719 		JBrowse link
G Pls1 plastin 1 ISO RGD PMID:20624897 RGD:8547669 NCBI chr 8:96,316,703...96,426,592
Ensembl chr 8:96,317,849...96,385,195 		JBrowse link
G Pls3 plastin 3 ISO RGD PMID:20624897 RGD:8547669 NCBI chr  X:111,589,193...111,683,908
Ensembl chr  X:111,589,254...111,683,891 		JBrowse link
G Ptprq protein tyrosine phosphatase, receptor type, Q ISO RGD PMID:20624897 RGD:8547669 NCBI chr 7:42,834,455...43,016,807
Ensembl chr 7:42,837,109...43,016,917 		JBrowse link
G Slc17a8 solute carrier family 17 member 8 ISO RGD PMID:22715884 RGD:8547672 NCBI chr 7:23,994,212...24,049,498
Ensembl chr 7:23,994,217...24,048,079 		JBrowse link
G Ush1c USH1 protein network component harmonin ISO RGD PMID:19804752 PMID:22177415 RGD:8547667, RGD:8547671 NCBI chr 1:96,695,303...96,743,671
Ensembl chr 1:96,695,307...96,743,671 		JBrowse link
G Ush1g USH1 protein network component sans ISO RGD PMID:22177415 RGD:8547671 NCBI chr10:100,559,721...100,563,590
Ensembl chr10:100,557,629...100,563,590 		JBrowse link
G Ush2a usherin ISO RGD PMID:20624897 RGD:8547669 NCBI chr13:99,837,445...100,503,935
Ensembl chr13:99,837,445...100,503,922 		JBrowse link
G Whrn whirlin ISO RGD PMID:19804752 RGD:8547667 NCBI chr 5:76,828,308...76,911,945
Ensembl chr 5:76,828,301...76,912,223 		JBrowse link
integrin mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apbb1ip amyloid beta precursor protein binding family B member 1 interacting protein ISO RGD PMID:18363565 RGD:2300340 NCBI chr17:84,941,404...85,033,020
Ensembl chr17:84,982,243...85,033,010 		JBrowse link
G Fabp3 fatty acid binding protein 3 ISO RGD PMID:23719537 RGD:7364738 NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718 		JBrowse link
G Fblim1 filamin binding LIM protein 1 ISO RGD PMID:23860236 RGD:7349373 NCBI chr 5:153,883,945...153,915,524
Ensembl chr 5:153,883,960...153,913,757 		JBrowse link
G Fermt1 FERM domain containing kindlin 1 ISO RGD PMID:23860236 RGD:7349373 NCBI chr 3:120,171,301...120,213,555
Ensembl chr 3:120,171,561...120,213,555 		JBrowse link
G Fermt2 FERM domain containing kindlin 2 ISO RGD PMID:23860236 RGD:7349373 NCBI chr15:18,682,927...18,751,959
Ensembl chr15:18,682,927...18,751,811 		JBrowse link
G Fermt3 FERM domain containing kindlin 3 ISO RGD PMID:23860236 RGD:7349373 NCBI chr 1:204,189,483...204,207,683
Ensembl chr 1:204,189,484...204,207,587 		JBrowse link
G Flna filamin A ISO RGD PMID:23719537 RGD:7364738 NCBI chr  X:152,007,758...152,034,266
Ensembl chr  X:152,007,758...152,031,052 		JBrowse link
G Flnb filamin B ISO RGD PMID:23719537 RGD:7364738 NCBI chr15:16,961,999...17,095,059
Ensembl chr15:16,962,003...17,095,006 		JBrowse link
G Flnc filamin C ISO RGD PMID:23719537 RGD:7364738 NCBI chr 4:58,034,088...58,061,882
Ensembl chr 4:58,034,189...58,061,844 		JBrowse link
G Ilk integrin-linked kinase ISO
IMP		 RGD PMID:16493410 PMID:8538749 PMID:12629168 RGD:2300344, RGD:40924646, RGD:2302091 NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140 		JBrowse link
G Ilkap ILK associated serine/threonine phosphatase ISO RGD PMID:16493410 RGD:2300344 NCBI chr 9:91,966,440...91,988,791
Ensembl chr 9:91,966,441...91,988,892 		JBrowse link
G Itga1 integrin subunit alpha 1 ISS
ISO		 RGD PMID:2380249 PMID:17543136 RGD:729264, RGD:5135538 NCBI chr 2:46,646,125...46,812,237
Ensembl chr 2:46,653,193...46,812,238 		JBrowse link
G Itga10 integrin subunit alpha 10 ISO RGD PMID:12297042 PMID:17543136 RGD:1358329, RGD:5135538 NCBI chr 2:184,182,869...184,202,172
