CYP3A4 (cytochrome P450 family 3 subfamily A member 4) - Rat Genome Database

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Gene: CYP3A4 (cytochrome P450 family 3 subfamily A member 4) Homo sapiens
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Symbol: CYP3A4
Name: cytochrome P450 family 3 subfamily A member 4
RGD ID: 1352962
HGNC Page HGNC:2637
Description: Enables several functions, including caffeine oxidase activity; retinoic acid 4-hydroxylase activity; and steroid hydroxylase activity. Involved in several processes, including lipid hydroxylation; steroid metabolic process; and terpenoid metabolic process. Located in cytoplasm. Implicated in familial Mediterranean fever.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 1,4-cineole 2-exo-monooxygenase; 1,8-cineole 2-exo-monooxygenase; albendazole monooxygenase; albendazole monooxygenase (sulfoxide-forming); albendazole sulfoxidase; cholesterol 25-hydroxylase; CP33; CP34; CYP3A; CYP3A3; CYPIIIA3; CYPIIIA4; cytochrome P450 3A3; cytochrome P450 3A4; cytochrome P450 HLp; cytochrome P450 NF-25; cytochrome P450, family 3, subfamily A, polypeptide 4; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4; cytochrome P450-PCN1; glucocorticoid-inducible P450; HLP; MGC126680; NF-25; nifedipine oxidase; P450-III, steroid inducible; P450C3; P450PCN1; quinine 3-monooxygenase; taurochenodeoxycholate 6-alpha-hydroxylase; VDDR3
RGD Orthologs
Rat
Bonobo
Dog
Green Monkey
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38799,756,967 - 99,784,184 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl799,756,959 - 99,784,274 (-)Ensemblhg38GRCh38
GRCh37799,354,590 - 99,381,807 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36799,192,540 - 99,219,744 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34798,999,254 - 99,026,459NCBI
Celera794,088,849 - 94,116,044 (-)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef793,991,011 - 94,018,230 (-)NCBIHuRef
CHM1_1799,284,687 - 99,311,925 (-)NCBICHM1_1
T2T-CHM13v2.07100,996,482 - 101,023,683 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2798,714,396 - 98,741,615 (-)NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (EXP)
(+)-schisandrin B  (EXP)
(+)-Tetrandrine  (EXP)
(+)-trans-(S)-allethrin  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(-)-trans-epsilon-viniferin  (EXP)
(24S)-24-hydroxycholesterol  (EXP)
(3-phenoxyphenyl)methanol  (EXP)
(E)-roxithromycin  (EXP)
(E)-thiamethoxam  (EXP)
(E,E)-germacrone  (EXP)
(R)-lipoic acid  (EXP)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(S)-colchicine  (EXP)
(S)-naringenin  (EXP)
(S)-nicotine  (EXP,ISO)
(Z)-ligustilide  (EXP)
1,1,1-Trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2,3,5-tetrachlorobenzene  (EXP)
1,2-dichloroethene  (ISO)
1,2-dilauroyl-sn-glycero-3-phosphocholine(1+)  (EXP,ISO)
1,4-dichlorobenzene  (EXP)
1,4-naphthoquinone  (EXP)
1,6-Dinitropyrene  (EXP)
1,8-cineole  (EXP)
1-(1,3-benzodioxol-5-yl)-4,4-dimethyl-1-penten-3-ol  (EXP)
1-(3-chlorophenyl)piperazine  (EXP)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
1-\{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl\}-1H-imidazole  (EXP)
1-aminobenzotriazole  (EXP)
1-hydroxymidazolam  (EXP)
1-hydroxymidazolam beta-D-glucuronide  (EXP)
1-naphthol  (EXP)
1-naphthyl isothiocyanate  (ISO)
13-cis-retinal  (EXP)
14,15-EET  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
1H-indole  (EXP)
2'-deoxyguanosine  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,2'-Methylenebis(4-methyl-6-tert-butylphenol)  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2,8-bis-Trifluoromethyl-4-quinoline carboxylic acid  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-[cyclohexyl(oxo)methyl]-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one  (EXP)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (EXP)
2-hydroxy-17beta-estradiol  (EXP)
2-hydroxychrysophanol  (EXP)
2-methyl-1H-indole  (EXP)
2-Naphthalenethiol  (EXP)
2-naphthol  (EXP)
3',4'-dimethoxyflavone  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3,3'-diindolylmethane  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3,5,6-trichloro-2-pyridinol  (EXP)
3,5,6-trichloropyridine-2-one  (EXP)
3-(Methylthio)-1-propene  (ISO)
3-hydroxyquinine  (EXP)
3-methylcholanthrene  (EXP,ISO)
3-oxo-5beta-cholanic acid  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4'-tert-Butyl-2',6'-dimethyl-3',5'-dinitroacetophenone  (ISO)
4,4'-methanol-bisbenzonitrile  (EXP)
4,4'-methylene-bis-(2-chloroaniline)  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-[(1E)-1,2-diphenylbut-1-en-1-yl]phenol  (EXP)
4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide  (EXP)
4-bromo-2-chlorophenol  (EXP)
4-hydroxy-3-(2-hydroxy-3-oxo-1-phenylbutyl)-2H-chromen-2-one  (EXP)
4-hydroxy-3-[1-(4-hydroxyphenyl)-3-oxobutyl]-2H-chromen-2-one  (EXP)
4-Hydroxy-N-desmethyltamoxifen  (EXP)
4-Hydroxybenzyl isothiocyanate  (ISO)
4-hydroxycyclophosphamide  (EXP)
4-hydroxymidazolam  (EXP)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (EXP)
4-Ipomeanol  (EXP)
4-isopropylphenol  (EXP)
4beta-hydroxycholesterol  (EXP)
5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole  (EXP)
5,6-EET  (EXP)
5,7-dihydroxy-4'-methoxyflavone  (EXP,ISO)
5-azacytidine  (EXP)
5-fluorouracil  (EXP)
5-hydroxydiclofenac  (EXP)
5-Hydroxyflavone  (EXP)
5-Hydroxythalidomide  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
5-methoxyindole  (EXP)
6',7'-Dihydroxybergamottin  (EXP)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (EXP)
6-chrysenamine  (EXP)
6-Hydroxyflavone  (EXP)
6-Methylflavone  (EXP)
6alpha-methylprednisolone  (EXP)
6beta-hydroxycortisol  (EXP)
6beta-hydroxytestosterone  (EXP,ISO)
7,12-dimethyltetraphene  (EXP)
7-hydroxyflavone  (EXP)
8,9-EET  (EXP)
8-Epidiosbulbin E acetate  (EXP)
9-cis-retinal  (EXP)
9-cis-retinoic acid  (EXP)
9-hydroxyellipticine  (EXP)
[2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol  (EXP)
acalabrutinib  (EXP)
acenaphthylene  (EXP)
acetamide  (ISO)
acetochlor  (EXP)
Acetyl tributyl citrate  (EXP)
aconitine  (EXP)
acrolein  (EXP)
actinomycin D  (EXP,ISO)
adefovir pivoxil  (EXP)
adinazolam  (EXP)
afimoxifene  (EXP)
aflatoxin B1  (EXP,ISO)
aflatoxin B1 exo-8,9-epoxide  (EXP)
Aflatoxin G1  (EXP)
aflatoxin M1  (EXP)
aflatoxin Q1  (EXP)
ajmalicine  (EXP)
ajmaline  (EXP)
alachlor  (EXP)
albendazole  (EXP,ISO)
alcohol  (EXP)
aldrin  (EXP)
alectinib  (EXP)
alfacalcidol  (EXP)
alfentanil  (EXP)
all-trans-4-hydroxyretinoic acid  (EXP)
all-trans-4-oxoretinoic acid  (EXP)
all-trans-retinoic acid  (EXP)
allethrin  (ISO)
