GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CYP3A4 | increases activity | EXP | | 6480464 | CTD | Calcitriol results in increased activity of CYP3A4 protein | PMID:19766177 | CYP3A4 | increases expression | EXP | | 6480464 | CTD | [Calcitriol results in increased expression of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; Calcitriol results in increased expression of CYP3A4 mRNA; Calcitriol results in increased expression of CYP3A4 protein | PMID:11723248 PMID:15992766 PMID:17270371 PMID:17965521 PMID:19562681 PMID:21742782 PMID:22687401 PMID:26366751 PMID:27107558 PMID:29782822 | CYP3A4 | multiple interactions | EXP | | 6480464 | CTD | 2-acetyltributylcitrate promotes the reaction [Calcitriol results in increased expression of CYP3A4 mRNA]; [Calcitriol binds to and results in increased activity of VDR protein] which results in increased expression of CYP3A4 mRNA; Ajmaline inhibits the reaction [Calcitriol results in increased expression of CYP3A4 protein]; Calcitriol promotes the reaction [2-acetyltributylcitrate results in increased activity of CYP3A4 protein]; Calcitriol promotes the reaction [2-acetyltributylcitrate results in increased expression of CYP3A4 mRNA]; Calcitriol promotes the reaction [Rifampin results in increased activity of CYP3A4 protein]; Calcitriol promotes the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; Calcitriol results in increased expression of and results in increased activity of CYP3A4 protein; chrysin inhibits the reaction [Calcitriol results in increased activity of CYP3A4 protein]; Curcumin inhibits the reaction [Calcitriol results in increased expression of and results in increased activity of CYP3A4 protein]; Curcumin inhibits the reaction [Calcitriol results in increased expression of CYP3A4 mRNA]; Genistein inhibits the reaction [Calcitriol results in increased activity of CYP3A4 protein]; Ketoconazole inhibits the reaction [Calcitriol results in increased expression of CYP3A4 protein]; Plant Extracts inhibits the reaction [Calcitriol results in increased expression of CYP3A4 protein]; pyrazolanthrone inhibits the reaction [Calcitriol results in increased expression of CYP3A4 mRNA]; Quercetin inhibits the reaction [Calcitriol results in increased activity of CYP3A4 protein]; raubasine inhibits the reaction [Calcitriol results in increased expression of CYP3A4 protein]; reserpic acid inhibits the reaction [Calcitriol results in increased expression of CYP3A4 protein]; Reserpine inhibits the reaction [Calcitriol results in increased expression of CYP3A4 protein]; Rifampin promotes the reaction [Calcitriol results in increased expression of CYP3A4 mRNA]; Staurosporine inhibits the reaction [Calcitriol results in increased expression of CYP3A4 mRNA]; VDR protein affects the reaction [Calcitriol results in increased expression of CYP3A4 mRNA]; Yohimbine analog inhibits the reaction [Calcitriol results in increased expression of CYP3A4 protein] | PMID:15489543 PMID:15578590 PMID:17270371 PMID:17965521 PMID:19766177 PMID:21742782 PMID:29782822 | CYP3A4 | increases expression | ISO | Cyp3a2 (Rattus norvegicus) | 6480464 | CTD | Calcitriol results in increased expression of CYP3A2 mRNA | PMID:20006981 | CYP3A4 | multiple interactions | ISO | Cyp3a2 (Rattus norvegicus) | 6480464 | CTD | Chenodeoxycholic Acid inhibits the reaction [Calcitriol results in increased expression of CYP3A2 mRNA] | PMID:20006981 | | ||||||||||||||||||||||
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