(+)-artemisinin increases expression EXP 6480464 artemisinin results in increased expression of CYP3A4 mRNA CTD PMID:15761118 and PMID:18332078 (+)-artemisinin affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of artemisinin CTD PMID:12920490 (+)-artemisinin multiple interactions EXP 6480464 [artemisinin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:17041008 (+)-schisandrin B increases expression EXP 6480464 schizandrin B results in increased expression of CYP3A4 mRNA CTD PMID:16267138 (+)-Tetrandrine increases glutathionylation EXP 6480464 CYP3A4 protein results in increased glutathionylation of tetrandrine CTD PMID:21992520 (+)-trans-(S)-allethrin increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of bioallethrin CTD PMID:19249324 (+)-trans-(S)-allethrin increases expression EXP 6480464 bioallethrin results in increased expression of CYP3A4 mRNA CTD PMID:19249324 (-)-epigallocatechin 3-gallate multiple interactions EXP 6480464 [epigallocatechin gallate co-treated with leptomycin B] results in increased expression of CYP3A4 mRNA CTD PMID:25922640 (-)-trans-epsilon-viniferin decreases activity EXP 6480464 epsilon-viniferin results in decreased activity of CYP3A4 protein CTD PMID:12818727 (24S)-24-hydroxycholesterol multiple interactions EXP 6480464 [24-hydroxycholesterol co-treated with NR1H3 protein] results in increased expression of CYP3A4 mRNA CTD PMID:23732298 (3-phenoxyphenyl)methanol increases abundance EXP 6480464 CYP3A4 protein results in increased abundance of 3-phenoxybenzylalcohol CTD PMID:24548679 (E)-roxithromycin multiple interactions EXP 6480464 Roxithromycin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone] CTD PMID:16416302 (E)-roxithromycin decreases activity EXP 6480464 Roxithromycin results in decreased activity of CYP3A4 protein CTD PMID:16416302 and PMID:17164692 (E)-roxithromycin decreases expression EXP 6480464 Roxithromycin results in decreased expression of CYP3A4 mRNA CTD PMID:16837568 (E)-thiamethoxam multiple interactions EXP 6480464 [NADP co-treated with CYP3A4 protein] results in increased activity of Thiamethoxam CTD PMID:16153789 (E,E)-germacrone decreases activity EXP 6480464 germacrone results in decreased activity of CYP3A4 protein CTD PMID:23850985 (E,E)-germacrone increases expression EXP 6480464 germacrone results in increased expression of CYP3A4 mRNA CTD PMID:23850985 (R)-lipoic acid multiple interactions EXP 6480464 Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 (R,R,R)-alpha-tocopherol multiple interactions EXP 6480464 alpha-Tocopherol inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone] more ... CTD PMID:17936189 and PMID:31102695 (R,R,R)-alpha-tocopherol multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA] CTD PMID:27919644 (R,R,R)-alpha-tocopherol increases expression EXP 6480464 alpha-Tocopherol results in increased expression of CYP3A4 mRNA CTD PMID:17936189 (S)-colchicine affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Colchicine CTD PMID:15914514 and PMID:16007523 (S)-naringenin decreases activity EXP 6480464 naringenin results in decreased activity of CYP3A4 protein CTD PMID:21053930 and PMID:29753067 (S)-naringenin increases expression EXP 6480464 naringenin results in increased expression of CYP3A4 mRNA CTD PMID:19148864 (S)-nicotine multiple interactions EXP 6480464 [Nicotine binds to CYP3A4 promoter] which results in increased expression of CYP3A4 mRNA CTD PMID:12851153 (S)-nicotine multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [Nicotine co-treated with 2 more ... CTD PMID:26463278 (Z)-ligustilide multiple interactions EXP 6480464 [ligustilide results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:21524698 1,1,1-Trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane increases hydroxylation EXP 6480464 CYP3A4 protein results in increased hydroxylation of 1 more ... CTD PMID:12167570 more ... 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expression EXP 6480464 o more ... CTD PMID:15548381 more ... 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane affects expression ISO Cyp3a2 (Rattus norvegicus) 6480464 o and p'-DDT affects the expression of CYP3A2 mRNA CTD PMID:17984292 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane multiple interactions EXP 6480464 Dactinomycin inhibits the reaction [o and p'-DDT results in increased expression of CYP3A4 mRNA] CTD PMID:15795092 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases activity EXP 6480464 o and p'-DDT results in increased activity of CYP3A4 protein CTD PMID:17035600 1,2,3,5-tetrachlorobenzene increases oxidation EXP 6480464 CYP3A4 protein results in increased oxidation of 1 more ... CTD PMID:7747284 1,2-dichloroethene decreases activity ISO Cyp3a2 (Rattus norvegicus) 6480464 1 and 2-dichloroethylene results in decreased activity of CYP3A2 protein CTD PMID:9493318 1,2-dichloroethene decreases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 1 and 2-dichloroethylene results in decreased expression of CYP3A2 protein CTD PMID:9493318 1,2-dilauroyl-sn-glycero-3-phosphocholine(1+) multiple interactions EXP 6480464 [1 more ... CTD PMID:1627548 1,2-dilauroyl-sn-glycero-3-phosphocholine(1+) multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [1 more ... CTD PMID:1627548 1,4-dichlorobenzene increases oxidation EXP 6480464 CYP3A4 protein results in increased oxidation of 4-dichlorobenzene CTD PMID:9817075 1,4-naphthoquinone increases expression EXP 6480464 1 and 4-naphthoquinone results in increased expression of CYP3A4 mRNA CTD PMID:18602459 1,4-naphthoquinone increases abundance EXP 6480464 CYP3A4 protein results in increased abundance of 1 and 4-naphthoquinone CTD PMID:16243959 1,6-Dinitropyrene affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of 1 and 6-dinitropyrene CTD PMID:2180560 1,8-cineole multiple interactions EXP 6480464 Eucalyptol inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] CTD PMID:18385293 1,8-cineole increases hydroxylation EXP 6480464 CYP3A4 protein results in increased hydroxylation of Eucalyptol CTD PMID:15715982 1-(1,3-benzodioxol-5-yl)-4,4-dimethyl-1-penten-3-ol decreases activity EXP 6480464 stiripentol results in decreased activity of CYP3A4 protein CTD PMID:16022579 1-(3-chlorophenyl)piperazine multiple interactions EXP 6480464 1-(3-chlorophenyl)piperazine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA] more ... CTD PMID:21402137 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile decreases methylation EXP 6480464 CYP3A4 protein results in decreased methylation of Citalopram analog CTD PMID:9110356 1-\{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl\}-1H-imidazole increases expression EXP 6480464 sulconazole results in increased expression of CYP3A4 mRNA CTD PMID:31312845 1-\{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl\}-1H-imidazole multiple interactions EXP 6480464 [sulconazole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:31312845 1-hydroxymidazolam increases abundance EXP 6480464 CYP3A4 protein results in increased abundance of 1-hydroxymethylmidazolam CTD PMID:12695342 1-hydroxymidazolam increases glucuronidation EXP 6480464 CYP3A4 protein results in increased glucuronidation of 1-hydroxymethylmidazolam CTD PMID:27485346 1-hydroxymidazolam multiple interactions EXP 6480464 [[3-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam more ... CTD PMID:10997946 more ... 1-hydroxymidazolam increases chemical synthesis EXP 6480464 CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam CTD PMID:12401345 more ... 1-hydroxymidazolam beta-D-glucuronide multiple interactions EXP 6480464 [CYP3A4 protein results in increased glucuronidation of 1-hydroxymethylmidazolam] which results in increased abundance of 1-hydroxymethylmidazolam glucuronide CTD PMID:27485346 1-naphthol increases abundance EXP 6480464 CYP3A4 protein results in increased abundance of 1-naphthol CTD PMID:16243959 1-naphthyl isothiocyanate multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 ginsenoside Rg1 inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CYP3A4 mRNA] more ... CTD PMID:32198087 1-naphthyl isothiocyanate decreases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 1-Naphthylisothiocyanate results in decreased expression of CYP3A2 mRNA CTD PMID:26365562 and PMID:30723492 1-naphthyl isothiocyanate increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 1-Naphthylisothiocyanate results in increased expression of CYP3A4 mRNA and 1-Naphthylisothiocyanate results in increased expression of CYP3A4 protein CTD PMID:32198087 13-cis-retinal increases activity EXP 6480464 13-cis-retinal results in increased activity of CYP3A4 protein CTD PMID:16632523 13-cis-retinal multiple interactions EXP 6480464 13-cis-retinal promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] CTD PMID:16632523 14,15-EET multiple interactions EXP 6480464 Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 14 more ... CTD PMID:12675279 14,15-EET increases chemical synthesis EXP 6480464 CYP3A4 protein results in increased chemical synthesis of 14 more ... CTD PMID:12675279 17alpha-ethynylestradiol affects hydroxylation EXP 6480464 CYP3A4 protein affects the hydroxylation of Ethinyl Estradiol CTD PMID:2271712 17alpha-ethynylestradiol decreases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Ethinyl Estradiol results in decreased expression of CYP3A2 mRNA CTD PMID:15953391 17alpha-ethynylestradiol increases hydroxylation EXP 6480464 CYP3A4 protein results in increased hydroxylation of Ethinyl Estradiol CTD PMID:15304426 and PMID:15554232 17alpha-ethynylestradiol multiple interactions EXP 6480464 [Carbamazepine results in increased expression of CYP3A4 protein] which results in decreased abundance of Ethinyl Estradiol more ... CTD PMID:11907170 more ... 17alpha-ethynylestradiol affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Ethinyl Estradiol CTD PMID:15286053 17beta-estradiol multiple interactions EXP 6480464 [Estradiol co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of CYP3A4 mRNA more ... CTD PMID:12505310 more ... 17beta-estradiol affects expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Estradiol affects the expression of CYP3A2 mRNA CTD PMID:32145629 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of CYP3A4 mRNA and Estradiol results in increased expression of CYP3A4 protein CTD PMID:12505310 more ... 17beta-estradiol increases hydroxylation EXP 6480464 CYP3A4 protein results in increased hydroxylation of Estradiol CTD PMID:9047321 and PMID:9714305 17beta-estradiol affects binding EXP 6480464 Estradiol binds to CYP3A4 protein CTD PMID:9047321 17beta-estradiol increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Estradiol CTD PMID:16790556 17beta-estradiol affects hydroxylation EXP 6480464 CYP3A4 protein affects the hydroxylation of Estradiol CTD PMID:2271712 17beta-hydroxy-5alpha-androstan-3-one multiple interactions EXP 6480464 Dihydrotestosterone inhibits the reaction [[Monocrotaline results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA] and Flutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [[Monocrotaline results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA]] CTD PMID:32682830 1H-indole multiple interactions EXP 6480464 NR1I2 protein promotes the reaction [indole results in increased expression of CYP3A4 mRNA] CTD PMID:33002526 1H-indole increases expression EXP 6480464 indole results in increased expression of CYP3A4 mRNA CTD PMID:33002526 2'-deoxyguanosine multiple interactions EXP 6480464 CYP3A4 protein promotes the reaction [Aflatoxin B1 binds to Deoxyguanosine] and CYP3A4 protein promotes the reaction [Estrone binds to Deoxyguanosine] CTD PMID:21907773 2,2',4,4',5,5'-hexachlorobiphenyl increases expression EXP 6480464 2 more ... CTD PMID:22664347 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions EXP 6480464 2 more ... CTD PMID:36893891 2,2',4,4'-Tetrabromodiphenyl ether increases expression EXP 6480464 2 more ... CTD PMID:24218150 2,2',4,4'-Tetrabromodiphenyl ether multiple interactions EXP 6480464 [2 more ... CTD PMID:24218150 2,2',5,5'-tetrachlorobiphenyl multiple interactions EXP 6480464 [POR protein co-treated with CYP3A4 protein] affects the susceptibility to 2 more ... CTD PMID:27913846 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of CYP3A4 mRNA CTD PMID:16985168 more ... 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin results in decreased expression of CYP3A2 mRNA CTD PMID:18796159 and PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 [Tetrachlorodibenzodioxin co-treated with Rifampin] results in increased expression of CYP3A4 mRNA more ... CTD PMID:28571685 and PMID:29162470 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of CYP3A4 mRNA CTD PMID:23669205 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of CYP3A4 mRNA CTD PMID:22298810 2,4,6-trinitrobenzenesulfonic acid multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 gadolinium chloride inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased activity of and results in decreased expression of CYP3A2 protein] more ... CTD PMID:18079364 2,4-dibromophenyl 2,4,5-tribromophenyl ether increases expression EXP 6480464 2 more ... CTD PMID:19270788 2,4-dibromophenyl 2,4,5-tribromophenyl ether multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [CYP3A2 protein results in increased oxidation of 2 more ... CTD PMID:21673328 2,4-dibromophenyl 2,4,5-tribromophenyl ether increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 2 more ... CTD PMID:22331496 2,4-dibromophenyl 2,4,5-tribromophenyl ether increases oxidation ISO Cyp3a2 (Rattus norvegicus) 6480464 CYP3A2 protein results in increased oxidation of 2 more ... CTD PMID:21673328 2,6-di-tert-butyl-4-methylphenol increases expression EXP 6480464 Butylated Hydroxytoluene results in increased expression of CYP3A4 mRNA CTD PMID:18570159 2,8-bis-Trifluoromethyl-4-quinoline carboxylic acid increases expression EXP 6480464 Ro 21-5104 results in increased expression of CYP3A4 mRNA and Ro 21-5104 results in increased expression of CYP3A4 protein CTD PMID:25313206 2,8-bis-Trifluoromethyl-4-quinoline carboxylic acid multiple interactions EXP 6480464 NR1I2 mRNA promotes the reaction [Ro 21-5104 results in increased expression of CYP3A4 mRNA] CTD PMID:25313206 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile decreases activity EXP 6480464 Verapamil results in decreased activity of CYP3A4 protein CTD PMID:15689501 more ... 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Verapamil CTD PMID:15286053 more ... 2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile multiple interactions EXP 6480464 [Verapamil results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA more ... CTD PMID:16013069 more ... 2-[cyclohexyl(oxo)methyl]-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Praziquantel CTD PMID:12920490 2-acetamidofluorene increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 2-Acetylaminofluorene results in increased expression of CYP3A2 protein CTD PMID:10445401 2-amino-2-deoxy-D-galactopyranose multiple interactions EXP 6480464 alpha-Tocopherol inhibits the reaction [Galactosamine results in decreased expression of CYP3A4 mRNA] more ... CTD PMID:17936189 2-amino-2-deoxy-D-galactopyranose decreases expression EXP 6480464 Galactosamine results in decreased expression of CYP3A4 mRNA CTD PMID:17936189 2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Itraconazole CTD PMID:18360572 2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one decreases expression EXP 6480464 Itraconazole results in decreased expression of CYP3A4 mRNA and Itraconazole results in decreased expression of CYP3A4 protein CTD PMID:28390928 2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Itraconazole CTD PMID:15905803 2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one increases hydroxylation EXP 6480464 CYP3A4 protein results in increased hydroxylation of Itraconazole CTD PMID:15383492 2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one decreases activity EXP 6480464 Itraconazole results in decreased activity of CYP3A4 protein CTD PMID:15328084 more ... 2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one multiple interactions EXP 6480464 Itraconazole binds to and results in decreased activity of CYP3A4 protein CTD PMID:18218784 2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one affects activity EXP 6480464 Itraconazole affects the activity of CYP3A4 protein CTD PMID:15964336 2-hydroxy-17beta-estradiol increases chemical synthesis EXP 6480464 CYP3A4 protein results in increased chemical synthesis of 2-hydroxyestradiol CTD PMID:16790556 2-hydroxy-17beta-estradiol multiple interactions EXP 6480464 Chlorpyrifos inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 2-hydroxyestradiol] more ... CTD PMID:16790556 2-hydroxychrysophanol multiple interactions EXP 6480464 [CYP3A4 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of 2-hydroxychrysophanol CTD PMID:29698620 2-hydroxychrysophanol increases chemical synthesis EXP 6480464 CYP3A4 protein results in increased chemical synthesis of 2-hydroxychrysophanol CTD PMID:29698620 2-methyl-1H-indole multiple interactions EXP 6480464 NR1I2 protein affects the reaction [2-methylindole results in increased expression of CYP3A4 mRNA] CTD PMID:32092453 2-methyl-1H-indole increases expression EXP 6480464 2-methylindole results in increased expression of CYP3A4 mRNA CTD PMID:32092453 2-Naphthalenethiol increases expression EXP 6480464 2-naphthalenethiol results in increased expression of CYP3A4 mRNA CTD PMID:36356836 2-naphthol increases abundance EXP 6480464 CYP3A4 protein results in increased abundance of 2-naphthol CTD PMID:16243959 3,3',4,4',5-pentachlorobiphenyl decreases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 3 more ... CTD PMID:31820026 3,3',5-triiodo-L-thyronine increases expression EXP 6480464 Triiodothyronine results in increased expression of CYP3A4 mRNA CTD PMID:21815645 3,3',5-triiodo-L-thyronine multiple interactions EXP 6480464 SJ 000311413 inhibits the reaction [Triiodothyronine results in increased expression of CYP3A4 mRNA] CTD PMID:21815645 3,3'-diindolylmethane decreases activity EXP 6480464 3 and 3'-diindolylmethane results in decreased activity of CYP3A4 protein CTD PMID:19770484 3,3'-diindolylmethane multiple interactions EXP 6480464 [3 more ... CTD PMID:25542144 3,3'-diindolylmethane increases expression EXP 6480464 3 and 3'-diindolylmethane results in increased expression of CYP3A4 mRNA CTD PMID:25542144 3,4-methylenedioxymethamphetamine multiple interactions EXP 6480464 N-Methyl-3 more ... CTD PMID:21402137 3,4-methylenedioxymethamphetamine decreases activity EXP 6480464 N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased activity of CYP3A4 protein CTD PMID:24211539 3,5,6-trichloro-2-pyridinol increases chemical synthesis EXP 6480464 CYP3A4 results in increased chemical synthesis of 3 more ... CTD PMID:20709133 3,5,6-trichloropyridine-2-one increases chemical synthesis EXP 6480464 CYP3A4 results in increased chemical synthesis of 3 more ... CTD PMID:20709133 3-(Methylthio)-1-propene increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 allyl methyl sulfide results in increased expression of CYP3A2 protein CTD PMID:16000231 3-hydroxyquinine affects chemical synthesis EXP 6480464 CYP3A4 protein affects the chemical synthesis of 3-hydroxyquinidine CTD PMID:15896247 3-methylcholanthrene decreases expression EXP 6480464 Methylcholanthrene results in decreased expression of CYP3A4 protein CTD PMID:10640517 3-methylcholanthrene multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 Dactinomycin inhibits the reaction [Methylcholanthrene results in increased expression of CYP3A2 mRNA] CTD PMID:11181506 3-methylcholanthrene increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Methylcholanthrene results in increased expression of CYP3A2 mRNA CTD PMID:11181506 3-methylcholanthrene multiple interactions EXP 6480464 [Methylcholanthrene co-treated with Rifampin co-treated with Phenobarbital] results in increased expression of CYP3A4 mRNA and Methylcholanthrene results in decreased expression of and results in decreased activity of CYP3A4 protein CTD PMID:23846873 and PMID:24999631 3-oxo-5beta-cholanic acid multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [CYP3A2 protein results in increased metabolism of Lithocholic Acid] which results in increased chemical synthesis of 3-oxocholan-24-oic acid CTD PMID:18039809 3H-1,2-dithiole-3-thione decreases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 1 and 2-dithiol-3-thione results in decreased expression of CYP3A2 mRNA CTD PMID:19162173 4'-tert-Butyl-2',6'-dimethyl-3',5'-dinitroacetophenone decreases activity ISO Cyp3a2 (Rattus norvegicus) 6480464 musk ketone results in decreased activity of CYP3A2 protein CTD PMID:10630706 4,4'-methanol-bisbenzonitrile increases chemical synthesis EXP 6480464 CYP3A4 protein results in increased chemical synthesis of 4 and 4'-methanol-bisbenzonitrile CTD PMID:19845430 4,4'-methylene-bis-(2-chloroaniline) multiple interactions EXP 6480464 alpha-naphthoflavone inhibits the reaction [CYP3A4 protein results in increased oxidation of Methylenebis(chloroaniline)] more ... CTD PMID:1740010 4,4'-methylene-bis-(2-chloroaniline) increases oxidation EXP 6480464 CYP3A4 protein results in increased oxidation of Methylenebis(chloroaniline) CTD PMID:1740010 4,4'-sulfonyldiphenol increases hydroxylation EXP 6480464 CYP3A4 protein results in increased hydroxylation of bisphenol S CTD PMID:27213244 4,4'-sulfonyldiphenol multiple interactions EXP 6480464 bisphenol S affects the reaction [SR 12813 results in increased expression of CYP3A4 protein] CTD PMID:28916285 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone CTD PMID:9029045 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one multiple interactions EXP 6480464 CYP3A4 protein affects the metabolism of and results in increased activity of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone CTD PMID:11774366 4-[(1E)-1,2-diphenylbut-1-en-1-yl]phenol multiple interactions EXP 6480464 [CYP3A4 protein results in increased metabolism of N more ... CTD PMID:29285606 4-[(1E)-1,2-diphenylbut-1-en-1-yl]phenol increases activity EXP 6480464 1-(4-hydroxyphenyl)-1 and 2-diphenyl-1-butene results in increased activity of CYP3A4 protein CTD PMID:29285606 4-[(1E)-1,2-diphenylbut-1-en-1-yl]phenol increases abundance EXP 6480464 CYP3A4 protein results in increased abundance of 1-(4-hydroxyphenyl)-1 and 2-diphenyl-1-butene CTD PMID:29285606 4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide decreases activity EXP 6480464 Cisapride results in decreased activity of CYP3A4 protein CTD PMID:15306208 4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Cisapride CTD PMID:11717173 4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide affects chemical synthesis EXP 6480464 CYP3A4 protein affects the chemical synthesis of Cisapride metabolite CTD PMID:11717173 4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide multiple interactions EXP 6480464 Cisapride inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] CTD PMID:19299527 4-bromo-2-chlorophenol multiple interactions EXP 6480464 [CYP3A4 protein results in increased metabolism of profenofos] which results in increased abundance of 4-bromo-2-chlorophenol CTD PMID:23415833 4-hydroxy-3-(2-hydroxy-3-oxo-1-phenylbutyl)-2H-chromen-2-one multiple interactions EXP 6480464 [10-hydroxywarfarin binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:20735727 4-hydroxy-3-(2-hydroxy-3-oxo-1-phenylbutyl)-2H-chromen-2-one affects chemical synthesis EXP 6480464 CYP3A4 protein affects the chemical synthesis of 10-hydroxywarfarin CTD PMID:16035367 4-hydroxy-3-[1-(4-hydroxyphenyl)-3-oxobutyl]-2H-chromen-2-one multiple interactions EXP 6480464 [4'-hydroxywarfarin binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:20735727 4-Hydroxy-N-desmethyltamoxifen multiple interactions EXP 6480464 [CYP3A4 protein results in increased metabolism of 4-hydroxy-N-desmethyltamoxifen] which results in increased abundance of 4-hydroxy-N-desmethyltamoxifen metabolite CTD PMID:29285606 4-Hydroxy-N-desmethyltamoxifen increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of 4-hydroxy-N-desmethyltamoxifen CTD PMID:29285606 4-Hydroxybenzyl isothiocyanate decreases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 4-hydroxybenzyl isothiocyanate results in decreased expression of CYP3A2 mRNA CTD PMID:22664424 4-Hydroxybenzyl isothiocyanate decreases activity ISO Cyp3a2 (Rattus norvegicus) 6480464 4-hydroxybenzyl isothiocyanate results in decreased activity of CYP3A2 protein CTD PMID:22664424 4-hydroxycyclophosphamide multiple interactions EXP 6480464 [CYP3A4 protein results in increased hydroxylation of Cyclophosphamide] which results in increased chemical synthesis of 4-hydroxycyclophosphamide CTD PMID:30500380 4-hydroxymidazolam increases chemical synthesis EXP 6480464 CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam CTD PMID:12695342 and PMID:18191104 4-hydroxymidazolam multiple interactions EXP 6480464 [CYP3A4 protein results in increased hydroxylation of Midazolam] which results in increased abundance of 4-hydroxymidazolam more ... CTD PMID:12695342 more ... 4-hydroxynon-2-enal multiple interactions EXP 6480464 [[CYP3A4 protein co-treated with Oxygen co-treated with NADP] results in increased reduction of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 1 more ... CTD PMID:21766881 4-hydroxyphenyl retinamide multiple interactions EXP 6480464 Fenretinide promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] CTD PMID:16632523 4-Ipomeanol increases activity EXP 6480464 CYP3A4 protein results in increased activity of 4-ipomeanol CTD PMID:15892579 4-isopropylphenol increases glutathionylation EXP 6480464 CYP3A4 protein results in increased glutathionylation of 4-isopropylphenol CTD PMID:23470418 4beta-hydroxycholesterol multiple interactions EXP 6480464 [CYP3A4 protein results in increased oxidation of Cholesterol] which results in increased chemical synthesis of cholest-5-ene-3 and 4-diol CTD PMID:11514559 4beta-hydroxycholesterol increases chemical synthesis EXP 6480464 CYP3A4 protein results in increased chemical synthesis of cholest-5-ene-3 and 4-diol CTD PMID:19954708 5,6-EET multiple interactions EXP 6480464 Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 5 more ... CTD PMID:12675279 5,6-EET increases chemical synthesis EXP 6480464 CYP3A4 protein results in increased chemical synthesis of 5 more ... CTD PMID:12675279 5,7-dihydroxy-4'-methoxyflavone multiple interactions EXP 6480464 acacetin binds to and results in decreased activity of CYP3A4 protein more ... CTD PMID:21053930 5,7-dihydroxy-4'-methoxyflavone decreases activity ISO Cyp3a2 (Rattus norvegicus) 6480464 acacetin results in decreased activity of CYP3A2 protein CTD PMID:32738202 5,7-dihydroxy-4'-methoxyflavone increases expression EXP 6480464 acacetin results in increased expression of CYP3A4 mRNA CTD PMID:29933105 5-azacytidine increases expression EXP 6480464 Azacitidine results in increased expression of CYP3A4 mRNA CTD PMID:27590069 5-fluorouracil affects expression EXP 6480464 Fluorouracil affects the expression of CYP3A4 mRNA CTD PMID:16584549 5-hydroxydiclofenac multiple interactions EXP 6480464 [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 5-hydroxydiclofenac more ... CTD PMID:24246759 5-Hydroxyflavone decreases activity EXP 6480464 5-hydroxyflavone results in decreased activity of CYP3A4 protein CTD PMID:21053930 5-Hydroxyflavone multiple interactions EXP 6480464 [5-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam and [[5-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam CTD PMID:31756459 5-Hydroxyflavone increases activity EXP 6480464 5-hydroxyflavone results in increased activity of CYP3A4 protein CTD PMID:31756459 5-Hydroxythalidomide multiple interactions EXP 6480464 [CYP3A4 protein results in increased hydroxylation of Thalidomide] which results in increased chemical synthesis of 5-hydroxythalidomide and CYP3A4 protein results in increased oxidation of and results in increased glutathionylation of 5-hydroxythalidomide CTD PMID:20443640 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole multiple interactions EXP 6480464 [Omeprazole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA more ... CTD PMID:12695340 more ... 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Omeprazole CTD PMID:15286053 and PMID:15626586 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Omeprazole CTD PMID:12485723 more ... 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole increases expression EXP 6480464 Omeprazole results in increased expression of CYP3A4 mRNA and Omeprazole results in increased expression of CYP3A4 protein CTD PMID:12235278 more ... 5-methoxyindole decreases activity EXP 6480464 5-methoxyindole results in decreased activity of CYP3A4 protein CTD PMID:18420780 6',7'-Dihydroxybergamottin decreases activity EXP 6480464 6' and 7'-dihydroxybergamottin results in decreased activity of CYP3A4 protein CTD PMID:15860655 and PMID:23146034 6',7'-Dihydroxybergamottin multiple interactions EXP 6480464 6' and 7'-dihydroxybergamottin inhibits the reaction [CYP3A4 protein results in increased oxidation of Nifedipine] CTD PMID:23146034 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime increases activity EXP 6480464 6-(4-chlorophenyl)imidazo(2 more ... CTD PMID:30364229 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime increases expression EXP 6480464 6-(4-chlorophenyl)imidazo(2 more ... CTD PMID:16608920 more ... 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime multiple interactions EXP 6480464 allyl isothiocyanate inhibits the reaction [6-(4-chlorophenyl)imidazo(2 more ... CTD PMID:16608920 more ... 6-chrysenamine affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of 6-chrysenamine CTD PMID:2271712 and PMID:2655891 6-Hydroxyflavone multiple interactions EXP 6480464 [6-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam and [[6-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam CTD PMID:31756459 6-Hydroxyflavone increases activity EXP 6480464 6-hydroxyflavone results in increased activity of CYP3A4 protein CTD PMID:31756459 6-Methylflavone increases activity EXP 6480464 6-methylflavone results in increased activity of CYP3A4 protein CTD PMID:31756459 6-Methylflavone multiple interactions EXP 6480464 [6-methylflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam and [[6-methylflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam CTD PMID:31756459 6alpha-methylprednisolone increases activity EXP 6480464 Methylprednisolone results in increased activity of CYP3A4 protein CTD PMID:15964336 6alpha-methylprednisolone decreases expression EXP 6480464 Methylprednisolone results in decreased expression of CYP3A4 mRNA CTD PMID:16837568 6beta-hydroxycortisol affects chemical synthesis EXP 6480464 CYP3A4 protein affects the chemical synthesis of 6 beta-hydroxycortisol CTD PMID:15941677 6beta-hydroxytestosterone multiple interactions EXP 6480464 [[CYP3A4 protein co-treated with NADP] results in increased oxidation of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone more ... CTD PMID:16595712 more ... 6beta-hydroxytestosterone multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [CYP3A4 protein results in increased metabolism of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone and isobavachalcone inhibits the reaction [[CYP3A4 protein results in increased metabolism of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone] CTD PMID:31870919 6beta-hydroxytestosterone increases chemical synthesis ISO Cyp3a2 (Rattus norvegicus) 6480464 CYP3A4 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone CTD PMID:27836570 and PMID:31870919 6beta-hydroxytestosterone increases chemical synthesis EXP 6480464 CYP3A4 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone CTD PMID:12401345 more ... 