Ensembl chr 2:184,182,869...184,202,172 		JBrowse link
G Itga11 integrin subunit alpha 11 ISO RGD PMID:12297042 PMID:17543136 RGD:1358329, RGD:5135538 NCBI chr 8:63,145,998...63,254,714
Ensembl chr 8:63,146,001...63,254,407 		JBrowse link
G Itga2 integrin subunit alpha 2 TAS
ISO		 RGD PMID:12941079 PMID:17543136 RGD:1302878, RGD:5135538 NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481 		JBrowse link
G Itga2b integrin subunit alpha 2b ISO based on Entrez HomoloGene, BLAST RGD PMID:17543136 RGD:5135538 NCBI chr10:87,408,532...87,426,055
Ensembl chr10:87,408,536...87,426,168 		JBrowse link
G Itga3 integrin subunit alpha 3 ISO RGD PMID:12297042 PMID:17543136 RGD:1358329, RGD:5135538 NCBI chr10:79,990,160...80,022,206
Ensembl chr10:79,990,161...80,022,118 		JBrowse link
G Itga4 integrin subunit alpha 4 TAS
ISO		 RGD PMID:11782963 PMID:17543136 RGD:1302879, RGD:5135538 NCBI chr 3:64,162,764...64,235,010
Ensembl chr 3:64,163,085...64,233,715 		JBrowse link
G Itga5 integrin subunit alpha 5 IDA
ISO		 RGD PMID:12821041 PMID:17543136 RGD:1300196, RGD:5135538 NCBI chr 7:134,478,963...134,502,837
Ensembl chr 7:134,478,968...134,502,837 		JBrowse link
G Itga6 integrin subunit alpha 6 ISS
ISO		 RGD PMID:12297042 PMID:17543136 RGD:1358329, RGD:5135538 NCBI chr 3:56,604,512...56,689,428
Ensembl chr 3:56,617,268...56,689,428 		JBrowse link
G Itga7 integrin subunit alpha 7 IDA
ISO		 RGD PMID:1315319 PMID:17543136 RGD:70774, RGD:5135538 NCBI chr 7:1,360,125...1,388,886
Ensembl chr 7:1,359,940...1,388,450 		JBrowse link
G Itga8 integrin subunit alpha 8 ISO RGD PMID:17543136 PMID:9054500 RGD:5135538, RGD:40903006 NCBI chr17:75,304,004...75,501,510
Ensembl chr17:75,304,008...75,501,510 		JBrowse link
G Itga9 integrin subunit alpha 9 ISO RGD PMID:12297042 PMID:17543136 RGD:1358329, RGD:5135538 NCBI chr 8:118,307,424...118,615,527
Ensembl chr 8:118,307,381...118,613,754 		JBrowse link
G Itgad integrin subunit alpha D ISS
ISO		 RGD PMID:12297042 PMID:17543136 RGD:1358329, RGD:5135538 NCBI chr 1:182,759,762...182,788,422
Ensembl chr 1:182,759,740...182,788,161 		JBrowse link
G Itgae integrin subunit alpha E TAS
ISO		 RGD PMID:9394838 PMID:17543136 RGD:633077, RGD:5135538 NCBI chr10:57,704,813...57,764,093
Ensembl chr10:57,591,753...57,764,093
Ensembl chr10:57,591,753...57,764,093 		JBrowse link
G Itgal integrin subunit alpha L ISS
ISO		 RGD PMID:12297042 PMID:17543136 RGD:1358329, RGD:5135538 NCBI chr 1:181,918,183...181,955,735
Ensembl chr 1:181,918,183...181,955,732 		JBrowse link
G Itgam integrin subunit alpha M ISO RGD PMID:34630381 PMID:17543136 RGD:329849126, RGD:5135538 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Itgav integrin subunit alpha V ISO
IDA		 RGD PMID:12297042 PMID:17543136 PMID:12639933 RGD:1358329, RGD:5135538, RGD:1625134 NCBI chr 3:68,838,514...68,926,653
Ensembl chr 3:68,838,189...68,926,639 		JBrowse link
G Itgax integrin subunit alpha X ISO RGD PMID:17543136 RGD:5135538 NCBI chr 1:182,709,653...182,740,709
Ensembl chr 1:182,719,609...182,740,698 		JBrowse link
G Itgb1 integrin subunit beta 1 ISS
ISO
IDA		 RGD PMID:9633916 PMID:17543136 PMID:12639933 RGD:1302874, RGD:5135538, RGD:1625134 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195 		JBrowse link
G Itgb1bp1 integrin subunit beta 1 binding protein 1 ISO RGD PMID:23860236 PMID:23719537 RGD:7349373, RGD:7364738 NCBI chr 6:40,820,693...40,836,074
