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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A4
Name: cytochrome P450 family 3 subfamily A member 4
Acc ID: CHEBI:39421
Term: perfluorooctane-1-sulfonic acid
Definition: A perfluoroalkanesulfonic acid that is octane-1-sulfonic acid in which all seventeen of the hydrogens that are attached to carbons hvae been replaced by fluorines.
Chemical ID: MESH:C076994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A4decreases activityEXP 6480464CTDperfluorooctane sulfonic acid results in decreased activity of CYP3A4 proteinPMID:31809754 PMID:35121066
CYP3A4decreases expressionEXP 6480464CTDperfluorooctane sulfonic acid results in decreased expression of CYP3A4 mRNAPMID:31809754
CYP3A4increases expressionEXP 6480464CTDperfluorooctane sulfonic acid results in increased expression of CYP3A4 mRNAPMID:21723365 PMID:23567314 PMID:27153767 PMID:32253466 PMID:32588087 PMID:33772556
CYP3A4multiple interactionsEXP 6480464CTDperfluorooctane sulfonic acid inhibits the reaction [CYP3A4 protein results in increased oxidation of Testosterone]PMID:21964418
CYP3A4increases expressionISOCyp3a2 (Rattus norvegicus)6480464CTDperfluorooctane sulfonic acid results in increased expression of CYP3A2 mRNAPMID:16221955 PMID:18692542 PMID:19162173
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