7,12-dimethyltetraphene increases response to substance EXP 6480464 CYP3A4 protein results in increased susceptibility to 9 more ... CTD PMID:20507880 7-hydroxyflavone decreases activity EXP 6480464 7-hydroxyflavone results in decreased activity of CYP3A4 protein CTD PMID:21053930 7-hydroxyflavone increases activity EXP 6480464 7-hydroxyflavone results in increased activity of CYP3A4 protein CTD PMID:31756459 7-hydroxyflavone multiple interactions EXP 6480464 [7-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam and [[7-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam CTD PMID:31756459 8,9-EET increases chemical synthesis EXP 6480464 CYP3A4 protein results in increased chemical synthesis of 8 and 9-epoxyeicosatrienoic acid CTD PMID:12675279 8,9-EET multiple interactions EXP 6480464 Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 8 and 9-epoxyeicosatrienoic acid] CTD PMID:12675279 8-Epidiosbulbin E acetate multiple interactions EXP 6480464 Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of 8-epidiosbulbin E acetate] CTD PMID:26286065 8-Epidiosbulbin E acetate increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of 8-epidiosbulbin E acetate CTD PMID:26286065 9-cis-retinal increases activity EXP 6480464 9-cis-retinal results in increased activity of CYP3A4 protein CTD PMID:16632523 9-cis-retinal multiple interactions EXP 6480464 1 more ... CTD PMID:16632523 and PMID:19686701 9-cis-retinoic acid multiple interactions EXP 6480464 1 more ... CTD PMID:16632523 and PMID:19686701 9-cis-retinoic acid increases activity EXP 6480464 Alitretinoin results in increased activity of CYP3A4 protein CTD PMID:16632523 9-hydroxyellipticine multiple interactions EXP 6480464 [[CYP3A4 protein co-treated with NADP] results in increased oxidation of ellipticine] which results in increased chemical synthesis of 9-hydroxyellipticine more ... CTD PMID:22390216 and PMID:30914192 [2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol multiple interactions EXP 6480464 Ketoconazole inhibits the reaction [CYP3A4 protein affects the metabolism of Mefloquine] CTD PMID:15896247 acalabrutinib increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of acalabrutinib CTD PMID:34153224 acalabrutinib multiple interactions EXP 6480464 Ketoconazole affects the reaction [CYP3A4 protein alternative form affects the metabolism of acalabrutinib] CTD PMID:34153224 acalabrutinib affects metabolic processing EXP 6480464 CYP3A4 protein alternative form affects the metabolism of acalabrutinib CTD PMID:34153224 acenaphthylene increases oxidation EXP 6480464 CYP3A4 protein results in increased oxidation of acenaphthylene CTD PMID:25642975 acetamide decreases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 acetamide results in decreased expression of CYP3A2 mRNA CTD PMID:31881176 acetochlor increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of acetochlor CTD PMID:11133395 Acetyl tributyl citrate multiple interactions EXP 6480464 2-acetyltributylcitrate promotes the reaction [Calcitriol results in increased expression of CYP3A4 mRNA] more ... CTD PMID:21742782 Acetyl tributyl citrate increases expression EXP 6480464 2-acetyltributylcitrate results in increased expression of CYP3A4 mRNA CTD PMID:21742782 Acetyl tributyl citrate increases activity EXP 6480464 2-acetyltributylcitrate results in increased activity of CYP3A4 protein CTD PMID:21742782 aconitine increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Aconitine CTD PMID:21277363 aconitine increases expression EXP 6480464 Aconitine results in increased expression of CYP3A4 mRNA CTD PMID:30303438 aconitine multiple interactions EXP 6480464 [Aconitine co-treated with mesaconitine co-treated with hypaconitine] results in increased expression of CYP3A4 mRNA and [CYP3A4 protein results in increased metabolism of Aconitine] which results in increased chemical synthesis of 16-O-demethylaconitine CTD PMID:21277363 and PMID:30303438 acrolein multiple interactions EXP 6480464 [CYP3A4 protein results in increased hydroxylation of Cyclophosphamide] which results in increased chemical synthesis of Acrolein CTD PMID:30500380 actinomycin D multiple interactions EXP 6480464 Dactinomycin inhibits the reaction [o more ... CTD PMID:15795092 and PMID:24819614 actinomycin D multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 Dactinomycin inhibits the reaction [Methylcholanthrene results in increased expression of CYP3A2 mRNA] more ... CTD PMID:11181506 adefovir pivoxil decreases activity EXP 6480464 adefovir dipivoxil results in decreased activity of CYP3A4 protein CTD PMID:17162464 adinazolam multiple interactions EXP 6480464 Ketoconazole inhibits the reaction [CYP3A4 protein results in decreased methylation of adinazolam] and Troleandomycin inhibits the reaction [CYP3A4 protein results in decreased methylation of adinazolam] CTD PMID:9600717 adinazolam decreases methylation EXP 6480464 CYP3A4 protein results in decreased methylation of adinazolam CTD PMID:9600717 afimoxifene decreases activity EXP 6480464 afimoxifene results in decreased activity of CYP3A4 protein CTD PMID:12419016 afimoxifene increases expression EXP 6480464 afimoxifene results in increased expression of CYP3A4 mRNA CTD PMID:29285606 afimoxifene increases activity EXP 6480464 afimoxifene results in increased activity of CYP3A4 protein CTD PMID:29285606 afimoxifene increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of afimoxifene CTD PMID:29285606 afimoxifene multiple interactions EXP 6480464 [CYP3A4 protein results in increased metabolism of afimoxifene] which results in increased abundance of afimoxifene metabolite and [CYP3A4 protein results in increased metabolism of Tamoxifen] which results in increased abundance of afimoxifene CTD PMID:20507880 and PMID:29285606 aflatoxin B1 affects expression EXP 6480464 Aflatoxin B1 affects the expression of CYP3A4 protein CTD PMID:20106945 aflatoxin B1 increases activity ISO Cyp3a2 (Rattus norvegicus) 6480464 CYP3A2 protein results in increased activity of Aflatoxin B1 CTD PMID:11346484 aflatoxin B1 decreases expression EXP 6480464 Aflatoxin B1 results in decreased expression of CYP3A4 mRNA and Aflatoxin B1 results in decreased expression of CYP3A4 protein CTD PMID:18347083 more ... aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of CYP3A4 mRNA CTD PMID:21641981 more ... aflatoxin B1 multiple interactions EXP 6480464 [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Aflatoxin B1 more ... CTD PMID:20655369 more ... aflatoxin B1 increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Aflatoxin B1 CTD PMID:20707407 aflatoxin B1 increases response to substance EXP 6480464 CYP3A4 mRNA results in increased susceptibility to Aflatoxin B1 and CYP3A4 protein results in increased susceptibility to Aflatoxin B1 CTD PMID:11189750 and PMID:29555536 aflatoxin B1 increases activity EXP 6480464 Aflatoxin B1 results in increased activity of CYP3A4 protein and CYP3A4 protein results in increased activity of Aflatoxin B1 CTD PMID:15988000 and PMID:33164849 aflatoxin B1 affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Aflatoxin B1 CTD PMID:2271712 and PMID:2655891 aflatoxin B1 exo-8,9-epoxide multiple interactions EXP 6480464 [CYP3A4 protein results in increased metabolism of Aflatoxin B1] which results in increased chemical synthesis of aflatoxin B1-2 and 3-oxide CTD PMID:20707407 Aflatoxin G1 multiple interactions EXP 6480464 aflatoxin G1 promotes the reaction [NR1I2 protein binds to CYP3A4 promoter] CTD PMID:21641981 Aflatoxin G1 increases expression EXP 6480464 aflatoxin G1 results in increased expression of CYP3A4 mRNA CTD PMID:21641981 Aflatoxin G1 increases response to substance EXP 6480464 CYP3A4 protein results in increased susceptibility to aflatoxin G1 CTD PMID:11189750 Aflatoxin G1 affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of aflatoxin G1 CTD PMID:2271712 and PMID:2655891 aflatoxin M1 increases expression EXP 6480464 Aflatoxin M1 results in increased expression of CYP3A4 mRNA CTD PMID:21641981 aflatoxin M1 multiple interactions EXP 6480464 Aflatoxin M1 promotes the reaction [NR1I2 protein binds to CYP3A4 promoter] CTD PMID:21641981 aflatoxin Q1 multiple interactions EXP 6480464 [CYP3A4 protein results in increased metabolism of Aflatoxin B1] which results in increased chemical synthesis of aflatoxin Q1 CTD PMID:20707407 ajmalicine multiple interactions EXP 6480464 raubasine inhibits the reaction [Calcitriol results in increased expression of CYP3A4 protein] CTD PMID:29782822 ajmaline multiple interactions EXP 6480464 Ajmaline inhibits the reaction [Calcitriol results in increased expression of CYP3A4 protein] CTD PMID:29782822 alachlor increases expression EXP 6480464 alachlor results in increased expression of CYP3A4 mRNA CTD PMID:16565514 alachlor multiple interactions EXP 6480464 [CYP3A4 protein results in increased metabolism of alachlor] which results in increased abundance of 2-chloro-N-(2 and 6-diethylphenyl)acetamide CTD PMID:18273908 alachlor increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of alachlor CTD PMID:10475613 and PMID:18273908 albendazole multiple interactions EXP 6480464 [Albendazole co-treated with CYP3A4 protein] results in increased expression of CD86 protein and [Albendazole co-treated with CYP3A4 protein] results in increased expression of ICAM1 protein CTD PMID:22785256 albendazole multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [SOD2 co-treated with CYP3A4] affects the susceptibility to Albendazole CTD PMID:19501153 alcohol multiple interactions EXP 6480464 Alcohols inhibits the reaction [ferric citrate results in increased expression of CYP3A4 mRNA] more ... CTD PMID:24025710 alcohol increases expression EXP 6480464 Alcohols results in increased expression of CYP3A4 mRNA and Alcohols results in increased expression of CYP3A4 protein CTD PMID:24025710 aldrin increases expression EXP 6480464 Aldrin results in increased expression of CYP3A4 protein CTD PMID:15548381 alectinib affects metabolic processing EXP 6480464 CYP3A4 polymorphism affects the metabolism of alectinib CTD PMID:37209178 alfacalcidol increases hydroxylation EXP 6480464 CYP3A4 protein results in increased hydroxylation of alfacalcidol CTD PMID:15005856 alfentanil multiple interactions EXP 6480464 CYB5A protein promotes the reaction [CYP3A4 protein affects the metabolism of Alfentanil] CTD PMID:15557344 alfentanil affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Alfentanil CTD PMID:15557344 and PMID:15731592 all-trans-4-hydroxyretinoic acid increases chemical synthesis EXP 6480464 CYP3A4 protein results in increased chemical synthesis of 4-hydroxyretinoic acid CTD PMID:10874126 all-trans-4-oxoretinoic acid increases chemical synthesis EXP 6480464 CYP3A4 protein results in increased chemical synthesis of 4-oxoretinoic acid CTD PMID:10874126 all-trans-retinoic acid multiple interactions EXP 6480464 [Tretinoin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA and Tretinoin promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] CTD PMID:16632523 and PMID:25455453 all-trans-retinoic acid increases hydroxylation EXP 6480464 CYP3A4 protein results in increased hydroxylation of Tretinoin CTD PMID:10874126 all-trans-retinoic acid decreases activity EXP 6480464 Tretinoin results in decreased activity of CYP3A4 protein CTD PMID:18420780 all-trans-retinoic acid decreases expression EXP 6480464 Tretinoin results in decreased expression of CYP3A4 mRNA CTD PMID:16985168 all-trans-retinoic acid increases activity EXP 6480464 Tretinoin results in increased activity of CYP3A4 protein CTD PMID:16632523 allethrin multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 Allethrins results in increased expression of and results in increased activity of CYP3A2 protein CTD PMID:22080754 allyl alcohol decreases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 allyl alcohol results in decreased expression of CYP3A2 protein CTD PMID:10445401 allyl isothiocyanate multiple interactions EXP 6480464 allyl isothiocyanate inhibits the reaction [6-(4-chlorophenyl)imidazo(2 more ... CTD PMID:25069801 allyl isothiocyanate decreases activity ISO Cyp3a2 (Rattus norvegicus) 6480464 allyl isothiocyanate results in decreased activity of CYP3A2 protein CTD PMID:22664424 allyl isothiocyanate decreases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 allyl isothiocyanate results in decreased expression of CYP3A2 mRNA CTD PMID:22664424 allyl isothiocyanate multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 allyl isothiocyanate inhibits the reaction [[NR1I2 protein co-treated with Pregnenolone Carbonitrile] results in increased expression of CYP3A4 mRNA] CTD PMID:25069801 allyl isothiocyanate decreases activity EXP 6480464 allyl isothiocyanate results in decreased activity of CYP3A4 protein CTD PMID:25069801 allyl methyl disulfide decreases activity EXP 6480464 allyl methyl disulfide results in decreased activity of CYP3A4 protein CTD PMID:18385293 allyl methyl disulfide multiple interactions EXP 6480464 allyl methyl disulfide inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] CTD PMID:18385293 almotriptan increases hydroxylation EXP 6480464 CYP3A4 protein results in increased hydroxylation of almotriptan CTD PMID:12642466 almotriptan decreases methylation EXP 6480464 CYP3A4 protein results in decreased methylation of almotriptan CTD PMID:12642466 Aloe emodin multiple interactions EXP 6480464 [CYP3A4 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of aloe emodin CTD PMID:29698620 Aloe emodin increases chemical synthesis EXP 6480464 CYP3A4 protein results in increased chemical synthesis of aloe emodin CTD PMID:29698620 alpha-hexachlorocyclohexane increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 alpha-hexachlorocyclohexane results in increased expression of CYP3A2 mRNA CTD PMID:16940010 alpha-hexachlorocyclohexane multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in decreased expression of CYP3A2 mRNA more ... CTD PMID:11165752 and PMID:16246485 alpha-Hydroxyalprazolam affects chemical synthesis EXP 6480464 CYP3A4 protein affects the chemical synthesis of alpha-hydroxyalprazolam CTD PMID:12196913 alpha-linolenic acid decreases activity EXP 6480464 alpha-Linolenic Acid results in decreased activity of CYP3A4 protein CTD PMID:16978661 alpha-naphthoflavone multiple interactions EXP 6480464 [[alpha-naphthoflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam more ... CTD PMID:1740010 more ... alpha-naphthoflavone increases activity EXP 6480464 alpha-naphthoflavone results in increased activity of CYP3A4 protein CTD PMID:2271712 and PMID:31756459 alpha-naphthoflavone decreases activity EXP 6480464 alpha-naphthoflavone results in decreased activity of CYP3A4 protein CTD PMID:15005856 alpha-naphthoflavone affects binding EXP 6480464 alpha-naphthoflavone binds to CYP3A4 protein CTD PMID:17198380 alpha-santonin multiple interactions EXP 6480464 [Santonin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:25455453 alpha-tocotrienol increases expression EXP 6480464 tocotrienol and alpha results in increased expression of CYP3A4 CTD PMID:15269186 alpha-tocotrienol multiple interactions EXP 6480464 tocotrienol more ... CTD PMID:31102695 alprazolam multiple interactions EXP 6480464 CYP3A4 protein binds to and affects the metabolism of Alprazolam CTD PMID:15856409 alprazolam affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Alprazolam CTD PMID:12196913 and PMID:16042670 Amaranth decreases activity EXP 6480464 Amaranth Dye results in decreased activity of CYP3A4 protein CTD PMID:20041016 amiodarone multiple interactions EXP 6480464 [Amiodarone co-treated with Benzoic Acid co-treated with cyproconazole co-treated with flusilazole co-treated with enilconazole co-treated with prochloraz co-treated with propiconazole co-treated with tebuconazole] results in increased expression of CYP3A4 protein more ... CTD PMID:15869686 more ... amiodarone increases degradation EXP 6480464 CYP3A4 protein results in increased degradation of Amiodarone CTD PMID:32305697 amiodarone increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Amiodarone results in increased expression of CYP3A4 mRNA CTD PMID:19224547 amiodarone increases response to substance EXP 6480464 CYP3A4 protein results in increased susceptibility to Amiodarone CTD PMID:21540358 and PMID:26477383 amiodarone decreases activity EXP 6480464 Amiodarone results in decreased activity of CYP3A4 protein CTD PMID:15304522 more ... amiodarone decreases ethylation EXP 6480464 CYP3A4 protein results in decreased ethylation of Amiodarone CTD PMID:7905403 amiodarone increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Amiodarone CTD PMID:15869686 more ... amitriptyline increases metabolic processing EXP 6480464 Amitriptyline results in increased metabolism of CYP3A4 protein CTD PMID:18359012 amitriptyline multiple interactions EXP 6480464 [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Amitriptyline CTD PMID:23397584 ammonium chloride affects expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Ammonium Chloride affects the expression of CYP3A2 mRNA CTD PMID:16483693 amodiaquine increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Amodiaquine CTD PMID:28478157 and PMID:31629065 amodiaquine multiple interactions EXP 6480464 [CYP3A4 protein results in increased metabolism of Amodiaquine] which results in increased abundance of and results in increased secretion of desethylamodiaquine more ... CTD PMID:28478157 and PMID:31629065 amodiaquine increases response to substance EXP 6480464 CYP3A4 protein results in increased susceptibility to Amodiaquine CTD PMID:31629065 amoxapine increases chemical synthesis EXP 6480464 CYP3A4 results in increased chemical synthesis of Amoxapine CTD PMID:21826677 amphetamine decreases alkylation EXP 6480464 CYP3A4 protein results in decreased alkylation of Amphetamine analog CTD PMID:29277574 amphetamine affects chemical synthesis EXP 6480464 CYP3A4 protein affects the chemical synthesis of Amphetamine CTD PMID:15294457 amphetamine multiple interactions EXP 6480464 Amphetamine promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA] more ... CTD PMID:21402137 amphetamine decreases methylation EXP 6480464 CYP3A4 protein results in decreased methylation of Amphetamine analog CTD PMID:29277574 ampicillin multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in decreased expression of CYP3A2 mRNA CTD PMID:30545405 amprenavir decreases activity EXP 6480464 amprenavir results in decreased activity of CYP3A4 protein CTD PMID:15523003 Ancriviroc affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Ancriviroc CTD PMID:16012074 Ancriviroc decreases ethylation EXP 6480464 CYP3A4 protein results in decreased ethylation of Ancriviroc CTD PMID:16012074 andrographolide decreases expression EXP 6480464 andrographolide results in decreased expression of CYP3A4 mRNA CTD PMID:19041297 androst-4-ene-3,17-dione multiple interactions EXP 6480464 Androstenedione promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] CTD PMID:19299527 aniline multiple interactions EXP 6480464 CYP3A4 protein affects the metabolism of [norharman co-treated with aniline] CTD PMID:15279827 anthocyanin increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Anthocyanins results in increased expression of CYP3A2 mRNA CTD PMID:18803703 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions EXP 6480464 pyrazolanthrone inhibits the reaction [Calcitriol results in increased expression of CYP3A4 mRNA] CTD PMID:17965521 antirheumatic drug decreases expression EXP 6480464 Antirheumatic Agents results in decreased expression of CYP3A4 mRNA CTD PMID:24449571 apigenin multiple interactions EXP 6480464 Apigenin inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam] and Apigenin promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam] CTD PMID:21053930 apigenin decreases activity EXP 6480464 Apigenin results in decreased activity of CYP3A4 protein CTD PMID:21053930 and PMID:29753067 arachidonic acid decreases activity EXP 6480464 Arachidonic Acid results in decreased activity of CYP3A4 protein CTD PMID:16978661 arachidonic acid multiple interactions EXP 6480464 Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Arachidonic Acid] CTD PMID:12675279 arachidonic acid increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Arachidonic Acid CTD PMID:12675279 Aroclor 1254 increases expression EXP 6480464 Chlorodiphenyl (54% Chlorine) results in increased expression of CYP3A4 mRNA CTD PMID:17851650 Aroclor 1254 increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Chlorodiphenyl (54% Chlorine) results in increased expression of CYP3A2 mRNA CTD PMID:22659317 arsane decreases activity ISO Cyp3a2 (Rattus norvegicus) 6480464 Arsenic results in decreased activity of CYP3A4 protein CTD PMID:19932728 arsane multiple interactions EXP 6480464 [Estradiol co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of CYP3A4 mRNA and [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CYP3A4 mRNA CTD PMID:35747940 arsane multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 Arsenic inhibits the reaction [Acetaminophen results in increased activity of CYP3A4 protein] CTD PMID:19932728 arsenic atom multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 Arsenic inhibits the reaction [Acetaminophen results in increased activity of CYP3A4 protein] CTD PMID:19932728 arsenic atom multiple interactions EXP 6480464 [Estradiol co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of CYP3A4 mRNA and [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CYP3A4 mRNA CTD PMID:35747940 arsenic atom decreases activity ISO Cyp3a2 (Rattus norvegicus) 6480464 Arsenic results in decreased activity of CYP3A4 protein CTD PMID:19932728 arsenite(3-) multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 arsenite inhibits the reaction [Rifampin results in increased expression of and results in increased activity of CYP3A2 protein] and arsenite inhibits the reaction [Rifampin results in increased expression of CYP3A2 mRNA] CTD PMID:22159698 arsenous acid increases expression EXP 6480464 Arsenic Trioxide results in increased expression of CYP3A4 mRNA CTD PMID:20458559 arsenous acid multiple interactions EXP 6480464 Arsenic Trioxide inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein] CTD PMID:16184197 Artemetin increases activity EXP 6480464 artemetin results in increased activity of CYP3A4 protein CTD PMID:31756459 Artemetin multiple interactions EXP 6480464 [[artemetin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam and [artemetin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam CTD PMID:31756459 Asiaticoside decreases activity EXP 6480464 asiaticoside results in decreased activity of CYP3A4 protein CTD PMID:21349323 astemizole increases degradation EXP 6480464 CYP3A4 protein results in increased degradation of Astemizole CTD PMID:15684493 atazanavir sulfate multiple interactions EXP 6480464 [Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of CYP3A4 mRNA CTD PMID:32152650 atazanavir sulfate decreases expression EXP 6480464 Atazanavir Sulfate results in decreased expression of CYP3A4 mRNA CTD PMID:32152650 atorvastatin calcium increases expression EXP 6480464 Atorvastatin results in increased expression of CYP3A4 protein CTD PMID:26616219 atorvastatin calcium decreases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Atorvastatin results in decreased expression of CYP3A4 mRNA and Atorvastatin results in decreased expression of CYP3A4 protein CTD PMID:30086269 atorvastatin calcium decreases activity ISO Cyp3a2 (Rattus norvegicus) 6480464 Atorvastatin results in decreased activity of CYP3A4 protein CTD PMID:30086269 atorvastatin calcium multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 Atorvastatin promotes the reaction [Berberine results in decreased activity of CYP3A4 protein] more ... CTD PMID:30086269 atorvastatin calcium affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Atorvastatin CTD PMID:15963098 and PMID:16011971 atorvastatin calcium affects response to substance EXP 6480464 CYP3A4 polymorphism affects the susceptibility to Atorvastatin CTD PMID:18528690 and PMID:19802823 atorvastatin calcium increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Atorvastatin CTD PMID:18846481 atorvastatin calcium decreases activity EXP 6480464 Atorvastatin results in decreased activity of CYP3A4 protein CTD PMID:16029222 atorvastatin calcium multiple interactions EXP 6480464 ABCB1 alternative form affects the reaction [CYP3A4 polymorphism affects the susceptibility to Atorvastatin] and Atorvastatin inhibits the reaction [CYP3A4 protein affects the metabolism of Midazolam] CTD PMID:16029222 and PMID:19802823 atrazine increases activity EXP 6480464 Atrazine results in increased activity of CYP3A4 protein CTD PMID:22310298 atrazine decreases activity EXP 6480464 Atrazine results in decreased activity of CYP3A4 protein CTD PMID:20183062 atrazine increases expression EXP 6480464 Atrazine results in increased expression of CYP3A4 mRNA CTD PMID:22310298 and PMID:24343343 atrazine multiple interactions EXP 6480464 [Atrazine co-treated with Chlorpyrifos co-treated with Endosulfan] results in increased expression of CYP3A4 protein more ... CTD PMID:22515965 and PMID:24343343 Auriculasin decreases activity EXP 6480464 auriculasin results in decreased activity of CYP3A4 protein CTD PMID:31515991 Avasimibe multiple interactions EXP 6480464 avasimibe results in increased activity of and results in increased expression of CYP3A4 protein CTD PMID:19202563 Avasimibe increases expression EXP 6480464 avasimibe results in increased expression of CYP3A4 mRNA CTD PMID:16837568 axitinib multiple interactions EXP 6480464 [Axitinib results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Loperamide CTD PMID:31299239 axitinib decreases activity EXP 6480464 Axitinib results in decreased activity of CYP3A4 protein CTD PMID:31299239 Azamulin decreases activity EXP 6480464 azamulin results in decreased activity of CYP3A4 protein CTD PMID:15860655 azithromycin multiple interactions EXP 6480464 Azithromycin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone] CTD PMID:16416302 azithromycin decreases activity EXP 6480464 Azithromycin results in decreased activity of CYP3A4 protein CTD PMID:16416302 azoxystrobin multiple interactions EXP 6480464 [azoxystrobin co-treated with cyproconazole] results in increased expression of CYP3A4 protein and [cyproconazole co-treated with azoxystrobin] results in increased expression of CYP3A4 mRNA CTD PMID:29294346 azoxystrobin increases expression EXP 6480464 azoxystrobin results in increased expression of CYP3A4 mRNA CTD PMID:29294346 baicalein decreases activity EXP 6480464 baicalein results in decreased activity of CYP3A4 protein CTD PMID:21053930 and PMID:29753067 barbiturates increases expression EXP 6480464 Barbiturates results in increased expression of CYP3A4 CTD PMID:15554232 and PMID:15955870 barnidipine decreases activity EXP 6480464 mepirodipine results in decreased activity of CYP3A4 protein CTD PMID:10805063 benfuracarb increases activity EXP 6480464 benfuracarb results in increased activity of CYP3A4 protein CTD PMID:22310298 benfuracarb multiple interactions EXP 6480464 [CYP3A4 protein results in increased metabolism of benfuracarb] which results in increased chemical synthesis of Carbofuran CTD PMID:24016712 benfuracarb increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of benfuracarb CTD PMID:24016712 benfuracarb increases expression EXP 6480464 benfuracarb results in increased expression of CYP3A4 mRNA CTD PMID:22310298 benidipine decreases activity EXP 6480464 benidipine results in decreased activity of CYP3A4 protein CTD PMID:10805063 benidipine increases expression EXP 6480464 benidipine results in increased expression of CYP3A4 mRNA CTD PMID:27732883 benidipine multiple interactions EXP 6480464 benidipine results in increased expression of and results in decreased activity of CYP3A4 protein CTD PMID:27732883 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of CYP3A4 mRNA CTD PMID:16545412 and PMID:31096615 benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of CYP3A4 mRNA CTD PMID:32234424 benzo[a]pyrene increases methylation EXP 6480464 Benzo(a)pyrene results in increased methylation of CYP3A4 promoter CTD PMID:27901495 benzo[a]pyrene multiple interactions EXP 6480464 [[POR protein co-treated with CYP3A4 protein] results in increased susceptibility to Benzo(a)pyrene] which results in increased mutagenesis of HPRT1 gene more ... CTD PMID:23845848 more ... benzo[a]pyrene increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Benzo(a)pyrene CTD PMID:2509067 benzo[a]pyrene diol epoxide I multiple interactions EXP 6480464 [7 more ... CTD PMID:23845848 Benzo[a]pyrene-7,8-diol affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of benzo(a)pyrene 7 and 8-dihydrodiol CTD PMID:2271712 and PMID:2655891 Benzo[a]pyrene-7,8-diol multiple interactions EXP 6480464 [benzo(a)pyrene 7 more ... CTD PMID:23845848 and PMID:2509067 benzo[c]phenanthrene multiple interactions EXP 6480464 [benzo(c)phenanthrene binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:23845848 benzoic acid multiple interactions EXP 6480464 [Amiodarone co-treated with Benzoic Acid co-treated with cyproconazole co-treated with flusilazole co-treated with enilconazole co-treated with prochloraz co-treated with propiconazole co-treated with tebuconazole] results in increased expression of CYP3A4 protein CTD PMID:34273450 benzphetamine multiple interactions EXP 6480464 Benzphetamine inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] CTD PMID:19299527 benzyl isothiocyanate decreases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 benzyl isothiocyanate results in decreased expression of CYP3A2 mRNA CTD PMID:22664424 benzyl isothiocyanate decreases activity ISO Cyp3a2 (Rattus norvegicus) 6480464 benzyl isothiocyanate results in decreased activity of CYP3A2 protein CTD PMID:22664424 bepridil affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Bepridil CTD PMID:15286053 berberine multiple interactions EXP 6480464 [Berberine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:21524698 berberine multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 Atorvastatin promotes the reaction [Berberine results in decreased activity of CYP3A4 protein] more ... CTD PMID:30086269 berberine decreases activity ISO Cyp3a2 (Rattus norvegicus) 6480464 Berberine results in decreased activity of CYP3A4 protein CTD PMID:30086269 berberine decreases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Berberine results in decreased expression of CYP3A4 mRNA and Berberine results in decreased expression of CYP3A4 protein CTD PMID:30086269 bergomottin decreases activity EXP 6480464 bergamottin results in decreased activity of CYP3A4 protein CTD PMID:11451028 and PMID:15860655 bergomottin increases expression EXP 6480464 bergamottin results in increased expression of CYP3A4 mRNA CTD PMID:19148864 Besigomsin increases expression EXP 6480464 schizandrol B results in increased expression of CYP3A4 mRNA CTD PMID:16267138 beta-carboline multiple interactions EXP 6480464 CYP3A4 protein affects the metabolism of [norharman co-treated with aniline] CTD PMID:15279827 beta-carotene multiple interactions EXP 6480464 beta Carotene promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] CTD PMID:16632523 beta-naphthoflavone decreases expression EXP 6480464 beta-Naphthoflavone results in decreased expression of CYP3A4 mRNA CTD PMID:16837568 more ... beta-naphthoflavone multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CYP3A2 mRNA more ... CTD PMID:18164116 more ... beta-naphthoflavone increases activity ISO Cyp3a2 (Rattus norvegicus) 6480464 beta-Naphthoflavone results in increased activity of CYP3A2 protein CTD PMID:26880746 beta-naphthoflavone multiple interactions EXP 6480464 [[beta-Naphthoflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam and [beta-Naphthoflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam CTD PMID:31756459 beta-naphthoflavone increases activity EXP 6480464 beta-Naphthoflavone results in increased activity of CYP3A4 protein CTD PMID:31756459 beta-naphthoflavone affects binding EXP 6480464 beta-Naphthoflavone binds to CYP3A4 protein CTD PMID:21053930 beta-naphthoflavone increases expression EXP 6480464 beta-Naphthoflavone results in increased expression of CYP3A4 mRNA CTD PMID:22258563 beta-tocotrienol increases expression EXP 6480464 tocotrienol and beta results in increased expression of CYP3A4 CTD PMID:15269186 Betanin multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 betanin inhibits the reaction [Paraquat results in increased expression of CYP3A2 mRNA] CTD PMID:24799198 bifenthrin increases expression EXP 6480464 bifenthrin results in increased expression of CYP3A4 mRNA CTD PMID:19249324 bifonazole decreases activity EXP 6480464 bifonazole results in decreased activity of CYP3A4 protein CTD PMID:15135088 bilirubin IXalpha increases expression EXP 6480464 Bilirubin results in increased expression of CYP3A4 mRNA CTD PMID:15382119 bilirubin IXalpha multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [CYP3A23-3A1 gene mutant form co-treated with CYP3A2 gene mutant form] results in increased abundance of Bilirubin CTD PMID:34461081 bilirubin IXalpha multiple interactions EXP 6480464 IL1B protein inhibits the reaction [Bilirubin results in increased expression of CYP3A4 mRNA] CTD PMID:15382119 bioresmethrin increases expression EXP 6480464 bioresmethrin results in increased expression of CYP3A4 mRNA CTD PMID:19249324 bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 [Dexamethasone co-treated with Diethylhexyl Phthalate] results in increased activity of CYP3A4 protein more ... CTD PMID:11581012 more ... bis(2-ethylhexyl) phthalate increases expression EXP 6480464 Diethylhexyl Phthalate results in increased expression of CYP3A4 mRNA CTD PMID:34801851 bis(2-ethylhexyl) phthalate increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Diethylhexyl Phthalate results in increased expression of CYP3A2 mRNA CTD PMID:19850644 bis(2-ethylhexyl) phthalate increases activity EXP 6480464 Diethylhexyl Phthalate results in increased activity of CYP3A4 protein CTD PMID:21742782 bisphenol A multiple interactions EXP 6480464 [bisphenol A binds to CYP3A4 promoter] which results in decreased expression of CYP3A4 mRNA more ... CTD PMID:11581012 more ... bisphenol A increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 bisphenol A results in increased expression of CYP3A2 protein CTD PMID:32145629 bisphenol A decreases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 bisphenol A results in decreased expression of CYP3A4 mRNA CTD PMID:25181051 bisphenol A multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [bisphenol A co-treated with Genistein] results in decreased methylation of CYP3A2 gene CTD PMID:28505145 bisphenol A increases methylation ISO Cyp3a2 (Rattus norvegicus) 6480464 bisphenol A results in increased methylation of CYP3A2 gene CTD PMID:28505145 bisphenol A affects expression ISO Cyp3a2 (Rattus norvegicus) 6480464 bisphenol A affects the expression of CYP3A2 mRNA CTD PMID:30903817 and PMID:32145629 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of CYP3A4 mRNA and bisphenol A results in increased expression of CYP3A4 protein CTD PMID:15650019 more ... bisphenol A increases glutathionylation EXP 6480464 CYP3A4 protein results in increased glutathionylation of bisphenol A and CYP3A4 protein results in increased glutathionylation of bisphenol A metabolite CTD PMID:23470418 bisphenol A increases hydroxylation EXP 6480464 CYP3A4 protein results in increased hydroxylation of bisphenol A and CYP3A4 protein results in increased hydroxylation of bisphenol A metabolite CTD PMID:23470418 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of CYP3A4 mRNA CTD PMID:24793377 bisphenol A increases activity EXP 6480464 bisphenol A results in increased activity of CYP3A4 protein CTD PMID:23384967 bisphenol A increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of bisphenol A CTD PMID:21402134 Bisphenol B increases expression EXP 6480464 bisphenol B results in increased expression of CYP3A4 mRNA CTD PMID:22214767 bisphenol F increases hydroxylation EXP 6480464 CYP3A4 protein results in increased hydroxylation of 4 and 4'-bisphenol F CTD PMID:23470418 bisphenol F increases glutathionylation EXP 6480464 CYP3A4 protein results in increased glutathionylation of 4 and 4'-bisphenol F CTD PMID:23470418 bortezomib affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Bortezomib CTD PMID:15764713 bosentan increases expression EXP 6480464 Bosentan results in increased expression of CYP3A4 mRNA CTD PMID:18332078 and PMID:29761207 Bromadiolone decreases response to substance ISO Cyp3a2 (Rattus norvegicus) 6480464 CYP3A2 protein results in decreased susceptibility to bromadiolone CTD PMID:18080289 Bromadiolone increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 bromadiolone results in increased expression of CYP3A2 mRNA CTD PMID:18080289 bromfenac increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of bromfenac metabolite CTD PMID:31815452 bromocriptine affects binding EXP 6480464 Bromocriptine binds to CYP3A4 protein CTD PMID:17198380 bromocriptine multiple interactions EXP 6480464 Bromocriptine inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] CTD PMID:19299527 bromocriptine affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Bromocriptine CTD PMID:15286053 bromodichloromethane increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of bromodichloromethane CTD PMID:12076521 Brotizolam affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of brotizolam CTD PMID:16042670 Brotizolam multiple interactions EXP 6480464 Erythromycin inhibits the reaction [CYP3A4 protein affects the metabolism of brotizolam] CTD PMID:16042670 budesonide increases expression EXP 6480464 Budesonide results in increased expression of CYP3A4 mRNA CTD PMID:19562681 budesonide decreases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Budesonide results in decreased expression of CYP3A2 mRNA CTD PMID:20888898 budesonide multiple interactions EXP 6480464 [Budesonide results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:25455453 bufalin multiple interactions EXP 6480464 bufalin promotes the reaction [CYP3A4 protein results