allyl alcohol  (ISO)
allyl isothiocyanate  (EXP,ISO)
allyl methyl disulfide  (EXP)
almotriptan  (EXP)
Aloe emodin  (EXP)
alpha-hexachlorocyclohexane  (ISO)
alpha-Hydroxyalprazolam  (EXP)
alpha-linolenic acid  (EXP)
alpha-naphthoflavone  (EXP)
alpha-santonin  (EXP)
alpha-tocotrienol  (EXP)
alprazolam  (EXP)
Amaranth  (EXP)
amiodarone  (EXP,ISO)
amitriptyline  (EXP)
amlodipine  (EXP)
ammonium chloride  (ISO)
amodiaquine  (EXP)
amoxapine  (EXP)
amphetamine  (EXP)
ampicillin  (ISO)
amprenavir  (EXP)
Ancriviroc  (EXP)
andrographolide  (EXP)
androst-4-ene-3,17-dione  (EXP)
aniline  (EXP)
anthocyanin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antirheumatic drug  (EXP)
apigenin  (EXP)
arachidonic acid  (EXP)
Aroclor 1254  (EXP,ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP)
Artemetin  (EXP)
asiaticoside  (EXP)
astemizole  (EXP)
atazanavir sulfate  (EXP)
atorvastatin calcium  (EXP,ISO)
atrazine  (EXP)
Auriculasin  (EXP)
Avasimibe  (EXP)
axitinib  (EXP)
Azamulin  (EXP)
azithromycin  (EXP)
azoxystrobin  (EXP)
baicalein  (EXP)
barbiturates  (EXP)
barnidipine  (EXP)
benfuracarb  (EXP)
benidipine  (EXP)
benzbromarone  (EXP)
benzo[a]pyrene  (EXP)
benzo[a]pyrene diol epoxide I  (EXP)
Benzo[a]pyrene-7,8-diol  (EXP)
benzo[c]phenanthrene  (EXP)
benzoic acid  (EXP)
benzphetamine  (EXP)
benzyl isothiocyanate  (ISO)
bepridil  (EXP)
berberine  (EXP,ISO)
bergomottin  (EXP)
Besigomsin  (EXP)
beta-carboline  (EXP)
beta-carotene  (EXP)
beta-naphthoflavone  (EXP,ISO)
beta-tocotrienol  (EXP)
Betanin  (ISO)
bexarotene  (ISO)
bifenthrin  (EXP)
bifonazole  (EXP)
bilirubin IXalpha  (EXP,ISO)
bioresmethrin  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP)
Bisphenol B  (EXP)
bisphenol F  (EXP)
bortezomib  (EXP)
bosentan  (EXP)
brequinar  (EXP)
Bromadiolone  (ISO)
bromfenac  (EXP)
bromocriptine  (EXP)
bromodichloromethane  (EXP)
brotizolam  (EXP)
budesonide  (EXP,ISO)
bufalin  (EXP)
bufogenin  (EXP)
Bufotalin  (EXP)
buprenorphine  (EXP)
buspirone  (EXP)
butachlor  (EXP)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (EXP)
C.I. Natural Red 20  (EXP,ISO)
cabozantinib  (EXP)
cafestol  (ISO)
caffeine  (EXP)
calciol  (EXP)
calcitriol  (EXP,ISO)
camptothecin  (EXP)
cannabidiol  (EXP)
capsaicin  (EXP,ISO)
captan  (EXP)
carbamazepine  (EXP,ISO)
carbamazepine-10,11-epoxide  (EXP)
carbaryl  (EXP)
carbendazim  (EXP)
carbofuran  (EXP)
carbosulfan  (EXP)
carfentanil  (EXP)
carmustine  (EXP)
Carnosol  (EXP)
carvedilol  (ISO)
cefaclor  (EXP)
cefadroxil  (EXP)
celecoxib  (EXP)
cerivastatin  (EXP)
cetirizine  (EXP)
CGP 52608  (EXP)
chelidonine  (EXP)
chenodeoxycholic acid  (EXP,ISO)
CHIR 99021  (EXP)
chitosan  (EXP)
chloramphenicol  (EXP)
chlordecone  (EXP)
chlorfenvinfos  (EXP)
chlorfluazuron  (EXP)
chloroquine  (EXP)
chlorpromazine  (EXP)
chlorpropham  (EXP)
chlorpyrifos  (EXP,ISO)
chlorzoxazone  (ISO)
cholesterol  (EXP,ISO)
cholic acid  (EXP,ISO)
choline  (ISO)
chrysin  (EXP)
chrysophanol  (EXP)
chrysosplenetin  (EXP)
cimetidine  (EXP)
cinitapride  (EXP)
Cinobufagin  (EXP)
ciprofibrate  (ISO)
ciprofloxacin  (EXP)
cisapride  (EXP)
cisplatin  (EXP)
citalopram  (EXP)
citral  (EXP)
Citreorosein  (EXP)
clarithromycin  (EXP)
clemizole  (EXP)
climbazole  (ISO)
clindamycin  (EXP)
clobetasol  (EXP)
clofibrate  (ISO)
clofibric acid  (EXP,ISO)
Clofop  (EXP)
clomiphene  (EXP)
clopidogrel  (EXP)
clothianidin  (EXP)
clotrimazole  (EXP,ISO)
clozapine  (EXP)
Clozapine N-oxide  (EXP)
cobalt dichloride  (EXP)
cobicistat  (EXP)
codeine  (EXP)
colforsin daropate hydrochloride  (EXP)
Columbin  (EXP)
cordycepin  (ISO)
corticosterone  (EXP)
cortisol  (EXP,ISO)
coumarin  (ISO)
crizotinib  (EXP)
Cryptotanshinone  (EXP)
curcumin  (EXP)
cycloheximide  (EXP,ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyfluthrin  (EXP)
cyhalothrin  (EXP,ISO)
cylindrospermopsin  (EXP)
cypermethrin  (EXP)
cyproconazole  (EXP,ISO)
cyprodinil  (EXP)
cyproterone acetate  (EXP)
dabrafenib  (EXP)
daidzein  (EXP,ISO)
dapsone  (EXP,ISO)
dauricine  (EXP)
DDD  (EXP)
DDE  (EXP)
DDT  (EXP,ISO)
decabromodiphenyl ether  (EXP)
Dechloroethylcyclophosphamide  (EXP)
dehydroepiandrosterone  (EXP)
dehydroepiandrosterone sulfate  (EXP,ISO)
delta-tocotrienol  (EXP)
deoxycholic acid  (EXP,ISO)
Deoxyelephantopin  (EXP)
deoxynivalenol  (EXP)
Deoxyschizandrin  (EXP)
Desethylchloroquine  (EXP)
desferrioxamine B  (EXP)
desipramine  (EXP)
dexamethasone  (EXP,ISO)
dextromethorphan  (EXP)
dextrorphan  (EXP)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diarsenic trioxide  (EXP)
diarylheptanoid  (EXP)
diazepam  (EXP)
diazinon  (EXP)
dibenziodolium  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (EXP)
dicloxacillin  (EXP)
dieldrin  (EXP)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP)
difenoconazole  (EXP)
diflubenzuron  (EXP)
dihydroartemisinin  (EXP)
dihydroergotamine  (EXP)
diltiazem  (EXP)
dimemorfan  (EXP)
dimethocaine  (EXP)
dimethyl sulfoxide  (EXP,ISO)
dimethylarsinous acid  (EXP)
dioleoyl phosphatidylcholine  (EXP,ISO)
diosmetin  (EXP)
dioxygen  (EXP)
diphenylamine  (EXP)
dipropyl disulfide  (ISO)
Dipropyl sulfide  (ISO)
diquat  (ISO)
disopyramide  (EXP)
disulfiram  (EXP,ISO)
Dithiopyr  (EXP)
diuron  (EXP)
domperidone  (EXP)
dopamine  (EXP)
doxorubicin  (EXP)
Droloxifene  (EXP)
drometrizole  (EXP)
dronedarone  (EXP)
Echimidine  (EXP)
econazole  (EXP)
efavirenz  (EXP)
elemental selenium  (EXP)
ellipticine  (EXP)
emodin  (EXP)
enalapril  (EXP)
endosulfan  (EXP)
endrin  (EXP)
enilconazole  (EXP)
eplerenone  (EXP)
epoxiconazole  (EXP,ISO)
Erdafitinib  (EXP)
erlotinib hydrochloride  (EXP)
erythromycin A  (EXP)
erythrosin B  (EXP)
estazolam  (EXP)
estrone  (EXP)
ethambutol  (ISO)
ethanol  (EXP,ISO)
ethion  (EXP)
ethoxyquin  (ISO)
eticlopride(1+)  (EXP)
etonogestrel  (EXP)
etoposide  (EXP)
etoricoxib  (EXP)
etoxazole  (EXP)
eupatilin  (EXP)
eupatorin  (EXP)
farnesol  (EXP,ISO)
farrerol  (EXP)
felbamate  (EXP)
felodipine  (EXP)
fenhexamid  (EXP)
fenitrothion  (EXP)
fenproporex  (EXP)
fentanyl  (EXP)
fenthion  (EXP)
fenvalerate  (EXP)
ferroheme b  (EXP)
fimasartan  (EXP)
fipronil  (EXP,ISO)
flavanone  (EXP)
flavone  (EXP)
flavonol  (EXP)
flucloxacillin  (EXP)
fluconazole  (EXP)
flucythrinate  (EXP)
fludioxonil  (EXP)
flunitrazepam  (EXP)
fluoren-9-one  (ISO)
fluorene  (ISO)
fluoxetine  (EXP)
fluphenazine  (EXP)
flusilazole  (EXP)
flutamide  (EXP,ISO)
fluticasone  (EXP)
flutolanil  (EXP)
flutriafol  (EXP,ISO)
fluvalinate  (EXP)
fluvastatin  (EXP)
fluvoxamine  (EXP)
fluxapyroxad  (EXP)
fonofos  (EXP)
Fraxinellone  (EXP)
fulvestrant  (ISO)
Furafylline  (ISO)
furan  (ISO)