Ensembl chr 6:40,821,339...40,836,037 		JBrowse link
G Itgb2 integrin subunit beta 2 ISO RGD PMID:12297042 PMID:17543136 RGD:1358329, RGD:5135538 NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600 		JBrowse link
G Itgb3 integrin subunit beta 3 ISS
ISO
IDA		 RGD PMID:12600920 PMID:17543136 PMID:12639933 RGD:633129, RGD:5135538, RGD:1625134 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679 		JBrowse link
G Itgb4 integrin subunit beta 4 TAS
ISO		 RGD PMID:8026337 PMID:17543136 RGD:729025, RGD:5135538 NCBI chr10:101,206,657...101,243,012
Ensembl chr10:101,206,665...101,243,012 		JBrowse link
G Itgb5 integrin subunit beta 5 ISO RGD PMID:17543136 PMID:8799848 RGD:5135538, RGD:41410438 NCBI chr11:66,828,428...66,944,231
Ensembl chr11:66,829,285...66,944,472 		JBrowse link
G Itgb6 integrin subunit beta 6 ISS
ISO		 RGD PMID:12297042 PMID:17543136 RGD:1358329, RGD:5135538 NCBI chr 3:45,046,295...45,170,532
Ensembl chr 3:45,048,044...45,121,671 		JBrowse link
G Itgb7 integrin subunit beta 7 TAS
ISO		 RGD PMID:9233649 PMID:17543136 RGD:633040, RGD:5135538 NCBI chr 7:133,347,927...133,364,955
Ensembl chr 7:133,347,960...133,364,876 		JBrowse link
G Itgb8 integrin subunit beta 8 ISO RGD PMID:12297042 PMID:17543136 RGD:1358329, RGD:5135538 NCBI chr 6:140,125,002...140,208,261
Ensembl chr 6:140,127,203...140,208,476 		JBrowse link
G Krit1 KRIT1, ankyrin repeat containing ISO RGD PMID:23860236 PMID:23719537 RGD:7349373, RGD:7364738 NCBI chr 4:30,299,203...30,333,366
Ensembl chr 4:30,299,203...30,333,359 		JBrowse link
G Lims1 LIM zinc finger domain containing 1 ISO RGD PMID:16493410 RGD:2300344 NCBI chr20:26,309,833...26,418,511
Ensembl chr20:26,309,895...26,418,500 		JBrowse link
G Lims2 LIM zinc finger domain containing 2 ISO RGD PMID:16493410 RGD:2300344 NCBI chr18:23,553,937...23,592,137
Ensembl chr18:23,553,937...23,592,137 		JBrowse link
G Nck2 NCK adaptor protein 2 ISO RGD PMID:16493410 RGD:2300344 NCBI chr 9:45,713,979...45,840,330
Ensembl chr 9:45,714,883...45,840,307 		JBrowse link
G Parva parvin, alpha ISO RGD PMID:16493410 RGD:2300344 NCBI chr 1:166,547,142...166,704,958
Ensembl chr 1:166,547,132...166,704,950 		JBrowse link
G Parvb parvin, beta ISO RGD PMID:16493410 RGD:2300344 NCBI chr 7:115,360,254...115,445,767
Ensembl chr 7:115,360,261...115,445,766 		JBrowse link
G Parvg parvin, gamma ISO RGD PMID:16493410 RGD:2300344 NCBI chr 7:115,456,183...115,475,707
Ensembl chr 7:115,456,209...115,475,104 		JBrowse link
G Ptk2 protein tyrosine kinase 2 ISO RGD PMID:15108811 RGD:2300402 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Pxn paxillin ISO RGD PMID:16493410 RGD:2300344 NCBI chr12:41,060,791...41,107,952
Ensembl chr12:41,060,791...41,107,931 		JBrowse link
G Sharpin SHANK-associated RH domain interactor ISO RGD PMID:23860236 PMID:23719537 RGD:7349373, RGD:7364738 NCBI chr 7:108,070,681...108,075,012
Ensembl chr 7:108,070,687...108,074,955 		JBrowse link
G Tln1 talin 1 ISO RGD PMID:18363565 PMID:23860236 RGD:2300340, RGD:7349373 NCBI chr 5:57,787,670...57,817,900
Ensembl chr 5:57,787,943...57,817,900 		JBrowse link
G Tln2 talin 2 ISO RGD PMID:23860236 RGD:7349373 NCBI chr 8:67,830,920...68,252,240
Ensembl chr 8:67,834,326...68,252,219 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2635
      mechanotransduction pathway 70
        altered mechanotransduction pathway + 0
        auditory mechanotransduction pathway + 20
        integrin mediated signaling pathway + 50
paths to the root