in increased metabolism of Midazolam] more ... CTD PMID:22178124 bufalin increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of bufalin CTD PMID:22178124 bufalin increases expression EXP 6480464 bufalin results in increased expression of CYP3A4 mRNA CTD PMID:22178124 bufogenin increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of bufogenin CTD PMID:22178124 bufogenin increases expression EXP 6480464 bufogenin results in increased expression of CYP3A4 mRNA CTD PMID:22178124 bufogenin increases activity EXP 6480464 bufogenin results in increased activity of CYP3A4 protein CTD PMID:22178124 bufogenin multiple interactions EXP 6480464 bufogenin promotes the reaction [CYP3A4 protein results in increased metabolism of Midazolam] and Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of bufogenin] CTD PMID:22178124 buprenorphine affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Buprenorphine CTD PMID:16010532 buprenorphine increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Buprenorphine CTD PMID:12756210 buprenorphine decreases alkylation EXP 6480464 CYP3A4 protein results in decreased alkylation of Buprenorphine CTD PMID:15966752 buprenorphine decreases activity EXP 6480464 Buprenorphine results in decreased activity of CYP3A4 protein CTD PMID:12756210 buspirone increases oxidation EXP 6480464 CYP3A4 protein results in increased oxidation of Buspirone CTD PMID:15640381 buspirone increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Buspirone CTD PMID:20716633 buspirone multiple interactions EXP 6480464 resveratrol inhibits the reaction [CYP3A4 protein results in increased metabolism of Buspirone] CTD PMID:20716633 butachlor increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of butachlor CTD PMID:11133395 butan-1-ol multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 1-Butanol promotes the reaction [Toluene results in increased expression of CYP3A2 mRNA] CTD PMID:17209515 C.I. Natural Red 20 decreases activity EXP 6480464 shikonin results in decreased activity of CYP3A4 protein CTD PMID:28941798 C.I. Natural Red 20 multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 shikonin inhibits the reaction [CYP3A2 protein results in increased hydroxylation of Midazolam] CTD PMID:28941798 C.I. Natural Red 20 decreases activity ISO Cyp3a2 (Rattus norvegicus) 6480464 shikonin results in decreased activity of CYP3A2 protein CTD PMID:28941798 cabozantinib multiple interactions EXP 6480464 Ketoconazole affects the reaction [CYP3A4 polymorphism affects the metabolism of cabozantinib] and Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of cabozantinib] CTD PMID:31293154 cabozantinib increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of cabozantinib CTD PMID:31293154 cabozantinib affects metabolic processing EXP 6480464 CYP3A4 polymorphism affects the metabolism of cabozantinib and CYP3A4 protein alternative form affects the metabolism of cabozantinib CTD PMID:31293154 and PMID:34648813 cafestol multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [cafestol co-treated with kahweol] results in decreased expression of CYP3A2 and [cafestol co-treated with kahweol] results in decreased expression of CYP3A2 protein CTD PMID:11346484 and PMID:9744531 caffeine decreases activity EXP 6480464 Caffeine results in decreased activity of CYP3A4 protein CTD PMID:24211539 calciol increases expression EXP 6480464 Cholecalciferol metabolite results in increased expression of CYP3A4 and Cholecalciferol results in increased expression of CYP3A4 mRNA CTD PMID:11991950 and PMID:16207822 calciol decreases activity EXP 6480464 Cholecalciferol results in decreased activity of CYP3A4 protein CTD PMID:18420780 calciol increases hydroxylation EXP 6480464 CYP3A4 protein results in increased hydroxylation of Cholecalciferol CTD PMID:16207822 calciol multiple interactions EXP 6480464 Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Cholecalciferol] more ... CTD PMID:16207822 calcitriol multiple interactions EXP 6480464 2-acetyltributylcitrate promotes the reaction [Calcitriol results in increased expression of CYP3A4 mRNA] more ... CTD PMID:15489543 more ... calcitriol multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 Chenodeoxycholic Acid inhibits the reaction [Calcitriol results in increased expression of CYP3A2 mRNA] CTD PMID:20006981 calcitriol increases expression EXP 6480464 [Calcitriol results in increased expression of NR1I2 protein] which results in increased expression of CYP3A4 mRNA more ... CTD PMID:11723248 more ... calcitriol increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Calcitriol results in increased expression of CYP3A2 mRNA CTD PMID:20006981 calcitriol increases activity EXP 6480464 Calcitriol results in increased activity of CYP3A4 protein CTD PMID:19766177 camptothecin multiple interactions EXP 6480464 Camptothecin inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA] CTD PMID:29356861 cannabidiol decreases activity EXP 6480464 Cannabidiol results in decreased activity of CYP3A4 protein CTD PMID:24667653 capsaicin decreases activity EXP 6480464 Capsaicin results in decreased activity of CYP3A4 protein CTD PMID:20388821 capsaicin decreases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Capsaicin results in decreased expression of CYP3A2 mRNA and Capsaicin results in decreased expression of CYP3A2 protein CTD PMID:24013073 captan multiple interactions EXP 6480464 [Omite co-treated with Diphenylamine co-treated with phosalone co-treated with Captan co-treated with N-dichlorofluoromethylthio-N' and N'-dimethyl-N-p-tolylsulfamide] results in increased expression of CYP3A4 mRNA CTD PMID:25028461 carbamazepine multiple interactions EXP 6480464 [Carbamazepine results in increased expression of CYP3A4 protein] which results in decreased abundance of Ethinyl Estradiol more ... CTD PMID:10219967 more ... carbamazepine multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [SOD2 co-treated with CYP3A4] affects the susceptibility to Carbamazepine CTD PMID:19501153 carbamazepine increases expression EXP 6480464 Carbamazepine results in increased expression of CYP3A4 mRNA and Carbamazepine results in increased expression of CYP3A4 protein CTD PMID:10219967 more ... carbamazepine increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Carbamazepine CTD PMID:12606595 and PMID:19255940 carbamazepine increases activity EXP 6480464 Carbamazepine results in increased activity of CYP3A4 protein CTD PMID:12065438 and PMID:9512926 carbamazepine affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Carbamazepine CTD PMID:15286053 and PMID:15915352 carbamazepine-10,11-epoxide affects chemical synthesis EXP 6480464 CYP3A4 protein affects the chemical synthesis of carbamazepine epoxide CTD PMID:15915352 carbamazepine-10,11-epoxide multiple interactions EXP 6480464 [CYP3A4 protein results in increased metabolism of Carbamazepine] which results in increased chemical synthesis of carbamazepine epoxide more ... CTD PMID:12606595 and PMID:15915352 carbaryl increases expression EXP 6480464 Carbaryl results in increased expression of CYP3A4 mRNA CTD PMID:22310298 carbendazim increases expression EXP 6480464 carbendazim results in increased expression of CYP3A4 mRNA CTD PMID:22310298 carbofuran multiple interactions EXP 6480464 [CYP3A4 protein results in increased metabolism of benfuracarb] which results in increased chemical synthesis of Carbofuran more ... CTD PMID:15560889 and PMID:24016712 carbofuran increases chemical synthesis EXP 6480464 CYP3A4 protein results in increased chemical synthesis of Carbofuran CTD PMID:24016712 carbofuran increases expression EXP 6480464 Carbofuran results in increased expression of CYP3A4 mRNA CTD PMID:22310298 carbofuran increases activity EXP 6480464 Carbofuran results in increased activity of CYP3A4 protein CTD PMID:22310298 carbofuran increases hydroxylation EXP 6480464 CYP3A4 protein results in increased hydroxylation of Carbofuran CTD PMID:15560889 carbosulfan decreases activity EXP 6480464 carbosulfan results in decreased activity of CYP3A4 protein CTD PMID:20307514 carbosulfan multiple interactions EXP 6480464 CYP3A4 protein results in increased metabolism of and results in increased activity of carbosulfan and Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of carbosulfan] CTD PMID:20307514 carbosulfan increases expression EXP 6480464 carbosulfan results in increased expression of CYP3A4 mRNA CTD PMID:22310298 carbosulfan increases activity EXP 6480464 carbosulfan results in increased activity of CYP3A4 protein CTD PMID:22310298 carfentanil increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of carfentanil CTD PMID:33652071 carmustine multiple interactions EXP 6480464 CYP3A4 gene affects the susceptibility to [Carmustine co-treated with Cyclophosphamide co-treated with Cisplatin] CTD PMID:16087946 Carnosol decreases activity EXP 6480464 carnosol results in decreased activity of CYP3A4 protein CTD PMID:34592323 carvedilol increases metabolic processing ISO Cyp3a2 (Rattus norvegicus) 6480464 CYP3A2 protein results in increased metabolism of Carvedilol CTD PMID:29415952 cefaclor increases expression EXP 6480464 Cefaclor results in increased expression of CYP3A4 mRNA and Cefaclor results in increased expression of CYP3A4 protein CTD PMID:18505790 cefadroxil increases expression EXP 6480464 Cefadroxil results in increased expression of CYP3A4 mRNA and Cefadroxil results in increased expression of CYP3A4 protein CTD PMID:18505790 cerivastatin increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of cerivastatin CTD PMID:15365880 cetirizine decreases activity EXP 6480464 Cetirizine analog results in decreased activity of CYP3A4 protein and Cetirizine results in decreased activity of CYP3A4 protein CTD PMID:15482930 CGP 52608 multiple interactions EXP 6480464 CGP 52608 promotes the reaction [RORA protein binds to CYP3A4 gene] CTD PMID:28238834 chelidonine increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of chelidonine CTD PMID:31102647 chelidonine multiple interactions EXP 6480464 [CYP3A4 protein results in increased metabolism of chelidonine] which results in increased abundance of Glutathione analog CTD PMID:31102647 chenodeoxycholic acid multiple interactions EXP 6480464 [Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of CYP3A4 mRNA more ... CTD PMID:19299527 more ... chenodeoxycholic acid increases hydroxylation EXP 6480464 CYP3A4 protein results in increased hydroxylation of Chenodeoxycholic Acid CTD PMID:36473578 chenodeoxycholic acid decreases activity ISO Cyp3a2 (Rattus norvegicus) 6480464 Chenodeoxycholic Acid results in decreased activity of CYP3A2 protein CTD PMID:8889968 chenodeoxycholic acid multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [CYP3A23-3A1 gene mutant form co-treated with CYP3A2 gene mutant form] results in increased abundance of Chenodeoxycholic Acid and Chenodeoxycholic Acid inhibits the reaction [Calcitriol results in increased expression of CYP3A2 mRNA] CTD PMID:20006981 and PMID:34461081 chenodeoxycholic acid decreases expression EXP 6480464 Chenodeoxycholic Acid results in decreased expression of CYP3A4 mRNA CTD PMID:27174168 CHIR 99021 increases expression EXP 6480464 Chir 99021 results in increased expression of CYP3A4 mRNA CTD PMID:26259606 chitosan increases activity EXP 6480464 Chitosan analog results in increased activity of CYP3A4 protein CTD PMID:20831879 chloramphenicol multiple interactions EXP 6480464 Chloramphenicol inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] CTD PMID:19299527 chlordecone increases expression EXP 6480464 Chlordecone results in increased expression of CYP3A4 protein CTD PMID:15548381 chlorfenvinfos multiple interactions EXP 6480464 [Chlorfenvinphos co-treated with ethion co-treated with Linuron] results in increased expression of CYP3A4 mRNA CTD PMID:25028461 chlorfluazuron increases expression EXP 6480464 chlorfluazuron results in increased expression of CYP3A4 mRNA CTD PMID:22310298 chloroquine decreases activity EXP 6480464 Chloroquine results in decreased activity of CYP3A4 protein CTD PMID:11124226 chloroquine multiple interactions EXP 6480464 [CYP3A4 protein results in increased metabolism of Chloroquine] which results in increased abundance of desethylchloroquine CTD PMID:12756207 chloroquine affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Chloroquine CTD PMID:12920490 chlorpromazine decreases activity EXP 6480464 Chlorpromazine results in decreased activity of CYP3A4 protein CTD PMID:15135088 chlorpromazine decreases response to substance EXP 6480464 CYP3A4 protein results in decreased susceptibility to Chlorpromazine CTD PMID:26477383 chlorpromazine affects oxidation EXP 6480464 CYP3A4 protein affects the oxidation of Chlorpromazine CTD PMID:20615392 chlorpromazine affects methylation EXP 6480464 CYP3A4 protein affects the methylation of Chlorpromazine CTD PMID:20615392 chlorpromazine multiple interactions EXP 6480464 [Chlorpromazine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA and [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Chlorpromazine CTD PMID:17041008 and PMID:23397584 chlorpropham multiple interactions EXP 6480464 [Maleic Hydrazide co-treated with Chlorpropham] results in increased expression of CYP3A4 mRNA CTD PMID:25028461 chlorpyrifos multiple interactions EXP 6480464 [Atrazine co-treated with Chlorpyrifos co-treated with Endosulfan] results in increased expression of CYP3A4 protein more ... CTD PMID:15560889 more ... chlorpyrifos affects metabolic processing ISO Cyp3a2 (Rattus norvegicus) 6480464 CYP3A2 protein affects the metabolism of Chlorpyrifos CTD PMID:15587241 chlorpyrifos decreases activity ISO Cyp3a2 (Rattus norvegicus) 6480464 Chlorpyrifos results in decreased activity of CYP3A2 protein CTD PMID:15587241 chlorpyrifos decreases activity EXP 6480464 Chlorpyrifos results in decreased activity of CYP3A4 protein CTD PMID:15560889 more ... chlorpyrifos affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Chlorpyrifos CTD PMID:16190164 more ... chlorpyrifos increases activity EXP 6480464 Chlorpyrifos results in increased activity of CYP3A4 protein CTD PMID:22310298 chlorpyrifos increases expression EXP 6480464 Chlorpyrifos results in increased expression of CYP3A4 mRNA and Chlorpyrifos results in increased expression of CYP3A4 protein CTD PMID:15548381 more ... chlorpyrifos increases metabolic processing EXP 6480464 CYP3A4 results in increased metabolism of Chlorpyrifos CTD PMID:20709133 chlorzoxazone affects metabolic processing ISO Cyp3a2 (Rattus norvegicus) 6480464 CYP3A2 protein affects the metabolism of Chlorzoxazone CTD PMID:15879494 cholesterol multiple interactions EXP 6480464 [CYP3A4 protein results in increased oxidation of Cholesterol] which results in increased chemical synthesis of cholest-5-ene-3 more ... CTD PMID:11514559 and PMID:19299527 cholesterol multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [CYP3A23-3A1 gene mutant form co-treated with CYP3A2 gene mutant form] results in decreased abundance of Cholesterol CTD PMID:34461081 cholic acid decreases activity EXP 6480464 Cholic Acid metabolite results in decreased activity of CYP3A4 protein CTD PMID:27871908 cholic acid multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [CYP3A23-3A1 gene mutant form co-treated with CYP3A2 gene mutant form] results in increased abundance of Cholic Acid CTD PMID:34461081 cholic acid decreases activity ISO Cyp3a2 (Rattus norvegicus) 6480464 Cholic Acid results in decreased activity of CYP3A2 protein CTD PMID:8889968 cholic acid multiple interactions EXP 6480464 Cholic Acid promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] CTD PMID:19299527 chrysin multiple interactions EXP 6480464 [[chrysin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam more ... CTD PMID:19766177 more ... chrysin increases activity EXP 6480464 chrysin results in increased activity of CYP3A4 protein CTD PMID:31756459 chrysophanol increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of chrysophanic acid CTD PMID:29698620 chrysophanol multiple interactions EXP 6480464 [CYP3A4 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of 2-hydroxychrysophanol and [CYP3A4 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of aloe emodin CTD PMID:29698620 chrysophanol increases chemical synthesis EXP 6480464 CYP3A4 protein results in increased chemical synthesis of chrysophanic acid metabolite CTD PMID:29698620 chrysosplenetin affects activity EXP 6480464 chrysosplenetin affects the activity of CYP3A4 protein CTD PMID:29753067 cimetidine decreases activity EXP 6480464 Cimetidine results in decreased activity of CYP3A4 protein CTD PMID:16041596 more ... cimetidine decreases expression EXP 6480464 Cimetidine results in decreased expression of CYP3A4 protein CTD PMID:22733800 cimetidine multiple interactions EXP 6480464 [Monocrotophos co-treated with Cimetidine] results in increased expression of CYP3A4 protein more ... CTD PMID:18846481 more ... cinitapride increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of cinitapride CTD PMID:17437965 Cinobufagin increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of cinobufagin CTD PMID:22178124 Cinobufagin multiple interactions EXP 6480464 cinobufagin promotes the reaction [CYP3A4 protein results in increased metabolism of Midazolam] more ... CTD PMID:22178124 Cinobufagin increases expression EXP 6480464 cinobufagin results in increased expression of CYP3A4 mRNA CTD PMID:22178124 ciprofibrate decreases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 ciprofibrate results in decreased expression of CYP3A2 mRNA CTD PMID:7676460 ciprofloxacin decreases activity EXP 6480464 Ciprofloxacin results in decreased activity of CYP3A4 protein CTD PMID:11145498 cisapride decreases activity EXP 6480464 Cisapride results in decreased activity of CYP3A4 protein CTD PMID:15306208 cisapride multiple interactions EXP 6480464 Cisapride inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] CTD PMID:19299527 cisapride affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Cisapride CTD PMID:11717173 cisapride affects chemical synthesis EXP 6480464 CYP3A4 protein affects the chemical synthesis of Cisapride metabolite CTD PMID:11717173 cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of CYP3A4 mRNA and Cisplatin results in increased expression of CYP3A4 protein CTD PMID:15650019 cisplatin decreases expression EXP 6480464 Cisplatin results in decreased expression of CYP3A4 protein CTD PMID:26721606 cisplatin multiple interactions EXP 6480464 [ACE2 protein promotes the reaction [CAV1 protein results in increased expression of CYP3A4 protein]] which results in decreased susceptibility to Cisplatin more ... CTD PMID:16087946 more ... citalopram decreases methylation EXP 6480464 CYP3A4 protein results in decreased methylation of Citalopram analog CTD PMID:9110356 citral multiple interactions EXP 6480464 citral inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] CTD PMID:18385293 Citreorosein increases chemical synthesis EXP 6480464 CYP3A4 protein results in increased chemical synthesis of 1 more ... CTD PMID:27989148 clarithromycin multiple interactions EXP 6480464 [Ofloxacin co-treated with Clarithromycin] inhibits the reaction [CYP3A4 protein results in increased metabolism of Theophylline] more ... CTD PMID:10234723 more ... clarithromycin decreases activity EXP 6480464 Clarithromycin results in decreased activity of CYP3A4 protein CTD PMID:16416302 and PMID:23748747 clarithromycin decreases expression EXP 6480464 Clarithromycin results in decreased expression of CYP3A4 mRNA CTD PMID:16837568 clemizole multiple interactions EXP 6480464 [clemizole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:31312845 clemizole increases expression EXP 6480464 clemizole results in increased expression of CYP3A4 mRNA CTD PMID:31312845 climbazole increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 climbazole results in increased expression of CYP3A2 protein CTD PMID:11552297 and PMID:11824557 clindamycin multiple interactions EXP 6480464 Clindamycin results in increased expression of and results in increased activity of CYP3A4 protein CTD PMID:18505790 clindamycin increases expression EXP 6480464 Clindamycin results in increased expression of CYP3A4 mRNA CTD PMID:18505790 clobetasol multiple interactions EXP 6480464 [Clobetasol results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:25455453 clofibric acid increases activity EXP 6480464 Clofibric Acid results in increased activity of CYP3A4 protein CTD PMID:15771232 clofibric acid increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Clofibric Acid results in increased expression of CYP3A2 mRNA CTD PMID:15788368 clofibric acid multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A2 protein] more ... CTD PMID:15788368 clofibric acid increases expression EXP 6480464 Clofibric Acid results in increased expression of CYP3A4 mRNA CTD PMID:15771232 Clofop increases expression EXP 6480464 fenofibric acid results in increased expression of CYP3A4 mRNA CTD PMID:15771232 Clofop increases activity EXP 6480464 fenofibric acid results in increased activity of CYP3A4 protein CTD PMID:15771232 clomiphene multiple interactions EXP 6480464 [Clomiphene results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:25455453 clopidogrel affects response to substance EXP 6480464 CYP3A4 gene polymorphism affects the susceptibility to clopidogrel CTD PMID:16645157 clopidogrel increases expression EXP 6480464 Clopidogrel results in increased expression of CYP3A4 mRNA CTD PMID:31312845 clopidogrel increases response to substance EXP 6480464 CYP3A4 protein results in increased susceptibility to clopidogrel CTD PMID:22651985 clopidogrel multiple interactions EXP 6480464 CYP3A4 protein results in increased oxidation of and results in increased cleavage of clopidogrel metabolite more ... CTD PMID:19170597 and PMID:22651985 clopidogrel increases degradation EXP 6480464 CYP3A4 protein results in increased degradation of clopidogrel CTD PMID:22651985 clothianidin increases expression EXP 6480464 clothianidin results in increased expression of CYP3A4 mRNA CTD PMID:32201337 clothianidin multiple interactions EXP 6480464 [clothianidin co-treated with enilconazole] results in increased expression of CYP3A4 mRNA more ... CTD PMID:32201337 clotrimazole decreases activity EXP 6480464 Clotrimazole results in decreased activity of CYP3A4 protein CTD PMID:15135088 clotrimazole multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 Clotrimazole inhibits the reaction [CYP3A2 protein results in increased metabolism of 7-benzyloxyquinoline] CTD PMID:19858067 clotrimazole multiple interactions EXP 6480464 Clotrimazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] more ... CTD PMID:17998298 more ... clotrimazole increases expression EXP 6480464 Clotrimazole results in increased expression of CYP3A4 mRNA and Clotrimazole results in increased expression of CYP3A4 protein CTD PMID:12505310 more ... clotrimazole increases activity EXP 6480464 Clotrimazole results in increased activity of CYP3A4 protein CTD PMID:12065438 and PMID:14977870 clozapine affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Clozapine CTD PMID:15286053 clozapine increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Clozapine CTD PMID:18809730 and PMID:27320963 clozapine multiple interactions EXP 6480464 [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Clozapine more ... CTD PMID:21402137 and PMID:23397584 Clozapine N-oxide increases abundance EXP 6480464 CYP3A4 protein results in increased abundance of clozapine N-oxide CTD PMID:27320963 Clozapine N-oxide increases chemical synthesis EXP 6480464 CYP3A4 protein results in increased chemical synthesis of clozapine N-oxide CTD PMID:18809730 Clozapine N-oxide multiple interactions EXP 6480464 Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of clozapine N-oxide] CTD PMID:18809730 cobalt dichloride decreases expression EXP 6480464 cobaltous chloride results in decreased expression of CYP3A4 mRNA and cobaltous chloride results in decreased expression of CYP3A4 protein CTD PMID:19695866 cobicistat multiple interactions EXP 6480464 [[Rifampin results in increased activity of NR1I2 protein] which results in increased activity of CYP3A4 protein] which results in increased metabolism of and results in increased activity of and results in increased susceptibility to Cobicistat CTD PMID:33629115 codeine increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Codeine CTD PMID:16595712 codeine multiple interactions EXP 6480464 [CYP3A4 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of norcodeine CTD PMID:16595712 codeine affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Codeine CTD PMID:15286053 colforsin daropate hydrochloride multiple interactions EXP 6480464 [S-(1 and 2-dichlorovinyl)cysteine co-treated with Colforsin] results in increased expression of CYP3A4 mRNA CTD PMID:37544576 colforsin daropate hydrochloride increases expression EXP 6480464 Colforsin results in increased expression of CYP3A4 mRNA CTD PMID:37544576 Columbin increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of columbin CTD PMID:32162908 cordycepin multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 cordycepin inhibits the reaction [pyridine results in increased expression of CYP3A2 mRNA] CTD PMID:11181506 corticosterone multiple interactions EXP 6480464 [Corticosterone binds to CYP3A4 promoter] which results in increased expression of CYP3A4 mRNA more ... CTD PMID:11581012 more ... corticosterone increases expression EXP 6480464 Corticosterone results in increased expression of CYP3A4 mRNA and Corticosterone results in increased expression of CYP3A4 protein CTD PMID:12072427 and PMID:35301062 cortisol increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Hydrocortisone CTD PMID:11907490 cortisol increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Hydrocortisone results in increased expression of CYP3A2 mRNA CTD PMID:10476907 cortisol increases expression EXP 6480464 Hydrocortisone results in increased expression of CYP3A4 mRNA CTD PMID:12505310 and PMID:23223499 cortisol affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Hydrocortisone CTD PMID:15025748 more ... cortisol multiple interactions EXP 6480464 CYP3A4 promoter mutant form inhibits the reaction [Hydrocortisone results in increased expression of CYP3A4 mRNA] more ... CTD PMID:12505310 and PMID:15266218 cortisol affects hydroxylation EXP 6480464 CYP3A4 protein affects the hydroxylation of Hydrocortisone CTD PMID:2271712 coumarin affects expression ISO Cyp3a2 (Rattus norvegicus) 6480464 coumarin affects the expression of CYP3A2 mRNA CTD PMID:16963487 crizotinib increases expression EXP 6480464 crizotinib results in increased expression of CYP3A4 mRNA CTD PMID:23129213 Cryptotanshinone increases expression EXP 6480464 cryptotanshinone results in increased expression of CYP3A4 protein CTD PMID:18805405 curcumin multiple interactions EXP 6480464 [Curcumin binds to and results in increased activity of VDR protein] which results in increased expression of CYP3A4 mRNA more ... CTD PMID:17270371 more ... curcumin decreases expression EXP 6480464 Curcumin results in decreased expression of CYP3A4 mRNA CTD PMID:20816778 curcumin increases expression EXP 6480464 Curcumin results in increased expression of CYP3A4 mRNA CTD PMID:17210444 cycloheximide decreases expression EXP 6480464 Cycloheximide results in decreased expression of CYP3A4 mRNA CTD PMID:21466820 cycloheximide multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 Cycloheximide inhibits the reaction [pyridine results in increased expression of CYP3A2 mRNA] CTD PMID:11181506 cyclophosphamide increases expression EXP 6480464 Cyclophosphamide results in increased expression of CYP3A4 mRNA CTD PMID:18839173 cyclophosphamide increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Cyclophosphamide results in increased expression of CYP3A2 mRNA and Cyclophosphamide results in increased expression of CYP3A2 protein CTD PMID:16019949 cyclophosphamide increases hydroxylation EXP 6480464 CYP3A4 protein results in increased hydroxylation of Cyclophosphamide CTD PMID:30500380 cyclophosphamide increases response to substance EXP 6480464 CYP3A4 protein results in increased susceptibility to Cyclophosphamide CTD PMID:26718876 and PMID:30500380 cyclophosphamide increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Cyclophosphamide CTD PMID:11377097 cyclophosphamide affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Cyclophosphamide CTD PMID:16087946 cyclophosphamide affects response to substance EXP 6480464 CYP3A4 gene polymorphism affects the susceptibility to Cyclophosphamide CTD PMID:16087946 cyclophosphamide multiple interactions EXP 6480464 [Cyclophosphamide results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA more ... CTD PMID:16087946 more ... cyclosporin A affects expression EXP 6480464 Cyclosporine affects the expression of CYP3A4 mRNA CTD PMID:24973091 cyclosporin A decreases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Cyclosporine results in decreased expression of CYP3A4 mRNA CTD PMID:19224547 cyclosporin A affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Cyclosporine CTD PMID:15286053 more ... cyclosporin A increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Cyclosporine CTD PMID:20599501 cyclosporin A increases expression EXP 6480464 Cyclosporine results in increased expression of CYP3A4 mRNA CTD PMID:12673034 cyclosporin A multiple interactions EXP 6480464 [Cyclosporine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of CYP3A4 mRNA more ... CTD PMID:19299527 more ... cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of CYP3A4 mRNA CTD PMID:20106945 more ... cyfluthrin increases expression EXP 6480464 cyfluthrin results in increased expression of CYP3A4 mRNA CTD PMID:19249324 cyhalothrin multiple interactions EXP 6480464 [procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin] results in increased expression of CYP3A4 mRNA CTD PMID:25028461 cyhalothrin increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 cyhalothrin results in increased expression of CYP3A2 mRNA CTD PMID:29727961 cyhalothrin decreases activity EXP 6480464 cyhalothrin results in decreased activity of CYP3A4 protein CTD PMID:20183062 cyhalothrin increases expression EXP 6480464 cyhalothrin results in increased expression of CYP3A4 mRNA and cyhalothrin results in increased expression of CYP3A4 protein CTD PMID:19249324 and PMID:22310298 cyhalothrin increases activity EXP 6480464 cyhalothrin results in increased activity of CYP3A4 protein CTD PMID:22310298 cylindrospermopsin decreases activity EXP 6480464 cylindrospermopsin results in decreased activity of CYP3A4 protein CTD PMID:30905859 cypermethrin increases expression EXP 6480464 cypermethrin results in increased expression of CYP3A4 mRNA and cypermethrin results in increased expression of CYP3A4 protein CTD PMID:15548381 and PMID:22310298 cypermethrin decreases activity EXP 6480464 cypermethrin results in decreased activity of CYP3A4 protein CTD PMID:18420780 and PMID:22634058 cypermethrin increases activity EXP 6480464 cypermethrin results in increased activity of CYP3A4 protein CTD PMID:22310298 cyproconazole increases expression EXP 6480464 cyproconazole results in increased expression of CYP3A4 mRNA and cyproconazole results in increased expression of CYP3A4 protein CTD PMID:29294346 more ... cyproconazole multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of CYP3A2 mRNA and [cyproconazole co-treated with epoxiconazole] results in increased expression of CYP3A2 mRNA CTD PMID:29038839 cyproconazole multiple interactions EXP 6480464 [Amiodarone co-treated with Benzoic Acid co-treated with cyproconazole co-treated with flusilazole co-treated with enilconazole co-treated with prochloraz co-treated with propiconazole co-treated with tebuconazole] results in increased expression of CYP3A4 protein more ... CTD PMID:29294346 and PMID:34273450 cyprodinil multiple interactions EXP 6480464 [procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin] results in increased expression of CYP3A4 mRNA CTD PMID:25028461 cyproterone acetate increases expression EXP 6480464 Cyproterone Acetate results in increased expression of CYP3A4 mRNA CTD PMID:12505310 dabrafenib increases expression EXP 6480464 dabrafenib results in increased expression of CYP3A4 mRNA CTD PMID:34780725 dabrafenib decreases activity EXP 6480464 dabrafenib results in decreased activity of CYP3A4 protein CTD PMID:34780725 dabrafenib multiple interactions EXP 6480464 dabrafenib inhibits the reaction [CYP3A4 protein results in decreased susceptibility to Docetaxel] CTD PMID:34780725 daidzein decreases activity EXP 6480464 daidzein results in decreased activity of CYP3A4 protein CTD PMID:18420780 daidzein increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 daidzein results in increased expression of CYP3A4 mRNA CTD PMID:31870919 dapsone affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Dapsone CTD PMID:12920490 and PMID:15327588 dapsone multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [SOD2 co-treated with CYP3A4] affects the susceptibility to Dapsone CTD PMID:19501153 dapsone multiple interactions EXP 6480464 CYP3A4 protein results in increased metabolism of and results in increased susceptibility to Dapsone CTD PMID:19998329 dauricine multiple interactions EXP 6480464 [CYP3A4 protein results in increased glutathionylation of dauricine] which results in increased chemical synthesis of N-desmethyldauricine more ... CTD PMID:19358519 dauricine increases glutathionylation EXP 6480464 CYP3A4 protein results in increased glutathionylation of dauricine CTD PMID:19358519 DDD increases expression EXP 6480464 Dichlorodiphenyldichloroethane results in increased expression of CYP3A4 mRNA CTD PMID:20686338 DDE increases expression EXP 6480464 Dichlorodiphenyl Dichloroethylene results in increased expression of CYP3A4 mRNA CTD PMID:20686338 DDT multiple interactions EXP 6480464 [DDT co-treated with Dieldrin] results in increased expression of CYP3A4 mRNA CTD PMID:25028461 DDT multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [DDT co-treated with Diethylnitrosamine] results in decreased expression of CYP3A2 mRNA and [DDT co-treated with Diethylnitrosamine] results in increased expression of CYP3A2 mRNA CTD PMID:15885732 DDT increases expression EXP 6480464 DDT results in increased expression of CYP3A4 mRNA and DDT results in increased expression of CYP3A4 protein CTD PMID:15548381 more ... decabromodiphenyl ether increases expression EXP 6480464 decabromobiphenyl ether results in increased expression of CYP3A4 mRNA CTD PMID:19270788 Dechloroethylcyclophosphamide affects chemical synthesis EXP 6480464 CYP3A4 protein affects the chemical synthesis of dechloroethylcyclophosphamide CTD PMID:15875221 dehydroepiandrosterone increases hydroxylation EXP 6480464 CYP3A4 protein results in increased hydroxylation of Dehydroepiandrosterone CTD PMID:15845858 dehydroepiandrosterone multiple interactions EXP 6480464 Dehydroepiandrosterone promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] CTD