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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A4
Name: cytochrome P450 family 3 subfamily A member 4
Acc ID: CHEBI:16227
Term: pyridine
Definition: An azaarene comprising a benzene core in which one -CH group is replaced by a nitrogen atom. It is the parent compound of the class pyridines.
Chemical ID: MESH:C023666
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A4increases activityISOCyp3a2 (Rattus norvegicus)6480464CTDpyridine results in increased activity of CYP3A2 proteinPMID:11181506
CYP3A4increases expressionISOCyp3a2 (Rattus norvegicus)6480464CTDpyridine results in increased expression of CYP3A2 mRNA; pyridine results in increased expression of CYP3A2 proteinPMID:11181506
CYP3A4multiple interactionsISOCyp3a2 (Rattus norvegicus)6480464CTDcordycepin inhibits the reaction [pyridine results in increased expression of CYP3A2 mRNA]; Cycloheximide inhibits the reaction [pyridine results in increased expression of CYP3A2 mRNA]; Dactinomycin inhibits the reaction [pyridine results in increased expression of CYP3A2 mRNA]PMID:11181506
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