GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CYP3A4 | multiple interactions | EXP | | 6480464 | CTD | [Berberine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA | PMID:21524698 | CYP3A4 | decreases activity | ISO | Cyp3a2 (Rattus norvegicus) | 6480464 | CTD | Berberine results in decreased activity of CYP3A4 protein | PMID:30086269 | CYP3A4 | decreases expression | ISO | Cyp3a2 (Rattus norvegicus) | 6480464 | CTD | Berberine results in decreased expression of CYP3A4 mRNA; Berberine results in decreased expression of CYP3A4 protein | PMID:30086269 | CYP3A4 | multiple interactions | ISO | Cyp3a2 (Rattus norvegicus) | 6480464 | CTD | Atorvastatin promotes the reaction [Berberine results in decreased activity of CYP3A4 protein]; Berberine promotes the reaction [Atorvastatin results in decreased activity of CYP3A4 protein]; Berberine promotes the reaction [Atorvastatin results in decreased expression of CYP3A4 mRNA]; Berberine promotes the reaction [Atorvastatin results in decreased expression of CYP3A4 protein]; Berberine promotes the reaction [Simvastatin results in decreased activity of CYP3A4 protein]; Berberine promotes the reaction [Simvastatin results in decreased expression of CYP3A4 protein]; Simvastatin promotes the reaction [Berberine results in decreased activity of CYP3A4 protein] | PMID:30086269 | | ||||||||||||||||||||||
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