GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CYP3A4 | increases glutathionylation | EXP | | 6480464 | CTD | CYP3A4 protein results in increased glutathionylation of neferine metabolite | PMID:25451576 | CYP3A4 | multiple interactions | EXP | | 6480464 | CTD | [CYP3A4 protein co-treated with neferine] results in decreased abundance of Glutathione; Acetylcysteine inhibits the reaction [[CYP3A4 protein co-treated with neferine] results in decreased abundance of Glutathione]; Buthionine Sulfoximine promotes the reaction [[CYP3A4 protein co-treated with neferine] results in decreased abundance of Glutathione]; CYP3A4 protein results in increased metabolism of and results in decreased methylation of neferine; neferine promotes the reaction [[CYP3A4 protein co-treated with Buthionine Sulfoximine] results in decreased abundance of Glutathione] | PMID:25451576 | | ||||||||||||||||||||||
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