PMID:19299527 dehydroepiandrosterone sulfate affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Dehydroepiandrosterone Sulfate CTD PMID:2271712 dehydroepiandrosterone sulfate multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CYP3A2 protein CTD PMID:25786523 delta-tocotrienol increases expression EXP 6480464 tocotrienol and delta results in increased expression of CYP3A4 CTD PMID:15269186 delta-tocotrienol multiple interactions EXP 6480464 tocotrienol more ... CTD PMID:31102695 deoxycholic acid affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Deoxycholic Acid CTD PMID:15708356 deoxycholic acid increases hydroxylation EXP 6480464 CYP3A4 protein results in increased hydroxylation of Deoxycholic Acid CTD PMID:36473578 deoxycholic acid multiple interactions EXP 6480464 [Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of CYP3A4 mRNA more ... CTD PMID:32152650 and PMID:33819548 deoxycholic acid decreases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Deoxycholic Acid results in decreased expression of CYP3A2 mRNA CTD PMID:10453939 deoxycholic acid multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [CYP3A23-3A1 gene mutant form co-treated with CYP3A2 gene mutant form] results in increased abundance of Deoxycholic Acid more ... CTD PMID:10453939 and PMID:34461081 deoxycholic acid decreases activity ISO Cyp3a2 (Rattus norvegicus) 6480464 Deoxycholic Acid results in decreased activity of CYP3A2 protein CTD PMID:8889968 deoxycholic acid increases expression EXP 6480464 Deoxycholic Acid metabolite results in increased expression of CYP3A4 mRNA CTD PMID:27871908 deoxycholic acid decreases activity EXP 6480464 Deoxycholic Acid metabolite results in decreased activity of CYP3A4 protein CTD PMID:27871908 Deoxyelephantopin multiple interactions EXP 6480464 deoxyelephantopin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] more ... CTD PMID:23876819 Deoxyelephantopin increases expression EXP 6480464 deoxyelephantopin results in increased expression of CYP3A4 mRNA CTD PMID:23876819 Deoxyelephantopin decreases activity EXP 6480464 deoxyelephantopin results in decreased activity of CYP3A4 protein CTD PMID:23876819 deoxynivalenol affects expression EXP 6480464 deoxynivalenol affects the expression of CYP3A4 mRNA CTD PMID:28865950 deoxynivalenol multiple interactions EXP 6480464 [deoxynivalenol co-treated with Zearalenone] affects the expression of CYP3A4 mRNA more ... CTD PMID:28865950 and PMID:28935499 Deoxyschizandrin increases expression EXP 6480464 schizandrin A results in increased expression of CYP3A4 mRNA CTD PMID:16267138 Desethylchloroquine decreases activity EXP 6480464 desethylchloroquine results in decreased activity of CYP3A4 protein CTD PMID:11124226 Desethylchloroquine multiple interactions EXP 6480464 [CYP3A4 protein results in increased metabolism of Chloroquine] which results in increased abundance of desethylchloroquine CTD PMID:12756207 desferrioxamine B decreases expression EXP 6480464 Deferoxamine results in decreased expression of CYP3A4 mRNA and Deferoxamine results in decreased expression of CYP3A4 protein CTD PMID:19695866 desipramine increases response to substance EXP 6480464 CYP3A4 protein results in increased susceptibility to Desipramine CTD PMID:21540358 desipramine decreases activity EXP 6480464 Desipramine results in decreased activity of CYP3A4 protein CTD PMID:15135088 dexamethasone affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Dexamethasone CTD PMID:8114683 dexamethasone increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Dexamethasone results in increased expression of CYP3A2 mRNA more ... CTD PMID:15258109 more ... dexamethasone multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 Plant Preparations promotes the reaction [Dexamethasone results in increased expression of CYP3A2 mRNA] CTD PMID:21084653 dexamethasone affects expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Dexamethasone affects the expression of CYP3A2 mRNA CTD PMID:15102944 dexamethasone increases activity EXP 6480464 Dexamethasone results in increased activity of CYP3A4 protein CTD PMID:10923861 more ... dexamethasone increases expression EXP 6480464 Dexamethasone results in increased expression of CYP3A4 mRNA and Dexamethasone results in increased expression of CYP3A4 protein CTD PMID:10219967 more ... dexamethasone multiple interactions EXP 6480464 [Dexamethasone binds to CYP3A4 promoter] which results in increased expression of CYP3A4 mRNA more ... CTD PMID:10219967 more ... dextromethorphan decreases methylation EXP 6480464 CYP3A4 protein results in decreased methylation of Dextromethorphan CTD PMID:15383492 dextromethorphan increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Dextromethorphan CTD PMID:16595712 and PMID:17267297 dextromethorphan multiple interactions EXP 6480464 Dextromethorphan inhibits the reaction [[retrorsine co-treated with NADP] results in decreased activity of CYP3A4 protein] CTD PMID:19818743 dextromethorphan increases oxidation EXP 6480464 CYP3A4 protein results in increased oxidation of Dextromethorphan CTD PMID:15383492 dextromethorphan affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Dextromethorphan CTD PMID:15988119 dextrorphan affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Dextrorphan CTD PMID:15988119 diallyl disulfide increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 diallyl disulfide results in increased expression of CYP3A2 protein CTD PMID:16000231 Diallyl sulfide increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 allyl sulfide results in increased expression of CYP3A2 protein CTD PMID:16000231 diarsenic trioxide increases expression EXP 6480464 Arsenic Trioxide results in increased expression of CYP3A4 mRNA CTD PMID:20458559 diarsenic trioxide multiple interactions EXP 6480464 Arsenic Trioxide inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein] CTD PMID:16184197 diarylheptanoid decreases activity EXP 6480464 Diarylheptanoids results in decreased activity of CYP3A4 protein CTD PMID:23850985 diarylheptanoid increases expression EXP 6480464 Diarylheptanoids results in increased expression of CYP3A4 mRNA CTD PMID:23850985 diazepam affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Diazepam CTD PMID:16048486 diazepam increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Diazepam CTD PMID:18846481 diazepam multiple interactions EXP 6480464 Diazepam inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] more ... CTD PMID:19299527 and PMID:21402137 diazinon affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Diazinon CTD PMID:15764407 diazinon increases methylation EXP 6480464 Diazinon results in increased methylation of CYP3A4 promoter CTD PMID:35331105 diazinon increases expression EXP 6480464 Diazinon results in increased expression of CYP3A4 mRNA CTD PMID:16757081 and PMID:35331105 diazinon multiple interactions EXP 6480464 CYP3A4 protein results in decreased sulfation of and results in increased activity of Diazinon and CYP3A4 protein results in increased metabolism of and results in increased activity of Diazinon CTD PMID:11708902 and PMID:15764407 dibenziodolium multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 diphenyleneiodonium inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP3A2 protein] CTD PMID:26880746 dibenziodolium decreases activity ISO Cyp3a2 (Rattus norvegicus) 6480464 diphenyleneiodonium results in decreased activity of CYP3A4 protein CTD PMID:26880746 dibutyl phthalate multiple interactions EXP 6480464 Dibutyl Phthalate promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA] and Dibutyl Phthalate promotes the reaction [NR1I2 protein results in increased expression of CYP3A4] CTD PMID:21742782 and PMID:36893891 diclofenac increases expression EXP 6480464 Diclofenac results in increased expression of CYP3A4 mRNA CTD PMID:19022234 and PMID:29027214 diclofenac increases response to substance EXP 6480464 CYP3A4 protein results in increased susceptibility to Diclofenac CTD PMID:28762043 diclofenac multiple interactions EXP 6480464 [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 5-hydroxydiclofenac more ... CTD PMID:23397584 more ... diclofenac increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Diclofenac CTD PMID:24104198 and PMID:33259822 diclofenac decreases activity EXP 6480464 Diclofenac metabolite results in decreased activity of CYP3A4 protein and Diclofenac results in decreased activity of CYP3A4 protein CTD PMID:15135088 and PMID:28960974 dicloxacillin multiple interactions EXP 6480464 Dicloxacillin results in increased expression of and results in increased activity of CYP3A4 protein CTD PMID:18505790 dicloxacillin increases expression EXP 6480464 Dicloxacillin results in increased expression of CYP3A4 mRNA CTD PMID:18505790 dieldrin multiple interactions EXP 6480464 [DDT co-treated with Dieldrin] results in increased expression of CYP3A4 mRNA and Dieldrin promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA] CTD PMID:12417264 and PMID:25028461 dieldrin increases expression EXP 6480464 Dieldrin results in increased expression of CYP3A4 protein CTD PMID:15548381 diethyl phthalate increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 diethyl phthalate results in increased expression of CYP3A2 protein CTD PMID:16641546 diethylstilbestrol increases activity EXP 6480464 Diethylstilbestrol results in increased activity of CYP3A4 protein CTD PMID:23384967 diethylstilbestrol increases expression EXP 6480464 Diethylstilbestrol results in increased expression of CYP3A4 mRNA CTD PMID:21924250 and PMID:23384967 difenoconazole increases expression EXP 6480464 difenoconazole results in increased expression of CYP3A4 mRNA CTD PMID:33575850 diflubenzuron affects binding EXP 6480464 Diflubenzuron binds to CYP3A4 protein CTD PMID:32278787 dihydroartemisinin decreases activity EXP 6480464 artenimol results in decreased activity of CYP3A4 protein CTD PMID:11124226 dihydroergotamine decreases activity EXP 6480464 Dihydroergotamine results in decreased activity of CYP3A4 protein CTD PMID:18420780 diltiazem affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Diltiazem CTD PMID:15286053 diltiazem multiple interactions EXP 6480464 Diltiazem inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] more ... CTD PMID:19299527 and PMID:22652334 diltiazem decreases activity EXP 6480464 Diltiazem results in decreased activity of CYP3A4 protein CTD PMID:22652334 diltiazem decreases methylation EXP 6480464 CYP3A4 protein results in decreased methylation of Diltiazem CTD PMID:15499178 dimemorfan increases oxidation EXP 6480464 CYP3A4 protein results in increased oxidation of dimemorfan CTD PMID:19593786 dimemorfan multiple interactions EXP 6480464 Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of dimemorfan] CTD PMID:19593786 dimethocaine decreases ethylation EXP 6480464 CYP3A4 protein results in decreased ethylation of dimethocaine CTD PMID:24309420 dimethocaine increases hydroxylation EXP 6480464 CYP3A4 protein results in increased hydroxylation of dimethocaine CTD PMID:24309420 dimethyl sulfoxide affects expression EXP 6480464 Dimethyl Sulfoxide affects the expression of CYP3A4 mRNA CTD PMID:12843640 dimethyl sulfoxide multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 Dimethyl Sulfoxide inhibits the reaction [CYP3A2 protein results in increased metabolism of 7-benzyloxyquinoline] CTD PMID:19858067 dimethyl sulfoxide increases expression EXP 6480464 Dimethyl Sulfoxide results in increased expression of CYP3A4 mRNA and Dimethyl Sulfoxide results in increased expression of CYP3A4 protein CTD PMID:30262279 and PMID:31096615 dimethyl sulfoxide multiple interactions EXP 6480464 [Dimethyl Sulfoxide co-treated with TGFB1 protein] results in decreased expression of CYP3A4 mRNA more ... CTD PMID:18347083 more ... dimethylarsinous acid increases activity EXP 6480464 dimethylarsinous acid results in increased activity of CYP3A4 protein CTD PMID:19084030 dimethylarsinous acid increases expression EXP 6480464 dimethylarsinous acid results in increased expression of CYP3A4 mRNA and dimethylarsinous acid results in increased expression of CYP3A4 protein CTD PMID:19084030 dioleoyl phosphatidylcholine multiple interactions EXP 6480464 [1 more ... CTD PMID:1627548 dioleoyl phosphatidylcholine multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [1 more ... CTD PMID:1627548 diosmetin multiple interactions EXP 6480464 diosmetin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam] and diosmetin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam] CTD PMID:18191104 dioxygen multiple interactions EXP 6480464 [[CYP3A4 protein co-treated with Oxygen co-treated with NADP] results in increased reduction of 4-hydroxy-2-nonenal] which results in increased chemical synthesis of 1 more ... CTD PMID:19695866 more ... dioxygen decreases expression EXP 6480464 Oxygen deficiency results in decreased expression of CYP3A4 mRNA CTD PMID:19695866 diphenylamine multiple interactions EXP 6480464 [Omite co-treated with Diphenylamine co-treated with phosalone co-treated with Captan co-treated with N-dichlorofluoromethylthio-N' and N'-dimethyl-N-p-tolylsulfamide] results in increased expression of CYP3A4 mRNA CTD PMID:25028461 dipropyl disulfide increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 n-propyl disulfide results in increased expression of CYP3A2 protein CTD PMID:16000231 Dipropyl sulfide increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 dipropyl sulfide results in increased expression of CYP3A2 protein CTD PMID:16000231 diquat decreases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Diquat results in decreased expression of CYP3A2 mRNA CTD PMID:7676460 disopyramide multiple interactions EXP 6480464 Clarithromycin inhibits the reaction [CYP3A4 protein results in increased metabolism of Disopyramide] CTD PMID:10234723 disopyramide increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Disopyramide CTD PMID:10901704 disulfiram increases response to substance EXP 6480464 CYP3A4 protein results in increased susceptibility to Disulfiram CTD PMID:21540358 disulfiram decreases activity ISO Cyp3a2 (Rattus norvegicus) 6480464 Disulfiram results in decreased activity of CYP3A2 protein CTD PMID:9393675 disulfiram decreases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Disulfiram results in decreased expression of CYP3A2 mRNA CTD PMID:9393675 Dithiopyr increases expression EXP 6480464 dithiopyr results in increased expression of CYP3A4 mRNA CTD PMID:17293382 diuron increases expression EXP 6480464 Diuron results in increased expression of CYP3A4 mRNA CTD PMID:22310298 domperidone multiple interactions EXP 6480464 CYP3A4 protein results in increased hydroxylation of and results in decreased alkylation of Domperidone CTD PMID:15327587 dopamine decreases activity EXP 6480464 Dopamine results in decreased activity of CYP3A4 protein CTD PMID:18420780 doxorubicin multiple interactions EXP 6480464 [Diethylhexyl Phthalate results in increased expression of CYP3A4] which results in increased metabolism of and results in decreased activity of Doxorubicin CTD PMID:34801851 Droloxifene decreases activity EXP 6480464 droloxifene results in decreased activity of CYP3A4 protein CTD PMID:12419016 dronedarone decreases response to substance EXP 6480464 CYP3A4 protein results in decreased susceptibility to dronedarone CTD PMID:29616291 dronedarone multiple interactions EXP 6480464 [CYP3A4 protein results in increased metabolism of Dronedarone] which results in increased abundance of N-desbutyldronedarone more ... CTD PMID:29616291 and PMID:31756459 dronedarone increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Dronedarone CTD PMID:29616291 and PMID:31756459 Echimidine multiple interactions EXP 6480464 [CYP3A4 protein results in increased metabolism of echimidine] which affects the expression of CDC20 mRNA more ... CTD PMID:33884520 Echimidine increases response to substance EXP 6480464 CYP3A4 protein results in increased susceptibility to echimidine CTD PMID:32910235 Echimidine increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of echimidine CTD PMID:33884520 econazole decreases activity EXP 6480464 Econazole results in decreased activity of CYP3A4 protein CTD PMID:15135088 econazole increases expression EXP 6480464 Econazole results in increased expression of CYP3A4 mRNA CTD PMID:17998298 econazole multiple interactions EXP 6480464 Econazole promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA] and Econazole promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA] CTD PMID:17998298 efavirenz increases activity EXP 6480464 efavirenz results in increased activity of CYP3A4 protein CTD PMID:15980690 efavirenz increases expression EXP 6480464 efavirenz results in increased expression of CYP3A4 mRNA CTD PMID:16837568 efavirenz decreases activity EXP 6480464 efavirenz results in decreased activity of CYP3A4 protein CTD PMID:15980690 elemental selenium decreases expression EXP 6480464 Selenium results in decreased expression of CYP3A4 mRNA CTD PMID:19244175 ellipticine increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of ellipticine CTD PMID:22917556 ellipticine multiple interactions EXP 6480464 [[CYP3A4 protein co-treated with NADP] results in increased oxidation of ellipticine] which results in increased chemical synthesis of 12-hydroxyellipticine more ... CTD PMID:22390216 and PMID:30914192 emodin increases oxidation EXP 6480464 CYP3A4 protein results in increased oxidation of Emodin CTD PMID:27989148 emodin decreases activity EXP 6480464 Emodin results in decreased activity of CYP3A4 protein CTD PMID:33438235 emodin affects response to substance EXP 6480464 CYP3A4 protein affects the susceptibility to Emodin CTD PMID:34875353 emodin increases hydroxylation EXP 6480464 CYP3A4 protein results in increased hydroxylation of Emodin CTD PMID:30672276 emodin multiple interactions EXP 6480464 [CYP3A4 protein co-treated with Acetylcysteine] results in increased metabolism of Emodin metabolite CTD PMID:27989148 enalapril multiple interactions EXP 6480464 Enalapril inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] CTD PMID:19299527 endosulfan affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Endosulfan CTD PMID:16581944 and PMID:16855053 endosulfan decreases activity EXP 6480464 Endosulfan results in decreased activity of CYP3A4 protein CTD PMID:24832206 endosulfan increases expression EXP 6480464 Endosulfan results in increased expression of CYP3A4 mRNA and Endosulfan results in increased expression of CYP3A4 protein CTD PMID:12417264 more ... endosulfan multiple interactions EXP 6480464 [Atrazine co-treated with Chlorpyrifos co-treated with Endosulfan] results in increased expression of CYP3A4 protein more ... CTD PMID:12417264 more ... endosulfan increases response to substance EXP 6480464 CYP3A4 protein results in increased susceptibility to Endosulfan CTD PMID:20507880 endrin increases expression EXP 6480464 Endrin results in increased expression of CYP3A4 protein CTD PMID:15548381 enilconazole multiple interactions EXP 6480464 [Amiodarone co-treated with Benzoic Acid co-treated with cyproconazole co-treated with flusilazole co-treated with enilconazole co-treated with prochloraz co-treated with propiconazole co-treated with tebuconazole] results in increased expression of CYP3A4 protein more ... CTD PMID:25028461 more ... enilconazole increases expression EXP 6480464 enilconazole results in increased expression of CYP3A4 protein CTD PMID:32201337 and PMID:34273450 enilconazole affects expression EXP 6480464 enilconazole affects the expression of CYP3A4 mRNA CTD PMID:32201337 enilconazole decreases activity EXP 6480464 enilconazole results in decreased activity of CYP3A4 protein CTD PMID:21762035 eplerenone increases abundance EXP 6480464 CYP3A4 protein results in increased abundance of Eplerenone metabolite CTD PMID:31408697 eplerenone increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Eplerenone CTD PMID:31408697 epoxiconazole increases expression EXP 6480464 epoxiconazole results in increased expression of CYP3A4 mRNA and epoxiconazole results in increased expression of CYP3A4 protein CTD PMID:29294346 epoxiconazole multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of CYP3A2 mRNA and [cyproconazole co-treated with epoxiconazole] results in increased expression of CYP3A2 mRNA CTD PMID:29038839 epoxiconazole increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 epoxiconazole results in increased expression of CYP3A2 mRNA CTD PMID:29038839 epoxiconazole multiple interactions EXP 6480464 [fluxapyroxad co-treated with epoxiconazole] results in increased expression of CYP3A4 mRNA and [fluxapyroxad co-treated with epoxiconazole] results in increased expression of CYP3A4 protein CTD PMID:29294346 erlotinib hydrochloride decreases activity EXP 6480464 Erlotinib Hydrochloride results in decreased activity of CYP3A4 protein CTD PMID:18839173 erlotinib hydrochloride increases expression EXP 6480464 Erlotinib Hydrochloride results in increased expression of CYP3A4 mRNA CTD PMID:18839173 erythromycin A increases expression EXP 6480464 Erythromycin results in increased expression of CYP3A4 mRNA and Erythromycin results in increased expression of CYP3A4 protein CTD PMID:18505790 erythromycin A decreases activity EXP 6480464 Erythromycin results in decreased activity of CYP3A4 protein CTD PMID:15466163 more ... erythromycin A increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Erythromycin CTD PMID:21466820 erythromycin A multiple interactions EXP 6480464 Erythromycin inhibits the reaction [CYP3A4 protein affects the metabolism of brotizolam] more ... CTD PMID:16042670 more ... erythromycin A decreases methylation EXP 6480464 CYP3A4 protein results in decreased methylation of Erythromycin CTD PMID:15383492 and PMID:2271712 erythromycin A affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Erythromycin CTD PMID:8114683 erythrosin B decreases activity EXP 6480464 Erythrosine results in decreased activity of CYP3A4 protein CTD PMID:20041016 estazolam increases hydroxylation EXP 6480464 CYP3A4 protein results in increased hydroxylation of Estazolam CTD PMID:16012077 estrone multiple interactions EXP 6480464 CYP3A4 protein promotes the reaction [Estrone binds to Deoxyguanosine] and Estrone inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] CTD PMID:19299527 and PMID:21907773 estrone affects binding EXP 6480464 CYP3A4 protein binds to Estrone CTD PMID:27966929 ethambutol multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA more ... CTD PMID:27919644 ethanol increases expression EXP 6480464 Ethanol results in increased expression of CYP3A4 mRNA and Ethanol results in increased expression of CYP3A4 protein CTD PMID:28062356 and PMID:35301062 ethanol decreases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Ethanol results in decreased expression of CYP3A2 mRNA CTD PMID:26109895 ethion multiple interactions EXP 6480464 [Chlorfenvinphos co-treated with ethion co-treated with Linuron] results in increased expression of CYP3A4 mRNA CTD PMID:25028461 eticlopride(1+) multiple interactions EXP 6480464 [eticlopride results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:25455453 etonogestrel affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of etonogestrel CTD PMID:15963096 etoposide multiple interactions EXP 6480464 [Etoposide results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA more ... CTD PMID:25455453 and PMID:8114683 etoposide increases expression EXP 6480464 Etoposide results in increased expression of CYP3A4 mRNA CTD PMID:31542801 etoposide decreases methylation EXP 6480464 CYP3A4 protein results in decreased methylation of Etoposide CTD PMID:8114683 etoposide affects response to substance EXP 6480464 CYP3A4 gene polymorphism affects the susceptibility to Etoposide and CYP3A4 protein affects the susceptibility to Etoposide CTD PMID:12969965 and PMID:17279585 etoricoxib increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of etoricoxib CTD PMID:18084859 etoxazole increases expression EXP 6480464 etoxazole results in increased expression of CYP3A4 mRNA CTD PMID:17293382 eupatilin increases activity EXP 6480464 eupatilin results in increased activity of CYP3A4 protein CTD PMID:31756459 eupatilin multiple interactions EXP 6480464 [[eupatilin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam and [eupatilin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam CTD PMID:31756459 eupatorin decreases activity EXP 6480464 eupatorin results in decreased activity of CYP3A4 protein CTD PMID:21276781 farnesol multiple interactions EXP 6480464 Farnesol analog inhibits the reaction [Oleic Acid results in decreased expression of CYP3A4 mRNA] CTD PMID:30611723 farnesol increases activity ISO Cyp3a2 (Rattus norvegicus) 6480464 Farnesol results in increased activity of CYP3A2 protein CTD PMID:15840382 farnesol increases expression EXP 6480464 Farnesol results in increased expression of CYP3A4 mRNA CTD PMID:30611723 farrerol decreases activity EXP 6480464 farrerol results in decreased activity of CYP3A4 protein CTD PMID:29753067 felbamate multiple interactions EXP 6480464 felbamate affects the reaction [[CYP3A4 protein results in increased metabolism of Carbamazepine] which results in increased chemical synthesis of carbamazepine epoxide] CTD PMID:12606595 felodipine increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Felodipine CTD PMID:23876819 felodipine increases expression EXP 6480464 Felodipine results in increased expression of CYP3A4 mRNA CTD PMID:27732883 felodipine multiple interactions EXP 6480464 deoxyelephantopin inhibits the reaction [CYP3A4 protein results in increased metabolism of Felodipine] more ... CTD PMID:23876819 and PMID:27732883 fenhexamid multiple interactions EXP 6480464 [N-(2 and 3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with pyrimethanil co-treated with Fenitrothion co-treated with triadimefon co-treated with quinoxyfen co-treated with penconazole] results in increased expression of CYP3A4 mRNA CTD PMID:25028461 fenitrothion multiple interactions EXP 6480464 [N-(2 and 3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with pyrimethanil co-treated with Fenitrothion co-treated with triadimefon co-treated with quinoxyfen co-treated with penconazole] results in increased expression of CYP3A4 mRNA CTD PMID:25028461 fenitrothion decreases activity EXP 6480464 Fenitrothion results in decreased activity of CYP3A4 protein CTD PMID:20183062 fenitrothion increases expression EXP 6480464 Fenitrothion results in increased expression of CYP3A4 mRNA CTD PMID:17293382 and PMID:22310298 fenitrothion increases activity EXP 6480464 Fenitrothion results in increased activity of CYP3A4 protein CTD PMID:22310298 fenproporex decreases alkylation EXP 6480464 CYP3A4 protein results in decreased alkylation of fenproporex CTD PMID:15294457 fentanyl increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Fentanyl CTD PMID:11811955 fenthion affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Fenthion CTD PMID:17110060 fenvalerate increases expression EXP 6480464 fenvalerate results in increased expression of CYP3A4 mRNA and fenvalerate results in increased expression of CYP3A4 protein CTD PMID:15548381 more ... fenvalerate decreases activity EXP 6480464 fenvalerate results in decreased activity of CYP3A4 protein CTD PMID:22634058 fenvalerate multiple interactions EXP 6480464 Dexamethasone promotes the reaction [fenvalerate results in increased expression of CYP3A4 mRNA] and fenvalerate promotes the reaction [Dexamethasone results in increased expression of CYP3A4 mRNA] CTD PMID:20599767 fenvalerate increases activity EXP 6480464 fenvalerate results in increased activity of CYP3A4 protein CTD PMID:22310298 ferroheme b multiple interactions EXP 6480464 [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine] and [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine] CTD PMID:22390216 fimasartan increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of fimasartan CTD PMID:29596975 fimasartan increases oxidation EXP 6480464 CYP3A4 protein results in increased oxidation of fimasartan CTD PMID:29596975 fipronil multiple interactions EXP 6480464 [fipronil co-treated with DEET] results in increased expression of CYP3A4 mRNA more ... CTD PMID:17084830 and PMID:27091632 fipronil increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 fipronil results in increased expression of CYP3A2 mRNA CTD PMID:23962444 fipronil increases expression EXP 6480464 fipronil results in increased expression of CYP3A4 mRNA CTD PMID:17084830 and PMID:27091632 flavanone multiple interactions EXP 6480464 flavanone inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam] and flavanone promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam] CTD PMID:21053930 flavanone decreases activity EXP 6480464 flavanone results in decreased activity of CYP3A4 protein CTD PMID:21053930 flavone multiple interactions EXP 6480464 [[flavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam more ... CTD PMID:21053930 and PMID:31756459 flavone increases activity EXP 6480464 flavone results in increased activity of CYP3A4 protein CTD PMID:31756459 flavonol increases expression EXP 6480464 3-hydroxyflavone results in increased expression of CYP3A4 mRNA CTD PMID:26238175 flavonol increases activity EXP 6480464 3-hydroxyflavone results in increased activity of CYP3A4 protein CTD PMID:31756459 flavonol multiple interactions EXP 6480464 [3-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam and [[3-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam CTD PMID:31756459 flavonol decreases activity EXP 6480464 3-hydroxyflavone results in decreased activity of CYP3A4 protein CTD PMID:21053930 flucloxacillin increases metabolic processing EXP 6480464 CYP3A4 results in increased metabolism of Floxacillin CTD PMID:11409940 fluconazole decreases activity EXP 6480464 Fluconazole results in decreased activity of CYP3A4 protein CTD PMID:15784650 and PMID:15843491 flucythrinate affects binding EXP 6480464 flucythrinate binds to CYP3A4 protein CTD PMID:32278787 fludioxonil multiple interactions EXP 6480464 [procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin] results in increased expression of CYP3A4 mRNA CTD PMID:25028461 fludioxonil decreases activity EXP 6480464 fludioxonil results in decreased activity of CYP3A4 protein CTD PMID:33575850 flunitrazepam multiple interactions EXP 6480464 CYP3A4 protein affects the reaction [Flunitrazepam results in increased activity of CASP3 protein] more ... CTD PMID:19005028 and PMID:19299527 flunitrazepam increases hydroxylation EXP 6480464 CYP3A4 protein results in increased hydroxylation of Flunitrazepam CTD PMID:15383492 fluoren-9-one increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 9-fluorenone results in increased expression of CYP3A2 protein CTD PMID:10445401 fluorene increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 fluorene results in increased expression of CYP3A2 protein CTD PMID:10445401 fluoxetine multiple interactions EXP 6480464 Fluoxetine inhibits the reaction [CYP3A4 protein results in increased oxidation of and results in increased activity of Haloperidol] and Troleandomycin inhibits the reaction [CYP3A4 protein results in increased metabolism of Fluoxetine] CTD PMID:11752104 and PMID:12584149 fluoxetine increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Fluoxetine CTD PMID:11752104 and PMID:16595712 fluphenazine decreases activity EXP 6480464 Fluphenazine results in decreased activity of CYP3A4 protein CTD PMID:15135088 flusilazole increases expression EXP 6480464 flusilazole results in increased expression of CYP3A4 protein CTD PMID:34273450 flusilazole multiple interactions EXP 6480464 [Amiodarone co-treated with Benzoic Acid co-treated with cyproconazole co-treated with flusilazole co-treated with enilconazole co-treated with prochloraz co-treated with propiconazole co-treated with tebuconazole] results in increased expression of CYP3A4 protein CTD PMID:34273450 flutamide increases activity EXP 6480464 Flutamide results in increased activity of CYP3A4 protein CTD PMID:18839173 flutamide decreases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Flutamide results in decreased expression of CYP3A2 mRNA CTD PMID:24136188 flutamide multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [SOD2 co-treated with CYP3A4] affects the susceptibility to Flutamide CTD PMID:19501153 flutamide increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Flutamide results in increased expression of CYP3A2 mRNA CTD PMID:24793618 flutamide increases response to substance EXP 6480464 CYP3A4 protein results in increased susceptibility to Flutamide CTD PMID:28762043 flutamide multiple interactions EXP 6480464 [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Flutamide and Flutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [[Monocrotaline results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA]] CTD PMID:23397584 and PMID:32682830 flutamide increases expression EXP 6480464 Flutamide results in increased expression of CYP3A4 mRNA CTD PMID:18839173 fluticasone decreases activity EXP 6480464 Fluticasone results in decreased activity of CYP3A4 protein CTD PMID:20707410 flutolanil increases expression EXP 6480464 flutolanil results in increased expression of CYP3A4 mRNA CTD PMID:17293382 fluvalinate affects binding EXP 6480464 fluvalinate binds to CYP3A4 protein CTD PMID:32278787 fluvastatin multiple interactions EXP 6480464 [fluvastatin co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA and fluvastatin inhibits the reaction [CYP3A4 protein affects the metabolism of Midazolam] CTD PMID:16029222 and PMID:24204015 fluvastatin decreases activity EXP 6480464 fluvastatin results in decreased activity of CYP3A4 protein CTD PMID:16029222 fluvoxamine multiple interactions EXP 6480464 Fluvoxamine inhibits the reaction [CYP3A4 protein results in increased oxidation of and results in increased activity of Haloperidol] CTD PMID:12584149 fluxapyroxad multiple interactions EXP 6480464 [fluxapyroxad co-treated with epoxiconazole] results in increased expression of CYP3A4 mRNA and [fluxapyroxad co-treated with epoxiconazole] results in increased expression of CYP3A4 protein CTD PMID:29294346 fluxapyroxad increases expression EXP 6480464 fluxapyroxad results in increased expression of CYP3A4 mRNA CTD PMID:29294346 fonofos multiple interactions EXP 6480464 Fonofos inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 2-hydroxyestradiol] and Fonofos inhibits the reaction [CYP3A4 protein results in increased metabolism of Estradiol] CTD PMID:16790556 fonofos decreases activity EXP 6480464 Fonofos results in decreased activity of CYP3A4 protein CTD PMID:16790556 Fraxinellone increases glutathionylation EXP 6480464 CYP3A4 protein results in increased glutathionylation of fraxinellone CTD PMID:32484342 fulvestrant increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Fulvestrant results in increased expression of CYP3A2 mRNA CTD PMID:16837770 Furafylline decreases activity ISO Cyp3a2 (Rattus norvegicus) 6480464 furafylline