GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CYP3A4 | increases activity | EXP | | 6480464 | CTD | o,p'-DDT results in increased activity of CYP3A4 protein | PMID:17035600 | CYP3A4 | increases expression | EXP | | 6480464 | CTD | o,p'-DDT results in increased expression of CYP3A4 mRNA; o,p'-DDT results in increased expression of CYP3A4 protein | PMID:15548381 PMID:15795092 PMID:17035600 PMID:21924250 | CYP3A4 | multiple interactions | EXP | | 6480464 | CTD | Dactinomycin inhibits the reaction [o,p'-DDT results in increased expression of CYP3A4 mRNA] | PMID:15795092 | CYP3A4 | affects expression | ISO | Cyp3a2 (Rattus norvegicus) | 6480464 | CTD | o,p'-DDT affects the expression of CYP3A2 mRNA | PMID:17984292 | | ||||||||||||||||||||||
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