furathiocarb  (EXP)
furosemide  (EXP)
fusidic acid  (EXP)
gadolinium trichloride  (ISO)
galangin  (EXP)
gamma-hexachlorocyclohexane  (EXP,ISO)
gefitinib  (EXP)
Gelsemine  (EXP)
gemfibrozil  (EXP)
genistein  (EXP,ISO)
gentamycin  (ISO)
geranial  (EXP)
gestodene  (EXP)
gingerol  (EXP)
Ginkgolide A  (EXP,ISO)
ginkgolide B  (EXP)
ginsenoside Rg1  (ISO)
glafenine  (ISO)
glimepiride  (EXP)
glutathione  (EXP,ISO)
glycochenodeoxycholic acid  (EXP)
glycocholic acid  (EXP)
glycodeoxycholic acid  (EXP)
Glycohyodeoxycholic acid  (EXP)
glycolithocholic acid  (EXP)
glycoursodeoxycholic acid  (EXP)
glycyrrhizinic acid  (EXP,ISO)
glyoxal  (EXP)
granisetron  (EXP)
griseofulvin  (EXP)
guggulsterone  (EXP)
GW 3965  (EXP)
haloperidol  (EXP)
halothane  (EXP)
helenalin  (EXP)
Heliotrine  (EXP)
heme b  (EXP)
HET0016  (EXP)
Hexachloro-1,3-butadiene  (EXP)
hexachlorobenzene  (ISO)
hexaflumuron  (EXP)
hexobarbital  (EXP)
huperzine A  (ISO)
hydrocortisone succinate  (EXP)
hydrogen peroxide  (EXP)
hydroquinone  (EXP)
hydroxynefazodone  (EXP)
hyodeoxycholic acid  (EXP)
Hypaconitine  (EXP)
hyperforin  (EXP)
hypericin  (EXP)
iberin  (ISO)
ibrutinib  (EXP)
Icaritin  (EXP)
ifosfamide  (EXP)
iloperidone  (EXP)
imidacloprid  (EXP)
imidazoles  (EXP)
imipramine  (EXP)
indicine  (EXP)
indole-3-acetamide  (EXP)
indoline  (EXP)
indometacin  (EXP,ISO)
iprodione  (EXP)
irilone  (EXP)
irinotecan  (EXP)
iron(III) citrate  (EXP)
isobavachalcone  (ISO)
isocarbophos  (EXP)
isofenphos  (EXP)
isoliquiritigenin  (EXP)
isoniazide  (EXP,ISO)
isoprothiolane  (EXP)
isoproturon  (EXP)
isorhamnetin  (EXP)
Isosafrole  (EXP)
isotretinoin  (EXP)
isoxazoles  (EXP)
Isradipine  (EXP)
itraconazole  (EXP)
ivermectin  (EXP)
kaempferol  (EXP)
kahweol  (ISO)
ketamine  (EXP,ISO)
ketoconazole  (EXP,ISO)
L-methionine  (ISO)
lactacystin  (EXP)
lamotrigine  (EXP)
lansoprazole  (EXP)
lapatinib  (EXP)
laquinimod  (EXP)
Lasiocarpine  (EXP,ISO)
lead(0)  (EXP)
lefetamine  (EXP)
leflunomide  (EXP)
leptomycin B  (EXP)
letrozole  (EXP)
levofloxacin  (EXP)
Licochalcone A  (EXP)
lidocaine  (EXP)
Liensinine  (EXP)
limonene  (EXP)
limonin  (EXP)
linoleic acid  (EXP)
linuron  (EXP)
lipoic acid  (EXP)
lithocholic acid  (EXP,ISO)
loperamide  (EXP)
lopinavir  (EXP)
loratadine  (EXP)
lorlatinib  (EXP)
lovastatin  (EXP)
loxapine  (EXP)
luteolin  (EXP)
lycopene  (EXP)
madecassoside  (EXP)
malathion  (EXP)
Maleic hydrazide  (EXP)
mancozeb  (EXP)
mangiferin  (EXP)
Marrubiin  (EXP)
masitinib  (EXP)
Meclizine  (EXP)
Medazepam  (EXP)
medroxyprogesterone acetate  (EXP)
mefenamic acid  (EXP)
mefloquine  (EXP)
MeIQ  (EXP)
Melarsoprol  (EXP)
Mesaconitine  (EXP)
metazachlor  (EXP)
metformin  (EXP)
methadone  (EXP)
methamphetamine  (EXP)
methidathion  (EXP)
methotrexate  (EXP)
methoxsalen  (EXP,ISO)
methoxychlor  (EXP,ISO)
methoxyflurane  (EXP)
metolachlor  (EXP)
metolazone  (EXP)
metoprolol  (EXP)
metronidazole  (EXP,ISO)
metyrapone  (EXP)
mevastatin  (EXP)
Mibefradil  (EXP)
miconazole  (EXP)
midazolam  (EXP,ISO)
mifepristone  (EXP)
Mitotane  (EXP)
Mitragynine  (EXP)
mono(2-ethyl-5-hydroxyhexyl) phthalate  (EXP,ISO)
mono(2-ethyl-5-oxohexyl) phthalate  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
mono-isopropyl-disopyramide  (EXP)
monobenzone  (EXP)
monocrotaline  (EXP)
monocrotophos  (EXP)
monoethylglycinexylidide  (EXP)
monosodium L-glutamate  (ISO)
moricizine  (EXP)
Muscone  (EXP)
musk xylene  (ISO)
mycophenolic acid  (EXP)
myricetin  (EXP)
myristicin  (EXP)
N'-Nitrosoanabasine  (EXP)
N,N-Didesmethyltamoxifen  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-(2,6-diethylphenyl)-2-chloroacetamide  (EXP)
N-acetyl-1,4-benzoquinone imine  (EXP)
N-acetyl-L-cysteine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-desethylamiodarone  (EXP)
N-desmethylclozapine  (EXP)
N-Desmethyltamoxifen  (EXP)
N-Nitrosodi-n-propylamine  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
NADP zwitterion  (EXP,ISO)
NADP(+)  (EXP,ISO)
nafcillin  (EXP)
naphthalene  (EXP)
naringin  (EXP)
nefazodone  (EXP)
Neferine  (EXP)
nelfinavir  (EXP)
nemorubicin  (EXP,ISO)
neobavaisoflavone  (ISO)
neomycin  (ISO)
nevirapine  (EXP)
nicardipine  (EXP)
nickel atom  (EXP)
niclosamide  (EXP)
nicotinamide  (ISO)
nicotine  (EXP,ISO)
nifedipine  (EXP,ISO)
nimesulide  (EXP,ISO)
nimetazepam  (EXP)
nitrazepam  (EXP)
nitrendipine  (EXP)
nobiletin  (EXP)
Norbuprenorphine  (EXP)
norcisapride  (EXP)
norcodeine  (EXP)
nordazepam  (EXP)
Norfluoxetine  (EXP)
Noroxycodone  (EXP)
nortriptyline  (EXP)
notoginsenoside R1  (EXP)
Notopterol  (EXP)
o-anisidine  (EXP)
o-toluidine  (EXP)
obeticholic acid  (EXP,ISO)
ochratoxin A  (EXP)
octadecanoic acid  (EXP)
octamethylcyclotetrasiloxane  (ISO)
ofloxacin  (EXP)
okadaic acid  (EXP,ISO)
olanzapine  (EXP)
oleanolic acid  (EXP)
oleic acid  (EXP)
olmesartan  (EXP)
oltipraz  (EXP,ISO)
omeprazole  (EXP)
Omeprazole sulfide  (EXP)
Ondansetron  (EXP)
organophosphorus compound  (EXP)
orlistat  (EXP)
osthole  (EXP)
Oxadiazon  (EXP)
oxatomide  (EXP)
oxiconazole  (EXP)
oxycodone  (EXP,ISO)
p-menthan-3-ol  (EXP)
p-toluidine  (ISO)
paclitaxel  (EXP,ISO)
Panaxytriol  (EXP,ISO)
pantoprazole  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (EXP)
paricalcitol  (EXP)
pazopanib  (EXP)
PD 0325901  (EXP)
pedalitin  (EXP)
penconazole  (EXP)
pentachlorobenzene  (EXP)
pentachlorophenol  (EXP)
pentamidine  (EXP)
perazine  (EXP)
perfluorobutanesulfonic acid  (EXP)
perfluorodecanoic acid  (EXP)
perfluorododecanoic acid  (EXP)
perfluoroheptanoic acid  (EXP)
perfluorohexanesulfonic acid  (EXP,ISO)
perfluorohexanoic acid  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perhexiline  (EXP)
Perhexiline maleate  (EXP)
permethrin  (EXP)
phenacetin  (ISO)
phencyclidine  (EXP)
Phenelzine  (EXP)
phenethyl isothiocyanate  (EXP,ISO)
phenobarbital  (EXP,ISO)
Phenoxybenzamine  (EXP)
phenoxymethylpenicillin  (EXP)
phenthoate  (EXP)
phenylbutazone  (EXP)
phenytoin  (EXP,ISO)
PhIP  (EXP,ISO)
phosalone  (EXP)
phthalic acid  (EXP,ISO)
physcion  (EXP)
pimecrolimus  (EXP)
pimobendan  (EXP)
pinocembrin  (EXP)
pioglitazone  (EXP,ISO)
piperine  (EXP)
pirinixic acid  (EXP)
PK-11195  (EXP)
poly(styrene)  (EXP)
polymyxin B2  (ISO)
pomalidomide  (EXP)
posaconazole  (EXP)
potassium bromate  (EXP)
potassium hexacyanoferrate(3-)  (EXP)
Pramiconazole  (EXP)
pravastatin  (EXP)
prednisolone  (EXP)
pregnenolone  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
Pretilachlor  (EXP)
primaquine  (EXP)
primidone  (EXP)
probenecid  (EXP)
prochloraz  (EXP,ISO)
procymidone  (EXP)
profenofos  (EXP,ISO)
progesterone  (EXP)
proguanil  (EXP)
propargite  (EXP)
