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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP3A4
Name: cytochrome P450 family 3 subfamily A member 4
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP3A4multiple interactionsISOCyp3a2 (Rattus norvegicus)6480464CTD[DDT co-treated with Diethylnitrosamine] results in decreased expression of CYP3A2 mRNA; [DDT co-treated with Diethylnitrosamine] results in increased expression of CYP3A2 mRNA; [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in decreased expression of CYP3A2 mRNA; [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased activity of CYP3A2 protein; [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP3A2 mRNA; [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP3A2 protein; [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CYP3A2 mRNA; [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CYP3A2 protein; Diethylnitrosamine results in decreased expression of and results in decreased activity of CYP3A2 proteinPMID:11165752 PMID:15885732 PMID:16246485 PMID:18164116 PMID:29698782 PMID:9744545
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