results in decreased activity of CYP3A2 protein CTD PMID:15879494 furan decreases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 furan results in decreased expression of CYP3A2 mRNA CTD PMID:25539665 and PMID:26194646 furathiocarb increases activity EXP 6480464 deltanit results in increased activity of CYP3A4 protein CTD PMID:22310298 furathiocarb increases expression EXP 6480464 deltanit results in increased expression of CYP3A4 mRNA CTD PMID:22310298 fusidic acid multiple interactions EXP 6480464 Fusidic Acid inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] CTD PMID:26888941 gadolinium trichloride multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP3A2 mRNA] more ... CTD PMID:18079364 and PMID:18202523 galangin increases expression EXP 6480464 galangin results in increased expression of CYP3A4 mRNA CTD PMID:26238175 galangin increases activity EXP 6480464 galangin results in increased activity of CYP3A4 protein CTD PMID:31756459 galangin multiple interactions EXP 6480464 [[galangin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam more ... CTD PMID:21053930 and PMID:31756459 galangin decreases activity EXP 6480464 galangin results in decreased activity of CYP3A4 protein CTD PMID:21053930 gamma-hexachlorocyclohexane increases expression EXP 6480464 Hexachlorocyclohexane results in increased expression of CYP3A4 protein CTD PMID:15548381 gamma-hexachlorocyclohexane increases activity ISO Cyp3a2 (Rattus norvegicus) 6480464 Hexachlorocyclohexane results in increased activity of CYP3A2 protein CTD PMID:3569844 gamma-hexachlorocyclohexane increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Hexachlorocyclohexane results in increased expression of CYP3A2 mRNA and Hexachlorocyclohexane results in increased expression of CYP3A2 protein CTD PMID:11684361 and PMID:16837770 gefitinib affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of gefitinib CTD PMID:15788367 Gelsemine increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of gelsemine CTD PMID:34627953 Gelsemine decreases response to substance EXP 6480464 CYP3A4 protein results in decreased susceptibility to gelsemine CTD PMID:34627953 gemfibrozil increases expression EXP 6480464 Gemfibrozil results in increased expression of CYP3A4 mRNA CTD PMID:15771232 gemfibrozil increases activity EXP 6480464 Gemfibrozil results in increased activity of CYP3A4 protein CTD PMID:15771232 genistein multiple interactions EXP 6480464 Genistein inhibits the reaction [Calcitriol results in increased activity of CYP3A4 protein] CTD PMID:19766177 genistein multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [bisphenol A co-treated with Genistein] results in decreased methylation of CYP3A2 gene CTD PMID:28505145 genistein increases expression EXP 6480464 Genistein results in increased expression of CYP3A4 mRNA CTD PMID:29933105 genistein decreases activity EXP 6480464 Genistein results in decreased activity of CYP3A4 protein CTD PMID:21053930 gentamycin decreases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Gentamicins results in decreased expression of CYP3A2 mRNA CTD PMID:20849911 gentamycin increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Gentamicins results in increased expression of CYP3A2 mRNA CTD PMID:33387578 gentamycin multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in decreased expression of CYP3A2 mRNA CTD PMID:30545405 geranial multiple interactions EXP 6480464 citral inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] CTD PMID:18385293 gestodene decreases activity EXP 6480464 Gestodene results in decreased activity of CYP3A4 protein CTD PMID:2271712 gestodene multiple interactions EXP 6480464 Gestodene inhibits the reaction [CYP3A4 protein results in increased oxidation of Methylenebis(chloroaniline)] CTD PMID:1740010 gingerol multiple interactions EXP 6480464 gingerol inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] CTD PMID:18385293 Ginkgolide A increases expression EXP 6480464 ginkgolide A results in increased expression of CYP3A4 mRNA CTD PMID:19034627 Ginkgolide A increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 ginkgolide A results in increased expression of CYP3A2 mRNA CTD PMID:16258077 ginkgolide B multiple interactions EXP 6480464 NR1I2 protein affects the reaction [ginkgolide B results in increased expression of CYP3A4 mRNA] and sulforaphane inhibits the reaction [ginkgolide B results in increased expression of CYP3A4 mRNA] CTD PMID:26775663 ginkgolide B increases expression EXP 6480464 ginkgolide B results in increased expression of CYP3A4 mRNA CTD PMID:19034627 and PMID:26775663 ginsenoside Rg1 multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 ginsenoside Rg1 inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CYP3A4 mRNA] and ginsenoside Rg1 inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of CYP3A4 protein] CTD PMID:32198087 glafenine decreases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Glafenine results in decreased expression of CYP3A2 mRNA CTD PMID:24136188 glimepiride multiple interactions EXP 6480464 [glimepiride results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:25455453 glutathione multiple interactions EXP 6480464 [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 5-hydroxydiclofenac more ... CTD PMID:15523003 more ... glutathione multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [CYP3A2 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1 more ... CTD PMID:20825217 glutathione affects binding EXP 6480464 Glutathione binds to CYP3A4 protein CTD PMID:18206979 glycochenodeoxycholic acid multiple interactions EXP 6480464 [Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of CYP3A4 mRNA more ... CTD PMID:32152650 and PMID:33819548 glycochenodeoxycholic acid increases hydroxylation EXP 6480464 CYP3A4 protein results in increased hydroxylation of Glycochenodeoxycholic Acid CTD PMID:36473578 glycocholic acid multiple interactions EXP 6480464 [Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of CYP3A4 mRNA more ... CTD PMID:32152650 and PMID:33819548 glycodeoxycholic acid multiple interactions EXP 6480464 [Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of CYP3A4 mRNA more ... CTD PMID:32152650 and PMID:33819548 glycodeoxycholic acid increases hydroxylation EXP 6480464 CYP3A4 protein results in increased hydroxylation of Glycodeoxycholic Acid CTD PMID:36473578 Glycohyodeoxycholic acid multiple interactions EXP 6480464 [CYP3A4 protein results in increased hydroxylation of glycolithocholic acid] which results in increased abundance of glycohyodeoxycholic acid CTD PMID:36473578 glycolithocholic acid increases hydroxylation EXP 6480464 CYP3A4 protein results in increased hydroxylation of glycolithocholic acid CTD PMID:36473578 glycolithocholic acid multiple interactions EXP 6480464 [CYP3A4 protein results in increased hydroxylation of glycolithocholic acid] which results in increased abundance of glycohyodeoxycholic acid CTD PMID:36473578 glycoursodeoxycholic acid increases hydroxylation EXP 6480464 CYP3A4 protein results in increased hydroxylation of glycoursodeoxycholic acid CTD PMID:36473578 glycyrrhetinic acid decreases hydroxylation EXP 405820204 glycyrrhetinic acid decreases hydroxylation of CYP3A4 specific substrate Midazolam in human liver microsomes RGD glycyrrhizinic acid increases expression EXP 6480464 Glycyrrhizic Acid results in increased expression of CYP3A4 mRNA and Glycyrrhizic Acid results in increased expression of CYP3A4 protein CTD PMID:22982774 glycyrrhizinic acid multiple interactions EXP 6480464 NR1I2 protein affects the reaction [Glycyrrhizic Acid results in increased expression of CYP3A4 mRNA] CTD PMID:22982774 glyoxal multiple interactions EXP 6480464 [CYP3A4 protein results in increased metabolism of and results in increased susceptibility to sudoxicam] which results in increased chemical synthesis of Glyoxal CTD PMID:33253783 granisetron affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Granisetron CTD PMID:15286053 griseofulvin increases expression EXP 6480464 Griseofulvin results in increased expression of CYP3A4 mRNA and Griseofulvin results in increased expression of CYP3A4 protein CTD PMID:18505790 guggulsterone increases expression EXP 6480464 pregna-4 more ... CTD PMID:15075359 GW 3965 multiple interactions EXP 6480464 [GW 3965 co-treated with NR1H3 protein] results in increased expression of CYP3A4 mRNA and GW 3965 inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA] CTD PMID:23732298 GW 3965 increases expression EXP 6480464 GW 3965 results in increased expression of CYP3A4 mRNA CTD PMID:23732298 haloperidol multiple interactions EXP 6480464 CYP3A4 protein results in increased oxidation of and results in increased activity of Haloperidol more ... CTD PMID:12584149 halothane increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Halothane CTD PMID:8886607 helenalin decreases activity EXP 6480464 helenalin results in decreased activity of CYP3A4 protein CTD PMID:34989853 helenalin increases oxidation EXP 6480464 CYP3A4 protein results in increased oxidation of helenalin CTD PMID:34989853 Heliotrine increases response to substance EXP 6480464 CYP3A4 protein results in increased susceptibility to heliotrine CTD PMID:32910235 heme b multiple interactions EXP 6480464 [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 12-hydroxyellipticine] and [CYB5A protein co-treated with Heme] promotes the reaction [[CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased chemical synthesis of 13-hydroxyellipticine] CTD PMID:22390216 HET0016 decreases activity EXP 6480464 HET0016 results in decreased activity of CYP3A4 protein CTD PMID:11375247 Hexachloro-1,3-butadiene increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of hexachlorobutadiene CTD PMID:8555406 hexachlorobenzene increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Hexachlorobenzene results in increased expression of CYP3A2 mRNA CTD PMID:15159207 hexaflumuron increases expression EXP 6480464 hexafluoron results in increased expression of CYP3A4 mRNA CTD PMID:22310298 hexobarbital multiple interactions EXP 6480464 Hexobarbital inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] CTD PMID:19299527 huperzine A increases metabolic processing ISO Cyp3a2 (Rattus norvegicus) 6480464 CYP3A2 protein results in increased metabolism of huperzine A CTD PMID:12586202 hydrocortisone succinate multiple interactions EXP 6480464 [hydrocortisone hemisuccinate co-treated with Dimethyl Sulfoxide] results in increased expression of CYP3A4 CTD PMID:18347083 hydrogen peroxide increases abundance EXP 6480464 CYP3A4 protein results in increased abundance of Hydrogen Peroxide CTD PMID:25061110 hydrogen peroxide increases expression EXP 6480464 Hydrogen Peroxide results in increased expression of CYP3A4 mRNA and Hydrogen Peroxide results in increased expression of CYP3A4 protein CTD PMID:15056853 hydroquinone multiple interactions EXP 6480464 [CYP3A4 protein results in increased metabolism of bisphenol A] which results in increased chemical synthesis of hydroquinone CTD PMID:21402134 hydroxynefazodone multiple interactions EXP 6480464 [CYP3A4 protein results in increased hydroxylation of nefazodone] which results in increased abundance of hydroxynefazodone CTD PMID:27485346 hyodeoxycholic acid multiple interactions EXP 6480464 [CYP3A4 protein results in increased hydroxylation of Lithocholic Acid] which results in increased abundance of hyodeoxycholic acid and [CYP3A4 protein results in increased metabolism of Lithocholic Acid] which results in increased abundance of hyodeoxycholic acid CTD PMID:19487251 and PMID:36473578 Hypaconitine increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of hypaconitine CTD PMID:21550385 Hypaconitine increases expression EXP 6480464 hypaconitine results in increased expression of CYP3A4 mRNA CTD PMID:30303438 Hypaconitine multiple interactions EXP 6480464 [Aconitine co-treated with mesaconitine co-treated with hypaconitine] results in increased expression of CYP3A4 mRNA CTD PMID:30303438 hyperforin decreases activity EXP 6480464 hyperforin results in decreased activity of CYP3A4 protein CTD PMID:15100173 hyperforin increases expression EXP 6480464 hyperforin results in increased expression of CYP3A4 and hyperforin results in increased expression of CYP3A4 mRNA CTD PMID:15100173 more ... hyperforin multiple interactions EXP 6480464 hyperforin results in increased expression of and results in increased activity of CYP3A4 protein CTD PMID:15100173 hypericin decreases activity EXP 6480464 hypericin results in decreased activity of CYP3A4 protein CTD PMID:15266218 hypericin decreases expression EXP 6480464 hypericin results in decreased expression of CYP3A4 mRNA CTD PMID:15266218 hypericin increases expression EXP 6480464 hypericin results in increased expression of CYP3A4 CTD PMID:16005588 iberin decreases activity ISO Cyp3a2 (Rattus norvegicus) 6480464 iberin results in decreased activity of CYP3A2 protein CTD PMID:22664424 iberin decreases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 iberin results in decreased expression of CYP3A2 mRNA CTD PMID:22664424 ibrutinib multiple interactions EXP 6480464 [CYP3A4 protein results in increased metabolism of ibrutinib] which results in increased abundance of PCI-45227 CTD PMID:34153224 ibrutinib increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of ibrutinib CTD PMID:34153224 ibrutinib affects metabolic processing EXP 6480464 CYP3A4 protein alternative form affects the metabolism of ibrutinib CTD PMID:34153224 Icaritin affects activity EXP 6480464 icaritin affects the activity of CYP3A4 protein CTD PMID:29753067 Icaritin increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of icaritin CTD PMID:30938510 ifosfamide affects hydroxylation EXP 6480464 CYP3A4 protein affects the hydroxylation of Ifosfamide CTD PMID:12136253 ifosfamide increases expression EXP 6480464 Ifosfamide results in increased expression of CYP3A4 mRNA CTD PMID:18839173 ifosfamide increases response to substance EXP 6480464 CYP3A4 protein results in increased susceptibility to Ifosfamide and CYP3A4 results in increased susceptibility to Ifosfamide CTD PMID:20507880 and PMID:9766669 ifosfamide decreases ethylation EXP 6480464 CYP3A4 gene mutant form results in decreased ethylation of Ifosfamide and CYP3A4 protein results in decreased ethylation of Ifosfamide CTD PMID:15821045 ifosfamide affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Ifosfamide CTD PMID:15875221 ifosfamide affects degradation EXP 6480464 CYP3A4 protein affects the degradation of Ifosfamide CTD PMID:12136253 iloperidone decreases expression EXP 6480464 iloperidone results in decreased expression of CYP3A4 mRNA CTD PMID:32941854 iloperidone decreases activity EXP 6480464 iloperidone results in decreased activity of CYP3A4 protein CTD PMID:32941854 imidacloprid multiple interactions EXP 6480464 [NADP co-treated with CYP3A4 protein] results in increased activity of imidacloprid analog CTD PMID:16153789 imidazoles multiple interactions EXP 6480464 Imidazoles inhibits the reaction [6-(4-chlorophenyl)imidazo(2 more ... CTD PMID:21778469 imipramine multiple interactions EXP 6480464 CYP3A4 protein results in decreased methylation of and results in increased activity of Imipramine and Organophosphorus Compounds inhibits the reaction [CYP3A4 protein results in decreased methylation of and results in increased activity of Imipramine] CTD PMID:15922009 indicine increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of indicine CTD PMID:33884520 indicine increases response to substance EXP 6480464 CYP3A4 protein results in increased susceptibility to indicine CTD PMID:32910235 indole-3-acetamide multiple interactions EXP 6480464 NR1I2 protein promotes the reaction [indoleacetamide results in increased expression of CYP3A4 mRNA] CTD PMID:33002526 indole-3-acetamide increases expression EXP 6480464 indoleacetamide results in increased expression of CYP3A4 mRNA CTD PMID:33002526 indoline increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of indoline CTD PMID:17502430 indometacin increases expression EXP 6480464 Indomethacin results in increased expression of CYP3A4 mRNA CTD PMID:29027214 iprodione multiple interactions EXP 6480464 [procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin] results in increased expression of CYP3A4 mRNA CTD PMID:25028461 irilone decreases activity EXP 6480464 irilone results in decreased activity of CYP3A4 protein CTD PMID:29753067 irinotecan affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Irinotecan CTD PMID:15523087 and PMID:15655543 irinotecan decreases activity EXP 6480464 Irinotecan metabolite results in decreased activity of CYP3A4 protein and Irinotecan results in decreased activity of CYP3A4 protein CTD PMID:11901092 irinotecan increases oxidation EXP 6480464 CYP3A4 protein results in increased oxidation of Irinotecan CTD PMID:15100172 irinotecan increases response to substance EXP 6480464 CYP3A4 mRNA results in increased susceptibility to Irinotecan CTD PMID:15239142 iron(III) citrate multiple interactions EXP 6480464 Alcohols inhibits the reaction [ferric citrate results in increased expression of CYP3A4 mRNA] more ... CTD PMID:24025710 iron(III) citrate increases expression EXP 6480464 ferric citrate results in increased expression of CYP3A4 mRNA and ferric citrate results in increased expression of CYP3A4 protein CTD PMID:24025710 isobavachalcone multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 isobavachalcone inhibits the reaction [[CYP3A4 protein results in increased metabolism of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone] CTD PMID:31870919 isobavachalcone decreases activity ISO Cyp3a2 (Rattus norvegicus) 6480464 isobavachalcone results in decreased activity of CYP3A4 protein CTD PMID:31870919 isocarbophos multiple interactions EXP 6480464 CYP3A4 protein results in increased metabolism of and results in decreased sulfation of and affects the activity of isocarbophos CTD PMID:24752505 isofenphos increases expression EXP 6480464 isofenphos results in increased expression of CYP3A4 mRNA CTD PMID:17293382 isoliquiritigenin decreases activity EXP 6480464 isoliquiritigenin results in decreased activity of CYP3A4 protein CTD PMID:29753067 isoniazide increases response to substance EXP 6480464 CYP3A4 protein results in increased susceptibility to Isoniazid CTD PMID:21540358 isoniazide multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA more ... CTD PMID:19501153 and PMID:27919644 isoniazide decreases activity EXP 6480464 Isoniazid results in decreased activity of CYP3A4 protein CTD PMID:15005856 and PMID:15304522 isoprothiolane increases expression EXP 6480464 isoprothiolane results in increased expression of CYP3A4 mRNA CTD PMID:17293382 isoproturon increases activity EXP 6480464 isoproturon results in increased activity of CYP3A4 protein CTD PMID:22310298 isoproturon decreases activity EXP 6480464 isoproturon results in decreased activity of CYP3A4 protein CTD PMID:18420780 isoproturon increases expression EXP 6480464 isoproturon results in increased expression of CYP3A4 mRNA CTD PMID:22310298 isorhamnetin increases expression EXP 6480464 3-methylquercetin results in increased expression of CYP3A4 mRNA CTD PMID:26238175 Isosafrole increases expression EXP 6480464 isosafrole results in increased expression of CYP3A4 protein CTD PMID:8632764 isotretinoin multiple interactions EXP 6480464 [Isotretinoin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA and Isotretinoin promotes the reaction [[RXRA protein binds to NR1I2 protein] which results in increased expression of CYP3A4 mRNA] CTD PMID:16632523 and PMID:25455453 isotretinoin increases activity EXP 6480464 Isotretinoin results in increased activity of CYP3A4 protein CTD PMID:16632523 isoxazoles decreases activity EXP 6480464 Isoxazoles analog results in decreased activity of CYP3A4 protein CTD PMID:21924250 Isradipine multiple interactions EXP 6480464 Isradipine results in increased expression of and results in decreased activity of CYP3A4 protein CTD PMID:27732883 Isradipine affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Isradipine CTD PMID:15286053 Isradipine increases expression EXP 6480464 Isradipine results in increased expression of CYP3A4 mRNA CTD PMID:27732883 itraconazole affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Itraconazole CTD PMID:15905803 itraconazole decreases expression EXP 6480464 Itraconazole results in decreased expression of CYP3A4 mRNA and Itraconazole results in decreased expression of CYP3A4 protein CTD PMID:28390928 itraconazole decreases activity EXP 6480464 Itraconazole results in decreased activity of CYP3A4 protein CTD PMID:15328084 more ... itraconazole multiple interactions EXP 6480464 Itraconazole binds to and results in decreased activity of CYP3A4 protein CTD PMID:18218784 itraconazole affects activity EXP 6480464 Itraconazole affects the activity of CYP3A4 protein CTD PMID:15964336 itraconazole increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Itraconazole CTD PMID:18360572 itraconazole increases hydroxylation EXP 6480464 CYP3A4 protein results in increased hydroxylation of Itraconazole CTD PMID:15383492 ivermectin decreases activity EXP 6480464 Ivermectin results in decreased activity of CYP3A4 protein CTD PMID:11124226 and PMID:18420780 kaempferol increases expression EXP 6480464 kaempferol results in increased expression of CYP3A4 mRNA CTD PMID:16442130 kaempferol decreases activity EXP 6480464 kaempferol results in decreased activity of CYP3A4 protein CTD PMID:15266218 and PMID:21053930 kaempferol multiple interactions EXP 6480464 [kaempferol results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA and kaempferol inhibits the reaction [CYP3A4 protein results in increased degradation of Hydrocortisone] CTD PMID:15266218 and PMID:25455453 kahweol multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [cafestol co-treated with kahweol] results in decreased expression of CYP3A2 and [cafestol co-treated with kahweol] results in decreased expression of CYP3A2 protein CTD PMID:11346484 and PMID:9744531 ketamine multiple interactions EXP 6480464 Ketamine results in decreased expression of and results in decreased activity of CYP3A4 protein CTD PMID:18845661 ketamine increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Ketamine results in increased expression of CYP3A2 protein CTD PMID:16076768 ketamine decreases expression EXP 6480464 Ketamine results in decreased expression of CYP3A4 mRNA CTD PMID:18845661 ketoconazole decreases metabolic processing EXP 405820204 ketoconazole decreases metabolic processing of glycyrrhetinic acid by CYP3A4 in human liver microsomes RGD ketoconazole decreases activity ISO Cyp3a2 (Rattus norvegicus) 6480464 Ketoconazole results in decreased activity of CYP3A2 protein and Ketoconazole results in decreased activity of CYP3A4 protein CTD PMID:12814958 more ... ketoconazole multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 Ketoconazole inhibits the reaction [CYP3A2 protein results in increased metabolism of 7-benzyloxyquinoline] and Ketoconazole inhibits the reaction [Phenytoin results in increased expression of CYP3A2 protein] CTD PMID:19226368 and PMID:19858067 ketoconazole decreases expression EXP 6480464 Ketoconazole results in decreased expression of CYP3A4 mRNA and Ketoconazole results in decreased expression of CYP3A4 protein CTD PMID:31629065 and PMID:36893891 ketoconazole decreases activity EXP 6480464 Ketoconazole results in decreased activity of CYP3A2 protein and Ketoconazole results in decreased activity of CYP3A4 protein CTD PMID:10997946 more ... ketoconazole increases expression EXP 6480464 Ketoconazole results in increased expression of CYP3A4 mRNA CTD PMID:17998298 and PMID:25343516 ketoconazole increases response to substance EXP 6480464 CYP3A4 protein results in increased susceptibility to Ketoconazole CTD PMID:12695342 more ... ketoconazole multiple interactions EXP 6480464 [Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of BCL2 protein more ... CTD PMID:10952769 more ... ketoconazole increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Ketoconazole CTD PMID:17702393 L-methionine multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA] and Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA] CTD PMID:27919644 lactacystin multiple interactions EXP 6480464 lactacystin inhibits the reaction [6-(4-chlorophenyl)imidazo(2 more ... CTD PMID:24224465 lamotrigine increases glutathionylation EXP 6480464 CYP3A4 protein results in increased glutathionylation of lamotrigine CTD PMID:19961160 lansoprazole increases expression EXP 6480464 Lansoprazole results in increased expression of CYP3A4 mRNA and Lansoprazole results in increased expression of CYP3A4 protein CTD PMID:10859152 and PMID:9744552 lansoprazole increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Lansoprazole CTD PMID:11829200 more ... lansoprazole affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Lansoprazole CTD PMID:15010519 lansoprazole increases hydroxylation EXP 6480464 CYP3A4 protein results in increased hydroxylation of Lansoprazole CTD PMID:12975331 and PMID:8627562 lapatinib increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Lapatinib CTD PMID:26958860 more ... lapatinib multiple interactions EXP 6480464 [CYP3A4 protein results in increased metabolism of lapatinib] which results in increased activity of NFE2L2 protein more ... CTD PMID:26958860 laquinimod increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of laquinimod CTD PMID:15764719 laquinimod multiple interactions EXP 6480464 Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of laquinimod] and Troleandomycin inhibits the reaction [CYP3A4 protein results in increased metabolism of laquinimod] CTD PMID:15764719 Lasiocarpine multiple interactions EXP 6480464 [CYP3A4 protein results in increased metabolism of lasiocarpine] which affects the expression of KIF23 mRNA more ... CTD PMID:31103741 and PMID:33884520 Lasiocarpine increases response to substance EXP 6480464 CYP3A4 protein results in increased susceptibility to lasiocarpine CTD PMID:32910235 Lasiocarpine increases metabolic processing ISO Cyp3a2 (Rattus norvegicus) 6480464 CYP3A2 protein results in increased metabolism of lasiocarpine CTD PMID:31103741 Lasiocarpine increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of lasiocarpine CTD PMID:31103741 more ... lead(0) increases expression EXP 6480464 Lead results in increased expression of CYP3A4 mRNA CTD PMID:19921347 lefetamine decreases alkylation EXP 6480464 CYP3A4 protein results in decreased alkylation of lephetamine CTD PMID:26276083 leflunomide multiple interactions EXP 6480464 [leflunomide results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA and CYP3A4 protein results in increased metabolism of and results in decreased susceptibility to leflunomide CTD PMID:25455453 and PMID:25860621 leflunomide increases response to substance EXP 6480464 CYP3A4 protein results in increased susceptibility to leflunomide CTD PMID:21540358 leptomycin B multiple interactions EXP 6480464 [epigallocatechin gallate co-treated with leptomycin B] results in increased expression of CYP3A4 mRNA CTD PMID:25922640 leptomycin B increases expression EXP 6480464 leptomycin B results in increased expression of CYP3A4 mRNA CTD PMID:25922640 letrozole increases oxidation EXP 6480464 CYP3A4 protein results in increased oxidation of letrozole CTD PMID:19845430 Licochalcone A decreases activity EXP 6480464 licochalcone A results in decreased activity of CYP3A4 protein CTD PMID:26100226 lidocaine affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Lidocaine CTD PMID:15447735 lidocaine increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Lidocaine CTD PMID:18846481 lidocaine multiple interactions EXP 6480464 Rifampin promotes the reaction [CYP3A4 protein results in increased metabolism of Lidocaine] CTD PMID:9298257 lidocaine decreases methylation EXP 6480464 CYP3A4 protein results in decreased methylation of Lidocaine CTD PMID:15383492 lidocaine decreases ethylation EXP 6480464 CYP3A4 protein results in decreased ethylation of Lidocaine CTD PMID:15887009 Liensinine increases chemical synthesis EXP 6480464 CYP3A4 protein results in increased chemical synthesis of liensinine CTD PMID:25451576 limonene multiple interactions EXP 6480464 limonene inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] CTD PMID:18385293 limonin decreases activity EXP 6480464 limonin results in decreased activity of CYP3A4 protein CTD PMID:22001672 linoleic acid decreases activity EXP 6480464 Linoleic Acid results in decreased activity of CYP3A4 protein CTD PMID:16978661 linuron multiple interactions EXP 6480464 [Chlorfenvinphos co-treated with ethion co-treated with Linuron] results in increased expression of CYP3A4 mRNA CTD PMID:25028461 lipoic acid multiple interactions EXP 6480464 Thioctic Acid inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 lithocholic acid affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Lithocholic Acid CTD PMID:15708356 lithocholic acid increases hydroxylation EXP 6480464 CYP3A4 protein results in increased hydroxylation of Lithocholic Acid CTD PMID:36473578 lithocholic acid increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Lithocholic Acid results in increased expression of CYP3A2 mRNA CTD PMID:20006981 and PMID:20888898 lithocholic acid multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [CYP3A2 protein results in increased metabolism of Lithocholic Acid] which results in increased chemical synthesis of 3-oxocholan-24-oic acid more ... CTD PMID:18039809 and PMID:34461081 lithocholic acid decreases activity ISO Cyp3a2 (Rattus norvegicus) 6480464 Lithocholic Acid results in decreased activity of CYP3A2 protein CTD PMID:8889968 lithocholic acid increases metabolic processing ISO Cyp3a2 (Rattus norvegicus) 6480464 CYP3A2 protein results in increased metabolism of Lithocholic Acid CTD PMID:18039809 lithocholic acid increases oxidation EXP 6480464 CYP3A4 protein results in increased oxidation of Lithocholic Acid CTD PMID:31102695 lithocholic acid increases expression EXP 6480464 Lithocholic Acid results in increased expression of CYP3A4 mRNA CTD PMID:17965521 more ... lithocholic acid increases activity EXP 6480464 Lithocholic Acid results in increased activity of CYP3A4 protein mutant form CTD PMID:19299527 lithocholic acid multiple interactions EXP 6480464 [CYP3A4 protein results in increased hydroxylation of Lithocholic Acid] which results in increased abundance of hyodeoxycholic acid more ... CTD PMID:15489543 more ... lithocholic acid increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Lithocholic Acid CTD PMID:19487251 loperamide multiple interactions EXP 6480464 [Axitinib results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Loperamide CTD PMID:31299239 lopinavir multiple interactions EXP 6480464 CAT protein inhibits the reaction [Lopinavir results in decreased activity of CYP3A4 protein] CTD PMID:15523003 lopinavir decreases activity EXP 6480464 Lopinavir results in decreased activity of CYP3A4 protein CTD PMID:15523003 loratadine decreases activity EXP 6480464 Loratadine analog results in decreased activity of CYP3A4 protein and Loratadine results in decreased activity of CYP3A4 protein CTD PMID:15482930 lorlatinib multiple interactions EXP 6480464 lorlatinib inhibits the reaction [Rifampin results in increased activity of CYP3A4 protein] CTD PMID:34021354 lovastatin multiple interactions EXP 6480464 [Lovastatin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:17041008 lovastatin increases expression EXP 6480464 Lovastatin results in increased expression of CYP3A4 mRNA CTD PMID:12505310 loxapine increases metabolic processing EXP 6480464 CYP3A4 results in increased metabolism of Loxapine CTD PMID:21826677 luteolin multiple interactions EXP 6480464 Luteolin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam] and Luteolin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam] CTD PMID:18191104 lycopene increases activity EXP 6480464 lycopene results in increased activity of CYP3A4 protein CTD PMID:16632523 madecassoside decreases activity EXP 6480464 madecassoside results in decreased activity of CYP3A4 protein CTD PMID:21349323 malathion affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Malathion CTD PMID:15557345 and PMID:17110060 malathion multiple interactions EXP 6480464 [Malathion co-treated with isomalathion] results in increased expression of CYP3A4 mRNA CTD PMID:24333466 malathion increases expression EXP 6480464 Malathion results in increased expression of CYP3A4 mRNA CTD PMID:22310298 Maleic hydrazide multiple interactions EXP 6480464 [Maleic Hydrazide co-treated with Chlorpropham] results in increased expression of CYP3A4 mRNA CTD PMID:25028461 mancozeb decreases expression EXP 6480464 mancozeb results in decreased expression of CYP3A4 mRNA and mancozeb results in decreased expression of CYP3A4 protein CTD PMID:31096615 mangiferin decreases activity EXP 6480464 mangiferin results in decreased activity of CYP3A4 protein CTD PMID:22815239 Marrubiin increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of marrubiin CTD PMID:34431289 masitinib increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of masitinib CTD PMID:36048877 Meclizine multiple interactions EXP 6480464 [Meclizine results in decreased activity of CYP3A4 protein] which results in decreased chemical synthesis of 6 beta-hydroxytestosterone and [Meclizine results in decreased activity of CYP3A4 protein] which results in decreased hydroxylation of Testosterone CTD PMID:26239802 Meclizine decreases activity EXP 6480464 Meclizine results in decreased activity of CYP3A4 protein CTD PMID:26239802 Meclizine increases expression EXP 6480464 Meclizine results in increased expression of CYP3A4 mRNA CTD PMID:26239802 Medazepam increases expression EXP 6480464 Medazepam results in increased expression of CYP3A4 mRNA CTD PMID:20080160 medroxyprogesterone acetate increases expression EXP 6480464 Medroxyprogesterone Acetate results in increased expression of CYP3A4 mRNA and Medroxyprogesterone Acetate results in increased expression of CYP3A4 protein CTD PMID:15650019 mefenamic acid increases hydroxylation EXP 6480464 CYP3A4 protein results in increased hydroxylation of Mefenamic Acid CTD PMID:25372302 mefenamic acid increases glutathionylation EXP 6480464 CYP3A4 protein results in increased glutathionylation of Mefenamic Acid analog CTD PMID:25372302 mefloquine multiple interactions EXP 6480464 Ketoconazole inhibits the reaction [CYP3A4 protein affects the metabolism of Mefloquine] CTD PMID:15896247 MeIQ affects activity EXP 6480464 CYP3A4 affects the activity of 2-amino-3 more ... CTD PMID:8844805 Melarsoprol decreases activity EXP 6480464 Melarsoprol results in decreased activity of CYP3A4 protein CTD PMID:11124226 Mesaconitine multiple interactions EXP 6480464 [Aconitine co-treated with mesaconitine co-treated with hypaconitine] results in increased expression of CYP3A4 mRNA CTD PMID:30303438 Mesaconitine increases expression EXP 6480464 mesaconitine results in increased