propiconazole  (EXP,ISO)
propranolol  (EXP)
propyzamide  (EXP)
psoralidin  (ISO)
pyrantel  (EXP)
pyrazinecarboxamide  (ISO)
pyrethrins  (EXP)
pyridine  (ISO)
pyrimethanil  (EXP)
pyrimidin-2-amine  (EXP)
pyrrolidines  (ISO)
quercetin  (EXP)
quetiapine fumarate  (EXP)
quinacrine  (EXP)
quinidine  (EXP)
quinine  (EXP)
quinoxyfen  (EXP)
raloxifene  (EXP)
reactive oxygen species  (EXP)
regorafenib  (EXP)
reserpic acid  (EXP)
reserpine  (EXP)
resveratrol  (EXP)
Retrorsine  (EXP)
riddelliine  (EXP,ISO)
rifabutin  (EXP)
rifampicin  (EXP,ISO)
rifapentine  (EXP)
rifaximin  (EXP)
risperidone  (EXP)
ritonavir  (EXP)
rivaroxaban  (EXP)
romidepsin  (EXP)
rose bengal  (EXP)
rubiarbonone C  (EXP)
Rutaevin  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
S-allylcysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
safrole  (EXP)
Salinomycin  (EXP)
saquinavir  (EXP)
saracatinib  (EXP)
satraplatin  (EXP)
secobarbital  (EXP)
selenium atom  (EXP)
semicarbazide  (ISO)
senecionine  (EXP)
seneciphylline  (EXP)
Senkirkine  (EXP)
sertraline  (EXP)
sevoflurane  (EXP)
Shikonin  (EXP,ISO)
sibutramine  (EXP)
silibinin  (EXP)
silicon dioxide  (EXP)
simvastatin  (EXP,ISO)
sinensetin  (EXP)
sirolimus  (EXP)
skatole  (EXP)
sodium arsenite  (EXP)
sodium cholate  (EXP,ISO)
sophoraflavanone B  (EXP)
sophoranone  (EXP)
spironolactone  (EXP)
staurosporine  (EXP)
stavudine  (ISO)
sterigmatocystin  (EXP)
steviol  (EXP)
stevioside  (EXP)
styrene  (ISO)
Sudan I  (EXP)
Sudan III  (ISO)
sulconazole  (EXP)
sulfamethazine  (EXP)
sulfamethoxazole  (ISO)
sulfaphenazole  (EXP)
sulfinpyrazone  (EXP)
sulfisoxazole  (EXP)
sulforaphane  (EXP,ISO)
sunitinib  (EXP,ISO)
tacrine  (EXP,ISO)
tacrolimus hydrate  (EXP)
tamarixetin  (EXP)
tamoxifen  (EXP,ISO)
tangeretin  (EXP)
Tanshinone I  (EXP)
tartrazine  (EXP)
taurochenodeoxycholic acid  (EXP)
taurocholic acid  (ISO)
taurodeoxycholic acid  (EXP)
taurolithocholic acid  (EXP)
tauroursodeoxycholic acid  (EXP)
tebuconazole  (EXP)
tebufenozide  (EXP)
telaprevir  (EXP)
telithromycin  (EXP)
Temazepam  (EXP)
teniposide  (EXP)
terbinafine  (EXP)
Terfenadine  (EXP)
teriflunomide  (EXP)
Territrem B  (ISO)
tert-butyl ethyl ether  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
tetracycline  (EXP,ISO)
tetramethrin  (EXP)
thalidomide  (EXP)
thapsigargin  (EXP)
theophylline  (EXP)
thiabendazole  (EXP)
thiacloprid  (EXP)
thiamethoxam  (EXP)
thiamine(1+) chloride  (ISO)
thioacetamide  (ISO)
Thiocoraline  (EXP)
thioridazine  (EXP)
Thiotepa  (EXP)
thiram  (EXP)
thyroxine  (EXP)
ticlopidine  (EXP)
tinidazole  (EXP)
tiratricol  (EXP)
tofacitinib  (EXP)
tolcapone  (EXP)
toluene  (ISO)
tolylfluanid  (EXP)
topiramate  (EXP)
trabectedin  (ISO)
tranexamic acid  (EXP)
trans-1,2-dichloroethene  (ISO)
trans-cinnamic acid  (EXP)
transfluthrin  (ISO)
tranylcypromine  (EXP)
trazodone  (EXP,ISO)
triadimefon  (EXP,ISO)
triazolam  (EXP)
Tributyl citrate  (EXP)
trichloroethene  (ISO)
trichostatin A  (EXP)
triclosan  (EXP,ISO)
triflumuron  (EXP)
trifluridine  (EXP)
Triptolide  (ISO)
Tris(1-aziridinyl)phosphine oxide  (EXP)
tris(2,3-dibromopropyl) phosphate  (EXP)
tris(2-butoxyethyl) phosphate  (EXP)
troglitazone  (EXP,ISO)
troleandomycin  (EXP)
uranium atom  (ISO)
ursodeoxycholic acid  (EXP,ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vandetanib  (EXP)
vanoxerine dihydrochloride  (EXP)
veliparib  (EXP)
verapamil  (EXP)
vinclozolin  (ISO)
vincristine  (EXP)
vitamin D  (EXP)
vitamin E  (EXP)
voriconazole  (EXP)
VX nerve agent  (EXP)
warfarin  (EXP,ISO)
xanthenes  (EXP)
yohimbine  (EXP)
zafirlukast  (EXP)
zearalenone  (EXP,ISO)
zidovudine  (ISO)
zileuton  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)
zolpidem  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
artemether pharmacokinetics pathway   (EXP)
axitinib pharmacokinetics pathway  (TAS)
bile acid transport pathway  (IEA)
caffeine pharmacokinetics pathway  (EXP)
carbamazepine pharmacokinetics pathway  (EXP)
celecoxib pharmacodynamics pathway  (EXP)
celecoxib pharmacokinetics pathway  (EXP)
clomipramine pharmacokinetics pathway  (EXP)
clopidogrel pharmacodynamics pathway  (EXP)
clopidogrel pharmacokinetics pathway  (EXP)
codeine and morphine pharmacodynamics pathway  (EXP)
codeine and morphine pharmacokinetics pathway  (EXP)
cyclophosphamide pharmacodynamics pathway  (EXP)
cyclophosphamide pharmacokinetics pathway  (EXP)
doxepin pharmacokinetics pathway  (EXP)
etoposide pharmacodynamics pathway  (EXP)
etoposide pharmacokinetics pathway  (EXP)
felbamate pharmacokinetics pathway  (EXP)
fluoxetine pharmacodynamics pathway  (EXP)
fluoxetine pharmacokinetics pathway   (EXP)
gefitinib pharmacokinetics pathway  (TAS)
ibuprofen pharmacodynamics pathway  (EXP)
ibuprofen pharmacokinetics pathway  (EXP)
ifosfamide pharmacodynamics pathway  (EXP)
ifosfamide pharmacokinetics pathway  (EXP)
imipramine pharmacodynamics pathway  (EXP)
imipramine pharmacokinetics pathway  (EXP)
irinotecan pharmacodynamics pathway  (EXP)
irinotecan pharmacokinetics pathway  (EXP)
lidocaine pharmacodynamics pathway  (EXP)
lidocaine pharmacokinetics pathway  (EXP)
linoleic acid metabolic pathway   (IEA)
losartan pharmacokinetics pathway  (IMP)
methadone pharmacodynamics pathway  (EXP)
methadone pharmacokinetics pathway  (EXP)
mycophenolic acid pharmacokinetics pathway   (EXP)
nateglinide pharmacokinetics pathway  (TAS)
neviparine pharmacokinetics pathway   (EXP)
paracetamol pharmacokinetics pathway  (EXP)
phenytoin pharmacodynamics pathway  (EXP)
prednisone pharmacodynamics pathway  (EXP)
prednisone pharmacokinetics pathway   (EXP)
repaglinide pharmacokinetics pathway   (TAS)
retinol metabolic pathway  (EXP,IEA)
sorafenib pharmacokinetics pathway   (EXP)
statin pharmacokinetics pathway   (TAS)
steroid hormone biosynthetic pathway   (IEA)
tamoxifen pharmacodynamics pathway   (EXP)
tamoxifen pharmacokinetics pathway  (EXP,IDA)
teniposide pharmacodynamics pathway  (EXP)
teniposide pharmacokinetics pathway  (EXP)
tramadol pharmacokinetics pathway  (EXP)
venlafaxine pharmacokinetics pathway  (EXP)
vinblastine pharmacodynamics pathway  (EXP)
vinorelbine pharmacodynamics pathway  (EXP)
vitamin A deficiency pathway   (EXP)
warfarin pharmacokinetics pathway  (TAS)

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cytochrome P450 gene polymorphism and cancer. Agundez JA Curr Drug Metab. 2004 Jun;5(3):211-24.
2. Gene-specific effects of inflammatory cytokines on cytochrome P450 2C, 2B6 and 3A4 mRNA levels in human hepatocytes. Aitken AE and Morgan ET, Drug Metab Dispos. 2007 Sep;35(9):1687-93. Epub 2007 Jun 18.
