GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CYP3A4 | increases expression | EXP | | 6480464 | CTD | alpha-Tocopherol results in increased expression of CYP3A4 mRNA | PMID:17936189 | CYP3A4 | multiple interactions | EXP | | 6480464 | CTD | alpha-Tocopherol inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Testosterone]; alpha-Tocopherol inhibits the reaction [Galactosamine results in decreased expression of CYP3A4 mRNA]; Galactosamine inhibits the reaction [alpha-Tocopherol results in increased expression of CYP3A4 mRNA] | PMID:17936189 PMID:31102695 | CYP3A4 | multiple interactions | ISO | Cyp3a2 (Rattus norvegicus) | 6480464 | CTD | [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA] | PMID:27919644 | | ||||||||||||||||||||||
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