GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CYP3A4 | affects metabolic processing | EXP | | 6480464 | CTD | CYP3A4 protein affects the metabolism of Nifedipine | PMID:15286053 PMID:15634941 PMID:15784650 | CYP3A4 | affects oxidation | EXP | | 6480464 | CTD | CYP3A4 protein affects the oxidation of Nifedipine | PMID:2271712 | CYP3A4 | increases expression | EXP | | 6480464 | CTD | Nifedipine results in increased expression of CYP3A4 mRNA; Nifedipine results in increased expression of CYP3A4 protein | PMID:16837568 PMID:17954527 PMID:22524704 PMID:25069801 | CYP3A4 | increases hydroxylation | EXP | | 6480464 | CTD | CYP3A4 protein results in increased hydroxylation of Nifedipine | PMID:18846481 | CYP3A4 | increases metabolic processing | EXP | | 6480464 | CTD | CYP3A4 protein results in increased metabolism of Nifedipine | PMID:16712844 PMID:19230594 | CYP3A4 | increases oxidation | EXP | | 6480464 | CTD | CYP3A4 protein results in increased oxidation of Nifedipine | PMID:15618748 PMID:15937564 PMID:20863320 PMID:23146034 | CYP3A4 | multiple interactions | EXP | | 6480464 | CTD | 6',7'-dihydroxybergamottin inhibits the reaction [CYP3A4 protein results in increased oxidation of Nifedipine]; [Nifedipine binds to CYP3A4 promoter] which results in decreased expression of CYP3A4 mRNA; [Nifedipine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; allyl isothiocyanate inhibits the reaction [NR1I2 protein promotes the reaction [Nifedipine results in increased expression of CYP3A4 mRNA]]; Cimetidine inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Nifedipine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Nifedipine]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased oxidation of Nifedipine]; Nifedipine inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]; NR1I2 protein promotes the reaction [Nifedipine results in increased expression of CYP3A4 mRNA]; Troleandomycin inhibits the reaction [CYP3A4 protein results in increased oxidation of Nifedipine]; YM 758 inhibits the reaction [CYP3A4 protein results in increased metabolism of Nifedipine] | PMID:12851153 PMID:17041008 PMID:18846481 PMID:19230594 PMID:19299527 PMID:20863320 PMID:23146034 PMID:25069801 | CYP3A4 | multiple interactions | ISO | Cyp3a2 (Rattus norvegicus) | 6480464 | CTD | [SOD2 co-treated with CYP3A4] affects the susceptibility to Nifedipine; Nifedipine inhibits the reaction [CYP3A2 protein results in increased metabolism of 7-benzyloxyquinoline] | PMID:19501153 PMID:19858067 | | ||||||||||||||||||||||
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