3. Meta-analysis of contribution of genetic polymorphisms in drug-metabolizing enzymes or transporters to axitinib pharmacokinetics. Brennan M, etal., Eur J Clin Pharmacol. 2012 May;68(5):645-55. Epub 2011 Dec 15.
4. Lack of an effect of CYP3A4 and MDR1 gene polymorphisms on colchicine pharmacogenetics in the treatment of Familial Mediterranean fever. Dogruer D, etal., Genet Mol Res. 2013 Jan 24;12(3):3521-8. doi: 10.4238/2013.January.24.2.
5. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
6. Alpha-hydroxylation of tamoxifen and toremifene by human and rat cytochrome P450 3A subfamily enzymes. Kim SY, etal., Chem Res Toxicol. 2003 Sep;16(9):1138-44.
7. Downregulation of intestinal cytochrome p450 in chronic renal failure. Leblond FA, etal., J Am Soc Nephrol. 2002 Jun;13(6):1579-85.
8. Autoantibodies against cytochromes P-4502E1 and P-4503A in alcoholics. Lytton SD, etal., Mol Pharmacol. 1999 Feb;55(2):223-33. doi: 10.1124/mol.55.2.223.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Drug-drug and food-drug pharmacokinetic interactions with new insulinotropic agents repaglinide and nateglinide. Scheen AJ Clin Pharmacokinet. 2007;46(2):93-108.
14. Pharmacogenetics and pharmacogenomics of cholesterol-lowering therapy. Schmitz G, etal., Curr Opin Lipidol. 2007 Apr;18(2):164-73.
15. Comparison of enzyme kinetics of warfarin analyzed by LC-MS/MS QTrap and differential mobility spectrometry. Shaik AN, etal., J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jan 1;1008:164-73. doi: 10.1016/j.jchromb.2015.11.036. Epub 2015 Nov 23.
16. Clinical pharmacokinetics of tyrosine kinase inhibitors. van Erp NP, etal., Cancer Treat Rev. 2009 Dec;35(8):692-706. Epub 2009 Sep 5.
17. Genetic factors for ischemic and hemorrhagic stroke in Japanese individuals. Yamada Y, etal., Stroke. 2008 Aug;39(8):2211-8. Epub 2008 Jun 19.
18. Effects of ticlopidine on pharmacokinetics of losartan and its main metabolite EXP-3174 in rats. Yang SH, etal., Acta Pharmacol Sin. 2011 Jul;32(7):967-72. doi: 10.1038/aps.2011.32. Epub 2011 Jun 13.
19. In-vitro metabolism of glycyrrhetinic acid by human and rat liver microsomes and its interactions with six CYP substrates. Zhao K, etal., J Pharm Pharmacol. 2012 Oct;64(10):1445-51. doi: 10.1111/j.2042-7158.2012.01516.x. Epub 2012 May 2.
Additional References at PubMed
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PMID:15770075   PMID:15778453   PMID:15801936   PMID:15817670   PMID:15820320   PMID:15882469   PMID:15896485   PMID:15900215   PMID:15900284   PMID:15901749   PMID:15931768   PMID:15932952  
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PMID:19802823   PMID:19812066   PMID:19823875   PMID:19833260   PMID:19842932   PMID:19846565   PMID:19865079   PMID:19907160   PMID:19913121   PMID:19921206   PMID:19926050   PMID:19934400  
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PMID:22101235   PMID:22106171   PMID:22108774   PMID:22157006   PMID:22194603   PMID:22277676   PMID:22292071   PMID:22333269   PMID:22369694   PMID:22388796   PMID:22472546   PMID:22510778  
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PMID:32366712   PMID:32423188   PMID:32456253   PMID:32464168   PMID:32485484   PMID:32713008   PMID:32738269   PMID:32794756   PMID:32814053   PMID:32818874   PMID:32843687   PMID:32949580  
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PMID:37584614   PMID:37615099   PMID:37686184   PMID:37759317   PMID:37863381   PMID:37902256   PMID:37935069   PMID:37958656   PMID:37962984   PMID:38117809   PMID:38176619   PMID:38199567  
PMID:38457234   PMID:38884784   PMID:38996572   PMID:39079373  


Genomics

Comparative Map Data
CYP3A4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38799,756,967 - 99,784,184 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl799,756,959 - 99,784,274 (-)Ensemblhg38GRCh38
GRCh37799,354,590 - 99,381,807 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36799,192,540 - 99,219,744 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34798,999,254 - 99,026,459NCBI
Celera794,088,849 - 94,116,044 (-)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef793,991,011 - 94,018,230 (-)NCBIHuRef
CHM1_1799,284,687 - 99,311,925 (-)NCBICHM1_1
T2T-CHM13v2.07100,996,482 - 101,023,683 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2798,714,396 - 98,741,615 (-)NCBI
Cyp3a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81214,321,771 - 14,343,886 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1214,321,771 - 14,343,857 (-)EnsemblGRCr8
mRatBN7.2129,207,978 - 9,230,064 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl129,015,383 - 9,285,008 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1210,009,578 - 10,031,654 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01210,632,755 - 10,654,831 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0129,656,186 - 9,678,268 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01211,641,500 - 11,677,818 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1211,655,402 - 11,733,136 (-)Ensemblrn6Rnor6.0
Rnor_5.01213,719,927 - 13,740,743 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4129,517,016 - 9,541,000 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1210,992,673 - 11,037,068 (-)NCBICelera
RGSC_v3.1129,546,940 - 9,570,928 (-)NCBI
Cytogenetic Map12p11NCBI
CYP3A4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26117,681,786 - 117,708,910 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17165,946,433 - 165,973,544 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0791,797,037 - 91,824,696 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17105,230,666 - 105,258,401 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7105,230,666 - 105,258,401 (-)EnsemblpanPan2panpan1.1
CYP3A4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.169,836,685 - 9,869,520 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl69,777,659 - 9,869,352 (-)EnsemblcanFam3CanFam3.1
ROS_Cfam_1.069,832,300 - 9,903,807 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl69,659,807 - 9,864,478 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.169,696,608 - 9,729,112 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.069,680,218 - 9,712,769 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.069,914,720 - 9,947,146 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
CYP3A4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12813,297,566 - 13,330,023 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660702,940,765 - 2,971,719 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in CYP3A4
29 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh37/hg19 7q21.2-22.1(chr7:92445452-99686985)x1 copy number loss Split hand-foot malformation 1 [RCV000656540] Chr7:92445452..99686985 [GRCh37]
Chr7:7q21.2-22.1		 pathogenic
NC_000007.14:g.99784473C>T single nucleotide variant CYP3A4 PROMOTER POLYMORPHISM [RCV000018417]|Cyp3a4-v [RCV000018418]|not provided [RCV004711997] Chr7:99784473 [GRCh38]
Chr7:99382096 [GRCh37]
Chr7:7q22.1		 pathogenic|benign|drug response
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7q22.1(chr7:99195836-100348063)x3 copy number gain See cases [RCV000135630] Chr7:99195836..100348063 [GRCh38]
Chr7:98793459..99945686 [GRCh37]
Chr7:98631395..99783622 [NCBI36]
Chr7:7q22.1		 likely benign
GRCh38/hg38 7q21.3-22.1(chr7:98288474-101259804)x3 copy number gain See cases [RCV000053573] Chr7:98288474..101259804 [GRCh38]
Chr7:97917786..100903085 [GRCh37]
Chr7:97755722..100689805 [NCBI36]
Chr7:7q21.3-22.1		 pathogenic
GRCh38/hg38 7q22.1(chr7:99219420-100902269)x1 copy number loss See cases [RCV000054154] Chr7:99219420..100902269 [GRCh38]
Chr7:98817043..100499889 [GRCh37]
Chr7:98654979..100337825 [NCBI36]
Chr7:7q22.1		 pathogenic
NM_017460.5(CYP3A4):c.940C>T (p.Leu314Phe) single nucleotide variant Malignant melanoma [RCV000068037] Chr7:99763941 [GRCh38]
Chr7:99361564 [GRCh37]
Chr7:99199500 [NCBI36]
Chr7:7q22.1		 not provided
NM_017460.5(CYP3A4):c.865+667C>A single nucleotide variant Lung cancer [RCV000106735] Chr7:99765710 [GRCh38]
Chr7:99363333 [GRCh37]
Chr7:7q22.1		 uncertain significance