expression of CYP3A4 mRNA CTD PMID:30303438 metazachlor increases expression EXP 6480464 metazachlor results in increased expression of CYP3A4 mRNA CTD PMID:31465819 metformin increases expression EXP 6480464 Metformin results in increased expression of CYP3A4 mRNA CTD PMID:19022234 metformin decreases expression EXP 6480464 Metformin results in decreased expression of CYP3A4 mRNA CTD PMID:21920351 metformin multiple interactions EXP 6480464 Metformin inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA] and Metformin inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein] CTD PMID:21920351 methadone increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Methadone CTD PMID:16595712 methadone affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Methadone CTD PMID:15986265 methamphetamine affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Methamphetamine metabolite CTD PMID:16038959 methamphetamine multiple interactions EXP 6480464 [Methamphetamine binds to CYP3A4 promoter] which results in increased expression of CYP3A4 mRNA CTD PMID:12851153 methidathion multiple interactions EXP 6480464 [enilconazole co-treated with methidathion] results in increased expression of CYP3A4 mRNA CTD PMID:25028461 methotrexate decreases expression EXP 6480464 Methotrexate results in decreased expression of CYP3A4 mRNA CTD PMID:16837568 methotrexate increases expression EXP 6480464 Methotrexate results in increased expression of CYP3A4 mRNA CTD PMID:29027214 methoxsalen multiple interactions EXP 6480464 Dichlororibofuranosylbenzimidazole inhibits the reaction [Methoxsalen results in increased expression of CYP3A4 mRNA] and NR1I2 protein promotes the reaction [Methoxsalen results in increased expression of CYP3A4 mRNA] CTD PMID:17003103 methoxsalen decreases activity ISO Cyp3a2 (Rattus norvegicus) 6480464 Methoxsalen results in decreased activity of CYP3A2 protein CTD PMID:15879494 methoxsalen decreases activity EXP 6480464 Methoxsalen results in decreased activity of CYP3A4 protein CTD PMID:18420780 methoxsalen increases expression EXP 6480464 Methoxsalen results in increased expression of CYP3A4 mRNA and Methoxsalen results in increased expression of CYP3A4 protein CTD PMID:17003103 methoxychlor increases expression EXP 6480464 Methoxychlor results in increased expression of CYP3A4 mRNA and Methoxychlor results in increased expression of CYP3A4 protein CTD PMID:15466163 more ... methoxychlor decreases methylation ISO Cyp3a2 (Rattus norvegicus) 6480464 CYP3A4 protein results in decreased methylation of Methoxychlor CTD PMID:12433799 methoxychlor increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Methoxychlor results in increased expression of CYP3A2 protein CTD PMID:12919727 methoxychlor increases activity EXP 6480464 Methoxychlor results in increased activity of CYP3A4 protein CTD PMID:24832206 methoxychlor multiple interactions EXP 6480464 [Endosulfan co-treated with Methoxychlor] results in increased activity of CYP3A4 protein more ... CTD PMID:24832206 methoxychlor decreases activity EXP 6480464 Methoxychlor results in decreased activity of CYP3A4 protein CTD PMID:18420780 methoxyflurane increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Methoxyflurane CTD PMID:7879937 metolachlor increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of metolachlor CTD PMID:11133395 metolachlor increases expression EXP 6480464 metolachlor results in increased expression of CYP3A4 mRNA CTD PMID:16565514 metolazone multiple interactions EXP 6480464 [Metolazone results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:25455453 metoprolol multiple interactions EXP 6480464 Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Metoprolol] CTD PMID:30087611 metoprolol increases hydroxylation EXP 6480464 CYP3A4 protein results in increased hydroxylation of Metoprolol CTD PMID:30087611 metronidazole multiple interactions EXP 6480464 Metronidazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Amiodarone] more ... CTD PMID:15855244 more ... metronidazole multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in decreased expression of CYP3A2 mRNA CTD PMID:30545405 metyrapone multiple interactions EXP 6480464 [Metyrapone results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:17041008 metyrapone increases expression EXP 6480464 Metyrapone results in increased expression of CYP3A4 mRNA CTD PMID:10219967 and PMID:12505310 mevastatin increases expression EXP 6480464 mevastatin results in increased expression of CYP3A4 mRNA CTD PMID:12235278 and PMID:15466163 mevastatin multiple interactions EXP 6480464 [mevastatin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA and NR1I2 protein promotes the reaction [mevastatin results in increased expression of CYP3A4 mRNA] CTD PMID:12235278 and PMID:17041008 Mibefradil decreases activity EXP 6480464 Mibefradil results in decreased activity of CYP3A4 protein CTD PMID:15860655 miconazole decreases activity EXP 6480464 Miconazole results in decreased activity of CYP3A4 protein CTD PMID:15135088 and PMID:15969931 miconazole increases expression EXP 6480464 Miconazole results in increased expression of CYP3A4 mRNA CTD PMID:17998298 miconazole multiple interactions EXP 6480464 Miconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] and Miconazole promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA] CTD PMID:17998298 and PMID:19299527 midazolam increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Midazolam CTD PMID:12401345 more ... midazolam affects metabolic processing ISO Cyp3a2 (Rattus norvegicus) 6480464 CYP3A4 protein affects the metabolism of Midazolam CTD PMID:15801540 midazolam multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 shikonin inhibits the reaction [CYP3A2 protein results in increased hydroxylation of Midazolam] CTD PMID:28941798 midazolam increases hydroxylation ISO Cyp3a2 (Rattus norvegicus) 6480464 CYP3A2 protein results in increased hydroxylation of Midazolam CTD PMID:11911841 and PMID:28941798 midazolam increases glucuronidation EXP 6480464 CYP3A4 protein results in increased glucuronidation of Midazolam CTD PMID:27485346 midazolam multiple interactions EXP 6480464 [3-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam more ... CTD PMID:10997946 more ... midazolam increases hydroxylation EXP 6480464 CYP3A4 protein results in increased hydroxylation of Midazolam CTD PMID:12433797 more ... midazolam increases expression EXP 6480464 Midazolam results in increased expression of CYP3A4 mRNA CTD PMID:20080160 midazolam increases oxidation EXP 6480464 CYP3A4 protein results in increased oxidation of Midazolam CTD PMID:21053930 midazolam affects metabolic processing EXP 6480464 CYP3A4 gene polymorphism affects the metabolism of Midazolam and CYP3A4 protein affects the metabolism of Midazolam CTD PMID:15286053 more ... midazolam decreases abundance EXP 6480464 CYP3A4 protein results in decreased abundance of Midazolam CTD PMID:12695342 mifepristone multiple interactions EXP 6480464 [Mifepristone results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA more ... CTD PMID:10219967 more ... mifepristone increases expression EXP 6480464 Mifepristone results in increased expression of CYP3A4 mRNA CTD PMID:12235278 more ... mifepristone decreases activity EXP 6480464 Mifepristone results in decreased activity of CYP3A4 protein CTD PMID:15860655 more ... Mitotane increases activity EXP 6480464 Mitotane results in increased activity of CYP3A4 protein CTD PMID:23179081 Mitotane multiple interactions EXP 6480464 [Mitotane results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA more ... CTD PMID:23179081 and PMID:31312845 Mitotane increases expression EXP 6480464 Mitotane results in increased expression of CYP3A4 mRNA CTD PMID:23179081 and PMID:31312845 Mitragynine increases expression EXP 6480464 mitragynine results in increased expression of CYP3A4 mRNA and mitragynine results in increased expression of CYP3A4 protein CTD PMID:23274770 Mitragynine increases activity EXP 6480464 mitragynine results in increased activity of CYP3A4 protein CTD PMID:23274770 mono(2-ethyl-5-hydroxyhexyl) phthalate multiple interactions EXP 6480464 [CYP3A4 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-hydroxyhexyl) phthalate CTD PMID:23545481 mono(2-ethyl-5-hydroxyhexyl) phthalate multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [CYP3A2 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-hydroxyhexyl) phthalate CTD PMID:23545481 mono(2-ethyl-5-oxohexyl) phthalate multiple interactions EXP 6480464 [CYP3A4 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-oxohexyl)phthalate CTD PMID:23545481 mono(2-ethyl-5-oxohexyl) phthalate multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [CYP3A2 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-oxohexyl)phthalate CTD PMID:23545481 mono(2-ethylhexyl) phthalate multiple interactions EXP 6480464 [CYP3A4 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-hydroxyhexyl) phthalate more ... CTD PMID:18332045 more ... mono(2-ethylhexyl) phthalate multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [CYP3A2 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of mono(2-ethyl-5-hydroxyhexyl) phthalate more ... CTD PMID:22186153 and PMID:23545481 mono(2-ethylhexyl) phthalate increases metabolic processing ISO Cyp3a2 (Rattus norvegicus) 6480464 CYP3A2 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate CTD PMID:22186153 and PMID:23545481 mono(2-ethylhexyl) phthalate increases expression EXP 6480464 mono-(2-ethylhexyl)phthalate results in increased expression of CYP3A4 mRNA CTD PMID:27551952 mono(2-ethylhexyl) phthalate increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate CTD PMID:22186153 and PMID:23545481 mono-isopropyl-disopyramide increases chemical synthesis EXP 6480464 CYP3A4 protein results in increased chemical synthesis of 4-(isopropylamino)-2-(2-pyridyl)-2-phenylbutyramide CTD PMID:10901704 monobenzone multiple interactions EXP 6480464 [monobenzone results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:25455453 monocrotaline multiple interactions EXP 6480464 [CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of BRCA2 mRNA more ... CTD PMID:19818743 more ... monocrotaline increases response to substance EXP 6480464 CYP3A4 protein results in increased susceptibility to Monocrotaline CTD PMID:32910235 monocrotaline increases expression EXP 6480464 Monocrotaline results in increased expression of CYP3A4 mRNA CTD PMID:32682830 monocrotaline increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Monocrotaline CTD PMID:33884520 monocrotophos increases activity EXP 6480464 Monocrotophos results in increased activity of CYP3A4 protein CTD PMID:22733800 monocrotophos increases expression EXP 6480464 Monocrotophos results in increased expression of CYP3A4 mRNA and Monocrotophos results in increased expression of CYP3A4 protein CTD PMID:22733800 monocrotophos multiple interactions EXP 6480464 [Monocrotophos co-treated with Cimetidine] results in increased expression of CYP3A4 protein more ... CTD PMID:22733800 monoethylglycinexylidide affects chemical synthesis EXP 6480464 CYP3A4 protein affects the chemical synthesis of monoethylglycinexylidide CTD PMID:15887009 monosodium L-glutamate multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 GH1 protein inhibits the reaction [Sodium Glutamate results in decreased expression of and results in decreased activity of CYP3A2 protein] and Sodium Glutamate results in decreased expression of and results in decreased activity of CYP3A2 protein CTD PMID:7476908 moricizine increases expression EXP 6480464 Moricizine results in increased expression of CYP3A4 mRNA CTD PMID:18332078 Muscone increases activity EXP 6480464 muscone results in increased activity of CYP3A4 protein CTD PMID:22178124 Muscone multiple interactions EXP 6480464 muscone promotes the reaction [CYP3A4 protein results in increased metabolism of Midazolam] CTD PMID:22178124 musk xylene increases activity ISO Cyp3a2 (Rattus norvegicus) 6480464 musk xylene results in increased activity of CYP3A2 protein CTD PMID:10630706 musk xylene increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 musk xylene results in increased expression of CYP3A2 protein CTD PMID:10630706 mycophenolic acid increases methylation EXP 6480464 CYP3A4 protein results in increased methylation of Mycophenolic Acid CTD PMID:15570183 mycophenolic acid multiple interactions EXP 6480464 [Mycophenolic Acid results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:25455453 myricetin decreases activity EXP 6480464 myricetin results in decreased activity of CYP3A4 protein CTD PMID:29753067 myristicin affects oxidation EXP 6480464 CYP3A4 protein affects the oxidation of myristicin CTD PMID:12523956 N'-Nitrosoanabasine multiple interactions EXP 6480464 CYP3A4 protein affects the metabolism of and results in increased activity of N'-nitrosoanabasine CTD PMID:11774366 N,N-Didesmethyltamoxifen increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of N and N-didesmethyltamoxifen CTD PMID:29285606 N,N-Didesmethyltamoxifen multiple interactions EXP 6480464 [CYP3A4 protein results in increased metabolism of N more ... CTD PMID:29285606 N,N-diethyl-m-toluamide increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of DEET CTD PMID:11854147 N,N-diethyl-m-toluamide increases expression EXP 6480464 DEET results in increased expression of CYP3A4 mRNA CTD PMID:19326769 more ... N,N-diethyl-m-toluamide multiple interactions EXP 6480464 [fipronil co-treated with DEET] results in increased expression of CYP3A4 mRNA CTD PMID:27091632 N-(2,6-diethylphenyl)-2-chloroacetamide multiple interactions EXP 6480464 [CYP3A4 protein results in increased metabolism of alachlor] which results in increased abundance of 2-chloro-N-(2 and 6-diethylphenyl)acetamide CTD PMID:18273908 N-(2,6-diethylphenyl)-2-chloroacetamide increases chemical synthesis EXP 6480464 CYP3A4 protein results in increased chemical synthesis of 2-chloro-N-(2 and 6-diethylphenyl)acetamide CTD PMID:10475613 N-(2,6-diethylphenyl)-2-chloroacetamide increases abundance EXP 6480464 CYP3A4 protein results in increased abundance of 2-chloro-N-(2 and 6-diethylphenyl)acetamide CTD PMID:18273908 N-acetyl-1,4-benzoquinone imine increases abundance EXP 6480464 CYP3A4 protein results in increased abundance of N-acetyl-4-benzoquinoneimine CTD PMID:24661219 N-acetyl-L-cysteine multiple interactions EXP 6480464 [CYP3A4 protein co-treated with Acetylcysteine] results in increased metabolism of Emodin metabolite and Acetylcysteine inhibits the reaction [[CYP3A4 protein co-treated with neferine] results in decreased abundance of Glutathione] CTD PMID:25451576 and PMID:27989148 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions EXP 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [6-(4-chlorophenyl)imidazo(2 more ... CTD PMID:24224465 N-desethylamiodarone increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of desethylamiodarone CTD PMID:22785256 N-desethylamiodarone multiple interactions EXP 6480464 [desethylamiodarone co-treated with CYP3A4 protein] results in increased expression of CXCL8 mRNA more ... CTD PMID:22785256 N-desethylamiodarone increases chemical synthesis EXP 6480464 CYP3A4 protein results in increased chemical synthesis of desethylamiodarone CTD PMID:8445979 N-desmethylclozapine increases chemical synthesis EXP 6480464 CYP3A4 protein results in increased chemical synthesis of norclozapine CTD PMID:18809730 N-desmethylclozapine multiple interactions EXP 6480464 Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of norclozapine] CTD PMID:18809730 N-Desmethyltamoxifen multiple interactions EXP 6480464 [CYP3A4 protein results in increased metabolism of N-desmethyltamoxifen] which results in increased abundance of 1-(4-hydroxyphenyl)-1 more ... CTD PMID:14652237 and PMID:29285606 N-Desmethyltamoxifen increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of N-desmethyltamoxifen CTD PMID:29285606 N-Desmethyltamoxifen decreases activity EXP 6480464 N-desmethyltamoxifen results in decreased activity of CYP3A4 protein CTD PMID:12419016 N-Nitrosodi-n-propylamine affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of N-nitroso(di-n-propyl)amine CTD PMID:10910959 N-Nitrosodi-n-propylamine decreases nitrosation EXP 6480464 CYP3A4 protein results in decreased nitrosation of N-nitroso(di-n-propyl)amine CTD PMID:10910959 N-nitrosodiethylamine multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [DDT co-treated with Diethylnitrosamine] results in decreased expression of CYP3A2 mRNA more ... CTD PMID:11165752 more ... NADP zwitterion multiple interactions EXP 6480464 [2 more ... CTD PMID:16153789 more ... NADP zwitterion multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [CYP3A2 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1 more ... CTD PMID:20825217 NADP(+) multiple interactions EXP 6480464 [2 more ... CTD PMID:16153789 more ... NADP(+) multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [CYP3A2 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1 more ... CTD PMID:20825217 nafcillin increases expression EXP 6480464 Nafcillin results in increased expression of CYP3A4 mRNA and Nafcillin results in increased expression of CYP3A4 protein CTD PMID:18505790 naphthalene increases expression EXP 6480464 naphthalene results in increased expression of CYP3A4 mRNA CTD PMID:20500019 naringin multiple interactions EXP 6480464 naringin inhibits the reaction [CYP3A4 protein affects the metabolism of Verapamil] CTD PMID:16013069 naringin decreases activity EXP 6480464 naringin results in decreased activity of CYP3A4 protein CTD PMID:16013069 and PMID:21053930 nefazodone increases response to substance EXP 6480464 CYP3A4 protein results in increased susceptibility to nefazodone CTD PMID:21540358 nefazodone decreases expression EXP 6480464 nefazodone results in decreased expression of CYP3A4 mRNA CTD PMID:32152650 nefazodone increases hydroxylation EXP 6480464 CYP3A4 protein results in increased hydroxylation of nefazodone CTD PMID:27485346 nefazodone multiple interactions EXP 6480464 [CYP3A4 protein results in increased hydroxylation of nefazodone] which results in increased abundance of hydroxynefazodone more ... CTD PMID:12584149 more ... Neferine multiple interactions EXP 6480464 [CYP3A4 protein co-treated with neferine] results in decreased abundance of Glutathione more ... CTD PMID:25451576 Neferine increases glutathionylation EXP 6480464 CYP3A4 protein results in increased glutathionylation of neferine metabolite CTD PMID:25451576 nelfinavir decreases activity EXP 6480464 Nelfinavir results in decreased activity of CYP3A4 protein CTD PMID:15523003 nemorubicin multiple interactions EXP 6480464 [CYP3A4 protein co-treated with POR protein] results in increased metabolism of methoxy-morpholinyl-doxorubicin CTD PMID:15465924 nemorubicin increases metabolic processing ISO Cyp3a2 (Rattus norvegicus) 6480464 CYP3A2 protein results in increased metabolism of methoxy-morpholinyl-doxorubicin CTD PMID:15465924 nemorubicin increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of methoxy-morpholinyl-doxorubicin CTD PMID:15465924 neobavaisoflavone increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 neobavaisoflavone results in increased expression of CYP3A4 mRNA CTD PMID:31870919 neomycin multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in decreased expression of CYP3A2 mRNA CTD PMID:30545405 nevirapine affects binding EXP 6480464 Nevirapine binds to CYP3A4 protein CTD PMID:22793666 nicardipine decreases activity EXP 6480464 Nicardipine results in decreased activity of CYP3A4 protein CTD PMID:10805063 more ... nicardipine affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Nicardipine CTD PMID:15863898 nicardipine multiple interactions EXP 6480464 [Nicardipine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA and Nicardipine inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Triazolam] CTD PMID:15863898 and PMID:17041008 nickel atom decreases expression EXP 6480464 Nickel results in decreased expression of CYP3A4 mRNA CTD PMID:24768652 niclosamide decreases activity EXP 6480464 Niclosamide results in decreased activity of CYP3A4 protein CTD PMID:11124226 nicotinamide multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA] CTD PMID:27919644 nicotine multiple interactions EXP 6480464 [Nicotine binds to CYP3A4 promoter] which results in increased expression of CYP3A4 mRNA CTD PMID:12851153 nicotine multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [Nicotine co-treated with 2 more ... CTD PMID:26463278 nifedipine multiple interactions EXP 6480464 6' more ... CTD PMID:12851153 more ... nifedipine multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [SOD2 co-treated with CYP3A4] affects the susceptibility to Nifedipine and Nifedipine inhibits the reaction [CYP3A2 protein results in increased metabolism of 7-benzyloxyquinoline] CTD PMID:19501153 and PMID:19858067 nifedipine increases hydroxylation EXP 6480464 CYP3A4 protein results in increased hydroxylation of Nifedipine CTD PMID:18846481 nifedipine increases oxidation EXP 6480464 CYP3A4 protein results in increased oxidation of Nifedipine CTD PMID:15618748 more ... nifedipine affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Nifedipine CTD PMID:15286053 more ... nifedipine increases expression EXP 6480464 Nifedipine results in increased expression of CYP3A4 mRNA and Nifedipine results in increased expression of CYP3A4 protein CTD PMID:16837568 more ... nifedipine increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Nifedipine CTD PMID:16712844 and PMID:19230594 nifedipine affects oxidation EXP 6480464 CYP3A4 protein affects the oxidation of Nifedipine CTD PMID:2271712 nimesulide increases glutathionylation EXP 6480464 CYP3A4 protein results in increased glutathionylation of nimesulide CTD PMID:26524229 nimesulide multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 nimesulide inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased activity of and results in decreased expression of CYP3A2 protein] CTD PMID:18079364 nimetazepam multiple interactions EXP 6480464 CYP3A4 protein affects the reaction [nimetazepam results in increased activity of CASP3 protein] more ... CTD PMID:19005028 nitrazepam multiple interactions EXP 6480464 CYP3A4 protein affects the reaction [Nitrazepam results in increased activity of CASP3 protein] more ... CTD PMID:19005028 nitrendipine affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Nitrendipine CTD PMID:15286053 nobiletin increases activity EXP 6480464 nobiletin results in increased activity of CYP3A4 protein CTD PMID:31756459 nobiletin multiple interactions EXP 6480464 [[nobiletin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam and [nobiletin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam CTD PMID:31756459 Norbuprenorphine decreases activity EXP 6480464 norbuprenorphine results in decreased activity of CYP3A4 protein CTD PMID:12756210 Norbuprenorphine affects chemical synthesis EXP 6480464 CYP3A4 protein affects the chemical synthesis of norbuprenorphine CTD PMID:15966752 norcisapride affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of norcisapride CTD PMID:11717173 norcisapride affects chemical synthesis EXP 6480464 CYP3A4 protein affects the chemical synthesis of norcisapride CTD PMID:11717173 norcodeine multiple interactions EXP 6480464 [CYP3A4 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of norcodeine CTD PMID:16595712 nordazepam increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Nordazepam CTD PMID:18846481 Norfluoxetine multiple interactions EXP 6480464 norfluoxetine inhibits the reaction [CYP3A4 protein results in increased oxidation of and results in increased activity of Haloperidol] CTD PMID:12584149 Noroxycodone multiple interactions EXP 6480464 telithromycin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of noroxycodone] CTD PMID:19755414 nortriptyline increases metabolic processing EXP 6480464 Nortriptyline results in increased metabolism of CYP3A4 protein CTD PMID:18359012 notoginsenoside R1 increases expression EXP 6480464 notoginsenoside R1 results in increased expression of CYP3A4 mRNA CTD PMID:25472953 Notopterol increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of notopterol CTD PMID:32198085 Notopterol decreases activity EXP 6480464 notopterol results in decreased activity of CYP3A4 protein CTD PMID:32198085 Notopterol multiple interactions EXP 6480464 [CYP3A4 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol] more ... CTD PMID:32198085 o-anisidine increases oxidation EXP 6480464 CYP3A4 protein results in increased oxidation of 2-anisidine CTD PMID:15828049 o-toluidine increases expression EXP 6480464 2-toluidine results in increased expression of CYP3A4 mRNA and 2-toluidine results in increased expression of CYP3A4 protein CTD PMID:36870411 obeticholic acid decreases activity EXP 6480464 obeticholic acid results in decreased activity of CYP3A4 protein CTD PMID:27939613 obeticholic acid decreases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 obeticholic acid results in decreased expression of CYP3A2 mRNA CTD PMID:35267068 obeticholic acid multiple interactions EXP 6480464 obeticholic acid inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone] and obeticholic acid inhibits the reaction [CYP3A4 protein results in increased metabolism of Testosterone] CTD PMID:27939613 obeticholic acid decreases expression EXP 6480464 obeticholic acid results in decreased expression of CYP3A4 mRNA CTD PMID:27939613 ochratoxin A increases expression EXP 6480464 ochratoxin A results in increased expression of CYP3A4 mRNA and ochratoxin A results in increased expression of CYP3A4 protein CTD PMID:21834667 and PMID:30291945 ochratoxin A decreases expression EXP 6480464 ochratoxin A results in decreased expression of CYP3A4 mRNA CTD PMID:26505656 ochratoxin A multiple interactions EXP 6480464 ochratoxin A inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA] and ochratoxin A inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein] CTD PMID:26341324 ochratoxin A increases response to substance EXP 6480464 CYP3A4 protein results in increased susceptibility to ochratoxin A CTD PMID:21781659 and PMID:8542584 octadecanoic acid decreases expression EXP 6480464 stearic acid results in decreased expression of CYP3A4 mRNA and stearic acid results in decreased expression of CYP3A4 protein CTD PMID:26739624 octadecanoic acid multiple interactions EXP 6480464 INS protein inhibits the reaction [stearic acid results in decreased expression of CYP3A4 mRNA] CTD PMID:26739624 octamethylcyclotetrasiloxane increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 octamethylcyclotetrasiloxane results in increased expression of CYP3A2 protein CTD PMID:15849718 octamethylcyclotetrasiloxane multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 octamethylcyclotetrasiloxane results in increased expression of and results in increased activity of CYP3A2 protein CTD PMID:36100151 ofloxacin multiple interactions EXP 6480464 [Ofloxacin co-treated with Clarithromycin] inhibits the reaction [CYP3A4 protein results in increased metabolism of Theophylline] CTD PMID:11408986 okadaic acid decreases response to substance EXP 6480464 CYP3A4 protein results in decreased susceptibility to Okadaic Acid CTD PMID:24504163 okadaic acid multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 CYP3A2 protein results in increased metabolism of and results in increased hydroxylation of and results in increased susceptibility to Okadaic Acid CTD PMID:26374342 okadaic acid multiple interactions EXP 6480464 CYP3A4 protein results in increased metabolism of and results in increased hydroxylation of and results in decreased susceptibility to Okadaic Acid CTD PMID:26374342 oleanolic acid decreases activity EXP 6480464 Oleanolic Acid results in decreased activity of CYP3A4 protein CTD PMID:15043991 oleanolic acid multiple interactions EXP 6480464 Oleanolic Acid inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam] CTD PMID:15043991 oleic acid decreases expression EXP 6480464 Oleic Acid results in decreased expression of CYP3A4 mRNA and Oleic Acid results in decreased expression of CYP3A4 protein CTD PMID:26739624 and PMID:30611723 oleic acid multiple interactions EXP 6480464 Farnesol analog inhibits the reaction [Oleic Acid results in decreased expression of CYP3A4 mRNA] CTD PMID:30611723 oltipraz decreases activity EXP 6480464 oltipraz metabolite results in decreased activity of CYP3A4 protein and oltipraz results in decreased activity of CYP3A4 protein CTD PMID:10775323 and PMID:19833192 oltipraz affects metabolic processing ISO Cyp3a2 (Rattus norvegicus) 6480464 CYP3A2 protein affects the metabolism of oltipraz CTD PMID:15831204 and PMID:15920769 oltipraz affects activity EXP 6480464 oltipraz affects the activity of CYP3A4 protein CTD PMID:10775323 omeprazole multiple interactions EXP 6480464 [Omeprazole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA more ... CTD PMID:12695340 more ... omeprazole increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Omeprazole CTD PMID:12485723 more ... omeprazole affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Omeprazole CTD PMID:15286053 and PMID:15626586 omeprazole increases expression EXP 6480464 Omeprazole results in increased expression of CYP3A4 mRNA and Omeprazole results in increased expression of CYP3A4 protein CTD PMID:12235278 more ... Omeprazole sulfide increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of omeprazole sulfide CTD PMID:16109480 Ondansetron affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Ondansetron CTD PMID:15286053 organophosphorus compound multiple interactions EXP 6480464 Organophosphorus Compounds inhibits the reaction [CYP3A4 protein results in decreased methylation of and results in increased activity of Imipramine] CTD PMID:15922009 orlistat increases expression EXP 6480464 orlistat results in increased expression of CYP3A4 mRNA and orlistat results in increased expression of CYP3A4 protein CTD PMID:20599501 Oxadiazon increases expression EXP 6480464 oxadiazon results in increased expression of CYP3A4 mRNA CTD PMID:16565514 oxatomide decreases activity EXP 6480464 oxatomide results in decreased activity of CYP3A4 protein CTD PMID:15684493 oxatomide increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of oxatomide CTD PMID:15684493 oxiconazole multiple interactions EXP 6480464 oxiconazole inhibits the reaction [Rifampin promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA]] and oxiconazole promotes the reaction [NR1I2 results in increased expression of CYP3A4 mRNA] CTD PMID:17998298 oxiconazole increases expression EXP 6480464 oxiconazole results in increased expression of CYP3A4 mRNA CTD PMID:17998298 oxycodone multiple interactions EXP 6480464 telithromycin inhibits the reaction [CYP3A4 protein results in decreased methylation of Oxycodone] CTD PMID:19755414 oxycodone multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 Oxycodone inhibits the reaction [CYP3A2 protein results in increased hydroxylation of Testosterone] CTD PMID:20487198 oxycodone decreases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Oxycodone results in decreased expression of CYP3A2 mRNA and Oxycodone results in decreased expression of CYP3A2 protein CTD PMID:20487198 oxycodone affects metabolic processing EXP 6480464 CYP3A4 protein alternative form affects the metabolism of Oxycodone CTD PMID:33393779 p-menthan-3-ol increases expression EXP 6480464 Menthol results in increased expression of CYP3A4 mRNA CTD PMID:24594507 p-toluidine decreases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 4-toluidine results in decreased expression of CYP3A2 mRNA CTD PMID:27638505 paclitaxel multiple interactions EXP 6480464 Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of Paclitaxel] more ... CTD PMID:12237780 more ... paclitaxel multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 Plant Extracts inhibits the reaction [Paclitaxel results in increased expression of CYP3A4 protein] CTD PMID:15918522 paclitaxel increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Paclitaxel results in increased expression of CYP3A4 protein CTD PMID:15918522 paclitaxel increases activity EXP 6480464 Paclitaxel results in increased activity of CYP3A4 protein CTD PMID:12065438 and PMID:18839173 paclitaxel increases expression EXP 6480464 Paclitaxel results in increased expression of CYP3A4 mRNA and Paclitaxel results in increased expression of CYP3A4 protein CTD PMID:15650019 more ... paclitaxel affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Paclitaxel CTD PMID:15901749 paclitaxel increases hydroxylation EXP 6480464 CYP3A4 protein results in increased hydroxylation of Paclitaxel CTD PMID:19695866 paclitaxel decreases activity EXP 6480464 Paclitaxel results in decreased activity of CYP3A4 protein CTD PMID:19909766 paclitaxel increases oxidation EXP 6480464 CYP3A4 protein results in increased oxidation of Paclitaxel CTD PMID:12237780 pantoprazole increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of pantoprazole CTD PMID:8930576 pantoprazole increases expression EXP 6480464 pantoprazole results in increased expression of CYP3A4 protein CTD PMID:9744552 pantoprazole multiple interactions EXP 6480464 pantoprazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] CTD PMID:15258107 paracetamol increases response to substance EXP 6480464 CYP3A4 protein results in increased susceptibility to Acetaminophen CTD PMID:26706816 more ... paracetamol multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [Acetaminophen co-treated with Uranium analog] results in decreased expression of CYP3A2 mRNA and Arsenic inhibits the reaction [Acetaminophen results in increased activity of CYP3A4 protein] CTD PMID:17126469 and PMID:19932728 paracetamol decreases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Acetaminophen results in decreased expression of CYP3A2 mRNA CTD PMID:17126469 more ... paracetamol increases activity ISO Cyp3a2 (Rattus norvegicus) 6480464 Acetaminophen results in increased activity of CYP3A4 protein CTD PMID:19932728 paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of CYP3A4 mRNA and Acetaminophen results in decreased expression of CYP3A4 protein CTD PMID:29067470 and PMID:32112222 paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of CYP3A4 mRNA CTD PMID:26497421 and PMID:30008028 paracetamol increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Acetaminophen and CYP3A4 results in increased metabolism of Acetaminophen CTD PMID:19460945 more ... paracetamol multiple interactions EXP 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen] results in decreased expression of CYP3A4 mRNA more ... CTD PMID:11811955 more ... paraquat multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 betanin inhibits the reaction [Paraquat results in increased expression of CYP3A2 mRNA] CTD PMID:24799198 paraquat increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Paraquat results in increased expression of CYP3A2 mRNA CTD PMID:24799198 parathion affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Parathion