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7q22.1(chr7:99195836-102258175)x1 copy number loss See cases [RCV000135782] Chr7:99195836..102258175 [GRCh38]
Chr7:98793459..101718950 [GRCh37]
Chr7:98631395..101688175 [NCBI36]
Chr7:7q22.1		 pathogenic|uncertain significance
NM_017460.6(CYP3A4):c.1463C>A (p.Pro488His) single nucleotide variant not specified [RCV000216029] Chr7:99758182 [GRCh38]
Chr7:99355805 [GRCh37]
Chr7:7q22.1		 uncertain significance
TMEM106B-BRAF fusion deletion Pleomorphic xanthoastrocytoma [RCV000454357] Chr7:12258147..140494267 [GRCh37]
Chr7:7p21.3-q34		 pathogenic
GRCh38/hg38 7q21.3-36.3(chr7:97419852-158923762)x3 copy number gain See cases [RCV000136717] Chr7:97419852..158923762 [GRCh38]
Chr7:97049164..158716453 [GRCh37]
Chr7:96887100..158409214 [NCBI36]
Chr7:7q21.3-36.3		 pathogenic
GRCh38/hg38 7q22.1(chr7:99643456-99913142)x3 copy number gain See cases [RCV000140269] Chr7:99643456..99913142 [GRCh38]
Chr7:99241079..99510765 [GRCh37]
Chr7:99079015..99348701 [NCBI36]
Chr7:7q22.1		 likely benign
GRCh37/hg19 7p22.3-q36.3(chr7:43360-159119707)x1 copy number loss See cases [RCV000446044] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7q22.1-36.3(chr7:98969247-159119707)x3 copy number gain See cases [RCV000447709] Chr7:98969247..159119707 [GRCh37]
Chr7:7q22.1-36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707) copy number gain See cases [RCV000510686] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707)x3 copy number gain See cases [RCV000511549] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
NM_017460.6(CYP3A4):c.375A>T (p.Glu125Asp) single nucleotide variant not specified [RCV004301653] Chr7:99770179 [GRCh38]
Chr7:99367802 [GRCh37]
Chr7:7q22.1		 uncertain significance
GRCh37/hg19 7q22.1(chr7:98847725-102472176)x1 copy number loss not provided [RCV000682904] Chr7:98847725..102472176 [GRCh37]
Chr7:7q22.1		 pathogenic
NC_000007.13:g.(20954043_21001537)_(114528369_114556605)inv inversion Childhood apraxia of speech [RCV000234948] Chr7:21001537..114528369 [GRCh37]
Chr7:7p15.3-q31.1		 pathogenic
NM_017460.6(CYP3A4):c.579C>T (p.Ile193=) single nucleotide variant not provided [RCV000947046] Chr7:99768445 [GRCh38]
Chr7:99366068 [GRCh37]
Chr7:7q22.1		 benign
GRCh37/hg19 7q22.1-36.3(chr7:98693388-159119707)x3 copy number gain not provided [RCV000682911] Chr7:98693388..159119707 [GRCh37]
Chr7:7q22.1-36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10704-159122532)x3 copy number gain not provided [RCV000746278] Chr7:10704..159122532 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:44935-159126310)x3 copy number gain not provided [RCV000746280] Chr7:44935..159126310 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10365-159119707)x3 copy number gain not provided [RCV000848126] Chr7:10365..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
NM_017460.6(CYP3A4):c.1253+9C>T single nucleotide variant not provided [RCV000954679] Chr7:99762032 [GRCh38]
Chr7:99359655 [GRCh37]
Chr7:7q22.1		 benign
GRCh37/hg19 7q22.1(chr7:98758955-99368262)x1 copy number loss not provided [RCV000848016] Chr7:98758955..99368262 [GRCh37]
Chr7:7q22.1		 uncertain significance
NM_017460.6(CYP3A4):c.1088C>T (p.Thr363Met) single nucleotide variant not provided [RCV000830071] Chr7:99762206 [GRCh38]
Chr7:99359829 [GRCh37]
Chr7:7q22.1		 likely benign
Single allele complex Ring chromosome 7 [RCV002280646] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
NM_017460.6(CYP3A4):c.902T>C (p.Ile301Thr) single nucleotide variant Vitamin D-dependent rickets, type 3 [RCV001261942] Chr7:99763979 [GRCh38]
Chr7:99361602 [GRCh37]
Chr7:7q22.1		 pathogenic
NM_017460.6(CYP3A4):c.640G>T (p.Asp214Tyr) single nucleotide variant not specified [RCV004608541] Chr7:99768384 [GRCh38]
Chr7:99366007 [GRCh37]
Chr7:7q22.1		 uncertain significance
GRCh37/hg19 7p22.3-q36.3(chr7:56604613-96692931)x1 copy number loss See cases [RCV002287832] Chr7:56604613..96692931 [GRCh37]
Chr7:7p22.3-q36.3		 uncertain significance
GRCh38/hg38 7q22.1(chr7:98454022-100723798)x1 copy number loss Multiple congenital anomalies/dysmorphic syndrome [RCV003327701] Chr7:98454022..100723798 [GRCh38]
Chr7:7q22.1		 pathogenic
NM_017460.6(CYP3A4):c.1327A>G (p.Ile443Val) single nucleotide variant not specified [RCV004370459] Chr7:99760908 [GRCh38]
Chr7:99358531 [GRCh37]
Chr7:7q22.1		 uncertain significance
NM_017460.6(CYP3A4):c.600A>G (p.Gln200=) single nucleotide variant CYP3A4-related disorder [RCV003962239] Chr7:99768424 [GRCh38]
Chr7:99366047 [GRCh37]
Chr7:7q22.1		 likely benign
NM_017460.6(CYP3A4):c.878T>C (p.Leu293Pro) single nucleotide variant Vitamin D-dependent rickets, type 3 [RCV005035962] Chr7:99764003 [GRCh38]
Chr7:99361626 [GRCh37]
Chr7:7q22.1		 uncertain significance
NM_017460.6(CYP3A4):c.325G>A (p.Gly109Ser) single nucleotide variant Vitamin D-dependent rickets, type 3 [RCV005360111] Chr7:99770229 [GRCh38]
Chr7:99367852 [GRCh37]
Chr7:7q22.1		 uncertain significance
GRCh37/hg19 7q21.12-22.1(chr7:87477185-100333327) copy number gain Isolated Pierre-Robin syndrome [RCV001352649] Chr7:87477185..100333327 [GRCh37]
Chr7:7q21.12-22.1		 pathogenic
NM_017460.6(CYP3A4):c.1461dup (p.Pro488fs) duplication not provided [RCV001752887] Chr7:99758183..99758184 [GRCh38]
Chr7:99355806..99355807 [GRCh37]
Chr7:7q22.1		 likely benign
NM_017460.6(CYP3A4):c.671-202C>T single nucleotide variant tacrolimus response - Metabolism/PK [RCV001787698] Chr7:99767460 [GRCh38]
Chr7:99365083 [GRCh37]
Chr7:7q22.1		 drug response
GRCh37/hg19 7q22.1(chr7:98755291-99886571)x3 copy number gain not provided [RCV001836489] Chr7:98755291..99886571 [GRCh37]
Chr7:7q22.1		 uncertain significance
NC_000007.13:g.(?_97816327)_(99382096_?)dup duplication not provided [RCV001916368] Chr7:97816327..99382096 [GRCh37]
Chr7:7q21.3-22.1		 uncertain significance
NC_000007.13:g.(?_98983338)_(100860555_?)del deletion not provided [RCV001877526] Chr7:98983338..100860555 [GRCh37]
Chr7:7q22.1		 pathogenic|uncertain significance
NC_000007.13:g.(?_98507659)_(100860555_?)dup duplication not provided [RCV003113282] Chr7:98507659..100860555 [GRCh37]
Chr7:7q22.1		 uncertain significance
NM_017460.6(CYP3A4):c.73T>C (p.Tyr25His) single nucleotide variant not specified [RCV004327275] Chr7:99780084 [GRCh38]
Chr7:99377707 [GRCh37]
Chr7:7q22.1		 uncertain significance
NM_017460.6(CYP3A4):c.1040A>G (p.Tyr347Cys) single nucleotide variant not specified [RCV004117833] Chr7:99762254 [GRCh38]
Chr7:99359877 [GRCh37]
Chr7:7q22.1		 uncertain significance
NM_017460.6(CYP3A4):c.576C>G (p.Asn192Lys) single nucleotide variant not specified [RCV004092212] Chr7:99768448 [GRCh38]
Chr7:99366071 [GRCh37]
Chr7:7q22.1		 uncertain significance
NM_017460.6(CYP3A4):c.1026+12G>A single nucleotide variant fentanyl response - Dosage [RCV003228705]|tacrolimus response - Metabolism/PK [RCV003228706] Chr7:99763843 [GRCh38]
Chr7:99361466 [GRCh37]
Chr7:7q22.1		 drug response
GRCh37/hg19 7q22.1(chr7:99263437-100105272)x1 copy number loss not provided [RCV003482973] Chr7:99263437..100105272 [GRCh37]
Chr7:7q22.1		 uncertain significance
GRCh37/hg19 7q22.1(chr7:99114000-101878272)x1 copy number loss not provided [RCV003482971] Chr7:99114000..101878272 [GRCh37]
Chr7:7q22.1		 pathogenic
NM_017460.6(CYP3A4):c.219-8T>C single nucleotide variant Vitamin D-dependent rickets, type 3 [RCV004818831] Chr7:99772697 [GRCh38]
Chr7:99370320 [GRCh37]
Chr7:7q22.1		 uncertain significance
NM_017460.6(CYP3A4):c.614A>G (p.Glu205Gly) single nucleotide variant not provided [RCV003433970] Chr7:99768410 [GRCh38]
Chr7:99366033 [GRCh37]
Chr7:7q22.1		 uncertain significance
GRCh37/hg19 7q22.1(chr7:98396469-102108193)x1 copy number loss not specified [RCV003986701] Chr7:98396469..102108193 [GRCh37]
Chr7:7q22.1		 likely pathogenic
NM_017460.6(CYP3A4):c.1154G>A (p.Gly385Glu) single nucleotide variant not specified [RCV004370458] Chr7:99762140 [GRCh38]
Chr7:99359763 [GRCh37]
Chr7:7q22.1		 uncertain significance
NC_000007.13:g.(?_94024344)_(100860555_?)del deletion not provided [RCV004578536] Chr7:94024344..100860555 [GRCh37]
Chr7:7q21.3-22.1		 pathogenic
NM_017460.6(CYP3A4):c.1046C>T (p.Thr349Ile) single nucleotide variant not specified [RCV004913341] Chr7:99762248 [GRCh38]
Chr7:99359871 [GRCh37]
Chr7:7q22.1		 uncertain significance
NM_017460.6(CYP3A4):c.1245C>G (p.Leu415=) single nucleotide variant not provided [RCV005245030] Chr7:99762049 [GRCh38]
Chr7:99359672 [GRCh37]
Chr7:7q22.1		 likely benign
NM_017460.6(CYP3A4):c.1359dup (p.Leu454fs) duplication Vitamin D-dependent rickets, type 3 [RCV005400584] Chr7:99760875..99760876 [GRCh38]
Chr7:99358498..99358499 [GRCh37]
Chr7:7q22.1		 uncertain significance
miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR27Bhsa-miR-27b-3pMirtarbaseexternal_infoImmunoblot//Luciferase reporter assayFunctional MTI19581388

Predicted Target Of
Summary Value
Count of predictions:858
Count of miRNA genes:520
Interacting mature miRNAs:562
Transcripts:ENST00000336411, ENST00000354593, ENST00000415003, ENST00000480043
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407010530GWAS659506_HCXCL5 measurement, protein measurement, parental genotype effect measurement QTL GWAS659506 (human)3e-08CXCL5 measurement, protein measurement, parental genotype effect measurement79977708799777088Human
628865146GWAS2773375_Hglycohyocholate measurement QTL GWAS2773375 (human)2e-27glycohyocholate measurement79976869399768694Human
597141045GWAS1237119_Hmethionine sulfone measurement QTL GWAS1237119 (human)1e-13methionine sulfone measurement79976869399768694Human
597137076GWAS1233150_Hglycohyocholate measurement QTL GWAS1233150 (human)2e-27glycohyocholate measurement79976869399768694Human
597276570GWAS1372644_HX-17612 measurement QTL GWAS1372644 (human)6e-11X-17612 measurement79976090199760902Human
406920196GWAS569172_Hmethionine sulfone measurement QTL GWAS569172 (human)1e-13methionine sulfone measurement79976869399768694Human
628446992GWAS2355221_HCXCL5 measurement, protein measurement, parental genotype effect measurement QTL GWAS2355221 (human)3e-08protein amount (VT:0010120)79977708799777088Human
597068720GWAS1164794_Htacrolimus measurement QTL GWAS1164794 (human)2e-17blood xenobiotic amount (VT:0010622)79976869399768694Human
628890075GWAS2798304_HX-17612 measurement QTL GWAS2798304 (human)6e-11X-17612 measurement79976090199760902Human
628495294GWAS2403523_Hviral load QTL GWAS2403523 (human)3e-18response to viral infection trait (VT:0010439)79977117799771180Human
406895337GWAS544313_Hglycohyocholate measurement QTL GWAS544313 (human)2e-27glycohyocholate measurement79976869399768694Human
597110332GWAS1206406_Hviral load QTL GWAS1206406 (human)3e-18viral load79977117799771180Human
628865456GWAS2773685_Hmethionine sulfone measurement QTL GWAS2773685 (human)1e-13methionine sulfone measurement79976869399768694Human
597316695GWAS1412769_HX-17357 measurement QTL GWAS1412769 (human)2e-22X-17357 measurement79976869399768694Human
407094701GWAS743677_HX-17357 measurement QTL GWAS743677 (human)2e-22X-17357 measurement79976869399768694Human
597104760GWAS1200834_Hpost-traumatic stress disorder symptom measurement QTL GWAS1200834 (human)0.000005stress-related behavior trait (VT:0010451)79976908699769087Human
628863124GWAS2771353_HX-17357 measurement QTL GWAS2771353 (human)2e-22X-17357 measurement79976869399768694Human
407312983GWAS961959_HX-17612 measurement QTL GWAS961959 (human)6e-11X-17612 measurement79976090199760902Human
407221747GWAS870723_Htacrolimus measurement QTL GWAS870723 (human)2e-17tacrolimus measurement79976869399768694Human
407211293GWAS860269_Hviral load QTL GWAS860269 (human)3e-18viral load79977117799771180Human
406981695GWAS630671_Hpost-traumatic stress disorder symptom measurement QTL GWAS630671 (human)0.000005post-traumatic stress disorder symptom measurement79976908699769087Human
597111658GWAS1207732_HCXCL5 measurement, protein measurement, parental genotype effect measurement QTL GWAS1207732 (human)3e-08CXCL5 measurement, protein measurement, parental genotype effect measurement79977708799777088Human
407275128GWAS924104_Htacrolimus measurement QTL GWAS924104 (human)6e-18blood xenobiotic amount (VT:0010622)79976869399768694Human

Markers in Region
SHGC-16521  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37799,376,166 - 99,376,294UniSTSGRCh37
GRCh37799,320,439 - 99,320,568UniSTSGRCh37
Build 36799,158,375 - 99,158,504RGDNCBI36
Celera794,110,401 - 94,110,529UniSTS
Celera794,054,690 - 94,054,819RGD
Cytogenetic Map7q21.3-q22.1UniSTS
Cytogenetic Map7q21.1UniSTS
Cytogenetic Map7q21-q22.1UniSTS
HuRef793,956,873 - 93,957,002UniSTS
HuRef794,012,584 - 94,012,712UniSTS
CRA_TCAGchr7v2798,735,969 - 98,736,097UniSTS
CRA_TCAGchr7v2798,680,258 - 98,680,387UniSTS
GeneMap99-G3 RH Map74864.0UniSTS
RH68186  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37799,355,494 - 99,355,723UniSTSGRCh37
Build 36799,193,430 - 99,193,659RGDNCBI36
Celera794,089,739 - 94,089,968RGD
Cytogenetic Map7q21.1UniSTS
Cytogenetic Map7q21.3-q22.1UniSTS
HuRef793,991,922 - 93,992,151UniSTS
CRA_TCAGchr7v2798,715,307 - 98,715,536UniSTS
GeneMap99-GB4 RH Map7515.73UniSTS
SHGC-36965  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37799,364,384 - 99,364,485UniSTSGRCh37
Build 36799,202,320 - 99,202,421RGDNCBI36
Celera794,098,629 - 94,098,730RGD
Cytogenetic Map7q21.3-q22.1UniSTS
Cytogenetic Map7q21.1UniSTS
HuRef794,000,812 - 94,000,913UniSTS
CRA_TCAGchr7v2798,724,197 - 98,724,298UniSTS
TNG Radiation Hybrid Map742908.0UniSTS
D7S2832  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37799,355,420 - 99,355,752UniSTSGRCh37
Build 36799,193,356 - 99,193,688RGDNCBI36
Celera794,089,665 - 94,089,997RGD
Cytogenetic Map7q21.3-q22.1UniSTS
Cytogenetic Map7q21.1UniSTS
HuRef793,991,848 - 93,992,180UniSTS
CRA_TCAGchr7v2798,715,233 - 98,715,565UniSTS
TNG Radiation Hybrid Map742908.0UniSTS
GeneMap99-GB4 RH Map7511.03UniSTS
Whitehead-RH Map7474.3UniSTS
Whitehead-YAC Contig Map7 UniSTS
GeneMap99-G3 RH Map74829.0UniSTS
CYP3A4_2210  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37799,354,516 - 99,355,303UniSTSGRCh37
Build 36799,192,452 - 99,193,239RGDNCBI36
Celera794,088,761 - 94,089,548RGD
HuRef793,990,944 - 93,991,731UniSTS
CRA_TCAGchr7v2798,714,329 - 98,715,116UniSTS
D7S2874  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37799,361,364 - 99,361,528UniSTSGRCh37
GRCh37799,258,008 - 99,258,172UniSTSGRCh37
Build 36799,095,944 - 99,096,108RGDNCBI36
Celera793,992,243 - 93,992,407RGD
Celera794,095,609 - 94,095,773UniSTS
Cytogenetic Map7q21.3-q22.1UniSTS
Cytogenetic Map7q21.1UniSTS
HuRef793,894,378 - 93,894,542UniSTS
HuRef793,997,792 - 93,997,956UniSTS
CRA_TCAGchr7v2798,617,812 - 98,617,976UniSTS
CRA_TCAGchr7v2798,721,177 - 98,721,341UniSTS
CYPNOA  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37799,355,374 - 99,355,438UniSTSGRCh37
Build 36799,193,310 - 99,193,374RGDNCBI36
Celera794,089,619 - 94,089,683RGD
Cytogenetic Map7q21.1UniSTS
Cytogenetic Map7q21.3-q22.1UniSTS
HuRef793,991,802 - 93,991,866UniSTS
CRA_TCAGchr7v2798,715,187 - 98,715,251UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
1175 2346 2698 2081 4515 1657 2066 3 614 1531 452 2108 6569 5816 13 3407 782 1575 1360 165

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_008421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001202855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_017460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC069294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF182273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF209389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF280107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF307089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY606313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC069352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC069418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC101631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH236956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D00003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA639071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ005611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ924960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M13785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M14096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M18907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X12387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000336411   ⟹   ENSP00000337915