CTD PMID:12669189 more ... parathion increases expression EXP 6480464 Parathion results in increased expression of CYP3A4 mRNA and Parathion results in increased expression of CYP3A4 protein CTD PMID:26196221 paricalcitol increases expression EXP 6480464 paricalcitol results in increased expression of CYP3A4 mRNA CTD PMID:11723248 pazopanib increases expression EXP 6480464 pazopanib results in increased expression of CYP3A4 mRNA CTD PMID:29356861 PD 0325901 increases expression EXP 6480464 mirdametinib results in increased expression of CYP3A4 mRNA CTD PMID:24819614 pedalitin decreases activity EXP 6480464 pedalitin results in decreased activity of CYP3A4 protein CTD PMID:29753067 penconazole multiple interactions EXP 6480464 [N-(2 and 3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with pyrimethanil co-treated with Fenitrothion co-treated with triadimefon co-treated with quinoxyfen co-treated with penconazole] results in increased expression of CYP3A4 mRNA CTD PMID:25028461 pentachlorobenzene increases oxidation EXP 6480464 CYP3A4 protein results in increased oxidation of pentachlorobenzene CTD PMID:7747284 pentachlorophenol increases expression EXP 6480464 Pentachlorophenol results in increased expression of CYP3A4 protein CTD PMID:15548381 pentamidine decreases activity EXP 6480464 Pentamidine results in decreased activity of CYP3A4 protein CTD PMID:11124226 perazine decreases methylation EXP 6480464 CYP3A4 protein results in decreased methylation of Perazine CTD PMID:11026737 perfluorobutanesulfonic acid increases expression EXP 6480464 perfluorobutanesulfonic acid results in increased expression of CYP3A4 mRNA CTD PMID:33772556 perfluorodecanoic acid increases expression EXP 6480464 perfluorodecanoic acid results in increased expression of CYP3A4 mRNA CTD PMID:23567314 perfluorodecanoic acid decreases activity EXP 6480464 perfluorodecanoic acid results in decreased activity of CYP3A4 protein CTD PMID:35121066 perfluorododecanoic acid decreases expression EXP 6480464 perfluorododecanoic acid results in decreased expression of CYP3A4 mRNA CTD PMID:23567314 perfluoroheptanoic acid increases expression EXP 6480464 perfluoro-n-heptanoic acid results in increased expression of CYP3A4 mRNA CTD PMID:23567314 perfluorohexanesulfonic acid increases expression EXP 6480464 perfluorohexanesulfonic acid results in increased expression of CYP3A4 mRNA CTD PMID:23567314 perfluorohexanesulfonic acid decreases activity EXP 6480464 perfluorohexanesulfonic acid results in decreased activity of CYP3A4 protein CTD PMID:35121066 perfluorononanoic acid increases expression EXP 6480464 perfluoro-n-nonanoic acid results in increased expression of CYP3A4 mRNA CTD PMID:32588087 perfluorooctane-1-sulfonic acid multiple interactions EXP 6480464 perfluorooctane sulfonic acid inhibits the reaction [CYP3A4 protein results in increased oxidation of Testosterone] CTD PMID:21964418 perfluorooctane-1-sulfonic acid increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 perfluorooctane sulfonic acid results in increased expression of CYP3A2 mRNA CTD PMID:16221955 more ... perfluorooctane-1-sulfonic acid increases expression EXP 6480464 perfluorooctane sulfonic acid results in increased expression of CYP3A4 mRNA CTD PMID:21723365 more ... perfluorooctane-1-sulfonic acid decreases activity EXP 6480464 perfluorooctane sulfonic acid results in decreased activity of CYP3A4 protein CTD PMID:31809754 and PMID:35121066 perfluorooctane-1-sulfonic acid decreases expression EXP 6480464 perfluorooctane sulfonic acid results in decreased expression of CYP3A4 mRNA CTD PMID:31809754 perfluorooctanoic acid increases expression EXP 6480464 perfluorooctanoic acid results in increased expression of CYP3A4 mRNA CTD PMID:23567314 more ... perfluorooctanoic acid increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 perfluorooctanoic acid results in increased expression of CYP3A2 mRNA and perfluorooctanoic acid results in increased expression of CYP3A2 protein CTD PMID:28511854 and PMID:34958885 perfluorooctanoic acid decreases activity EXP 6480464 perfluorooctanoic acid results in decreased activity of CYP3A4 protein CTD PMID:31809754 and PMID:35121066 perfluorooctanoic acid decreases expression EXP 6480464 perfluorooctanoic acid results in decreased expression of CYP3A4 mRNA CTD PMID:31809754 perhexiline multiple interactions EXP 6480464 CYP3A4 protein results in increased hydroxylation of [perhexiline maleate results in increased abundance of Perhexiline] and CYP3A4 protein results in increased metabolism of [perhexiline maleate results in increased abundance of Perhexiline] CTD PMID:36083301 permethrin multiple interactions EXP 6480464 [Permethrin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA more ... CTD PMID:16790556 and PMID:31312845 permethrin increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Permethrin CTD PMID:24548679 permethrin decreases activity EXP 6480464 Permethrin results in decreased activity of CYP3A4 protein CTD PMID:16790556 and PMID:21924250 permethrin increases expression EXP 6480464 Permethrin results in increased expression of CYP3A4 mRNA CTD PMID:19249324 and PMID:19326768 phenacetin affects metabolic processing ISO Cyp3a2 (Rattus norvegicus) 6480464 CYP3A2 protein affects the metabolism of Phenacetin CTD PMID:15879494 phencyclidine affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Phencyclidine CTD PMID:16782764 Phenelzine decreases activity EXP 6480464 Phenelzine results in decreased activity of CYP3A4 protein CTD PMID:15304522 phenethyl isothiocyanate decreases expression EXP 6480464 phenethyl isothiocyanate results in decreased expression of CYP3A4 mRNA CTD PMID:20442190 phenethyl isothiocyanate increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 phenethyl isothiocyanate results in increased expression of CYP3A4 protein CTD PMID:20025923 phenethyl isothiocyanate decreases activity ISO Cyp3a2 (Rattus norvegicus) 6480464 phenethyl isothiocyanate results in decreased activity of CYP3A2 protein CTD PMID:22664424 phenethyl isothiocyanate decreases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 phenethyl isothiocyanate results in decreased expression of CYP3A2 mRNA CTD PMID:22664424 phenethyl isothiocyanate decreases activity EXP 6480464 phenethyl isothiocyanate results in decreased activity of CYP3A4 mRNA CTD PMID:20442190 phenobarbital multiple interactions EXP 6480464 [Celsior co-treated with Phenobarbital] results in increased expression of CYP3A4 mRNA more ... CTD PMID:10219967 more ... phenobarbital multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [Dehydroepiandrosterone Sulfate co-treated with Phenobarbital] results in increased expression of CYP3A2 protein more ... CTD PMID:11181506 more ... phenobarbital decreases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Phenobarbital results in decreased expression of CYP3A2 CTD PMID:15975961 phenobarbital increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Phenobarbital results in increased expression of CYP3A2 mRNA and Phenobarbital results in increased expression of CYP3A2 protein CTD PMID:10506011 more ... phenobarbital increases activity EXP 6480464 Phenobarbital results in increased activity of CYP3A4 mRNA and Phenobarbital results in increased activity of CYP3A4 protein CTD PMID:12065438 more ... phenobarbital affects expression EXP 6480464 Phenobarbital affects the expression of CYP3A4 mRNA CTD PMID:19159669 phenobarbital decreases activity EXP 6480464 Phenobarbital results in decreased activity of CYP3A4 protein CTD PMID:19909766 phenobarbital increases expression EXP 6480464 Phenobarbital results in increased expression of CYP3A4 more ... CTD PMID:10219967 more ... Phenoxybenzamine multiple interactions EXP 6480464 [Phenoxybenzamine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:31312845 phenoxymethylpenicillin increases expression EXP 6480464 Penicillin V results in increased expression of CYP3A4 mRNA and Penicillin V results in increased expression of CYP3A4 protein CTD PMID:18505790 phenthoate increases expression EXP 6480464 phenthoate results in increased expression of CYP3A4 mRNA CTD PMID:22310298 phenthoate decreases activity EXP 6480464 phenthoate results in decreased activity of CYP3A4 protein CTD PMID:20183062 phenthoate increases activity EXP 6480464 phenthoate results in increased activity of CYP3A4 protein CTD PMID:22310298 phenylbutazone multiple interactions EXP 6480464 NR3C1 protein promotes the reaction [Phenylbutazone results in increased expression of CYP3A4 mRNA] CTD PMID:10219967 phenylbutazone increases activity EXP 6480464 Phenylbutazone results in increased activity of CYP3A4 protein CTD PMID:9512926 phenylbutazone increases expression EXP 6480464 Phenylbutazone results in increased expression of CYP3A4 mRNA CTD PMID:10219967 phenytoin multiple interactions EXP 6480464 [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Phenytoin more ... CTD PMID:10219967 more ... phenytoin increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Phenytoin results in increased expression of CYP3A2 mRNA and Phenytoin results in increased expression of CYP3A2 protein CTD PMID:17505019 and PMID:19226368 phenytoin multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 Ketoconazole inhibits the reaction [Phenytoin results in increased expression of CYP3A2 protein] CTD PMID:19226368 phenytoin increases activity EXP 6480464 Phenytoin results in increased activity of CYP3A4 protein CTD PMID:12065438 more ... phenytoin increases expression EXP 6480464 Phenytoin results in increased expression of CYP3A4 mRNA and Phenytoin results in increased expression of CYP3A4 protein CTD PMID:10219967 more ... PhIP increases expression EXP 6480464 2-amino-1-methyl-6-phenylimidazo(4 and 5-b)pyridine results in increased expression of CYP3A4 mRNA CTD PMID:29549414 and PMID:31542801 PhIP multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 CYP3A4 protein results in increased metabolism of and results in increased activity of 2-amino-1-methyl-6-phenylimidazo(4 and 5-b)pyridine CTD PMID:1913651 phosalone multiple interactions EXP 6480464 [Omite co-treated with Diphenylamine co-treated with phosalone co-treated with Captan co-treated with N-dichlorofluoromethylthio-N' and N'-dimethyl-N-p-tolylsulfamide] results in increased expression of CYP3A4 mRNA CTD PMID:25028461 phthalic acid increases expression EXP 6480464 phthalic acid results in increased expression of CYP3A4 mRNA and phthalic acid results in increased expression of CYP3A4 protein CTD PMID:15650019 phthalic acid multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [CYP3A2 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of phthalic acid CTD PMID:22186153 and PMID:23545481 phthalic acid multiple interactions EXP 6480464 [CYP3A4 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of phthalic acid CTD PMID:22186153 and PMID:23545481 physcion increases hydroxylation EXP 6480464 CYP3A4 protein results in increased hydroxylation of physcione CTD PMID:29667811 pimecrolimus increases expression EXP 6480464 pimecrolimus results in increased expression of CYP3A4 mRNA CTD PMID:29356861 pimobendan decreases methylation EXP 6480464 CYP3A4 protein results in decreased methylation of pimobendan CTD PMID:10611143 pinocembrin affects activity EXP 6480464 pinocembrin affects the activity of CYP3A4 protein CTD PMID:29753067 pioglitazone affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of pioglitazone CTD PMID:15900286 pioglitazone multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 Pioglitazone inhibits the reaction [Endotoxins results in decreased expression of CYP3A2 protein] CTD PMID:15364003 pioglitazone decreases activity EXP 6480464 pioglitazone results in decreased activity of CYP3A4 protein CTD PMID:12642470 and PMID:15860655 pioglitazone increases expression EXP 6480464 Pioglitazone results in increased expression of CYP3A4 mRNA and Pioglitazone results in increased expression of CYP3A4 protein CTD PMID:12642470 more ... pioglitazone multiple interactions EXP 6480464 [pioglitazone results in increased expression of CYP3A4 protein] which results in decreased abundance of Ethinyl Estradiol more ... CTD PMID:12642470 and PMID:22524704 piperine increases expression EXP 6480464 piperine results in increased expression of CYP3A4 mRNA and piperine results in increased expression of CYP3A4 protein CTD PMID:23707768 piperine multiple interactions EXP 6480464 [piperine co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA more ... CTD PMID:23707768 pirinixic acid multiple interactions EXP 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CYP3A4 mRNA CTD PMID:19710929 pirinixic acid increases expression EXP 6480464 pirinixic acid results in increased expression of CYP3A4 mRNA CTD PMID:27551952 PK-11195 increases expression EXP 6480464 PK 11195 results in increased expression of CYP3A4 mRNA CTD PMID:21315811 poly(styrene) decreases activity EXP 6480464 styrofoam analog results in decreased activity of CYP3A4 protein CTD PMID:19909766 poly(styrene) multiple interactions EXP 6480464 styrofoam analog promotes the reaction [Cimetidine results in decreased activity of CYP3A4 protein] CTD PMID:19909766 polymyxin B2 multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 Polymyxin B inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased activity of and results in decreased expression of CYP3A2 protein] CTD PMID:18079364 pomalidomide increases oxidation EXP 6480464 CYP3A4 protein results in increased oxidation of pomalidomide CTD PMID:24350712 posaconazole decreases activity EXP 6480464 posaconazole results in decreased activity of CYP3A4 protein CTD PMID:19346885 potassium bromate decreases expression EXP 6480464 potassium bromate results in decreased expression of CYP3A4 mRNA CTD PMID:30008028 potassium hexacyanoferrate(3-) multiple interactions EXP 6480464 potassium ferricyanide inhibits the reaction [Diltiazem inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]] more ... CTD PMID:22652334 Pramiconazole decreases activity EXP 6480464 pramiconazole results in decreased activity of CYP3A4 protein CTD PMID:15328084 prednisolone increases expression EXP 6480464 Prednisolone results in increased expression of CYP3A4 mRNA CTD PMID:12673034 pregnenolone increases expression EXP 6480464 Pregnenolone results in increased expression of CYP3A4 mRNA and Pregnenolone results in increased expression of CYP3A4 protein CTD PMID:15650019 pregnenolone 16alpha-carbonitrile multiple interactions EXP 6480464 [Pregnenolone Carbonitrile results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA more ... CTD PMID:10219967 more ... pregnenolone 16alpha-carbonitrile increases activity ISO Cyp3a2 (Rattus norvegicus) 6480464 Pregnenolone Carbonitrile results in increased activity of CYP3A2 protein CTD PMID:12458634 and PMID:29366910 pregnenolone 16alpha-carbonitrile increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Pregnenolone Carbonitrile results in increased expression of CYP3A2 mRNA and Pregnenolone Carbonitrile results in increased expression of CYP3A2 protein CTD PMID:15588932 more ... pregnenolone 16alpha-carbonitrile multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [NR1I2 protein co-treated with Pregnenolone Carbonitrile] results in increased expression of CYP3A4 mRNA more ... CTD PMID:15946133 and PMID:25069801 pregnenolone 16alpha-carbonitrile increases expression EXP 6480464 Pregnenolone Carbonitrile results in increased expression of CYP3A4 mRNA and Pregnenolone Carbonitrile results in increased expression of CYP3A4 protein CTD PMID:10219967 more ... Pretilachlor increases expression EXP 6480464 pretilachlor results in increased expression of CYP3A4 mRNA CTD PMID:16565514 primaquine increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Primaquine CTD PMID:19616568 primaquine multiple interactions EXP 6480464 [CYP3A4 protein results in increased expression of HBG2 protein] which affects the susceptibility to Primaquine CTD PMID:19616568 probenecid decreases expression EXP 6480464 Probenecid results in decreased expression of CYP3A4 mRNA CTD PMID:16837568 probenecid multiple interactions EXP 6480464 Probenecid promotes the reaction [CYP3A4 protein affects the chemical synthesis of carbamazepine epoxide] and Probenecid promotes the reaction [CYP3A4 protein affects the metabolism of Carbamazepine] CTD PMID:15915352 prochloraz multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [cyproconazole co-treated with epoxiconazole co-treated with prochloraz] results in increased expression of CYP3A2 mRNA CTD PMID:29038839 prochloraz multiple interactions EXP 6480464 [Amiodarone co-treated with Benzoic Acid co-treated with cyproconazole co-treated with flusilazole co-treated with enilconazole co-treated with prochloraz co-treated with propiconazole co-treated with tebuconazole] results in increased expression of CYP3A4 protein CTD PMID:34273450 prochloraz increases expression EXP 6480464 prochloraz results in increased expression of CYP3A4 protein CTD PMID:33150952 and PMID:34273450 procymidone multiple interactions EXP 6480464 [procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin] results in increased expression of CYP3A4 mRNA CTD PMID:25028461 profenofos increases activity EXP 6480464 profenofos results in increased activity of CYP3A4 protein CTD PMID:22310298 profenofos decreases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 profenofos results in decreased expression of CYP3A2 mRNA and profenofos results in decreased expression of CYP3A2 protein CTD PMID:18828448 profenofos increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of profenofos CTD PMID:23415833 profenofos multiple interactions EXP 6480464 [CYP3A4 protein results in increased metabolism of profenofos] which results in increased abundance of 4-bromo-2-chlorophenol CTD PMID:23415833 profenofos increases expression EXP 6480464 profenofos results in increased expression of CYP3A4 mRNA CTD PMID:22310298 progesterone increases expression EXP 6480464 Progesterone results in increased expression of CYP3A4 mRNA CTD PMID:22837389 progesterone multiple interactions EXP 6480464 Progesterone promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] CTD PMID:19299527 progesterone increases hydroxylation EXP 6480464 CYP3A4 protein results in increased hydroxylation of Progesterone CTD PMID:18957504 proguanil decreases activity EXP 6480464 Proguanil results in decreased activity of CYP3A4 protein CTD PMID:11124226 propargite multiple interactions EXP 6480464 [Omite co-treated with Diphenylamine co-treated with phosalone co-treated with Captan co-treated with N-dichlorofluoromethylthio-N' and N'-dimethyl-N-p-tolylsulfamide] results in increased expression of CYP3A4 mRNA CTD PMID:25028461 propiconazole increases expression EXP 6480464 propiconazole results in increased expression of CYP3A4 mRNA and propiconazole results in increased expression of CYP3A4 protein CTD PMID:30293151 more ... propiconazole increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 propiconazole results in increased expression of CYP3A2 mRNA CTD PMID:15603923 propiconazole decreases activity EXP 6480464 propiconazole results in decreased activity of CYP3A4 protein CTD PMID:29420809 propiconazole multiple interactions EXP 6480464 [Amiodarone co-treated with Benzoic Acid co-treated with cyproconazole co-treated with flusilazole co-treated with enilconazole co-treated with prochloraz co-treated with propiconazole co-treated with tebuconazole] results in increased expression of CYP3A4 protein and [propiconazole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:29420809 and PMID:34273450 propranolol increases oxidation EXP 6480464 CYP3A4 protein results in increased oxidation of Propranolol CTD PMID:19853591 propyzamide increases expression EXP 6480464 pronamide results in increased expression of CYP3A4 mRNA CTD PMID:17293382 psoralidin increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 psoralidin results in increased expression of CYP3A4 mRNA CTD PMID:31870919 pyrantel decreases activity EXP 6480464 Pyrantel results in decreased activity of CYP3A4 protein CTD PMID:11124226 pyrazinecarboxamide multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA more ... CTD PMID:27919644 pyrethrins increases expression EXP 6480464 Pyrethrins results in increased expression of CYP3A4 mRNA CTD PMID:18022748 pyridine multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 cordycepin inhibits the reaction [pyridine results in increased expression of CYP3A2 mRNA] more ... CTD PMID:11181506 pyridine increases activity ISO Cyp3a2 (Rattus norvegicus) 6480464 pyridine results in increased activity of CYP3A2 protein CTD PMID:11181506 pyridine increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 pyridine results in increased expression of CYP3A2 mRNA and pyridine results in increased expression of CYP3A2 protein CTD PMID:11181506 pyrimethanil multiple interactions EXP 6480464 [N-(2 and 3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with pyrimethanil co-treated with Fenitrothion co-treated with triadimefon co-treated with quinoxyfen co-treated with penconazole] results in increased expression of CYP3A4 mRNA CTD PMID:25028461 pyrimidin-2-amine decreases activity EXP 6480464 2-aminopyrimidine analog results in decreased activity of CYP3A4 protein CTD PMID:19317514 pyrrolidines decreases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Pyrrolidines analog results in decreased expression of CYP3A2 mRNA CTD PMID:26365562 quercetin decreases activity EXP 6480464 Quercetin results in decreased activity of CYP3A4 protein CTD PMID:15266218 more ... quercetin increases expression EXP 6480464 Quercetin results in increased expression of CYP3A4 mRNA and Quercetin results in increased expression of CYP3A4 protein CTD PMID:12695340 more ... quercetin multiple interactions EXP 6480464 [Quercetin results in decreased activity of CYP3A4 protein] which results in decreased degradation of vanoxerine more ... CTD PMID:11502731 more ... quetiapine fumarate multiple interactions EXP 6480464 Carbamazepine promotes the reaction [CYP3A4 protein results in increased metabolism of and results in decreased abundance of Quetiapine Fumarate] more ... CTD PMID:16390352 quinacrine increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Quinacrine CTD PMID:16581945 quinidine affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Quinidine CTD PMID:15784650 and PMID:2271712 quinidine multiple interactions EXP 6480464 Quinidine inhibits the reaction [CYP3A4 protein results in increased metabolism of YM 758] and Quinidine inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] CTD PMID:19230594 and PMID:19299527 quinine decreases activity EXP 6480464 Quinine results in decreased activity of CYP3A4 protein CTD PMID:11124226 quinine affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Quinine CTD PMID:12920490 and PMID:15896247 quinoxyfen multiple interactions EXP 6480464 [N-(2 and 3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with pyrimethanil co-treated with Fenitrothion co-treated with triadimefon co-treated with quinoxyfen co-treated with penconazole] results in increased expression of CYP3A4 mRNA CTD PMID:25028461 raloxifene multiple interactions EXP 6480464 Raloxifene Hydrochloride inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] CTD PMID:19299527 raloxifene decreases activity EXP 6480464 Raloxifene Hydrochloride results in decreased activity of CYP3A4 protein CTD PMID:15860655 and PMID:23721565 reactive oxygen species multiple interactions EXP 6480464 CAT protein inhibits the reaction [CYP3A4 protein results in increased abundance of Reactive Oxygen Species] CTD PMID:21566342 reactive oxygen species increases abundance EXP 6480464 CYP3A4 protein results in increased abundance of Reactive Oxygen Species CTD PMID:21566342 regorafenib increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of regorafenib CTD PMID:31293154 regorafenib affects metabolic processing EXP 6480464 CYP3A4 polymorphism affects the metabolism of regorafenib CTD PMID:31293154 reserpic acid multiple interactions EXP 6480464 reserpic acid inhibits the reaction [Calcitriol results in increased expression of CYP3A4 protein] CTD PMID:29782822 reserpine increases expression EXP 6480464 Reserpine results in increased expression of CYP3A4 mRNA and Reserpine results in increased expression of CYP3A4 protein CTD PMID:16837568 and PMID:8632764 reserpine multiple interactions EXP 6480464 [Reserpine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA and Reserpine inhibits the reaction [Calcitriol results in increased expression of CYP3A4 protein] CTD PMID:17041008 and PMID:29782822 resveratrol multiple interactions EXP 6480464 [resveratrol results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA more ... CTD PMID:12569440 more ... resveratrol decreases activity EXP 6480464 resveratrol results in decreased activity of CYP3A4 protein CTD PMID:12569440 and PMID:18420780 resveratrol increases expression EXP 6480464 Resveratrol results in increased expression of CYP3A4 mRNA CTD PMID:17210444 and PMID:29933105 Retrorsine multiple interactions EXP 6480464 [retrorsine co-treated with NADP] results in decreased activity of CYP3A4 protein more ... CTD PMID:19818743 and PMID:24799337 Retrorsine increases response to substance EXP 6480464 CYP3A4 protein results in increased susceptibility to retrorsine CTD PMID:24799337 and PMID:32910235 riddelliine multiple interactions EXP 6480464 [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of ANAPC1 mRNA more ... CTD PMID:33884520 riddelliine increases response to substance EXP 6480464 CYP3A4 protein results in increased susceptibility to riddelliine CTD PMID:32910235 riddelliine decreases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 riddelliine results in decreased expression of CYP3A2 mRNA CTD PMID:18047727 riddelliine increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of riddelliine CTD PMID:33884520 rifabutin multiple interactions EXP 6480464 AADAC mRNA affects the reaction [Rifabutin results in increased expression of CYP3A4 mRNA] CTD PMID:21856291 rifabutin affects activity EXP 6480464 Rifabutin affects the activity of CYP3A4 protein CTD PMID:37285043 rifabutin increases expression EXP 6480464 Rifabutin results in increased expression of CYP3A4 mRNA CTD PMID:16837568 more ... rifampicin multiple interactions EXP 6480464 [[Rifampin results in increased activity of NR1I2 protein] which results in increased activity of CYP3A4 protein] which results in increased metabolism of and results in increased activity of and results in increased susceptibility to Cobicistat more ... CTD PMID:10219967 more ... rifampicin multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA more ... CTD PMID:22159698 and PMID:27919644 rifampicin increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Rifampin results in increased expression of CYP3A2 mRNA and Rifampin results in increased expression of CYP3A4 mRNA CTD PMID:22159698 and PMID:31870919 rifampicin decreases response to substance EXP 6480464 CYP3A4 protein results in decreased susceptibility to Rifampin CTD PMID:12695342 rifampicin increases expression EXP 6480464 Rifampin results in increased expression of CYP3A4 more ... CTD PMID:10219967 more ... rifampicin increases activity EXP 6480464 [Rifampin results in increased activity of NR1I2 protein] which results in increased activity of CYP3A4 protein and Rifampin results in increased activity of CYP3A4 protein CTD PMID:12065438 more ... rifampicin affects activity EXP 6480464 Rifampin affects the activity of CYP3A4 protein CTD PMID:15964336 and PMID:37285043 rifapentine multiple interactions EXP 6480464 AADAC mRNA affects the reaction [rifapentine results in increased expression of CYP3A4 mRNA] CTD PMID:21856291 rifapentine increases expression EXP 6480464 rifapentine results in increased expression of CYP3A4 mRNA CTD PMID:16837568 and PMID:21856291 rifaximin increases expression EXP 6480464 rifaximin results in increased expression of CYP3A4 mRNA CTD PMID:21141967 and PMID:27506419 risperidone affects response to substance EXP 6480464 CYP3A4 gene polymorphism affects the susceptibility to Risperidone and CYP3A4 protein affects the susceptibility to Risperidone CTD PMID:19395426 risperidone multiple interactions EXP 6480464 N-Methyl-3 more ... CTD PMID:21402137 ritonavir increases expression EXP 6480464 Ritonavir results in increased expression of CYP3A4 mRNA CTD PMID:16837568 ritonavir affects binding EXP 6480464 CYP3A4 protein binds to Ritonavir analog CTD PMID:27966929 ritonavir decreases activity EXP 6480464 Ritonavir results in decreased activity of CYP3A4 protein CTD PMID:15523003 more ... ritonavir affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Ritonavir CTD PMID:15286053 rivaroxaban increases hydroxylation EXP 6480464 CYP3A4 protein results in increased hydroxylation of Rivaroxaban CTD PMID:34189909 rivaroxaban multiple interactions EXP 6480464 erdafitinib inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Rivaroxaban] CTD PMID:34189909 romidepsin affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of romidepsin CTD PMID:15635176 rose bengal decreases activity EXP 6480464 Rose Bengal results in decreased activity of CYP3A4 protein CTD PMID:20041016 rubiarbonone C affects activity EXP 6480464 rubiarbonone C affects the activity of CYP3A4 protein CTD PMID:30259074 Rutaevin increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of rutaevin CTD PMID:33305580 Rutaevin decreases activity EXP 6480464 rutaevin results in decreased activity of CYP3A4 protein CTD PMID:33305580 S-(1,2-dichlorovinyl)-L-cysteine increases expression EXP 6480464 S-(1 and 2-dichlorovinyl)cysteine results in increased expression of CYP3A4 mRNA CTD PMID:37544576 S-(1,2-dichlorovinyl)-L-cysteine multiple interactions EXP 6480464 [S-(1 and 2-dichlorovinyl)cysteine co-treated with Colforsin] results in increased expression of CYP3A4 mRNA CTD PMID:37544576 S-allylcysteine increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 S-allylcysteine results in increased expression of CYP3A2 protein CTD PMID:16000231 S-butyl-DL-homocysteine (S,R)-sulfoximine multiple interactions EXP 6480464 [CYP3A4 protein co-treated with Buthionine Sulfoximine] results in decreased abundance of Glutathione more ... CTD PMID:25451576 safrole decreases activity EXP 6480464 Safrole results in decreased activity of CYP3A4 protein CTD PMID:15778010 Salinomycin decreases activity EXP 6480464 salinomycin results in decreased activity of CYP3A4 protein CTD PMID:26282489 Salinomycin decreases expression EXP 6480464 salinomycin results in decreased expression of CYP3A4 mRNA CTD PMID:34806536 Salinomycin increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of salinomycin CTD PMID:26282489 saquinavir multiple interactions EXP 6480464 Glutathione inhibits the reaction [Saquinavir results in decreased activity of CYP3A4 protein] CTD PMID:15523003 saquinavir increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Saquinavir CTD PMID:11824416 saquinavir decreases activity EXP 6480464 Saquinavir results in decreased activity of CYP3A4 protein CTD PMID:15523003 saracatinib increases oxidation EXP 6480464 CYP3A4 protein results in increased oxidation of saracatinib CTD PMID:27769111 satraplatin decreases activity EXP 6480464 satraplatin results in decreased activity of CYP3A4 protein CTD PMID:24882083 secobarbital multiple interactions EXP 6480464 Secobarbital inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] CTD PMID:19299527 selenium atom decreases expression EXP 6480464 Selenium results in decreased expression of CYP3A4 mRNA CTD PMID:19244175 semicarbazide increases activity ISO Cyp3a2 (Rattus norvegicus) 6480464 carbamylhydrazine results in increased activity of CYP3A2 protein CTD PMID:19788891 semicarbazide multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [carbamylhydrazine results in increased activity of CYP3A2 protein] which results in increased abundance of Testosterone metabolite CTD PMID:19788891 senecionine increases expression EXP 6480464 senecionine results in increased expression of CYP3A4 mRNA CTD PMID:26100227 senecionine increases response to substance EXP 6480464 CYP3A4 protein results in increased susceptibility to senecionine CTD PMID:32910235 seneciphylline increases response to substance EXP 6480464 CYP3A4 protein results in increased susceptibility to seneciphylline CTD PMID:32910235 Senkirkine increases expression EXP 6480464 senkirkine results in increased expression of CYP3A4 mRNA CTD PMID:26100227 sertraline multiple interactions EXP 6480464 CYP3A4 protein results in decreased amination of and results in increased metabolism of Sertraline more ... CTD PMID:15547048 and PMID:19299527 sevoflurane increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of sevoflurane CTD PMID:7879937 Shikonin decreases activity ISO Cyp3a2 (Rattus norvegicus) 6480464 shikonin results in decreased activity of CYP3A2 protein CTD PMID:28941798 Shikonin decreases activity EXP 6480464 shikonin results in decreased activity of CYP3A4 protein CTD PMID:28941798 Shikonin multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 shikonin inhibits the reaction [CYP3A2 protein results in increased hydroxylation of Midazolam] CTD PMID:28941798 sibutramine affects response to substance EXP 6480464 CYP3A4 protein affects the susceptibility to sibutramine CTD PMID:27838152 sibutramine affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of sibutramine CTD PMID:27838152 silibinin decreases activity EXP 6480464 Silybin results in decreased activity of CYP3A4 protein CTD PMID:15155549 silibinin multiple interactions EXP 6480464 Silybin inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone] CTD PMID:15155549 silicon dioxide decreases expression EXP 6480464 Silicon Dioxide results in decreased expression of CYP3A4 mRNA CTD PMID:25351596 simvastatin affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Simvastatin CTD PMID:16011971 simvastatin multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 Berberine promotes the reaction [Simvastatin results in decreased activity of CYP3A4 protein] more ... CTD PMID:30086269 simvastatin decreases activity ISO Cyp3a2 (Rattus norvegicus) 6480464 Simvastatin results in decreased activity of CYP3A4 protein CTD PMID:30086269 simvastatin decreases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Simvastatin results in decreased expression of CYP3A4 mRNA and Simvastatin results in decreased expression of CYP3A4 protein CTD PMID:30086269 simvastatin increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Simvastatin CTD PMID:24927617 simvastatin affects response to substance EXP 6480464 CYP3A4 polymorphism affects the susceptibility to Simvastatin CTD PMID:15650881 and PMID:19802823 simvastatin increases expression EXP 6480464 Simvastatin results in increased expression of CYP3A4 mRNA CTD PMID:12505310 simvastatin multiple interactions EXP 6480464 [Simvastatin co-treated with NR1I2 protein] results in increased expression of CYP3A4 mRNA more ... CTD PMID:17041008 more ... sinensetin increases activity EXP 