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl799,757,676 - 99,784,184 (-)Ensembl
Ensembl Acc Id: ENST00000354593   ⟹   ENSP00000346607
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl799,756,960 - 99,784,188 (-)Ensembl
Ensembl Acc Id: ENST00000415003   ⟹   ENSP00000397208
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl799,770,132 - 99,784,184 (-)Ensembl
Ensembl Acc Id: ENST00000480043
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl799,769,535 - 99,780,053 (-)Ensembl
Ensembl Acc Id: ENST00000651162
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl799,757,679 - 99,767,822 (-)Ensembl
Ensembl Acc Id: ENST00000651514   ⟹   ENSP00000498939
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl799,756,967 - 99,784,184 (-)Ensembl
Ensembl Acc Id: ENST00000651783   ⟹   ENSP00000498924
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl799,758,133 - 99,783,403 (-)Ensembl
Ensembl Acc Id: ENST00000652018   ⟹   ENSP00000498733
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl799,757,683 - 99,784,248 (-)Ensembl
Ensembl Acc Id: ENST00000859200   ⟹   ENSP00000529259
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl799,756,959 - 99,784,274 (-)Ensembl
Ensembl Acc Id: ENST00000859201   ⟹   ENSP00000529260
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl799,756,969 - 99,784,274 (-)Ensembl
Ensembl Acc Id: ENST00000859202   ⟹   ENSP00000529261
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl799,756,969 - 99,784,184 (-)Ensembl
Ensembl Acc Id: ENST00000859203   ⟹   ENSP00000529262
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl799,756,969 - 99,784,184 (-)Ensembl
Ensembl Acc Id: ENST00000859204   ⟹   ENSP00000529263
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl799,756,969 - 99,784,184 (-)Ensembl
Ensembl Acc Id: ENST00000859205   ⟹   ENSP00000529264
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl799,756,981 - 99,784,184 (-)Ensembl
Ensembl Acc Id: ENST00000859206   ⟹   ENSP00000529265
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl799,756,983 - 99,784,184 (-)Ensembl
Ensembl Acc Id: ENST00000859207   ⟹   ENSP00000529266
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl799,757,675 - 99,784,192 (-)Ensembl
Ensembl Acc Id: ENST00000859208   ⟹   ENSP00000529267
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl799,757,674 - 99,784,184 (-)Ensembl
Ensembl Acc Id: ENST00000859209   ⟹   ENSP00000529268
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl799,757,677 - 99,784,184 (-)Ensembl
Ensembl Acc Id: ENST00000859210   ⟹   ENSP00000529269
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl799,757,683 - 99,784,184 (-)Ensembl
Ensembl Acc Id: ENST00000859211   ⟹   ENSP00000529270
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl799,757,683 - 99,784,184 (-)Ensembl
Ensembl Acc Id: ENST00000859212   ⟹   ENSP00000529271
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl799,757,683 - 99,784,184 (-)Ensembl
Ensembl Acc Id: ENST00000859213   ⟹   ENSP00000529272
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl799,757,683 - 99,784,184 (-)Ensembl
Ensembl Acc Id: ENST00000859214   ⟹   ENSP00000529273
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl799,757,683 - 99,784,184 (-)Ensembl
Ensembl Acc Id: ENST00000859215   ⟹   ENSP00000529274
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl799,757,683 - 99,784,181 (-)Ensembl
RefSeq Acc Id: NM_001202855   ⟹   NP_001189784
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38799,756,967 - 99,784,184 (-)NCBI
GRCh37799,354,583 - 99,381,811 (-)ENTREZGENE
HuRef793,991,011 - 94,018,230 (-)ENTREZGENE
CHM1_1799,284,687 - 99,311,925 (-)NCBI
T2T-CHM13v2.07100,996,482 - 101,023,683 (-)NCBI
CRA_TCAGchr7v2798,714,396 - 98,741,615 (-)ENTREZGENE
Sequence:
RefSeq Acc Id: NM_017460   ⟹   NP_059488
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38799,756,967 - 99,784,184 (-)NCBI
GRCh37799,354,583 - 99,381,811 (-)ENTREZGENE
Build 36799,192,540 - 99,219,744 (-)NCBI Archive
HuRef793,991,011 - 94,018,230 (-)ENTREZGENE
CHM1_1799,284,687 - 99,311,925 (-)NCBI
T2T-CHM13v2.07100,996,482 - 101,023,683 (-)NCBI
CRA_TCAGchr7v2798,714,396 - 98,741,615 (-)ENTREZGENE
Sequence:
RefSeq Acc Id: NP_001189784   ⟸   NM_001202855
- Peptide Label: isoform 2
- UniProtKB: Q86SK3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_059488   ⟸   NM_017460
- Peptide Label: isoform 1
- UniProtKB: Q16757 (UniProtKB/Swiss-Prot),   P05184 (UniProtKB/Swiss-Prot),   Q9UK50 (UniProtKB/Swiss-Prot),   P08684 (UniProtKB/Swiss-Prot),   Q6GRK0 (UniProtKB/TrEMBL),   Q86SK3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000337915   ⟸   ENST00000336411
Ensembl Acc Id: ENSP00000397208   ⟸   ENST00000415003
Ensembl Acc Id: ENSP00000498924   ⟸   ENST00000651783
Ensembl Acc Id: ENSP00000498939   ⟸   ENST00000651514
Ensembl Acc Id: ENSP00000498733   ⟸   ENST00000652018
Ensembl Acc Id: ENSP00000346607   ⟸   ENST00000354593
Ensembl Acc Id: ENSP00000529268   ⟸   ENST00000859209
Ensembl Acc Id: ENSP00000529269   ⟸   ENST00000859210
Ensembl Acc Id: ENSP00000529261   ⟸   ENST00000859202
Ensembl Acc Id: ENSP00000529264   ⟸   ENST00000859205
Ensembl Acc Id: ENSP00000529263   ⟸   ENST00000859204
Ensembl Acc Id: ENSP00000529271   ⟸   ENST00000859212
Ensembl Acc Id: ENSP00000529272   ⟸   ENST00000859213
Ensembl Acc Id: ENSP00000529266   ⟸   ENST00000859207
Ensembl Acc Id: ENSP00000529267   ⟸   ENST00000859208
Ensembl Acc Id: ENSP00000529262   ⟸   ENST00000859203
Ensembl Acc Id: ENSP00000529270   ⟸   ENST00000859211
Ensembl Acc Id: ENSP00000529265   ⟸   ENST00000859206
Ensembl Acc Id: ENSP00000529274   ⟸   ENST00000859215
Ensembl Acc Id: ENSP00000529260   ⟸   ENST00000859201
Ensembl Acc Id: ENSP00000529259   ⟸   ENST00000859200
Ensembl Acc Id: ENSP00000529273   ⟸   ENST00000859214

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08684-F1-model_v2 AlphaFold P08684 1-503 view protein structure

Promoters
RGD ID:7211255
Promoter ID:EPDNEW_H11373
Type:multiple initiation site
Name:CYP3A4_1
Description:cytochrome P450 family 3 subfamily A member 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H11374  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38799,784,184 - 99,784,244EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:2637 AgrOrtholog
COSMIC CYP3A4 COSMIC
Ensembl Genes ENSG00000160868 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000651514 ENTREZGENE
  ENST00000651514.1 UniProtKB/Swiss-Prot
  ENST00000859200 ENTREZGENE
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot
GTEx ENSG00000160868 GTEx
HGNC ID HGNC:2637 ENTREZGENE
Human Proteome Map CYP3A4 Human Proteome Map
InterPro Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_E_CYP3A UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-II UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot
  Cytochrome_P450_3A UniProtKB/Swiss-Prot
KEGG Report hsa:1576 UniProtKB/Swiss-Prot
NCBI Gene 1576 ENTREZGENE
OMIM 124010 OMIM
PANTHER CYTOCHROME P450 3A4 UniProtKB/Swiss-Prot
  CYTOCHROME P450 FAMILY 3 UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot
PharmGKB CYP3A4 RGD, PharmGKB
PRINTS EP450II UniProtKB/Swiss-Prot
  EP450IICYP3A UniProtKB/Swiss-Prot
  P450 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
UniProt A0A494C0W7_HUMAN UniProtKB/TrEMBL
  A0A499FJM4_HUMAN UniProtKB/TrEMBL
  C9JBD2_HUMAN UniProtKB/TrEMBL
  CP3A4_HUMAN UniProtKB/Swiss-Prot
  E7EVM8_HUMAN UniProtKB/TrEMBL
  P05184 ENTREZGENE
  P08684 ENTREZGENE
  Q16757 ENTREZGENE
  Q6GRK0 ENTREZGENE, UniProtKB/TrEMBL
  Q7Z448_HUMAN UniProtKB/TrEMBL
  Q86SK3 ENTREZGENE, UniProtKB/TrEMBL
  Q9UK50 ENTREZGENE
UniProt Secondary P05184 UniProtKB/Swiss-Prot
  Q16757 UniProtKB/Swiss-Prot
  Q9UK50 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-15 CYP3A4  cytochrome P450 family 3 subfamily A member 4    cytochrome P450, family 3, subfamily A, polypeptide 4  Symbol and/or name change 5135510 APPROVED