6480464 sinensetin analog results in increased activity of CYP3A4 protein and sinensetin results in increased activity of CYP3A4 protein CTD PMID:31756459 sinensetin multiple interactions EXP 6480464 [[sinensetin analog results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam more ... CTD PMID:31756459 sirolimus affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Sirolimus and CYP3A4 protein polymorphism affects the metabolism of Sirolimus CTD PMID:15707415 and PMID:15964407 skatole decreases expression EXP 6480464 Skatole results in decreased expression of CYP3A4 mRNA CTD PMID:28571685 skatole multiple interactions EXP 6480464 Skatole inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA] and Skatole inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein] CTD PMID:28571685 sodium arsenite multiple interactions EXP 6480464 [Estradiol co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of CYP3A4 mRNA more ... CTD PMID:15833926 more ... sodium arsenite increases activity EXP 6480464 sodium arsenite results in increased activity of CYP3A4 protein CTD PMID:19084030 sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of CYP3A4 mRNA and sodium arsenite results in increased expression of CYP3A4 protein CTD PMID:19084030 sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of CYP3A4 mRNA CTD PMID:15833926 and PMID:29301061 sodium cholate multiple interactions EXP 6480464 [1 more ... CTD PMID:1627548 sodium cholate multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [1 more ... CTD PMID:1627548 sophoraflavanone B decreases activity EXP 6480464 8-prenylnaringenin results in decreased activity of CYP3A4 protein CTD PMID:19770484 sophoranone decreases activity EXP 6480464 sophoranone results in decreased activity of CYP3A4 protein CTD PMID:29753067 spironolactone increases expression EXP 6480464 Spironolactone results in increased expression of CYP3A4 mRNA CTD PMID:12505310 staurosporine multiple interactions EXP 6480464 Staurosporine inhibits the reaction [Calcitriol results in increased expression of CYP3A4 mRNA] CTD PMID:17965521 sterigmatocystin affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Sterigmatocystin CTD PMID:2271712 and PMID:2655891 sterigmatocystin increases glutathionylation EXP 6480464 CYP3A4 protein results in increased glutathionylation of Sterigmatocystin CTD PMID:20929267 sterigmatocystin multiple interactions EXP 6480464 [CYP3A4 protein results in increased glutathionylation of and results in increased hydroxylation of Sterigmatocystin] which results in increased chemical synthesis of Sterigmatocystin metabolite CTD PMID:20929267 steviol multiple interactions EXP 6480464 steviol binds to and results in decreased activity of CYP3A4 protein CTD PMID:28887089 steviol increases expression EXP 6480464 steviol results in increased expression of CYP3A4 mRNA and steviol results in increased expression of CYP3A4 protein CTD PMID:28887089 stevioside increases expression EXP 6480464 stevioside results in increased expression of CYP3A4 mRNA and stevioside results in increased expression of CYP3A4 protein CTD PMID:28887089 stevioside multiple interactions EXP 6480464 stevioside binds to and results in decreased activity of CYP3A4 protein CTD PMID:28887089 styrene increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Styrene results in increased expression of CYP3A2 protein CTD PMID:18202523 styrene multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP3A2 mRNA] and gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP3A2 protein] CTD PMID:18202523 Sudan I increases oxidation EXP 6480464 CYP3A4 protein results in increased oxidation of 1-phenylazo-2-naphthol CTD PMID:17159775 and PMID:19358889 Sudan I multiple interactions EXP 6480464 CYB5A protein promotes the reaction [CYP3A4 protein results in increased oxidation of 1-phenylazo-2-naphthol] CTD PMID:17159775 and PMID:19358889 Sudan III multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A2 protein] more ... CTD PMID:15788368 Sudan III decreases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 sudan III results in decreased expression of CYP3A2 mRNA CTD PMID:15788368 sulconazole increases expression EXP 6480464 sulconazole results in increased expression of CYP3A4 mRNA CTD PMID:31312845 sulconazole multiple interactions EXP 6480464 [sulconazole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:31312845 sulfamethazine increases activity EXP 6480464 Sulfamethazine results in increased activity of CYP3A4 protein CTD PMID:12065438 sulfamethoxazole multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [SOD2 co-treated with CYP3A4] affects the susceptibility to Sulfamethoxazole CTD PMID:19501153 sulfaphenazole multiple interactions EXP 6480464 Sulfaphenazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone] CTD PMID:31102695 sulfinpyrazone increases expression EXP 6480464 Sulfinpyrazone results in increased expression of CYP3A4 mRNA CTD PMID:10219967 more ... sulfinpyrazone increases activity EXP 6480464 Sulfinpyrazone results in increased activity of CYP3A4 protein CTD PMID:12065438 and PMID:9512926 sulfisoxazole multiple interactions EXP 6480464 Sulfisoxazole results in increased expression of and results in increased activity of CYP3A4 protein CTD PMID:18505790 sulfisoxazole increases expression EXP 6480464 Sulfisoxazole results in increased expression of CYP3A4 mRNA CTD PMID:18505790 sulforaphane decreases expression EXP 6480464 sulforaphane results in decreased expression of CYP3A4 mRNA CTD PMID:20442190 and PMID:26775663 sulforaphane increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 sulforaphane results in increased expression of CYP3A2 protein CTD PMID:18823965 sulforaphane decreases activity ISO Cyp3a2 (Rattus norvegicus) 6480464 sulforaphane results in decreased activity of CYP3A2 protein CTD PMID:22664424 sulforaphane multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 sulforaphane results in decreased expression of and results in decreased activity of CYP3A2 protein CTD PMID:15906351 sulforaphane multiple interactions EXP 6480464 sulforaphane inhibits the reaction [ginkgolide B results in increased expression of CYP3A4 mRNA] and sulforaphane inhibits the reaction [Rifampin results in increased expression of CYP3A4] CTD PMID:23153560 and PMID:26775663 sunitinib multiple interactions EXP 6480464 [CYP3A4 protein results in increased metabolism of Sunitinib] which results in increased chemical synthesis of SU 12662 CTD PMID:29847931 sunitinib increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Sunitinib results in increased expression of CYP3A2 mRNA CTD PMID:26797788 sunitinib increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Sunitinib CTD PMID:29847931 tacrine increases response to substance EXP 6480464 CYP3A4 protein results in increased susceptibility to Tacrine CTD PMID:21540358 tacrine increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Tacrine analog results in increased expression of CYP3A2 protein and Tacrine results in increased expression of CYP3A2 protein CTD PMID:20533758 tacrolimus hydrate affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Tacrolimus CTD PMID:15010519 more ... tacrolimus hydrate decreases methylation EXP 6480464 CYP3A4 protein results in decreased methylation of Tacrolimus CTD PMID:15951320 tacrolimus hydrate increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Tacrolimus CTD PMID:15855244 tacrolimus hydrate multiple interactions EXP 6480464 Metronidazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Tacrolimus] CTD PMID:15855244 tamarixetin increases expression EXP 6480464 tamarixetin results in increased expression of CYP3A4 mRNA CTD PMID:26238175 tamoxifen increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Tamoxifen CTD PMID:20507880 and PMID:29285606 tamoxifen increases hydroxylation ISO Cyp3a2 (Rattus norvegicus) 6480464 CYP3A2 protein results in increased hydroxylation of Tamoxifen CTD PMID:15587933 tamoxifen multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 Tamoxifen promotes the reaction [testosterone enanthate results in increased expression of CYP3A2 protein] CTD PMID:8573203 tamoxifen increases activity EXP 6480464 Tamoxifen metabolite results in increased activity of CYP3A4 protein and Tamoxifen results in increased activity of CYP3A4 protein CTD PMID:29285606 tamoxifen increases response to substance EXP 6480464 CYP3A4 protein results in increased susceptibility to Tamoxifen CTD PMID:26718876 tamoxifen increases expression EXP 6480464 Tamoxifen metabolite results in increased expression of CYP3A4 mRNA and Tamoxifen results in increased expression of CYP3A4 mRNA CTD PMID:18839173 and PMID:29285606 tamoxifen decreases activity EXP 6480464 Tamoxifen results in decreased activity of CYP3A4 protein CTD PMID:12419016 tamoxifen multiple interactions EXP 6480464 [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Tamoxifen more ... CTD PMID:14652237 more ... tangeretin multiple interactions EXP 6480464 [[tangeretin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam and [tangeretin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam CTD PMID:31756459 tangeretin increases activity EXP 6480464 tangeretin results in increased activity of CYP3A4 protein CTD PMID:31756459 Tanshinone I multiple interactions EXP 6480464 NR1I2 protein promotes the reaction [tanshinone results in increased expression of CYP3A4 protein] more ... CTD PMID:18805405 Tanshinone I increases expression EXP 6480464 tanshinone results in increased expression of CYP3A4 protein CTD PMID:18805405 tartrazine multiple interactions EXP 6480464 [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Tartrazine] results in decreased expression of CYP3A4 mRNA CTD PMID:33819548 taurochenodeoxycholic acid increases hydroxylation EXP 6480464 CYP3A4 protein results in increased hydroxylation of Taurochenodeoxycholic Acid CTD PMID:36473578 taurocholic acid decreases activity ISO Cyp3a2 (Rattus norvegicus) 6480464 Taurocholic Acid results in decreased activity of CYP3A2 protein CTD PMID:8889968 taurocholic acid multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [CYP3A23-3A1 gene mutant form co-treated with CYP3A2 gene mutant form] results in increased abundance of Taurocholic Acid CTD PMID:34461081 taurodeoxycholic acid increases hydroxylation EXP 6480464 CYP3A4 protein results in increased hydroxylation of Taurodeoxycholic Acid CTD PMID:36473578 taurolithocholic acid increases hydroxylation EXP 6480464 CYP3A4 protein results in increased hydroxylation of Taurolithocholic Acid CTD PMID:36473578 tauroursodeoxycholic acid increases hydroxylation EXP 6480464 CYP3A4 protein results in increased hydroxylation of ursodoxicoltaurine CTD PMID:36473578 tebuconazole multiple interactions EXP 6480464 [Amiodarone co-treated with Benzoic Acid co-treated with cyproconazole co-treated with flusilazole co-treated with enilconazole co-treated with prochloraz co-treated with propiconazole co-treated with tebuconazole] results in increased expression of CYP3A4 protein and [tebuconazole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:29420809 and PMID:34273450 tebuconazole decreases activity EXP 6480464 tebuconazole results in decreased activity of CYP3A4 protein CTD PMID:37422065 tebuconazole increases expression EXP 6480464 tebuconazole results in increased expression of CYP3A4 mRNA CTD PMID:30458266 and PMID:33575850 tebufenozide increases expression EXP 6480464 tebufenozide results in increased expression of CYP3A4 mRNA CTD PMID:22310298 telaprevir multiple interactions EXP 6480464 telaprevir inhibits the reaction [CYP3A4 protein results in increased metabolism of Simvastatin] CTD PMID:24927617 telithromycin multiple interactions EXP 6480464 telithromycin inhibits the reaction [CYP3A4 protein results in decreased methylation of Oxycodone] and telithromycin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of noroxycodone] CTD PMID:19755414 Temazepam multiple interactions EXP 6480464 Temazepam promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] CTD PMID:19299527 teniposide multiple interactions EXP 6480464 Cyclosporine inhibits the reaction [CYP3A4 protein results in decreased methylation of Teniposide] more ... CTD PMID:8114683 teniposide decreases methylation EXP 6480464 CYP3A4 protein results in decreased methylation of Teniposide CTD PMID:8114683 terbinafine increases response to substance EXP 6480464 CYP3A4 protein results in increased susceptibility to terbinafine CTD PMID:21540358 terbinafine increases expression EXP 6480464 Terbinafine results in increased expression of CYP3A4 mRNA CTD PMID:36356836 Terfenadine increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Terfenadine CTD PMID:15869686 Terfenadine increases expression EXP 6480464 Terfenadine analog results in increased expression of CYP3A4 mRNA CTD PMID:12505310 Terfenadine multiple interactions EXP 6480464 Ketoconazole inhibits the reaction [CYP3A4 protein results in increased metabolism of Terfenadine] and Terfenadine promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] CTD PMID:15869686 and PMID:19299527 Terfenadine increases degradation EXP 6480464 CYP3A4 protein results in increased degradation of Terfenadine CTD PMID:15684493 Terfenadine affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Terfenadine CTD PMID:15383492 teriflunomide increases activity EXP 6480464 teriflunomide results in increased activity of CYP3A4 protein CTD PMID:30364229 teriflunomide increases expression EXP 6480464 teriflunomide results in increased expression of CYP3A4 mRNA CTD PMID:30364229 Territrem B affects metabolic processing ISO Cyp3a2 (Rattus norvegicus) 6480464 CYP3A2 protein affects the metabolism of territrem B CTD PMID:15799453 tert-butyl ethyl ether increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 ethyl tert-butyl ether results in increased expression of CYP3A2 protein CTD PMID:24090815 testosterone multiple interactions EXP 6480464 [[CYP3A4 protein co-treated with NADP] results in increased oxidation of Testosterone] which results in increased chemical synthesis of 6 beta-hydroxytestosterone more ... CTD PMID:11377097 more ... testosterone increases metabolic processing ISO Cyp3a2 (Rattus norvegicus) 6480464 CYP3A4 protein results in increased metabolism of Testosterone CTD PMID:31870919 testosterone multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [carbamylhydrazine results in increased activity of CYP3A2 protein] which results in increased abundance of Testosterone metabolite more ... CTD PMID:19788891 more ... testosterone increases hydroxylation ISO Cyp3a2 (Rattus norvegicus) 6480464 CYP3A2 protein results in increased hydroxylation of Testosterone CTD PMID:20487198 testosterone increases hydroxylation EXP 6480464 CYP3A4 protein results in increased hydroxylation of Testosterone CTD PMID:12433797 more ... testosterone increases metabolic processing EXP 6480464 CYP3A4 mRNA results in increased metabolism of Testosterone and CYP3A4 protein results in increased metabolism of Testosterone CTD PMID:12401345 more ... testosterone increases hydrolysis EXP 6480464 CYP3A4 protein results in increased hydrolysis of Testosterone CTD PMID:11377097 and PMID:19299527 testosterone affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Testosterone CTD PMID:12818727 more ... testosterone increases oxidation EXP 6480464 CYP3A4 protein results in increased oxidation of Testosterone CTD PMID:21964418 testosterone affects hydroxylation EXP 6480464 CYP3A4 protein affects the hydroxylation of Testosterone CTD PMID:2271712 testosterone enanthate increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 testosterone enanthate results in increased expression of CYP3A2 protein CTD PMID:8573203 testosterone enanthate multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 Tamoxifen promotes the reaction [testosterone enanthate results in increased expression of CYP3A2 protein] CTD PMID:8573203 tetrachloromethane increases metabolic processing ISO Cyp3a2 (Rattus norvegicus) 6480464 CYP3A2 protein results in increased metabolism of Carbon Tetrachloride CTD PMID:15988118 tetrachloromethane decreases activity ISO Cyp3a2 (Rattus norvegicus) 6480464 Carbon Tetrachloride results in decreased activity of CYP3A2 protein CTD PMID:14706259 tetrachloromethane increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Carbon Tetrachloride results in increased expression of CYP3A2 mRNA CTD PMID:31150632 tetrachloromethane decreases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Carbon Tetrachloride results in decreased expression of CYP3A2 mRNA more ... CTD PMID:10445401 more ... tetracycline multiple interactions EXP 6480464 Tetracycline results in increased expression of and results in increased activity of CYP3A4 protein CTD PMID:18505790 tetracycline decreases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Tetracycline results in decreased expression of CYP3A4 mRNA CTD PMID:19224547 tetracycline increases expression EXP 6480464 Tetracycline results in increased expression of CYP3A4 mRNA CTD PMID:18505790 tetramethrin increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of tetramethrin CTD PMID:19249324 thalidomide multiple interactions EXP 6480464 [CYP3A4 protein results in increased hydroxylation of Thalidomide] which results in increased chemical synthesis of 5-hydroxythalidomide CTD PMID:20443640 thalidomide increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Thalidomide CTD PMID:28745489 thalidomide increases expression EXP 6480464 Thalidomide results in increased expression of CYP3A4 mRNA and Thalidomide results in increased expression of CYP3A4 protein CTD PMID:24460184 and PMID:28496040 thalidomide increases hydroxylation EXP 6480464 CYP3A4 protein results in increased hydroxylation of Thalidomide CTD PMID:20443640 thapsigargin multiple interactions EXP 6480464 NR1I2 protein inhibits the reaction [Thapsigargin inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]] and Thapsigargin inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA] CTD PMID:25616597 theophylline multiple interactions EXP 6480464 [Ofloxacin co-treated with Clarithromycin] inhibits the reaction [CYP3A4 protein results in increased metabolism of Theophylline] CTD PMID:11408986 thiabendazole increases expression EXP 6480464 Thiabendazole results in increased expression of CYP3A4 mRNA CTD PMID:18570159 thiacloprid multiple interactions EXP 6480464 [clothianidin co-treated with thiacloprid] results in increased expression of CYP3A4 protein more ... CTD PMID:32201337 thiacloprid increases expression EXP 6480464 thiacloprid results in increased expression of CYP3A4 mRNA and thiacloprid results in increased expression of CYP3A4 protein CTD PMID:32201337 thiamethoxam multiple interactions EXP 6480464 [NADP co-treated with CYP3A4 protein] results in increased activity of thiamethoxam CTD PMID:16153789 thiamine(1+) chloride multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA] CTD PMID:27919644 thioacetamide decreases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Thioacetamide results in decreased expression of CYP3A2 mRNA CTD PMID:23411599 and PMID:34492290 Thiocoraline affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of thiocoraline CTD PMID:15122071 thioridazine decreases activity EXP 6480464 Thioridazine results in decreased activity of CYP3A4 protein CTD PMID:15135088 thioridazine multiple interactions EXP 6480464 [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Thioridazine CTD PMID:23397584 Thiotepa affects response to substance EXP 6480464 CYP3A4 protein affects the susceptibility to Thiotepa CTD PMID:19076156 Thiotepa affects export EXP 6480464 CYP3A4 gene SNP affects the export of Thiotepa CTD PMID:19076156 thyroxine multiple interactions EXP 6480464 [Thyroxine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:25455453 ticlopidine multiple interactions EXP 6480464 CYP3A4 protein results in increased oxidation of and results in increased cleavage of Ticlopidine metabolite more ... CTD PMID:19170597 more ... ticlopidine increases response to substance EXP 6480464 CYP3A4 protein results in increased susceptibility to Ticlopidine CTD PMID:22651985 ticlopidine increases degradation EXP 6480464 CYP3A4 protein results in increased degradation of Ticlopidine CTD PMID:22651985 tinidazole affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Tinidazole CTD PMID:12920490 tiratricol multiple interactions EXP 6480464 [3 more ... CTD PMID:25455453 tofacitinib increases oxidation EXP 6480464 CYP3A4 protein results in increased oxidation of tofacitinib metabolite CTD PMID:27117606 tofacitinib increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of tofacitinib CTD PMID:31414593 tolcapone increases response to substance EXP 6480464 CYP3A4 protein results in increased susceptibility to tolcapone CTD PMID:21540358 toluene increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Toluene results in increased expression of CYP3A2 mRNA CTD PMID:17209515 toluene multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 1-Butanol promotes the reaction [Toluene results in increased expression of CYP3A2 mRNA] CTD PMID:17209515 tolylfluanid multiple interactions EXP 6480464 [Omite co-treated with Diphenylamine co-treated with phosalone co-treated with Captan co-treated with N-dichlorofluoromethylthio-N' and N'-dimethyl-N-p-tolylsulfamide] results in increased expression of CYP3A4 mRNA CTD PMID:25028461 topiramate increases activity EXP 6480464 topiramate results in increased activity of CYP3A4 protein CTD PMID:14636322 topiramate increases expression EXP 6480464 topiramate results in increased expression of CYP3A4 mRNA and topiramate results in increased expression of CYP3A4 protein CTD PMID:14636322 trabectedin decreases activity ISO Cyp3a2 (Rattus norvegicus) 6480464 Trabectedin results in decreased activity of CYP3A2 protein CTD PMID:12154027 trans-1,2-dichloroethene decreases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 1 and 2-dichloroethylene results in decreased expression of CYP3A2 protein CTD PMID:9493318 trans-1,2-dichloroethene decreases activity ISO Cyp3a2 (Rattus norvegicus) 6480464 1 and 2-dichloroethylene results in decreased activity of CYP3A2 protein CTD PMID:9493318 trans-cinnamic acid decreases activity EXP 6480464 cinnamic acid analog results in decreased activity of CYP3A4 protein CTD PMID:15072549 transfluthrin multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 transfluthrin results in increased expression of and results in increased activity of CYP3A2 protein CTD PMID:22080754 tranylcypromine multiple interactions EXP 6480464 Tranylcypromine affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid] CTD PMID:24120545 trazodone multiple interactions EXP 6480464 Trazodone inhibits the reaction [CYP3A4 protein results in increased oxidation of and results in increased activity of Haloperidol] CTD PMID:12584149 trazodone multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [SOD2 co-treated with CYP3A4] affects the susceptibility to Trazodone CTD PMID:19501153 triadimefon multiple interactions EXP 6480464 [N-(2 and 3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide co-treated with pyrimethanil co-treated with Fenitrothion co-treated with triadimefon co-treated with quinoxyfen co-treated with penconazole] results in increased expression of CYP3A4 mRNA CTD PMID:25028461 triadimefon increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 triadimefon results in increased expression of CYP3A2 mRNA and triadimefon results in increased expression of CYP3A2 protein CTD PMID:17484520 triazolam affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Triazolam CTD PMID:15286053 and PMID:16042670 triazolam multiple interactions EXP 6480464 [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Triazolam more ... CTD PMID:10952769 more ... Tributyl citrate multiple interactions EXP 6480464 tributyl citrate promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA] CTD PMID:21742782 trichloroethene increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Trichloroethylene results in increased expression of CYP3A2 mRNA CTD PMID:33387578 trichostatin A multiple interactions EXP 6480464 trichostatin A affects the reaction [Dimethyl Sulfoxide promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]] and trichostatin A promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA] CTD PMID:31877331 triclosan increases activity EXP 6480464 Triclosan results in increased activity of CYP3A4 protein CTD PMID:23899473 triclosan affects expression EXP 6480464 Triclosan affects the expression of CYP3A4 mRNA CTD PMID:34681664 triclosan increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Triclosan results in increased expression of CYP3A2 mRNA CTD PMID:22659317 triclosan increases expression EXP 6480464 Triclosan results in increased expression of CYP3A4 mRNA CTD PMID:29849464 triflumuron multiple interactions EXP 6480464 Troleandomycin inhibits the reaction [CYP3A4 protein results in increased metabolism of triflumuron] CTD PMID:31082524 triflumuron increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of triflumuron CTD PMID:31082524 trifluridine multiple interactions EXP 6480464 [Trifluridine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:25455453 Triptolide decreases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 triptolide results in decreased expression of CYP3A4 protein CTD PMID:33600922 Triptolide affects metabolic processing ISO Cyp3a2 (Rattus norvegicus) 6480464 CYP3A2 affects the metabolism of triptolide CTD PMID:20223271 Tris(1-aziridinyl)phosphine oxide affects export EXP 6480464 CYP3A4 gene SNP affects the export of Triethylenephosphoramide CTD PMID:19076156 Tris(1-aziridinyl)phosphine oxide affects response to substance EXP 6480464 CYP3A4 protein affects the susceptibility to Triethylenephosphoramide CTD PMID:19076156 Tris(2,3-dibromopropyl) phosphate affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of tris(2 and 3-dibromopropyl)phosphate CTD PMID:2271712 and PMID:2655891 troglitazone increases response to substance EXP 6480464 CYP3A4 protein results in increased susceptibility to troglitazone CTD PMID:26706816 and PMID:28762043 troglitazone multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [SOD2 co-treated with CYP3A4] affects the susceptibility to Troglitazone CTD PMID:19501153 troglitazone increases expression EXP 6480464 Troglitazone results in increased expression of CYP3A4 mRNA and Troglitazone results in increased expression of CYP3A4 protein CTD PMID:10752642 more ... troglitazone decreases activity EXP 6480464 troglitazone results in decreased activity of CYP3A4 protein CTD PMID:12642470 and PMID:15860655 troglitazone increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of troglitazone CTD PMID:19356091 troglitazone increases activity EXP 6480464 troglitazone results in increased activity of CYP3A4 protein CTD PMID:10752642 troglitazone multiple interactions EXP 6480464 [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to troglitazone more ... CTD PMID:12642470 more ... troleandomycin multiple interactions EXP 6480464 [Troleandomycin results in decreased activity of CYP3A4 protein] which results in decreased chemical synthesis of N-desmethyltamoxifen more ... CTD PMID:11752104 more ... troleandomycin increases expression EXP 6480464 Troleandomycin results in increased expression of CYP3A4 mRNA CTD PMID:18505790 troleandomycin increases activity EXP 6480464 Troleandomycin results in increased activity of CYP3A4 protein CTD PMID:9512926 troleandomycin decreases activity EXP 6480464 Troleandomycin results in decreased activity of CYP3A4 protein CTD PMID:11409940 more ... uranium atom increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Uranium results in increased expression of CYP3A2 mRNA CTD PMID:16039771 uranium atom multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [Acetaminophen co-treated with Uranium analog] results in decreased expression of CYP3A2 mRNA CTD PMID:17126469 ursodeoxycholic acid affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Ursodeoxycholic Acid CTD PMID:15708356 ursodeoxycholic acid increases hydroxylation EXP 6480464 CYP3A4 protein results in increased hydroxylation of Ursodeoxycholic Acid CTD PMID:36473578 ursodeoxycholic acid increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Ursodeoxycholic Acid results in increased expression of CYP3A2 mRNA CTD PMID:19255942 ursodeoxycholic acid multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [CYP3A23-3A1 gene mutant form co-treated with CYP3A2 gene mutant form] results in increased abundance of Ursodeoxycholic Acid more ... CTD PMID:10453939 more ... ursodeoxycholic acid multiple interactions EXP 6480464 [CYP3A4 protein results in increased metabolism of Lithocholic Acid] which results in increased abundance of Ursodeoxycholic Acid CTD PMID:19487251 ursodeoxycholic acid increases expression EXP 6480464 Ursodeoxycholic Acid results in increased expression of CYP3A4 mRNA CTD PMID:16678547 valproic acid decreases expression EXP 6480464 Valproic Acid results in decreased expression of CYP3A4 mRNA CTD PMID:29154799 and PMID:29501571 valproic acid increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Valproic Acid results in increased expression of CYP3A2 mRNA CTD PMID:35594946 valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of CYP3A4 mRNA CTD PMID:25084468 and PMID:30008028 vancomycin multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [Ampicillin co-treated with Neomycin co-treated with Gentamicins co-treated with Metronidazole co-treated with Vancomycin] results in decreased expression of CYP3A2 mRNA CTD PMID:30545405 vandetanib affects metabolic processing EXP 6480464 CYP3A4 protein alternative form affects the metabolism of vandetanib CTD PMID:34648813 vandetanib multiple interactions EXP 6480464 Ketoconazole affects the reaction [CYP3A4 protein alternative form affects the metabolism of vandetanib] CTD PMID:34648813 vanoxerine dihydrochloride decreases degradation EXP 6480464 CYP3A4 protein results in decreased degradation of vanoxerine CTD PMID:11502731 vanoxerine dihydrochloride multiple interactions EXP 6480464 [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased degradation of vanoxerine and [Quercetin results in decreased activity of CYP3A4 protein] which results in decreased degradation of vanoxerine CTD PMID:11502731 veliparib increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of veliparib CTD PMID:21436403 verapamil multiple interactions EXP 6480464 [Verapamil results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA more ... CTD PMID:16013069 more ... verapamil affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Verapamil CTD PMID:15286053 more ... verapamil decreases activity EXP 6480464 Verapamil results in decreased activity of CYP3A4 protein CTD PMID:15689501 more ... vinclozolin affects chemical synthesis ISO Cyp3a2 (Rattus norvegicus) 6480464 CYP3A2 protein affects the chemical synthesis of vinclozolin metabolite CTD PMID:22002493 vinclozolin increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 vinclozolin results in increased expression of CYP3A2 protein CTD PMID:25929820 vincristine increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of Vincristine CTD PMID:19346885 vitamin D increases expression EXP 6480464 Vitamin D analog results in increased expression of CYP3A4 mRNA CTD PMID:17965521 vitamin E decreases expression EXP 6480464 Vitamin E results in decreased expression of CYP3A4 mRNA CTD PMID:19244175 voriconazole decreases activity EXP 6480464 Voriconazole results in decreased activity of CYP3A4 protein CTD PMID:15328084 and PMID:15914520 voriconazole affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Voriconazole CTD PMID:15914520 warfarin decreases activity EXP 6480464 Warfarin results in decreased activity of CYP3A4 protein CTD PMID:18420780 warfarin affects response to substance ISO Cyp3a2 (Rattus norvegicus) 6480464 CYP3A2 mRNA affects the susceptibility to Warfarin CTD PMID:11531004 warfarin increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Warfarin results in increased expression of CYP3A2 mRNA CTD PMID:11531004 warfarin decreases expression EXP 6480464 Warfarin results in decreased expression of CYP3A4 mRNA CTD PMID:30963258 warfarin affects response to substance EXP 6480464 CYP3A4 SNP affects the susceptibility to Warfarin CTD PMID:28079798 warfarin multiple interactions EXP 6480464 [Warfarin binds to and results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:20735727 warfarin affects metabolic processing EXP 6480464 CYP3A4 protein affects the metabolism of Warfarin CTD PMID:15280511 more ... warfarin affects hydroxylation EXP 6480464 CYP3A4 protein affects the hydroxylation of Warfarin CTD PMID:2271712 xanthenes decreases activity EXP 6480464 Xanthenes results in decreased activity of CYP3A4 protein CTD PMID:18686201 and PMID:20041016 yohimbine affects metabolic processing EXP 6480464 CYP3A4 gene polymorphism affects the metabolism of Yohimbine CTD PMID:15289791 yohimbine multiple interactions EXP 6480464 Yohimbine analog inhibits the reaction [Calcitriol results in increased expression of CYP3A4 protein] CTD PMID:29782822 zafirlukast multiple interactions EXP 6480464 zafirlukast inhibits the reaction [CYP3A4 protein results in increased metabolism of Midazolam] CTD PMID:15370959 zafirlukast decreases activity EXP 6480464 zafirlukast metabolite results in decreased activity of CYP3A4 protein and zafirlukast results in decreased activity of CYP3A4 protein CTD PMID:15370959 and PMID:16167835 zafirlukast increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of zafirlukast CTD PMID:16167835 zearalenone increases expression EXP 6480464 Zearalenone results in increased expression of CYP3A4 mRNA and Zearalenone results in increased expression of CYP3A4 protein CTD PMID:15569515 and PMID:28865950 zearalenone increases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Zearalenone results in increased expression of CYP3A2 mRNA CTD PMID:20607812 zearalenone multiple interactions EXP 6480464 [deoxynivalenol co-treated with Zearalenone] affects the expression of CYP3A4 mRNA more ... CTD PMID:28865950 more ... zidovudine multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [SOD2 co-treated with CYP3A4] affects the susceptibility to Zidovudine CTD PMID:19501153 zileuton decreases activity EXP 6480464 zileuton results in decreased activity of CYP3A4 protein CTD PMID:15482930 zinc atom multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA] CTD PMID:27919644 zinc atom decreases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Zinc deficiency results in decreased expression of CYP3A2 mRNA CTD PMID:11705462 zinc(0) multiple interactions ISO Cyp3a2 (Rattus norvegicus) 6480464 [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA] CTD PMID:27919644 zinc(0) decreases expression ISO Cyp3a2 (Rattus norvegicus) 6480464 Zinc deficiency results in decreased expression of CYP3A2 mRNA CTD PMID:11705462 zolpidem increases metabolic processing EXP 6480464 CYP3A4 protein results in increased metabolism of zolpidem CTD PMID:16449812
